Regulation of Proteolytic Activity in Tissues

Abstract

Degradation of tissue proteins is controlled by multiple means. These include regulation of the synthesis of proteinases, activation of the zymogen forms, the activity of the mature proteinase, and the degradation of these enzymes and the substrates. Mature proteinases can be controlled by pH, calcium ions, ATP, lipids and the formation of complexes with other proteinases, proteoglycans, and inhibitors.

Key Words:

• proteinases
• zymogen activation
• proteinase inhibitors
• proteasomes