The Hammersmith hospital hematopathology case of the month: hemophagocytic lymphohistiocytosis secondary to Epstein–Barr virus associated T-cell lymphoma

Abstract

We discuss the clinical presentation, investigations carried out, and the management issues in an elderly patient with hemophagocytic lymphohistiocytosis (HLH). The HLH was associated with an underlying Epstein–Barr virus positive peripheral T-cell lymphoma, not otherwise specified, and the lymphomatous cells harbored translocation t(5;9)(q11.2:p24). The 9p24 region contains the JAK2 gene. The disease had a fulminant course.

Keywords:

• Cytogenetics
• lymphoma and Hodgkin disease
• morphology
• infectious complications

Acknowledgement

We thank Dr. Ed Kanfer, Department of Haematology, Hammersmith Hospital for his critical comments.

Potential conflict of interest:

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