Free radicals and acute pancreatitis: Much ado about … something

Abstract

There is a convincing body of evidence that oxidative stress is involved in the pathogenesis of acute pancreatitis. The effects of different radical scavengers suggested that reactive oxygen metabolites are generated at very early stage of disease and contribute to amplify the pancreatic damage. Oxidative stress is also involved in the progression of the disease from a local damage to a systemic organ failure. However, therapeutic use of antioxidants failed to clearly show a clinical benefit in different trials. Therefore, although antioxidants alone seem to be not enough for the treatment of severe acute pancreatitis, future combined therapeutic strategies should include antioxidants in its composition.

Keywords::

• pancreatitis
• xanthine dehydrogenase/xanthine oxidase
• reactive oxygen species
• oxidative damage
• lipid peroxidation

Declaration of interest

The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.