Formulation study of directly compressible chewable polymers containing ascorbic acid

Abstract

The topic of this article is the compression physics of different gum bases which can be used to prepare chewing gum tablets by direct compression. Three different gum bases, Pharmagum^® C, M and S, were tested alone and in different combinations. The preparations were compressed with a Korsch EK0 eccentric tableting machine at compression forces of 5, 7.5, 10, 12.5 and 15 kN. The compression and breaking processes and the physical parameters of the tablets were investigated. The results revealed that increase of the compression force did not significantly change the studied parameters of the tablets.

Keywords::

• Chewing gum
• direct compression
• deformation
• dissolution
• Pharmagum
• ascorbic acid

Acknowledgments

The authors’ thanks go to Erweka GmbH, Heusenstamm, for help with the dissolution investigations.

Declaration of interest

The project named TÁMOP-4.2.1/B-09/1/Konv-2010-0005 − Creating the Center of Excellence at the University of Szeged” is supported by the European Union and co-financed by the European Regional Fund.