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Biomarkers Volume 17, 2012 - Issue 8
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Research Article

Application of faecal metabonomics on an experimental model of tubulointerstitial fibrosis by ultra performance liquid chromatography/high-sensitivity mass spectrometry with MSE data collection technique

Ying-Yong ZhaoKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, the College of Life Sciences, Northwest University, Xi’an, Shaanxi, PR ChinaCorrespondence[email protected] [email protected]
,
Xian-Long ChengNational Institutes for Food and Drug Control, State Food and Drug Administration, 2 Tiantan Xili, Beijing, China
,
Feng WeiNational Institutes for Food and Drug Control, State Food and Drug Administration, 2 Tiantan Xili, Beijing, China
,
Xu BaiWaters Technologies (Shanghai) Ltd., Shanghai, China
&
Rui-Chao LinNational Institutes for Food and Drug Control, State Food and Drug Administration, 2 Tiantan Xili, Beijing, China
Pages 721-729 | Received 27 Jun 2012, Accepted 22 Aug 2012, Published online: 01 Oct 2012
 
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Abstract

Chronic renal failure (CRF) is a major challenge for the public healthcare problem. A novel UPLC Q-TOF/MS method with MSE data collection mode was developed as a very effective biochemical analytical tool for precise identification of important biomarkers in the adenine-induced CRF rats. Nine endogenous metabolites were identified by using metabonomic method combined with multivariate data analysis, the accurate mass, isotopic pattern, MSE fragments information and MassLynx i-FIT algorithm. The identified metabolites indicated the perturbations of bile acid and phospholipid metabolism are related to CRF rats. This work shows that metabonomics method is a valuable tool in CRF mechanism study.

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