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Review Article

Assessing and mitigating pH-mediated DDI risks in drug development – formulation approaches and clinical considerations

Di Wua Pharmaceutical Sciences & Clinical Supply, Merck & Co., Inc, Rahway, NJ, USACorrespondence[email protected]
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Jiaying Liua Pharmaceutical Sciences & Clinical Supply, Merck & Co., Inc, Rahway, NJ, USAView further author information
,
Erickson M. Paragasb Pharmacokinetics and Drug Metabolism Department, Amgen Research, South San Francisco, CA, USAView further author information
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Jaydeep Yadavc Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc, Boston, MA, USAView further author information
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Theresa Aliwargab Pharmacokinetics and Drug Metabolism Department, Amgen Research, South San Francisco, CA, USAView further author information
,
Tycho Heimbacha Pharmaceutical Sciences & Clinical Supply, Merck & Co., Inc, Rahway, NJ, USAView further author information
&
M. Sebastian Escotet-Espinozaa Pharmaceutical Sciences & Clinical Supply, Merck & Co., Inc, Rahway, NJ, USAView further author information
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Received 28 Nov 2023, Accepted 10 Apr 2024, Published online: 03 May 2024

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