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Research Paper
Design, synthesis and evaluation of OA-tacrine hybrids as cholinesterase inhibitors with low neurotoxicity and hepatotoxicity against Alzheimer’s disease
Huali Yanga State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Pharmaceutical Co., Ltd, Jiangsu, Lianyungang, China;b Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, ChinaView further author information
, Hongwei Jiab Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, ChinaView further author information
, Minghui Dengb Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, ChinaView further author information
, Kaicheng Zhangb Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, ChinaView further author information
, Yaoyang Liub Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, ChinaView further author information
, Yang Liub Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Chinahttps://orcid.org/0000-0002-9284-1944View further author information
, Maosheng Chengb Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, ChinaCorrespondence[email protected]
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& View further author information
Wei Xiaoa State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Pharmaceutical Co., Ltd, Jiangsu, Lianyungang, ChinaCorrespondence[email protected]
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Article: 2192439
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Received 16 Jan 2023, Accepted 13 Mar 2023, Published online: 23 Mar 2023
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