Design issues in a randomized controlled trial of a pre-emptive versus empiric antifungal strategy for invasive aspergillosis in patients with high-risk hematologic malignancies

Sharon C.-A. ChenCentre for Infectious Diseases and Microbiology, Westmead, NSW, Australia

Tania C. SorrellCentre for Infectious Diseases and Microbiology and Westmead Millennium Institute, University of Sydney, Westmead, NSW, Australia

Kenneth F. BradstockDepartment of Haematology, Westmead Hospital, Westmead, NSW, Australia

Jeffrey SzerDepartment of Clinical Haematology and BMT Service, Royal Melbourne Hospital, Parkville, VIC, Australia

Catriona L. HallidayCentre for Infectious Diseases and Microbiology Laboratory Services, Westmead, NSW, Australia

Nicole M. GilroyCentre for Infectious Diseases and Microbiology, Westmead, NSW, Australia

Anthony P. SchwarerDepartment of Haematology and Medical Oncology, Box Hill Hospital, Box Hill, VIC, Australia

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