Stem cell-like ALDH^bright cellular states in EGFR-mutant non-small cell lung cancer: A novel mechanism of acquired resistance to erlotinib targetable with the natural polyphenol silibinin

BRUNA COROMINAS-FAJA Metabolism & Cancer Group; Translational Research Laboratory; Catalan Institute of Oncology; Girona, Catalonia, Spain; Girona Biomedical Research Institute (IDIBGI); Girona, Catalonia, Spain

Cristina Oliveras-Ferraros Metabolism & Cancer Group; Translational Research Laboratory; Catalan Institute of Oncology; Girona, Catalonia, Spain; Girona Biomedical Research Institute (IDIBGI); Girona, Catalonia, Spain

ELISABET CUYÀS Metabolism & Cancer Group; Translational Research Laboratory; Catalan Institute of Oncology; Girona, Catalonia, Spain; Girona Biomedical Research Institute (IDIBGI); Girona, Catalonia, Spain

Antonio Segura-Carretero Department of Analytical Chemistry; Faculty of Sciences; University of Granada; Granada, Spain

Jorge Joven Unitat de Recerca Biomèdica (URB-CRB); Institut d'Investigació Sanitaria Pere i Virgili (IISPV); Universitat Rovira i Virgili; Reus, Catalonia, Spain

Begoña Martin-Castillo Girona Biomedical Research Institute (IDIBGI); Girona, Catalonia, Spain; Clinical Research Unit; Catalan Institute of Oncology; Girona, Catalonia, Spain

ENRIQUE BARRAJÓN-CATALÁN Molecular and Cellular Biology Institute (IBMC); Miguel Hernández University; Elche, Alicante, Spain; Monteloeder, Inc.; Elche, Alicante, Spain

Vicente Micol Molecular and Cellular Biology Institute (IBMC); Miguel Hernández University; Elche, Alicante, Spain; Monteloeder, Inc.; Elche, Alicante, Spain

Joaquim Bosch-Barrera Girona Biomedical Research Institute (IDIBGI); Girona, Catalonia, Spain; Medical Oncology; Catalan Institute of Oncology; Girona, Catalonia, Spain

JAVIERABEL MENENDEZ MENENDEZ Girona Biomedical Research Institute (IDIBGI); Girona, Catalonia, Spain; Department of Analytical Chemistry; Faculty of Sciences; University of Granada; Granada, SpainCorrespondence[email protected]

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Stem cell-like ALDH^bright cellular states in EGFR-mutant non-small cell lung cancer: A novel mechanism of acquired resistance to erlotinib targetable with the natural polyphenol silibinin

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Stem cell-like ALDHbright cellular states in EGFR-mutant non-small cell lung cancer: A novel mechanism of acquired resistance to erlotinib targetable with the natural polyphenol silibinin

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Stem cell-like ALDH^bright cellular states in EGFR-mutant non-small cell lung cancer: A novel mechanism of acquired resistance to erlotinib targetable with the natural polyphenol silibinin