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Pharmaceutical Biology Volume 38, 2000 - Issue 1
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Research Article

The Natural Abundance Of L-Canavanine, An Active Anticancer Agent, in Alfalfa, Medicago Sativa (L.)

Gerald A. Rosenthal Laboratory of Biochemical Ecology, University of Kentucky, Lexington, USA
&
Palesa Nkomo Laboratory of Biochemical Ecology, University of Kentucky, Lexington, USA
Pages 1-6 | Published online: 10 Jan 2011

References

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  • Bell EA (1958): Canavanine and related compounds in the Leguminosae. J Biochem 70: 617–619.
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  • Fearon WR (1946): The amidine-pentacyanoferrate reaction: a test for guanidines, urea and thio-ureas. Analyst 71: 562–566.
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  • Kruse PF Jr, McCoy TA (1958): The competitive effect of canavanine on utilization of arginine in the growth of Walker carcinosarcoma 256 cells in vitro. Cancer Res 18: 279–282.
  • Kruse PF Jr, White PB, Carter HA, McCoy TA (1959): Incor-poration of canavanine into protein of Walker carcinosar-coma 256 cells cultured in vitro. Cancer Res 19: 122–125.
  • Malinow MR, Bardana EJ McLaughlin P (1982): Systemic lupus erythematosus-like syndrome in monkeys fed alfalfa sprouts: role of a nonprotein amino acid. Science 216: 415–417.
  • Malinow MR, McLaughlin P, Bardana EJ, Craig S (1984): Elimination of toxicity from diets containing alfalfa sprouts. Chem Toxicol 22: 583–587.
  • Rosenthal GA (1977a): The biological effects and mode of action of L-canavanine, a structural analogue of L-arginine. Q Rev Biol 52: 155–178.
  • Rosenthal GA (1977b): Preparation and colorimetric analysis of L-canavanine. Anal Biochem 77: 147–151.
  • Rosenthal GA (1992): L-canavanine and chemical defense in higher plants. In: Takai, (ed.), Frontiers and New Horizons in Amino Acid Research. New York, Elsevier Publ. Co.
  • Swaffar DS, Ang CY, Desai PB, Rosenthal GA (1994): Inhibition of the growth of human pancreatic cancer cells by the arginine antimetabolite, L-canavanine. Cancer Res 54: 6045–6048.
  • Thomas DA, Rosenthal GA, Gold DV, Dickey K (1986): Growth inhibition of a rat colon tumor by L-canavanine. Cancer Res 46: 2898–2903.
  • Thomas DA, Rosenthal GA (1987): Metabolism of L4guani-dinooxy-I4C1-canavanine in the rat. Toxicol & Appl Pharm 91: 406–414.

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