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Research Article

Antiviral Activity of Compounds Isolated From Plants

Pages 107-157 | Published online: 29 Sep 2008

References

  • Amoros M, Girre L (1987): Structure of two antiviral triterpene saponins from Anagallis arvensis. Phytochemistry 26: 787–791.
  • Amoros M, Lurton E, Boustie J, Girre L (1994): Comparison of the anti-Herpes simplex virus activities of propolis and 3-methyl-but-2-enyl-caffeate. J Nat Prod 57: 644–647.
  • Asano J, Chiba K, Tada M, Yoshi T (1996): Antiviral activity of lignans and their glycosides from Justicia procumbens. Phytochemistry 42: 713–717.
  • Ayres DC, Loike JD (1990): Lignans: Chemical, biological and clinical properties. Cambridge: Cambridge University Press.
  • Becher Y (1976): Monographs in Virology: Antiviral Drugs; Mode of Action and Chemotherapy of Viral Infection of Man. New York, Springer Verlag, and Wien, pp. 144–148.
  • Becher Y (1980): Antiviral agents from natural sources. Phar-macol Ther 10: 119–122.
  • Bedows E, Hatfield GM (1982): An investigation of the antivi-ral activity of Podophyllum peltatum. J Nat Prod 45: 725–729.
  • Beladi I, Pusztai R, Mucsi I, Bakay M, Gabor M (1977): Activ-ity of some flavonoids against viruses. Ann N Y Acad Sci 284: 358–364.
  • Berg All, Labiade RP (1989): Methods in plants biochemistry. In: Harborne JB, Plant Phenolic London, Academic Press.
  • Blevins RD, Dumic MP (1980): The effect of 4-9-tetrahydrocarmabinol on Herpes simplex virus replication. J Gen Virol 49: 427–431.
  • Bloor SJ (1992): Antiviral phloroglucinols from New Zealand Kunzea species. J Nat Prod 55: 43–47.
  • Bokesch HR, McKee TC, Currens MJ, Gulakowski RJ, McMahon JB, Cardellina JH, Boyd MR (1996): HIV-inhibitory gallotannins from Lepidobotrys staudtii. Nat Prod Letters 8: 133–136.
  • Boustie J, Stigliani J, Montanha J, Amoros M, Payard M, Girre L (1998): Antipoliovirus structure activity relationships of some aporphine alkaloids. J Nat Prod 61: 480–484.
  • Champagne DE, Opender K, Isman MB, Scudder E, Towers N (1992): Biological activity of limonoids from Rutales. Phytochemistry 31: 377–394.
  • Chen K, Shi Q, Fujioka T, Zhang D, Qihu C, Jin J (1992): Anti-aids agents 4. Tripterifordin A, novel anti-HIV principle from Triterygium wilfordii: Isolation and structural eluci-dation. J Nat Prod 55: 88–92.
  • Chen D, Zhang S, Wang H, Zhang S, Sun Q, Cosentino L, Lee K (1999): Novel anti-HIV lancilactone C and related triterpenes from Kadsura lancilimba. J Nat Prod 62: 94–97.
  • Clemens MJ (1977): Chemoprophylaxis and Virus Infections of Respiratory Tract II. Cleveland, Ohio, Chemical Rubber Co. Press, pp. 189–190.
  • Cody V, Middleton E, Harborne JB (1986): Plant Flavonoids in Biology and Medicine. New York, Alan R Liss.
  • Cordell GA (1981): Introduction to alkaloids: A biogenetic approach. New York, Wiley.
  • Corthout J, Pieters L, Claeys M, Vanden D, Vlietinck A (1992): Antiviral caffeoyl esters from Spondias mombin. Phyto-chemistry 31: 1979–1981.
  • Cracker LE, Simon J (1986): Herbs, Spices, and Medicinal Plants 2. New York, Harwarth Press, Inc., p. 22. de Clercq E (1973): Selective inhibitors of viral functions. Chemical Rubber Co. Press, Cleveland, Ohio, pp. 78–82.
  • Decostered LA, Parsons IC, Gustafson KR, Cardellina JH, McMahon J, Cragg GM, Murata Y, Pannell LK, Steiner JR, Clardy J (1993): Isolation, structure and synthesis of con-curvone, a potent, novel HIV-inhibitory naphthoquinone timer from Conospermum species. Planta Med 59: A581.
  • Diallo B, Vanhaelen M, Vanhaelen R, Konoshima T, Kozuka M, Tokuda H (1989): Studies on inhibitors of skin-tumor pro-motion inhibitory effects of triterpenes from Cochlosper-mun tinctorium on Epstein-Barr virus activation. J Nat Prod 52: 879–881.
  • Duan H, Takaishi Y, Imakura Y, Jia Y, Li D, Cosentino ML, Lee K (2000): Sesquiterpene alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii: A new class of potent anti-HIV agents. J Nat Prod 63: 357–361.
  • Eberhardt T, Young R (1996): Assessment of the anti-HIV activ-ity of a pine cone isolate. Planta Med 62: 63–65.
  • Elgamal MH, Soliman HS, Karawya M, Mikhova B, Duddeck H (1995): Isolation of triterpenes saponins from Gyp-sophila capilaris. Phytochemistry 38: 1481–1485.
  • El-Mekkawy S, Meselhy MR, Nakamura N, Hattori M, Kawahata T, Otake T (2000): Anti-HIV-1 phorbol esters the seeds of Croton tiglium. Phytochemistry 53: 457–464.
  • Erickson K, Beutler J, Csardellina J, McMahon J (1995): A novel phorbol ester from Excoecaria agallocha. J Nat Prod 58: 769–772.
  • El-Mekkawy S, Meselhy MR, Nakamura N, Tezuka Y, Hattori M, Kakiuchi N, Shimotohno K, Kawahata T, Otake T (1998): Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochemistry 49: 1651–1657.
  • Farnsworth NR, Svoboda GH, Blomster RN (1968): Antiviral activity of selected Catharanthus alkaloids. J Pharm Sci 57: 2174–2175.
  • Feliciano A, Gordaliza M, Del Corral M, Castro M, Gravalos G, Ruiz L (1993): Antineoplastic and antiviral activities of some cyclolignans. Planta Med 59: 246–249.
  • Fenglei Z, Yunlong X, Handong S (1989): Diterpenoids con-stituents of Rabdosia liangshanica. Phytochemistry 28: 1671–1674.
  • Foder GB, Colasanti B (1985): Alkaloids, Chemical and Bio-logical Perspectives 3. New York, Wiley, pp. 1–90.
  • French CJ, Towers N (1992): Inhibition of infectivity of potato virus X by flavonoids. Phytochemistry 31: 3017–3020.
  • Fujioka T, Kashiwada Y, Kilkuskie R, Cosentino M, Ballas L, Jiang B, Janzen W (1994): Anti-AIDS agents 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. J Nat Prod 57: 243–247.
  • Fuller RW, Cardellina JH, Boyd MR (1996): HIV-inhibitory natural products. 28. Diterpene carboxilic acid from fruits of Xylopia sp. Nat Prod Letters 8: 169–172.
  • Gabrielsen B, Monath T, Huggins JW, Kefauver F.m, Pettit G, Groszker (1992): Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances. J Nat Prod 55: 1569–1581.
  • Groweiss A, Cardellina JH, Boyd MR (2000): HIV-inhibitory prenylated xanthones and flavones from Maclura tinctoria. J Nat Prod 63: 1537–1539.
  • Gyorgy E, Koch A (1969): Heart glycosides in poliovirus host cell interaction. Effect of the time of addition on stimula-tory or inhibitory action. Acta Microbiol 16: 197–202.
  • Gustafson KR, Blunt JW, Munro M, Fuller R, McKee C, Cardellina JH, McMahon JB, Cragg, GM (1992): The guttiferones, HIV-inhibitory benzophenones from Symphonia globulifera, Garcinia livinstonei, Garcinia ovalifolia and Clusia rosea. Tetrahedron 48: 10093–10102.
  • Halloch YF, Manfredi KP, Dai J, Cardellina JH, Gulakowski RJ, McMahon J, Schaffer M, Stahl., Gulden K, Bringmann G, Francois G, Boyd M (1997): Michellamines D-F. New HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis. J Nat Prod 60: 677–683.
  • Hanish J, Vajda G, Liona B (1966).The mode of action of emetine. Acta Chir Acad Sci Hung 7: 51–54.
  • Hanson JR (1972): Chemistry of Terpenes and Terpenoids 155. New York, Academic Press.
  • Harborne JB (1988): The Flavonoids: Advances in research since 1980. London Chapman and Hall.
  • Harborne JB, Baxter H (1993): Phytochemical Dictionary a Handbook of Bioactive Compounds from Plants. Ed. London, Burgess Science Press Basingstoke, pp. 12–567.
  • Hasegawa H, Matsumiya S, Uchiyama M, Kurokawa T, Inouye Y, Kasai R, Ishibashi S, Yamasaki K (1994): Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities. Planta Med 60: 240–243.
  • Hatano T, Yasuhara T, Miyamoto K, Okuda T (1988): Anti-human inmunodeficiency virus phenolics from licorice. Chem Pharm Bull 36: 1386–1388.
  • Hayashi K, Niwayama S, Hayashi T, Nago R, Ochiai H, Morita N (1988): In vitro and in vivo antiviral activity of sco-padulcis acid B from Scoparia dukis, Scrophulariaceae, against Herpes simplex virus type 1. Antiviral Res 9: 345–354.
  • Hayashi T, Hayashi K, Uchida K, Niwayama S, Morita N (1990): Antiviral agents of plant origin II. Antiviral activity of sco-padulcic acid B derivatives. Chem Pharm Bull 38: 239–242.
  • Hiller K (1987): New results on the structure and biological activity of triterpenoid saponins. In: Hostettmann K, Lea PJ, eds, Oxford, Clarendon Press, pp. 167-168.
  • Hu K, Kobayashi H, Dong A, Iwasaki S, Yao X (2000): Anti-fungal, antimitotic and anti-HIV-1 agents from the roots of Wikstroemia indica. Planta Med 66: 564–567.
  • Huang R, Chen C, Huang H, Chang C, Chen C, Chang C, Hsieh M (2000): Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis. Planta Med 66: 694–698.
  • Hudson JB, Graham EA, Fong R, Finlayson J, Towers G (1986a): Antiviral properties of thiaubrine-A, a naturally occurring polyine. Planta Med 52: 51–54.
  • Hudson JB, Graham EA, Chan G, Finlayson J, Towers G (1986b): Comparison of the antiviral effects of naturally occurring thiophenes and polyacetylenes. Planta Med 52: 453–457.
  • Hudson JB, Harris L, Towers, GH (1993): The importance of light in anti-HIV effect of hypericin, Antiviral Research 20: 173–178.
  • Ieven M, Vlietinck AJ, Vanden DA, Berghe V, Totte J (1982): Plant antiviral agents. III. Isolation of alkaloids from Clivia miniata Regel. (Amaryllidaceae). J Nat Prod 45: 564–573.
  • Inada A, Somekawa M, Murata H, Nakanishi T, Tokuda H, Nishino H (1993): Phytochemical studies on Meliaceous plants. VIII. Structures and inhibitory effects Epstein-Barr virus activation of triterpenoids from leaves of Chisocheton macrophyllus King. Chem Pharm Bull 41: 617–619.
  • Inghman JL (1983): Natural occurring isoflavonoids. Progress in the Chemistry of Organic Natural Products 43: 1–20.
  • Ishikawa T, Nishigaya K, Uchikoshi H, Chen 1(1998): Cochi-nolide, a new y-alkylidene bicyclic butenolide with antivi-ral activity, and its 0-glucopyranoside from Homalium cochinchinesis. J Nat Prod 61: 534–537.
  • Ishitsuka H, Yasuyuki T, Chieko N, Fujiu M, Suhara Y (1982): Direct and specific inactivation of rhinovirus by chalcone Ro 09–0410. Antimicrob Agents Chemother 22: 617–619.
  • Kaij-a-Kamb M, Amoros M, Girre L (1992): Search for new antiviral agent of plant origin. Phar Acta Hely 67: 130–147.
  • Kaluza G, Scholtissek C, Rott R (1972): Inhibition of the mul-tiplication of enveloped RNA-viruses by glucosamine and 2-Deoxy-D-glucose. J Gen Virol 14: 251–259.
  • Karam M, Shier T (1992): Isolation and characterization of an antiviral flavonoid from Waldsteinia fragarioides. J Nat Prod 55: 1525–1527.
  • Kashiwada Y, Wang H, Nagao T, Kitanaka S, Yasuda I, Fujioka T, Yamagishi T, Cosentino L, Kosuka M, Okabe H, Ikeshiro Y, Hu C, Yeh E, Lee K (1998): Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid and structurally related triterpenoids. J Nat Prod 61: 1090–1095.
  • Kerman M, Amarquaye A, Chen J, Chan J, Sesin D, Parkinson N, Ye Z, Barret M, Bales C, Stoddart C, Sloan B, Blanc P, Limbach C, Mrisho S, Rozhon E (1998): Antiviral phenyl-propanoid glycosides from the medicinal plant Markhamia lutea. J Nat Prod 61: 564–570.
  • Kim H, Woo E, Shin C, Park H (1998): A new flavonol glyco-side gallate ester from Acer okamotoanum and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase. J Nat Prod 61: 145–148.
  • Kite GC, Fellows L, Fleet G, Liu P, Scofield A, Smith N (1988) a-homonojirimycin [2,6-dideoxy-2,6-imino-D-glycero-L-gulo-heptitol] from Omphalea diandra L. Isolation and glu-cosidase inhibition. Tetrahedron Lett 29: 6483–6486.
  • Koch A, Gyorgy E (1969): Heart glycosides in poliovirus host cell interaction. Effect of digitoxin and digitoxin and their aglucons on one step growth curves. Acta Microbiol 16: 189–196.
  • Koch A, Sandor G (1969): Heart glycosides in poliovirus host cell interaction III. Chemical structure and activity. Acta Microbiol 16: 245–251.
  • Kokumal M, Konoshima T, Kosuka M (1991): Euglobal Tl, a new euglobal from Eucalyptus tereticornis. J Nat Prod 54: 1082–1086.
  • Konoshima T, Kozuka M, Haruna M, Ito K, Kimura T, Tokuda H (1989): Studies on the constituents of Leguminous plants. XII. The structure of new triterpenoids saponins from Wistaria brachybotrys. Sieb Chem Pharm Bull 37: 2731–2735.
  • Konoshima T, Kozuka M (1991a): Studies on Inhibitors of skin tumor promotion, IX. Neolignans from Magnolia offici-nalis. J Nat Prod 54: 816–822.
  • Konoshima T, Kozuka M (199 lb): Constituents of Leguminous plants XIII. New triterpenoids saponins from Wistaria brachybotrys. J Nat Prod 54: 830–836.
  • Konoshima T, Okamato E, Kozuka M, Nishino H, Tokuda H (1988): Studies on inhibitors of skin tumor promotion, III. Inhibitory effects of isoflavonoids from Wisteria brachy-botrys on Epstein-Barr virus activation. J Nat Prod 51: 1266–1270.
  • Konoshima T, Takasaki M, Kozuka M, Haruna M, Ito K, Estes J, Lee KH (1993): Constituents of Rosae plants I Structures of new triterpenoids from Cowania mexicana. Chem Pharm Bull 41: 1612–1615.
  • Konoshima T, Yasuda I, Kashiwada Y, Cosentino L, Lee K (1995): Anti-AIDS agent 21. Triterpenoids as anti-HIV principles from fruits of Gleditsia japonica and Gymno-cladus chinensis and a structure-activity correlation. J Nat Prod 58: 1372–1377.
  • Leven M, Van den Berghe D, Vlietinck AJ (1983): Plant antivi-ral agents. Planta Med 49: 109–114.
  • Li HY, Sun NJ, Kashiwada Y, Sun L, Snider JV, Cosentino LM, Lee KH (1993): Anti-aids agents, 9. Suberosol A, new C31 lanostane type triterpene and anti-HIV principle from Polyalthia suberosa. J Nat Prod 56: 1130–1133.
  • Lin Y, Anderson H, Flavin M, Pai Y (1997): In vitro anti-HIV activity of biflavonoids isolated from Rims succedanea and Garcinia multiflora. J Nat Prod 60: 884–888.
  • Lin Y, Flavin MT, Schure R, Chen F, Sidwell R, Barnard D, Huffman J, Kern E (1999): Antiviral activities of biflavonoids. Planta Med 65: 120–125.
  • Lin L, Kuo Y, Chou C (2000): Anti-Herpes simplex virus type-1 flavonoids and a new flavanone from the root of Limo-nium sinense. Planta Med 66: 333–336.
  • Liu JS, Li L (1995): Kadsulignans L-N, three dibenzocyclooc-tadiene lignans from Kadsura coccinea. Phytochemistry 38: 241–245.
  • Ma C, Nakamura N, Hattori M, Kakuda H, Qiao J, Yu H (2000): Inhibitory effects on HIV-1 protease of constituents from the wood of Xanthoceras sorbifolia. J Nat Prod 63: 238–242.
  • MacRae WD, Towers NG (1984): Biological activities of lignans. Phytochemistry 23: 1207–1220.
  • McKee T, Bokesch H, McCormick J, Rashid M, Spielvogel D, Gustafson K, Alavanja M, Cardellina J, Boyd M (1997): Isolation and characterization of new anti-HIV and cyto-toxic leads from plants, marine and microbial organism. J Nat Prod 60: 441–438.
  • Mahmood N, Pizza C, Aquino R, Tommasi N, Piacente S, Colman S, Burke A, Hay AJ (1993): Inhibition of HIV infection by flavonoids. Antiviral Research 22: 189–199.
  • Manske RF, Brossi A (1985): The Alkaloids 24. London, Academic Press, pp. 153–154.
  • Manske RF, Brossi A (1987): The Alkaloids 15, London, Academic Press, pp. 83–164.
  • Manske RF, Brossi A (1988): The Alkaloids 18, London, Academic Press, pp. 99–216
  • Manske RF, Brossi A (1989): The Alkaloids 34, London, Academic Press, pp. 211–239.
  • Manske RF, Brossi A (1990): The Alkaloids 36. London, Academic Press, pp. 135–170.
  • Mifflin BJ (1981): Biochemistry of Plants 5. New York, Academic Press, p. 345.
  • Miller PA, Milstrey KP, Trown PW (1968): Specific inhibition of viral ribonucleic acid replication by gliotoxin. Science 159: 431–432.
  • Molgaard P, Ravn H (1988): Evolutionary aspects of caffeoyl ester distribution in dicotyledons. Phytochemistry 27: 2411–2421.
  • Montanha JA, Amoros M, Boustie J, Girre L (1995): Anti-Herpes virus activity of apporphine alkaloids. Planta Med 61: 419–424.1995.
  • Murakami A, Tanaka S, Ohigashi H, Irie R, Takeda N, Tatematsu A, Koshimizu K (1992): Possible anti-tumor promoters: Bi- and Tetraflavonoids from Lophira alata. Phytochemistry 31: 2689–2693.
  • Murray RDH, Mendez J, Brown L (1982): The Natural Coumarins. Chichester, Wiley.
  • Paris A, Strukelj B, Renko M, Turk V, Puki M, Umek A, Korant B (1993): Inhibitory effect of carnosolic acid on HIV-1 protease in cell-free assays. J Nat Prod 56: 1426–1430.
  • Patil AD, Freyer AJ, Eggleston DS, Haltiwanger RC, Bean M, Taylor PB, Caranfa M, Breen A, Bartus H, Johnson R (1993): The inophyllums, novel inhibitors of HIV-1 reverse transcriptase isolated from Malasyan tree Calophyllum inophyllum Linn. J Med Chem 36: 4131–4138.
  • Pengsuparp T, Cai L, Constant H, Fong H, Lin L, Kinghorn D, Pezzuto J, Cordell G (1995): Mechanistic evaluation of new plant-derived compounds that inhibit HIV-1 reverse tran-scriptase. J Nat Prod 58: 1024–1031.
  • Phillipson JD, Zenk MH (1980): Indole and Biogenetically Related Alkaloids. London, Academic Press.
  • Piatelli M, Tringali C (1995): Stereochemistry and conforma-tion of dolabellane diterpenes and NMR and molecular mechanics study. J Nat Prod 58: 697–704.
  • Pilcher KS, Soike KF, Smith V, Trosper F, Folston B (1955): Inhibition of multiplication of Lee influenza virus by cana-vanine. Proc Soc Exptl Biol Med 88: 79–86.
  • Porter LJ (1989): Tannins: Methods in plants biochemistry. London, Academic Press, 1, p. 390.
  • Qi-Hu C, Chen K, Shi Q, Kilkuskie R, Chi-Cheng Y, Lee YJ (1994): Anti-AIDS agent 10. Acacetin-7-0-0-D-galactopy-ranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids. J Nat Prod 57: 42–51.
  • Rashan LJ (1990): In vitro study of the antiviral activity of some 0-carboline alkaloids. Fitoterapia LXI: 153–155.
  • Rao GS, Cochran KW (1974): Antiviral activity of triterpenoid saponins containing acylated 0-amyrin aglycones. J Pharm Sci 63: 471–473.
  • Rathore A, Srivastava V, Srivastava C, Tandon JS (1990): Iridoid glucosides from Nyctanthes arbor-tristis. Phytochemistry 29: 1917–1920.
  • Rembold H (1989): The Azarirachtins. Economic and Medicinal Plant Research 3: 57.
  • Roccatagliata A, Maier M, Seldes A, Pujol C, Damonte E (1996): Antiviral sulfated steroids from the Ophiuroid Ophioplocus januarii. J Nat Prod 59: 887–889.
  • Rouhier P, Kopp M, Begot V, Fritig B (1995): Structural feature of fungal fl-D-glucans for the efficient inhibition of the initiation of virus infection on Nicotania tabacum. Phytochemistry 39: 57–62.
  • Roychoudhury R, Basu P (1983): Characterization of a plant virus inhibitor from two Solanum species. Indian J Exp Biology 21: 212–215.
  • Rwangabo PC, Laekeman G, Claeys M, Tone J, Pieters L (1986): Phytochemical and pharmacological investigation of the biologically active fraction from the flowers of Vernonia amygdalina. Planta Med 6: 547.
  • Sanchez I, Gomez-Garibay F, Taboada J, Ruiz BH (2000): Antiviral effect of flavonoids on the Dengue virus. Phy-tother Res 14: 89–92.
  • Sendl A, Chen J, Jolad SD, Stoddart C, Rozhon E, Kernan M (1996): Two new naphthoquinones with antiviral activity from Rhinacanthus nasutus. J Nat Prod 59: 808–811.
  • Serkedjieva J, Abrashev L, Gegova G, Manolova N (1992): A polyphenolic complex isolated from Geranium sanguineum inhibits influenza virus neuraminidase. Fitoterapia LXIII: 111–117.
  • Simoes CM, Girre M, Gleye J, Fauvel M (1990): Antiviral activ-ity of ternatin and meliternatin 3-methoxyflavones from species of Rutaceae. J Nat Prod 53: 989–992.
  • Sotanaphun U, Lipipun V, Suttisri R, Bavovada R (1999): A new antibiral and antimicrobial sesquiterpene from Glyp-topetalum sclerocarpum. Planta Med 65: 257–258.
  • Suganda AG, Amoros M, Fauconner B, Girre L (1984): Anti-herpetic and antipoliomyeletic effects of Matricaria inodora L. Plantes Med Phytother 18: 215–225.
  • Sun H, Qiu S, Lin L, Wang Z, Lin Z, Pengsuparpa T, Pezzuto J, Fong H, Cordell G, Farsworth N (1996): Nigranoic acid, a triterpenenoid from Schisandra sphaerandra that inhibits HIV-1 reverse transcriptase. J Nat Prod 59: 525–527.
  • Swallow DL, Sc. MA, Fric P (1975): Antiviral agents. Prog Drug Res 22: 267–270.
  • Tada M, Okuno K, Chiba K, Ohnishi E, Yoshi T (1994): Antivi-ral diterpenes from Salvia officinalis. Phytochemistry 35: 539–541.
  • Tafur S, Nelson Y, DeLong D, Gordon H (1976): Antiviral com-ponents of Ophiorrhiza mungos. Lloydia 39: 261–262.
  • Takaishi T, Ohshima S, Nakano K, Tomimatsu T, Tokuda H, Nishino H (1993): Structures of sesquiterpene polyol esters from Celastrus stephanotiifolius with potential tumor-promotion inhibitory activity. J Nat Prod 56: 815–824.
  • Takasaki M, Konoshima T, Shingu T, Tokuda H, Nishino H, Iwashima A, Kosuka M (1990): Structures of euglobal Gl, G2 and G3 from Eucalyptus grandis, three new inhibitores of Epstein-Barr virus activation. Chem Pharm Bull 38: 1444–1446.
  • Takeshi M, Tanaka Y (1981): Purification and characterization of antiviral substance from the bud of Syzyium aromatica. Planta Med 42: 69–74.
  • Takeshi M, Tanaka Y (1982): Antiviral substances from the root of Paeonia species. Planta Med 43: 252–253.
  • Takemura Y, Ju-ichi M, Ito C, Furukawa H, Tokuda H (1995): Studies on the inhibition effects of some acridone alkaloids on Epstein-Barr virus activation. Planta Med 61: 366–368.
  • Tan GT, Pezzuto JM, Kinghorn AD (1991): Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. J Nat Prod 54: 143–154.
  • Tommasi N, Pizza C, Conti C, Orsi N, Stein ML (1990): Structure and in vitro antiviral activity of sesquiterpene gly-cosides from Calendula arvensis. J Nat Prods 53: 830–835.
  • Tommasi N, De Simone F, Pizza C, Mahmood N, Moore P, Conti C, Orsi N, Stein M (1992): Constituents of Erio-
  • botrya japonica. A study of their antiviral propierties. J Nat Prod 55: 1067-1073.
  • Tschesche R, Hess B, Ziegler I, Machleidt H (1962): Separation of synthetic biopterin and isobiopterin. pteridine. Chem Proc Intern Symp Jr g. nv. 230–240.
  • Towers GHN (1989): Photosensitisers from plants and their photodynamic action. Progress in Phytochemistry 6: 183–189.
  • Tsuchiya Y, Shimizu M, Himaya Y, Itoh K, Hashimoto Y, Nakayama M, Hone T, Morita N (1985): Antiviral activity of natural occurring flavonoids in vitro. Chem Pharm Bull 33: 3881–3886.
  • Ueda S, Iwahashi Y (1991): Production of anti-tumor-promoting iridoid glucosides Genipa americana and its cell cultures. J Nat Prod 54: 1677–1680.
  • Van Hoff L, Totte J, Corthout J, Pieters LA, Mertens F, Vanden DA, Vlietinck AJ, Dommisse A, Esmans E (1989): Plant antiviral agents, VI. Isolation of antiviral phenolic gluco-sides from Populus cultivar beaupre by droplet counter-current chcromatography. J Nat Prod 52: 875–878.
  • Van Sumere CF (1989): Phenols and phenolic acids. In: Harborne JB, Methods in Plant Biochemistry. Plant Phenolics 29: London, Academic Press, pp. 29–31.
  • Vlietinck AJ, Bruyne D, Berghe V (1997): Plant substances as antiviral agents. In: Atta-ur-Rahman, ed., Current Organic Chemistry, Natural Product Chemistry Issue, The Nether-lands, Benthem Science Publishers, pp. 320–326.
  • Vlietinck AJ, Bruyne D, Apers S, Pieters LA (1998): Plant-derived leading compounds for chemotherapy of human
  • immunodeficiency virus (HIV) infection. Planta Med 64: 97–109.
  • Ueda S, Iwahashi Y (1991): Production of anti-tumor-promoting iridoid glucosides Genipa americana and its cell culture. J Nat Prod 54: 1677–1680.
  • Urones JG, Basabe P, Marcos IS, Pineda J, Lithgow AM, Moro RF, Brito FMS, Araujo MEM, Gravalos DG (1992): Meroterpenes from Cystoseira usneoides. Phytochemistry 31: 179–182.
  • Wacker A, Eilmes HG (1978): Antivirale wirkung von pffanzen-inhaltsstoffen. Arzneimittelforschung. Drug Res 28: 347–349.
  • Weber ND, Andersen DO, North JA, Murray B, Lawson LD, Hughes B (1992): In vitro virucidal effects of Allium sativa (garlic) extract and compounds. Planta Med 58: 417–423.
  • Yamazaki Z, Tagaya 1(1980): Antiviral effects of atropine and caffeine. J Gen Virol 50: 429–432.
  • Yang X, Zhao J, CuiY, Liu X, Ma C, Hattori M, Zhang L (1999): Anti-HIV protease triterpenoids from the seeds of Aescu-lus chinensis. J Nat Prod 62: 1510–1513.
  • Xiu-Wuei Y, Jing Z, Yu-Xin C, Xue-Hui L, Chao-Mei M, Masao H, Li-He Z (1999): Anti-HIV-1 protease triterpenoid saponins from the seeds of Aesculus chinensis. J Nat Prod 62: 1510–1513.
  • Xu HX, Kadota S, Kurokawa M, Shiraki K, Matsumoto T, Namba T (1993): Isolation and structure of woodorien, a new glucoside having antiviral activity, from Woodwardia orientalis. Chem Pharm Bull 41: 183–1806.

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