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International Journal of Neuroscience Volume 129, 2019 - Issue 6
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Original Articles

Neuroprotective effect of naringenin against MPTP-induced oxidative stress

Mani SugumarResearch and Development Centre, Bharathiar University, Coimbatore, Tamil Nadu, India;
,
Murugan SevananDepartment of Biotechnology, Karunya Institute of Technology and Sciences, Karunya Nagar, Coimbatore, Tamil Nadu, India; Correspondence[email protected]
&
Sathiya SekarDepartment of Biotechnology, Dr. M.G.R. Educational and Research Institute, Chennai, Tamil Nadu, India
Pages 534-539 | Received 16 Aug 2018, Accepted 03 Nov 2018, Published online: 02 Dec 2018

References

  • Fahn S. Description of Parkinson's disease as a clinical syndrome. Ann N Y Acad Sci. 2003;991:1–14.
  • Postuma RB, Berg D, Stern M, et al. MDS clinical diagnostic criteria for Parkinson's disease. Mov Disord. 2015;30:1591–1601.
  • Mhyre TR, Boyd JT, Hamill RW, et al. Protein aggregation and fibrillogenesis in cerebral and systemic amyloid disease. 2012; vol.65.
  • Paul R, Choudhury A, Kumar S, et al. Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson’s disease: Involvement of mitochondrial dysfunctions and oxidative stress. PLoS One. 2017;12:e0171285.
  • Alexander GE. Biology of Parkinson's disease: pathogenesis and pathophysiology of a multisystem neurodegenerative disorder. Dialog Clin Neurosci. 2004;6:259.
  • Nikam S, Nikam P, Ahaley S. Role of free radical and antioxidant imbalance in pathogenesis of Parkinson’s disease. Biomed Res. 2009;20:55–58.
  • Kumar H, Lim H-W, More SV, et al. The role of free radicals in the aging brain and Parkinson’s disease: convergence and parallelism. Int J Mol Sci. 2012;13:10478–10504.
  • Obata T. Dopamine efflux by MPTP and hydroxyl radical generation. J Neur Transm. 2002;109:1159–1180.
  • Hwang O. Role of oxidative stress in Parkinson's disease. Exp Neurobiol. 2013;22:11–17.
  • Albarracin SL, Stab B, Casas Z, et al. Effects of natural antioxidants in neurodegenerative disease. Nutr Neurosci. 2012;15:1–9.
  • Prasain J, Carlson S, Wyss J. Flavonoids and age-related disease: risk, benefits and critical windows. Maturitas. 2010;66:163–171.
  • Zbarsky V, Datla KP, Parkar S, et al. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free Radic Res. 2005;39:1119–1125.
  • Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. Neuron. 2003;39:889–909.
  • Luchtman DW, Shao D, Song C. Behavior, neurotransmitters and inflammation in three regimens of the MPTP mouse model of Parkinson's disease. Physiol Behav.. 2009;98:130–138.
  • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248–254.
  • Jin H, Kanthasamy A, Ghosh A, et al. Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes. Biochim Biophys Acta Mol Basis Dis. 2014;1842:1282–1294.
  • Mani S, Sekar S, Barathidasan R, et al. Naringenin decreases α-synuclein expression and neuroinflammation in MPTP-induced Parkinson’s disease model in mice. Neurotox Res. 2018;33:656–670.
  • Khan MM, Hoda MN, Ishrat T, et al. Amelioration of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced behavioural dysfunction and oxidative stress by Pycnogenol in mouse model of Parkinson's disease. Behav Pharmacol. 2010;21:563–571.
  • Cheng Y, He G, Mu X, et al. Neuroprotective effect of Baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile. Neurosci Lett. 2008;441:16–20.
  • Kröncke K, Fehsel K, Kolb-Bachofen V. Inducible nitric oxide synthase in human diseases. Clin Exp Immunol. 1998;113:147–156.
  • Whitton P. Inflammation as a causative factor in the aetiology of Parkinson's disease. Br J Pharmacol. 2007;150:963–976.

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