Potential mechanisms of Shenmai injection against POCD based on network pharmacology and molecular docking

References

• Needham MJ, Webb CE, Bryden DC. Postoperative cognitive dysfunction and dementia: what we need to know and do. Br J Anaesth. 2017;119(suppl_1):i115–i125.
   PubMed Web of Science ®Google Scholar
• MacLullich AMJ, Beaglehole A, Hall RJ, et al. Delirium and long-term cognitive impairment. Int Rev Psychiatry. 2009;21(1):30–42.
   PubMed Web of Science ®Google Scholar
• Steinmetz J, Christensen KB, Lund T, et al. Long-term consequences of postoperative cognitive dysfunction. Anesthesiology. 2009;110(3):548–555.
   PubMed Web of Science ®Google Scholar
• Crocker E, Beggs T, Hassan A, et al. Long-term effects of postoperative delirium in patients undergoing cardiac operation: a systematic review. Ann Thorac Surg. 2016;102(4):1391–1399.
   PubMed Web of Science ®Google Scholar
• Hartholt KA, van der Cammen TJ, Klimek M. Postoperative cognitive dysfunction in geriatric patients. Z Gerontol Geriatr. 2012;45(5):411–416.
   PubMed Web of Science ®Google Scholar
• Relander K, Hietanen M, Nuotio K, et al. Cognitive dysfunction and mortality after carotid endarterectomy. Front Neurol. 2020;11:593719.
   PubMed Web of Science ®Google Scholar
• Yu J, Li Y, Liu X, et al. Mitochondrial dynamics modulation as a critical contribution for Shenmai injection in attenuating hypoxia/reoxygenation injury. J Ethnopharmacol. 2019;237:9–19.
   PubMed Web of Science ®Google Scholar
• Wu YP, Zhang S, Xin YF, et al. Evidences for the mechanism of Shenmai injection antagonizing doxorubicin-induced cardiotoxicity. Phytomedicine. 2021;88:153597.
   PubMed Web of Science ®Google Scholar
• Lu LY, Zheng GQ, Wang Y. An overview of systematic reviews of Shenmai injection for healthcare. Evid Based Complement Alternat Med. 2014;2014:840650.
   PubMed Web of Science ®Google Scholar
• Chen XC, Zhu YG, Zhu LA, et al. Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress. Eur J Pharmacol. 2003;473(1):1–7.
   PubMed Web of Science ®Google Scholar
• Dijkstra JB, Jolles J. Postoperative cognitive dysfunction versus complaints: a discrepancy in longterm findings. Neuropsychol Rev. 2002;12(1):1–14.
   PubMed Web of Science ®Google Scholar
• Miao HH, Ye Z, Nan DG, et al. Ginsenoside Rb1 attenuates isoflurane/surgery-induced cognitive dysfunction via inhibiting neuroinflammation and oxidative stress. Biomed Environ Sci. 2017;30(5):363–372.
   PubMed Web of Science ®Google Scholar
• Zhang WL, Chi YL, Wang LZ, et al. Administrations of preoperative Shenmai injection and postoperative Shenfu injection, two ginseng containing TCM formulas, improve cognitive dysfunction in aged rats. Am J Chin Med. 2018;46(5):1065–1078.
   PubMed Web of Science ®Google Scholar
• Chen L, Wang L, Zhuo Q, et al. Effect of Shenmai injection on cognitive function after cardiopulmonary bypass in cardiac surgical patients: a randomized controlled trial. BMC Anesthesiol. 2018;18(1):142.
   PubMedGoogle Scholar
• Sauër AM, Kalkman C, van Dijk D. Postoperative cognitive decline. J Anesth. 2009;23(2):256–259.
   PubMed Web of Science ®Google Scholar
• Xu H, Liu Y, Wang D, et al. Shenmai injection maintains blood-brain barrier integrity following focal cerebral ischemia via modulating the expression and trafficking of occludin in lipid rafts. J Ethnopharmacol. 2019;237:55–63.
   PubMed Web of Science ®Google Scholar
• Zhang X, Gao R, Zhou Z, et al. Uncovering the mechanism of Huanglian-Wuzhuyu herb pair in treating nonalcoholic steatohepatitis based on network pharmacology and experimental validation. J Ethnopharmacol. 2022;296:115405.
   PubMed Web of Science ®Google Scholar
• Zhang X, Shen T, Zhou X, et al. Network pharmacology based virtual screening of active constituents of prunella vulgaris L. and the molecular mechanism against breast cancer. Sci Rep. 2020;10(1):15730.
   PubMed Web of Science ®Google Scholar
• Li S, Zhang B. Traditional Chinese medicine network pharmacology: theory, methodology and application. Chin J Nat Med. 2013;11(2):110–120.
   PubMed Web of Science ®Google Scholar
• Li X, Yang HW, Jiang Y, et al. Ishophloroglucin a isolated from Ishige Okamurae suppresses melanogenesis induced by α-MSH: in vitro and in vivo. Mar Drugs. 2020;18(9):470.
   PubMed Web of Science ®Google Scholar
• Wang CR, Chen HW, Li Y, et al. Network pharmacology exploration reveals anti-Apoptosis as a common therapeutic mechanism for Non-Alcoholic fatty liver disease treated with blueberry leaf polyphenols. Nutrients. 2021;13(11):4060.
   PubMed Web of Science ®Google Scholar
• Du W, Liang X, Wang S, et al. The underlying mechanism of Paeonia lactiflora Pall. in Parkinson’s disease based on a network pharmacology approach. Front Pharmacol. 2020;11:581984.
   PubMed Web of Science ®Google Scholar
• Wu C, Huang ZH, Meng ZQ, et al. A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound Kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation. Chin Med. 2021;16(1):121.
   PubMed Web of Science ®Google Scholar
• Wang Q, Du L, Hong J, et al. Molecular mechanism underlying the hypolipidemic effect of Shanmei capsule based on network pharmacology and molecular docking. Technol Health Care. 2021;29(S1):239–256.
   PubMedGoogle Scholar
• Kun YH, Samik G, Hiroaki K, et al. Combining machine learning systems and multiple docking simulation packages to improve docking prediction reliability for. Network Pharmacology. PLOS. 2013;8(12):83922.
   Google Scholar
• Liu L, Vollmer MK, Ahmad AS, et al. Pretreatment with Korean red ginseng or dimethyl fumarate attenuates reactive gliosis and confers sustained neuroprotection against cerebral hypoxic-ischemic damage by an Nrf2-dependent mechanism. Free Radic Biol Med. 2019;131:98–114.
   PubMed Web of Science ®Google Scholar
• Kim M, Kim J, Moon S, et al. Korean red ginseng improves astrocytic mitochondrial function by upregulating HO-1-Mediated AMPKα-PGC-1α-ERRα circuit after traumatic brain injury. IJMS. 2021;22(23):13081.
   Google Scholar
• Liu L, Vollmer MK, Kelly MG, et al. Reactive gliosis contributes to Nrf2-Dependent neuroprotection by pretreatment with dimethyl fumarate or Korean red ginseng against Hypoxic-Ischemia: focus on hippocampal injury. Mol Neurobiol. 2020;57(1):105–117.
   PubMed Web of Science ®Google Scholar
• Huang X, Duan X, Wang K, et al. Shengmai injection as an adjunctive therapy for the treatment of chronic obstructive pulmonary disease: a systematic review and meta-analysis. Complement Ther Med. 2019;43:140–147.
   PubMed Web of Science ®Google Scholar
• Yu JH, Guo HW, Liu MM. Impact of Shengmal injection on changes of immunological function in patients after cardiopulmonary bypass. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009;29(4):317–321.
   PubMedGoogle Scholar
• Liang Q, Yang J, He J, et al. Stigmasterol alleviates cerebral ischemia/reperfusion injury by attenuating inflammation and improving antioxidant defenses in rats. Biosci Rep. 2020;40(4):BSR20192133.
   PubMedGoogle Scholar
• Kotekar N, Shenkar A, Nagaraj R. Postoperative cognitive dysfunction – current preventive strategies. Clin Interv Aging. 2018;13:2267–2273.
   PubMed Web of Science ®Google Scholar
• Yang Y, Liu Y, Zhu J, et al. Neuroinflammation-mediated mitochondrial dysregulation involved in postoperative cognitive dysfunction. Free Radic Biol Med. 2022;178:134–146.
   PubMed Web of Science ®Google Scholar
• Wang L, Zhou Y, Qin Y, et al. Methylophiopogonanone B of radix ophiopogonis protects cells from H2O2-induced apoptosis through the NADPH oxidase pathway in HUVECs. Mol Med Rep. 2019;20(4):3691–3700.
   PubMed Web of Science ®Google Scholar
• Iang N, Jingwei L, Wang H, et al. Ginsenoside 20(S)-protopanaxadiol attenuates depressive-like behaviour and neuroinflammation in chronic unpredictable mild stress-induced depressive rats. Behav Brain Res. 2020;393:112710.
   PubMed Web of Science ®Google Scholar
• Gage MC, Thippeswamy T. Inhibitors of src family kinases, inducible nitric oxide synthase, and NADPH oxidase as potential CNS drug targets for neurological diseases. CNS Drugs. 2021;35(1):1–20.
   PubMed Web of Science ®Google Scholar
• Nie L, Ye WR, Chen S, et al. Src family kinases in the Central nervous system: their emerging role in pathophysiology of migraine and neuropathic pain. Curr Neuropharmacol. 2021;19(5):665–678.
   PubMed Web of Science ®Google Scholar
• Tian R, Wu B, Fu C, et al. miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of src-mediated MAPK signaling pathway in ischemic stroke. Aging (Albany NY). 2020;12(11):10873–10895.
   PubMedGoogle Scholar
• Liu B, Zhang G, Cui S, et al. Inhibition of RNF6 alleviates traumatic brain injury by suppressing STAT3 signaling in rats. Brain Behav. 2020;10(12):e01847.
   PubMed Web of Science ®Google Scholar
• Mehla J, Singh I, Diwan D, et al. STAT3 inhibitor mitigates cerebral amyloid angiopathy and parenchymal amyloid plaques while improving cognitive functions and brain networks. Acta Neuropathol Commun. 2021;9(1):193.
   PubMed Web of Science ®Google Scholar
• Xia QD, Xun Y, Lu JL, et al. Network pharmacology and molecular docking analyses on Lianhua qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID-19. Cell Prolif. 2020;53(12):e12949.
   PubMed Web of Science ®Google Scholar
• Miao B, Yin X-H, Pei D-S, et al. Neuroprotective effects of preconditioning ischemia on ischemic brain injury through down-regulating activation of JNK1/2 via N-methyl-D-aspartate receptor-mediated Akt1 activation. J Biol Chem. 2005;280(23):21693–21699.
   PubMed Web of Science ®Google Scholar
• Huang C-H, Pei J-C, Luo D-Z, et al. Investigation of gene effects and epistatic interactions between Akt1 and neuregulin 1 in the regulation of behavioral phenotypes and social functions in genetic mouse models of schizophrenia. Front Behav Neurosci. 2014;8:455.
   PubMed Web of Science ®Google Scholar
• Jiang Y, He Q, Zhang T, et al. Exploring the mechanism of Shengmai yin for coronary heart disease based on systematic pharmacology and chemoinformatics. Biosci Rep. 2020;40(6):BSR20200286.
   PubMedGoogle Scholar
• Netto MB, de Oliveira Junior AN, Goldim M, et al. Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats. Brain Behav Immun. 2018;73:661–669.
   PubMed Web of Science ®Google Scholar
• Bittencourt A, Brum PO, Ribeiro CT, et al. High fat diet-induced obesity causes a reduction in brain tyrosine hydroxylase levels and non-motor features in rats through metabolic dysfunction, neuroinflammation and oxidative stress. Nutr Neurosci. 2022;25(5):1026–1040.
   PubMed Web of Science ®Google Scholar
• Lv G, Li C, Wang W, et al. Silencing SP1 alleviated Sevoflurane-Induced POCD development via cholinergic anti-inflammatory pathway. Neurochem Res. 2020;45(9):2082–2090.
   PubMed Web of Science ®Google Scholar
• He X, Long G, Quan C, et al. Insulin resistance predicts postoperative cognitive dysfunction in elderly gastrointestinal patients. Front Aging Neurosci. 2019;11:197.
   PubMed Web of Science ®Google Scholar
• Anagnostou I, Reyes-Mendoza J, Morales T. Glial cells as mediators of protective actions of prolactin (PRL) in the CNS. Gen Comp Endocrinol. 2018;265:106–110.
   PubMed Web of Science ®Google Scholar
• Han X, Cheng X, Xu J, et al. Activation of TREM2 attenuates neuroinflammation via PI3K/akt signaling pathway to improve postoperative cognitive dysfunction in mice. Neuropharmacology. 2022;219:109231.
   PubMed Web of Science ®Google Scholar
• Wang YB, Xie JQ, Liu W, et al. BACE1 gene silencing alleviates isoflurane anesthesia-induced postoperative cognitive dysfunction in immature rats by activating the PI3K/akt signaling pathway. Mol Med Rep. 2018;18(5):4259–4270.
   PubMed Web of Science ®Google Scholar
• Qin J, Ma Q, Ma D. Low-dose sevoflurane attenuates cardiopulmonary bypass (CPB)-induced postoperative cognitive dysfunction (POCD) by regulating hippocampus apoptosis via PI3K/AKT pathway. Curr Neurovasc Res. 2020;17(3):232–240.
   PubMed Web of Science ®Google Scholar
• Lv Z, Che L, Du Y, et al. Mechanism of Mongolian medicine Eerdun Wurile in improving postoperative cognitive dysfunction through activation of the PI3K signaling pathway. Front Neurosci. 2021;15:769759.
   PubMed Web of Science ®Google Scholar
• Trott O, Olson AJ. AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem. 2010;31(2):455–461.
   PubMed Web of Science ®Google Scholar