Evaluation of Turkish propolis for its chemical composition, antioxidant capacity, anti-proliferative effect on several human breast cancer cell lines and proliferative effect on fibroblasts and mouse mesenchymal stem cell line

References

• Ahangari, Z., Naseri, M., Jalili, M., Mansouri, Y., Mashhadiabbas, F., & Torkaman, A. (2012). Effect of propolis on dentin regeneration and the potential role of dental pulp stem cell in Guinea pigs. Cell Journal, 13, 223–228.
   PubMed Web of Science ®Google Scholar
• Ahn, M., Kumazawa, S., Usui, Y., Nakamura, J., Matsuka, M., Zhu, F., & Nakayama, T. (2007). Antioxidant activity and constituents of propolis collected in various areas of China. Food Chemistry, 101, 1383–1392.
   Web of Science ®Google Scholar
• Apak, R., Guclu, K., Ozyurek, M., & Karademir, S. E. (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. Journal of Agricultural and Food Chemistry, 52, 7970–7981.
   PubMed Web of Science ®Google Scholar
• Apak, R., Guclu, K., Demirata, B., Ozyurek, M., Celik, S. E., Bektasoglu, B., … Ozyurt, D. (2007). Comparative evaluation of various total antioxidant capacity assays applied to phenolic compounds with the CUPRAC assay. Molecules, 12, 1496–1547.
   PubMed Web of Science ®Google Scholar
• Arnao, M. B. (2000). Some methodological problems in the determination of antioxidant activity using chromogen radicals: A practical case. Trends in Food Science and Technology, 11, 419–421.
   Web of Science ®Google Scholar
• Bankova, V. (2005a). Chemical diversity of propolis and the problem of standardization. Journal of Ethnopharmacology, 100, 114–117.
   PubMed Web of Science ®Google Scholar
• Bankova, V. (2005b). Recent trends and important developments in propolis research. Evidence-based Complementary and Alternative Medicine, 2, 29–32.
   PubMed Web of Science ®Google Scholar
• Bankova, V., de Castro, S. L., & Marcucci, M. C. (2000). Propolis: Recent advances in chemistry and plant origin. Apidologie, 31, 3–15.
   Web of Science ®Google Scholar
• Bankova, V., Popova, M., Bogdanov, S., & Sabatini, A. G. (2002). Chemical composition of European propolis: Expected and unexpected results. Zeitschrift Fur Naturforschung. Journal of Biosciences, 57, 530–533.
   PubMed Web of Science ®Google Scholar
• Barlak, Y., Deger, O., Colak, M., Karatayli, S. C., Bozdayi, A. M., & Yucesan, F. (2011). Effect of Turkish propolis extracts on proteome of prostate cancer cell line. Proteome Science, 9, 74.
   PubMed Web of Science ®Google Scholar
• Batista, C. M., Alves, A. V. F., Queiroz, L. A., Lima, B. S., Filho, R. N. P., Araújo, A. A. S., … Cardoso, J. C. (2018). The photoprotective and anti-inflammatory activity of red propolis extract in rats. Journal of Photochemistry and Photobiology B: Biology, 180, 198–207.
   PubMed Web of Science ®Google Scholar
• Benzie, I. F. F., & Strain, J. J. (1996). The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: The FRAP assay. Analytical Biochemistry, 239, 70–76.
   PubMed Web of Science ®Google Scholar
• Bino, R. J., De Vos, C. H. R., Lieberman, M., Hall, R. D., Bovy, A., Jonker, H. H., … Levin, I. (2005). The light-hyperresponsive high pigment-2dg mutation of tomato: Alterations in the fruit metabolome. New Phytologist, 166, 427–438.
   PubMed Web of Science ®Google Scholar
• Boisard, S., Le Ray, A. M., Gatto, J., Aumond, M. C., Blanchard, P., Derbré, S., … Richomme, P. (2014). Chemical composition, antioxidant and anti-AGEs activities of a French poplar type propolis. Journal of Agricultural and Food Chemistry, 62, 1344–1351.
   PubMed Web of Science ®Google Scholar
• Bolfa, P., Vidrighinescu, R., Petruta, A., Dezmirean, D., Stan, L., Vlase, L., … Clichici, S. (2013). Photoprotective effects of Romanian propolis on skin of mice exposed to UVB irradiation. Food and Chemical Toxicology, 62, 329–342.
   PubMed Web of Science ®Google Scholar
• Bueno-Silva, B., Alencar, S. M., Koo, H., Ikegaki, M., Silva, G. V., Napimoga, M. H., & Rosalen, P. L. (2013). Anti-inflammatory and antimicrobial evaluation of neovestitol and vestitol ısolated from Brazilian red propolis. Journal of Agriculture and Food Chemistry, 61, 4546–4550.
   PubMed Web of Science ®Google Scholar
• Burdock, G. A. (1998). Review of the biological properties and toxicity of bee propolis (propolis). Food and Chemical Toxicology, 36, 347–363.
   PubMed Web of Science ®Google Scholar
• Búfalo, M. C., Figueiredo, A. S., de Sousa, J. P. B., Candeias, J. M. G., Bastos, J. K., & Sforcin, J. M. (2009). Anti-poliovirus activity of baccharis dracunculifolia and propolis by cell viability determination and real-time PCR. Journal of Applied Microbiology, 107, 1669–1680.
   PubMed Web of Science ®Google Scholar
• Calabrese, E. J. (2013). Hormetic mechanisms. Critical Reviews in Toxicology, 43(7), 580–606.
   PubMed Web of Science ®Google Scholar
• Calabrese, E. J., & Baldwin, L. A. (2001). Hormesis: U-shaped dose responses and their centrality in toxicology. Trends in Pharmacological Sciences, 22(6), 285–291.
   PubMed Web of Science ®Google Scholar
• Capanoglu, E., Beekwilder, J., Boyacioglu, D., Hall, R. D., & De Vos, C. H. R. (2008). Changes in antioxidants and metabolite profiles during production of tomato paste. Journal of Agricultural and Food Chemistry, 56, 964–973.
   PubMed Web of Science ®Google Scholar
• Castro, C., Mura, F., Valenzuela, G., Figueroa, C., Salinas, R., Zuñiga, M. C. … Delporte, C. (2014). Identification of phenolic compounds by HPLC-ESI-MS/MS and antioxidant activity from Chilean propolis. Food Research International, 64, 873–879.
   PubMed Web of Science ®Google Scholar
• Celik, I., Sürücü, O., Dietz, C., Heymach, J. V., Force, J., Höschele, I., … Kisker, O. (2005). Therapeutic efficacy of endostatin exhibits a biphasic dose-response curve. Cancer Research, 65(23), 1044–1050.
   Web of Science ®Google Scholar
• Chan, G. C., Cheung, K. W., & Sze, D. M. (2013). The immunomodulatory and anticancer properties of propolis. Clinical Reviews in Allergy & Immunology, 44, 262–273.
   PubMed Web of Science ®Google Scholar
• Chirumbolo, S. (2011). Propolis as anti-ınflammatory and anti-allergic compounds: Which role for flavonoids? International Immunopharmacology, 11, 1386–1387.
   PubMed Web of Science ®Google Scholar
• Choi, Y. M., Noh, D. O., Cho, S. Y., Suh, H. J., Kim, K. M., & Kim, J. M. (2006). Antioxidant and antimicrobial activities of propolis from several regions of Korea. LWT Food Science and Technology, 39, 756–761.
   Web of Science ®Google Scholar
• Choudhari, M. K., Punekar, S. A., Ranade, R. V., & Paknikar, K. M. (2012). Antimicrobial activity of stingless bee (Trigona sp.) propolis used in the folk medicine of Western Maharashtra, India. Journal of Ethnopharmacology, 141, 363–367.
   PubMed Web of Science ®Google Scholar
• Czyżewska, U., Siemionow, K., Zaręba, I., & Miltyk, W. (2016). Proapoptotic activity of propolis and their components on human tongue squamous cell carcinoma cell line (CAL-27). PLoS One, 11(6), e0157091.
   PubMed Web of Science ®Google Scholar
• De Castro, S. L. (2001). Propolis: Biological and pharmacological activities. Annual Reviews of Biomedical Sciences, 3, 49–83.
   Google Scholar
• Deighton, N., Brennan, R., Finn, C., & Davies, H. V. (2000). Antioxidant properties of domesticated and wild Rubus species. Journal of the Science of Food and Agriculture, 80, 1307–1313.
   Web of Science ®Google Scholar
• Demir, S., Aliyazicioglu, Y., Turan, I., Misir, S., Mentese, A., Yaman, S. O., … Deger, O. (2016). Antiproliferative and proapoptotic activity of Turkish propolis on human lung cancer cell line. Nutrition and Cancer, 68(1), 165–172.
   PubMed Web of Science ®Google Scholar
• Draganova-Filipova, M. N., Georgieva, M. G., Peycheva, E. N., Miloshev, G. A., Sarafian, V. S., & Peychev, L. P. (2008). Effects of propolis and CAPE on proliferation and apoptosis of mccoy-plovdiv cell line. Folia Medica (Plovdiv), 50, 53–59.
   PubMedGoogle Scholar
• Endo, S., Hoshi, M., Matsunaga, T., Inoue, T., Ichihara, K., & Ikari, A. (2018). Autophagy inhibition enhances anticancer efficacy of artepillin C, a cinnamic acid derivative in Brazilian green propolis. Biochemical and Biophysical Research Communications, 497(1), 437–443.
   PubMed Web of Science ®Google Scholar
• Falcão, S. I., Vilas-Boas, M., Estevinho, L. M., Barros, C., Domingues, M. R., & Cardoso, S. M. (2010). Phenolic characterization of northeast Portuguese propolis: Usual and unusual compounds. Analytical and Bioanalytical Chemistry, 396, 887–897.
   PubMed Web of Science ®Google Scholar
• Fisher, B., Dignam, J., Bryant, J., DeCillis, A., Wickerham, D. L., Wolmark, N., … Lickley, H. L. (1996). Five versus more than five years of tamoxifen therapy for breast cancer patients with negative lymph nodes and estrogen receptor-positive tumors. Journal of the National Cancer Institute, 88, 1529–1542.
   PubMed Web of Science ®Google Scholar
• Fokt, A., Ferreira, A. M., Cunha, A., & Aguiar, C. (2010). The antimicrobial properties of propolis: How do bees prevent hive infections? In A. Mendez-Vilas (Ed.), Current Research, Technology and Education Topics in Applied Microbiology and Microbial Biotechnology Microbiology Book Series (pp. 481–493) Portugal: FORMATEX.
   Google Scholar
• Frión-Herrera, Y., Díaz-García, A., Ruiz-Fuentes, J., Rodríguez-Sánchez, H., & Maurício-Sforcina, J. (2015). Brazilian green propolis induced apoptosis in human lung cancer A549 cells through mitochondrial-mediated pathway. Journal of Pharmacy and Pharmacology, 67, 1448–1456.
   PubMed Web of Science ®Google Scholar
• Frozza, C. O. D. S., Garcia, C. S. C., Gambato, G., de Souza, M. D. O., Salvador, M., Moura, S., … Roesch-Ely M. (2013). Chemical characterization, antioxidant and cytotoxic activities of Brazilian red propolis. Food and Cemical Toxicology, 52, 137–142.
   PubMed Web of Science ®Google Scholar
• Fung, C. S., Mohamad, H., Hashim, S. N. M., Htun, A. T., & Ahmad, A. (2015). Proliferative effect of Malaysian propolis on stem cells from human exfoliated deciduous teeth: An in vitro study. British Journal of Pharmaceutical Research, 8, 1–8.
   Web of Science ®Google Scholar
• Ghisalberti, E. L. (1979). Propolis: A review. Bee World, 60(2), 59–84. doi: 10.1080/0005772X.1979.11097738
   Web of Science ®Google Scholar
• Gomez-Caravaca, A. M., Gomez-Romero, M., Arraez-Roman, D., Segura-Carretero, A., & Fernandez-Gutierrez, A. (2006). Advances in the analysis of phenolic compounds in products derived from bees. Journal of Pharmaceutical and Biomedical Analysis, 41, 1220–1234.
   PubMed Web of Science ®Google Scholar
• Gordaliza, M. (2007). Natural products as leads to anticancer drugs. Clinical and Translational Oncology, 9, 767–776.
   PubMed Web of Science ®Google Scholar
• Ishida, Y., Gao, R., Shah, N., Bhargava, P., Furune, T., Kaul, S. C., … Wadhwa, R. (2018). Anticancer activity in honey bee propolis: Functional insights to the role of caffeic acid phenethyl ester and its complex with γ-cyclodextrin. Integrative Cancer Therapies, 17(3), 867–873. doi: 10.1177/1534735417753545
   PubMed Web of Science ®Google Scholar
• Kabała-Dzik, A., Rzepecka-Stojko, A., Kubina, R., Jastrzębska-Stojko, Ż., Stojko, R., Wojtyczkand, R.D., & Stojko, J. (2017a). Comparison of two components of propolis: Caffeic acid (CA) and caffeic acid phenethyl ester (CAPE) induce apoptosis and cell cycle arrest of breast cancer cells MDA-MB-231. Molecules, 22(9), 1554.
   Web of Science ®Google Scholar
• Kabała-Dzik, A., Rzepecka-Stojko, A., Kubina, R., Jastrzębska-Stojko, Ż., Stojko, R., Wojtyczkand, R. D., & Stojko, J. (2017b). Migration rate inhibition of breast cancer cells treated by caffeic acid and caffeic acid phenethyl ester: An in vitro comparison study. Nutrients, 9(10), 1144.
   PubMed Web of Science ®Google Scholar
• Kamiloglu, S., Demirci, M., Selen, S., Toydemir, G., Boyacioglu, D., & Capanoglu, E. (2014). Home processing of tomatoes (Solanum lycopersicum): Effects on in vitro bioaccessibility of total lycopene, phenolics, flavonoids, and antioxidant capacity. Journal of the Science of Food and Agriculture, 94, 2225–2233.
   PubMed Web of Science ®Google Scholar
• Khacha-Ananda, S., Tragoolpua, K., Chantawannakul, P., & Tragoolpua, Y. (2013). Antioxidant and anti-cancer cell proliferation activity of propolis extracts from two extraction methods. Asian Pacific Journal of Cancer Prevention, 14, 6991–6995.
   PubMed Web of Science ®Google Scholar
• Kim, D. O., Jeong, S. W., & Chang, Y. L. (2003). Antioxidant capacity of phenolic phytochemicals from various cultivars of plums. Food Chemistry, 86, 321–326.
   Google Scholar
• Kolankaya, D., Selmanoglu, G., Sorkun, K., & Salih, B. (2002). Protective effects of Turkish propolis on alcohol induced serum lipid changes and liver ınjury in male rats. Food Chemistry, 78, 213–217.
   Web of Science ®Google Scholar
• Kouidhi, B., Zmantar, T., & Bakhrouf, A. (2010). Anti-cariogenic and anti-biofilms activity of Tunisian propolis extract and its potential protective effect against cancer cells proliferation. Anaerobe, 16, 566–571.
   PubMed Web of Science ®Google Scholar
• Kumaran, A., & Karunakaran, J. (2006). Antioxidant and free radical scavenging activity of an aqueous extract of Coleus aromaticus. Food Chemistry, 97, 109–117.
   Web of Science ®Google Scholar
• Kumazawa, S., Hamasaka, T., & Nakayama, T. (2004). Antioxidant activity of propolis of various geographic origins. Food Chemistry, 84, 329–339.
   Web of Science ®Google Scholar
• Lofty, M. (2006). Biological activity of bee propolis in health and disease. Asian Pacific Journal of Cancer Prevention, 7, 22–31.
   PubMedGoogle Scholar
• Ma, X., Guo, Z., Shen, Z., Liu, Y., Wang J., & Fan Y. (2015). The anti-porcine parvovirus activity of nanometer propolis flavone and propolis flavone in vitro and in vivo. Evidence-Based Complementary and Alternative Medicine, 2015, Article ID 472876 (10 pp).
   Web of Science ®Google Scholar
• Maccari, S., Buoncervello, M., Rampin, A., Spada, M., Macchia, D., Giordani, L., … Marano, G. (2016). Biphasic effects of propranolol on tumour growth in B16F10 melanoma-bearing mice. British Journal of Pharmacology, 174, 139–149.
   PubMed Web of Science ®Google Scholar
• Manach, C., Hubert, J., Llorach, R., & Scalbert, A. (2009). The complex links between dietary phytochemicals and human health deciphered by metabolomics. Molecular Nutrition and Food Research, 53, 1303–1315.
   PubMed Web of Science ®Google Scholar
• Marcucci, M. C., Ferreres, F., Custodio, A. R., Ferreira, M. M. C., Bankova, V. S., Garcia-Viguera, C., & Bretz, W. A. (2000). Evaluation of phenolic compounds in Brazilian propolis from different geographic regions. Zeitschrift fur Naturforschung, Journal of Biosciences, 55, 76–81.
   PubMedGoogle Scholar
• Marcucci, M. C., Ferreres, F., Garcia-Viguera, C., Bankova, V. S., De Castro, S. L., Dantas, A. P., … Paulino, N. (2001). Phenolic compounds from Brazilian propolis with pharmacological activities. Journal of Ethnopharmacology, 74, 105–112.
   PubMed Web of Science ®Google Scholar
• Miller, N. J., & Rice-Evans, C. A. (1997). Factors influencing the antioxidant activity determined by the ABTS + radical cation assay. Free Radical Research, 26, 195–199.
   PubMed Web of Science ®Google Scholar
• Moreira, L., Dias, L. G., Pereira, J. A., & Estevinho, L. (2008). Antioxidant properties, total phenols and pollen analysis of propolis samples from Portugal. Food and Chemical Toxicology, 46, 3482–3485.
   PubMed Web of Science ®Google Scholar
• Moreno, M. I., Isla, M. I., Sampietro, A. R., & Vattuone, M. A. (2000). Comparison of the free radical-scavenging activity of propolis from several regions of Argentina. Journal of Ethnopharmacology, 71, 109–114.
   PubMed Web of Science ®Google Scholar
• Mot, A. C., Silaghi-Dumitresco, R., & Sarbu, C. (2011). Rapid and effective evaluation of the antioxidant capacity of propolis extracts using DPPH bleaching kinetic profiles, FT-IR and UV-vis spectroscopic data. Journal of Food Composition and Analysis, 24, 516–522.
   Web of Science ®Google Scholar
• Motomura, M., Kwon, K. M., Suh, S. J., Lee, Y. C., Kim, Y. K., Lee, I. S., … Kim, C. H. (2008). Propolis induces cell cycle arrest and apoptosis in human leukemic U937 cells through Bcl-2/Bax regulation. Environmental Toxicology and Pharmacology, 26, 61–67.
   PubMed Web of Science ®Google Scholar
• Mutlu-Altundag, E., Kasaci, T., Yilmaz, A. M., Karademir, B., Kocturk, S., Taga, Y., & Yalcin, A. S. (2016). Quercetin-induced cell death in human papillary thyroid cancer (B-CPAP) cells. Journal of Thyroid Research., 2016, Article ID 9843675 (10 pp).
   PubMed Web of Science ®Google Scholar
• Peri, P., Kamiloglu, S., Capanoglu, E., & Ozcelik, B. (2015). Investigating the effect of aging on the phenolic content, antioxidant activity and anthocyanins in Turkish wines. Journal of Food Processing and Preservation, 39, 1845–1853.
   Web of Science ®Google Scholar
• Popova, M., Bankova, V., Butovska, D., Petkov, V., Nikolova-Damyanova, B., Sabatini, A. G., … Bogdanov, S. (2004). Validated methods for the quantification of biologically active constituents of poplar-type propolis. Phytochemical Analysis, 15, 235–240.
   PubMed Web of Science ®Google Scholar
• Popova, M. P., Chinou, I. B., Marekov, I. N., & Bankova, V. S. (2009). Terpenes with antimicrobial activity from Cretan propolis. Phytochemistry, 70, 1262–1271.
   PubMed Web of Science ®Google Scholar
• Rai, S., Wahile, A., Mukherjee, K., Saha, B. P., & Mukherjee, P. K. (2006). Antioxidant activity of Nelumbo nucifera (sacred lotus) seeds. Journal of Ethnopharmacology, 104, 322–327.
   PubMed Web of Science ®Google Scholar
• Sarikaya, A. O., Ulusoy, E., Ozturk, N., Tuncel, M., & Kolayli, S. (2009). Antioxidant activity and phenolic acid constituents of chesnut (Castania sativa Mill.) honey and propolis. Journal of Food Biochemistry, 33, 470–481.
   Web of Science ®Google Scholar
• Schnitzler, S., Neuner, A., Nolkemper, S., Zundel, C., Nowack, H., Sensch, K. H., & Reichling, J. (2010). Antiviral activity and mode of action of propolis extracts and selected compounds. Phytotherapy Research, 28, 20–28.
   Google Scholar
• Sforcin, J. M., & Bankova, V. (2011). Propolis: Is there a potential for the development of new drugs? Journal of Ethnopharmacology, 133, 253–260.
   PubMed Web of Science ®Google Scholar
• Sherif, M. S., Rehab, T. A., Hamdia, Z. A., & Torchilin, V. P. (2018). Cytotoxicity of propolis nanopreparations in cancer cell monolayers: Multimode of action including apoptotsis and nitric oxide production. General Physiology and Biophysics, 37(1), 101–110.
   PubMed Web of Science ®Google Scholar
• Shiner, M., Fuhrman, B., & Aviram, M., (2006). A biphasic U-shape effect of cellular oxidative stress on the macrophage anti-oxidant paraoxonase 2 (PON2) enzymatic activity. Biochemical and Biophysical Research Communications, 349(3), 1094–1099.
   PubMed Web of Science ®Google Scholar
• Silici, S., & Kutluca, S. (2005). Chemical composition and antibacterial activity of propolis collected by three different races of honeybees in the same region. Journal of Ethnopharmacology, 99, 69–73.
   PubMed Web of Science ®Google Scholar
• Silva, V., Genta, G., Möller, M. N., Masner, M., Thomson, L., Romero, N., … Denicola, A. (2011). Antioxidant activity of Uruguayan propolis. In vitro and cellular assays. Journal of Agriculture and Food Chemistry, 59, 6430–6437.
   PubMed Web of Science ®Google Scholar
• Suffness, M., & Pezzuto, J. M. (1990). Assays related to cancer drug discovery. In K. Hostettmann (Ed.), Methods in plant biochemistry: Assays for bioactivity (pp. 71–133). London: Academic Press.
   Google Scholar
• Sulaiman, G. M., Ad’hiah, A. H., Al-Sammarrae, K. W., Bagnati, R., Frapolli, R., Bello, E., … D'Incalci, M. (2012). Assessing the anti-tumour properties of Iraqi propolis in vitro and in vivo. Food and Chemical Toxicology, 50, 1632–1641.
   PubMed Web of Science ®Google Scholar
• Tartik, M., Darendelioglu, E., Aykutoglu, G., & Baydas, G. (2016). Turkish propolis supresses MCF-7 cell death induced by homocysteine. Biomedicine & Pharmacotherapy, 82, 704–712.
   PubMed Web of Science ®Google Scholar
• Tavarini, S., Degl’Innocenti, E., Guidi, L., & Pardossi, A. (2007). Biochemical aspects in two minimally processed lettuces upon storage. International Journal of Food Science and Technology, 42, 214–219.
   Web of Science ®Google Scholar
• Trusheva, B., Trunkova, D., & Bankova, V. (2007). Different extraction methods of biologically active components from propolis: A preliminary study. Chemistry Central Journal, 1, 1–4.
   PubMed Web of Science ®Google Scholar
• Turan, I., Değer, O., Aliyazicioğlu, Y., Demir, S., Kilinç, K., & Sümer, A. (2015a). Effects of Turkish propolis on expression of hOGG-1 and NEIL-1. Turkish Journal of Medicine, 45(4), 804–811.
   PubMed Web of Science ®Google Scholar
• Turan, I., Demir, S., Misir, S., Kilinc, K., Mentese, A., Aliyazicioglu, Y., & Deger, O. (2015b). Cytotoxic effect of Turkish propolis on liver, colon, breast, cervix and prostate cancer cell lines. Tropical Journal of Pharmaceutical Research, 14, 777–782.
   Web of Science ®Google Scholar
• Umthong, S., Phuwapraisirisan, P., Puthong, S., & Chanchao, C. (2011). In vitro antiproliferative activity of partially purified trigona laeviceps propolis from Thailand on human cancer cell lines. BMC Complementary and Alternative Medicine, 11, 37.
   PubMed Web of Science ®Google Scholar
• Valente, M. J., Baltazar, A. F., Henrique, R., Estevinho, L., & Carvalho, M. (2011). Biological activities of Portuguese propolis: Protection against free radical-induced erythrocyte damage and inhibition of human renal cancer cell growth in vitro. Food and Chemical Toxicology, 49, 86–92.
   PubMed Web of Science ®Google Scholar
• Vatansever, H. S., Sorkun, K., Delioglu-Gurhan, S. İ., Ozdal-Kurt, F., Turkoz, E., Gencay, O., & Salih, B. (2010). Propolis from Turkey induces apoptosis through activating caspases in human breast carcinoma cell lines. Acta Histochemica, 112, 546–556.
   PubMed Web of Science ®Google Scholar
• Velioglu, Y. S., Ekici, L., & Poyrazoğu, E. S. (2006). Phenolic composition of European cranberrybush (Viburnum opulus l.) berries and astringency removal of its commercial juice. International Journal of Food Science and Technology, 41, 1011–1015.
   Web of Science ®Google Scholar
• Watanabe, M. A., Amarante, M. K., Conti, B. J., & Sforcin, J. M. (2011). Cytotoxic constituents of propolis inducing anticancer effects: A review. The Journal of Pharmacy and Pharmacology, 63, 1378–1386.
   PubMed Web of Science ®Google Scholar
• Wojtyczka, R. D., Dziedzic, A., Idzik, D., Kępa, M., Kubina, R., Kabała-Dzik, A., … Wąsik, T. J. (2015). Susceptibility of Staphylococcus aureus clinical isolates to propolis extract alone or in combination with antimicrobial drugs. Molecules, 18(8), 9623–9640.
   Web of Science ®Google Scholar
• Wu, J., Omene, C., Karkoszka, J., Bosland, M., Eckard, J., Klein, C. B., & Frenkel, K. (2011). Caffeic acid phenethyl ester (CAPE), derived from a honey bee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer. Cancer Letters, 308, 43–53.
   PubMed Web of Science ®Google Scholar
• Xuan, H., Li, Z., Yan, H., Sang, Q., Wang, K., He, Q., … Hu, F. (2014). Antitumor activity of Chinese propolis in human breast cancer MCF-7 and MDA-MB-231 cells. Evidence-Based Complementary and Alternative Medicine, 2014, Article ID 280120 (11 pp).
   Web of Science ®Google Scholar
• Yesiltas, B., Capanoglu, E., Firatligil-Durmus, E., Sunay, A. E., Samanci, T., & Boyacioglu, D. (2015). Investigating the in-vitro bioaccessibility of propolis and pollen using a simulated gastrointestinal digestion system. Journal of Apicultural Research, 53(1), 101–108. doi: 10.3896/IBRA.1.53.1.10
   Web of Science ®Google Scholar
• Zizic, J. B., Vukovic, N. L., Jadranin, M. B., Andelkovic, B. D., Tesevic, V. V., Kacaniova, M. M., … Markovic, S. D. (2013). Chemical composition, cytotoxic and antioxidative activities of ethanolic extracts of propolis on HCT-116 cell line. Journal of the Science of Food and Agriculture, 93, 3001–3009.
   PubMed Web of Science ®Google Scholar