Transdifferentiation into biliary ductular cells of hepatocytes transplanted into the spleen

References

• Fogli L, Cappellari L, Gorini P, et al. The origin of bile ductular-like structures after transplantation of regenerating hepatocytes into the spleen of syngeneic rats. Ital J Surg Sci 1987; 17: 147–151
   PubMedGoogle Scholar
• Hillan K J, Burt A D, George W D, et al. Intrasplenic hepatocyte transplantation in rats with experimental liver injury: Morphological and morphometric studies. J Pathol 1989; 159: 67–73
   PubMed Web of Science ®Google Scholar
• Jiang B, Kasai S, Sawa M, et al. Beneficial effect of hepatic stimulatory substances on the survival of intrasplenically transplantation hepatocytes. Cell Transplant 1993; 2: 325–329
   PubMed Web of Science ®Google Scholar
• Sakata H, Jiang B, Kusano M, et al. Proliferation and morphogenesis of biliary epithelial cells in syngeneic hepatocytes transplantation into the spleen under FK 506. Int Hepatol Commun 1994; 2: 67–69
   Web of Science ®Google Scholar
• Alison M R, Golding M H, Sarraf C E. Pluripotential liver stem cells: Facultative stem cells located in the biliary tree. Cell Prolif 1996; 29: 373–402
   PubMed Web of Science ®Google Scholar
• Thorgeirsson S S. Hepatic stem cells in liver regeneration. FASEB J 1996; 10: 1249–1256
   PubMed Web of Science ®Google Scholar
• Shafritz D A, Dabeva M D. Liver stem cells and model systems for liver repopulation. J Hepatol 2002; 36: 552–564
   PubMed Web of Science ®Google Scholar
• Fukuda K, Sugihara A, Nakasho K, et al. The origin of biliary ductular cells that appear in the spleen after transplantation of hepatocytes. Cell Transplant 2004; 13: 27–33
   PubMed Web of Science ®Google Scholar
• Ise H, Nikaido T, Negishi N, et al. Effective hepatocyte transplantation using rat hepatocytes with low asialoglycoprotein receptor expression. Am J Pathol 2004; 165: 501–510
   PubMed Web of Science ®Google Scholar
• Berry M N, Friend D S. High-yield preparation of isolated rat liver parenchymal cells: A biochemical and fine structural study. J Cell Biol 1969; 43: 506–520
   PubMed Web of Science ®Google Scholar
• Laconi E, Oren R, Mukhopadhyay D K, et al. Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am J Pathol 1998; 153: 319–329
   PubMed Web of Science ®Google Scholar
• Michalopoulos G K, Bowen W C, Mulè K, et al. Hepatocytes undergo phenotypic transformation to biliary epithelium in organoid cultures. Hepatology 2002; 36: 278–283
   PubMed Web of Science ®Google Scholar
• Michalopoulos G K, Barua L, Bowen W C. Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury. Hepatology 2005; 41: 535–544
   PubMed Web of Science ®Google Scholar
• Van Eyken P, Sciot R, Van Damme B, et al. Keratin immunohistochemistry in normal human liver. Cytokeratin pattern of hepatocytes, bile ducts and acinar gradient. Virchow Arch A 1987; 412: 63–72
   Web of Science ®Google Scholar
• Lenzi R, Liu M H, Tarsetti F, et al. Histogenesis of bile duct-like cells proliferating during ethionine hepatocarcinogenesis. Evidence for a biliary epithelial nature of oval cells. Lab Invest 1992; 66: 390–402
   PubMed Web of Science ®Google Scholar
• Paku S, Dezső K, Kopper L, et al. Immunohistochemical analysis of cytokeratin 7 expression in resting and proliferating biliary structures of rat liver. Hepatology 2005; 42: 863–870
   PubMed Web of Science ®Google Scholar
• Mitaka T, Kojima T, Mizuguchi T, et al. Growth and maturation of small hepatocytes isolated from adult rat liver. Biochem Biophys Res Commun 1995; 214: 310–317
   PubMed Web of Science ®Google Scholar
• Tateno C, Yoshizato K. Growth and differentiation in culture of clonogenic hepatocytes that express both phenotypes of hepatocytes and biliary epithelial cells. Am J Pathol 1996; 149: 1593–1605
   PubMed Web of Science ®Google Scholar
• Katayama S, Tateno C, Asahara T, et al. Size-depedent in vivo growth potential of adult rat hepatocytes. Am J Pathol 2001; 158: 97–105
   PubMed Web of Science ®Google Scholar
• Nishikawa Y, Doi Y, Watanabe H, et al. Transdifferentiation of mature rat hepatocytes into bile duct-like cells in vitro. Am J Pathol 2005; 166: 1077–1088
   PubMed Web of Science ®Google Scholar
• Desmet V, Roskams T, Van Eyken P. Ductular reaction in the liver. Pathol Res Pract 1995; 191: 513–524
   PubMed Web of Science ®Google Scholar
• Alvaro D, Gigliozzi A, Attili A F. Regulation and deregulation of cholangiocyte proliferation. J Hepatol 2000; 33: 333–340
   PubMed Web of Science ®Google Scholar