Leg fat mass as measured by dual X‐ray absorptiometry (DXA) impacts insulin resistance differently in obese women versus men

References

• Abate N., Garg A., Peshock R. M., Stray‐Gundersen J., Grundy S. M. Relationship of generalized and regional adiposity to insulin sensitivity in men. J Clin Invest 1995; 96: 8–98
   Google Scholar
• Björntorp P. Metabolic implications of body fat distribution. Diabetes Care 1991; 14: 1132–43
   PubMed Web of Science ®Google Scholar
• Carey D. G., Jenkins A. B., Campbell L. V., Freund J., Chrisholm D. J. Abdominal fat and insulin resistance in normal and overweight women. Diabetes 1996; 45: 633–8
   PubMed Web of Science ®Google Scholar
• Despres J‐P. Abdominal obesity as important component of insulin resistance syndrome. Nutrition 1993; 9: 452–9
   PubMed Web of Science ®Google Scholar
• Snijder M. B., Dekker J. M., Visser M., Bouter L. M., Stehouwer C. D., Yudkin J. S., et al. Trunk fat and leg fat have independent and opposite associations with fasting and postload glucose levels. Diabetes Care 2004; 27: 372–7
   PubMed Web of Science ®Google Scholar
• Lissner L., Bjorkelund C., Heitmann B. L., Seidell J. C., Bengtsson C. Larger hip circumference independently predicts health and longevity in a Swedish female cohort. Obes Res 2001; 9: 644–9
   PubMedGoogle Scholar
• Heitmann B. L., Frederiksen P., Lissner L. Hip circumference and cardiovascular morbidity and mortality in men and women. Obes Res 2004; 12: 482–7
   PubMedGoogle Scholar
• Snijder M. B., Dekker J. M., Visser M., Bouter L. M., Stehouwer C. D., Kostense P. J., et al. Associations of hip and thigh circumferences independent of waist circumference with the incidence of type 2 diabetes: the Hoorn study. Am J Clin Nutr 2003; 77: 1192–7
   PubMed Web of Science ®Google Scholar
• Snijder M. B., Dekker J. M., Visser M., Yudkin J. S., Coen D. A., Stehouwer L. M., et al. Larger thigh and hip circumferences are associated with better glucose tolerance: the Hoorn study. Obes Res 2003; 11: 104–11
   PubMedGoogle Scholar
• Seidell J. C., Pérusse L., Deprés J‐P., Bouchard C. Waist and hip circumferences have independent and opposite effects on cardiovascular disease risk: the Quebec family study. Am J Clin Nutr 2001; 74: 315–21
   PubMed Web of Science ®Google Scholar
• Snijder M. B., Zimmet P. Z., Visser M., Dekker J. M., Seidell J. C., Shaw J. E. Independent and opposite associations of waist and hip circumferences with diabetes, hypertension and dyslipidemia: the AusDiab study. Int J Obes Relat Metab Disord 2004; 28: 402–9
   PubMed Web of Science ®Google Scholar
• Williams M. J., Hunter G. R., Kekes‐Szabo T., Snyder S., Treuth M. S. Regional fat distribution in women and risk of cardiovascular disease. Am J Clin Nutr 1997; 65: 855–60
   PubMed Web of Science ®Google Scholar
• Tankó L. B., Bagger Y. Z., Alexandersen P., Larsen P. J., Christiansen C. Peripheral adiposity exhibits an independent dominant antiatherogenic effect in elderly women. Circulation 2003; 107: 1626–31
   PubMed Web of Science ®Google Scholar
• Van Pelt R. E., Evans E. M., Schechtman K. B., Ehsani A. A., Kohrt W. M. Contribution of total and regional fat mass to risk for cardiovascular disease in older women. Am J Physiol Endocrinol Metab 2002; 282: E1023–8
   PubMed Web of Science ®Google Scholar
• Van Pelt R. E., Jankowski C. M., Gozansky W. S., Schwartz R. S., Kohrt W. M. Lower‐body adiposity and metabolic protection in postmenopausal women. J Clin Endocrinol Metab 2005; 90: 4573–8
   PubMed Web of Science ®Google Scholar
• Sakai Y., Ito H., Egami Y., Ohoto N., Hijii C., Yanagawa M., et al. Favourable association of leg fat with cardiovascular risk factors. J Inter Med 2005; 257: 194–200
   PubMed Web of Science ®Google Scholar
• Khee Gan Seng, Kriketos A. D., Poynten A. M., Furler S. M., Thompson C. H., Kraegen E. W., et al. Insulin action, regional fat, and myocyte lipid: altered relationships with increased adiposity. Obes Res 2003; 11: 1295–305
   PubMedGoogle Scholar
• Paradisi G., Smith L., Burtner C., Leaming R., Garvey W. T., Hook G., et al. Dual energy x‐ray absorptiometry assessment of fat mass distribution and its association with the insulin resistance syndrome. Diabetes Care 1999; 22: 1310–17
   PubMed Web of Science ®Google Scholar
• Pouliot M‐C., Despres J‐P., Nadeau A., Moorjani S., Prud'homme D., Lupien P. J., et al. Visceral obesity in men: association with glucose tolerance, plasma insulin, and lipoprotein levels. Diabetes 1992; 41: 826–34
   PubMed Web of Science ®Google Scholar
• Snijder M. B., Visser M., Dekker J. M., Goodpaster B. H., Harris T. B., Kritchevsky S. B., et al. Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study. Diabetologia 2005; 48: 301–8
   PubMed Web of Science ®Google Scholar
• Tatsukawa M., Kurokawa M., Tamari Y., Yoshimatsu H., Sakata T. Regional fat deposition in the legs is useful as a presumptive marker of antiatherogenesity in Japanese. Proc Soc Exp Bio Med 2000; 223: 156–62
   PubMed Web of Science ®Google Scholar
• Goodpaster B. H., Krishnaswami S., Harris T. B., Katsiaras A., Kritchevsky S. B., Simonsick E. M., et al. Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med 2005; 165: 777–83
   PubMed Web of Science ®Google Scholar
• Aasen G., Fagertun H., Halse J. Body composition analysis by dual X‐ ray absorptiometry: in vivo and in vitro comparison of three different fan‐beam instruments. Scand J Clin Lab Invest 2006; 66: 659–66
   PubMed Web of Science ®Google Scholar
• Aasen G., Fagertun H., Halse J. Regional fat mass by DXA: High leg fat mass attenuates relative risk for insulin resistance and dyslipidemia in obese but not in overweight postmenopausal women. Scand J Clin Lab Invest 2008; 68: 204–11
   PubMed Web of Science ®Google Scholar
• Matthews D. R., Hosker J. P., Rudenski A. S., Naylor B. A., Treacher D. F., Turner R. C. Homeostasis model assessment: insulin resistance and beta‐cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412–19
   PubMed Web of Science ®Google Scholar
• Bonora E., Targher G., Alberiche M., Bonadonna R. C., Saggianai F., Zenere M. B., et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care 2000; 23: 57–63
   PubMed Web of Science ®Google Scholar
• Stumvoll M., Mitrakou A., Pimenta W., Jenssen T., Jarvinen H. Y., Van Haften T., et al. Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 2000; 23: 295–301
   PubMed Web of Science ®Google Scholar
• Friedewald W. T., Levy R. I., Fredrichson D. S. Estimation of the concentration of low‐density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499–502
   PubMed Web of Science ®Google Scholar
• Tchernof A., Poehlman E. T., Despres J. P. Body fat distribution, the menopause transition, and hormone replacement therapy. Diabetes & Metabolism (Paris) 2000; 26: 12–20
   Google Scholar
• Abate N., Haffner S. M., Abhimanyu G., Peshock R. M., Scott M. G. Sex steroid hormones, upper body obesity, and insulin resistance. J Clin Endocrinol Metab 2002; 87: 4522–7
   PubMed Web of Science ®Google Scholar
• Shand B. I., Scott R. S., Elder P. A., George P. M. Plasme adiponectin in overweight, nondiabetic individuals with or without insulin resistance. Diabetes Obes Metab 2003; 5: 349–53
   PubMed Web of Science ®Google Scholar
• Hanley A. J. G., Bowden D., Wagenknecht L. E., Balasubramanyam A., Langfeld C., Saad M. F., et al. Associations of adiponectin with body fat distribution and insulin sensitivity in non‐diabetic Hispanic and African Americans. J Clin Endocrinol Metab 2007, doi: 10.1210/jc.2006‐614
   Google Scholar
• Buemann B., Sørensen T. I. A., Pedersen O., Black E., Holst C., Toubro S., et al. Lower‐body fat mass as an independent marker of insulin sensitivity – the role of adiponectin. Int J Obes 2005; 29: 624–31
   Google Scholar
• Buemann B., Astrup A., Pedersen O., Black E., Holst C., Toubro S., et al. Possible role of adiponectin and insulin sensitivity in mediating the favourable effects of lower body fat mass on blood lipids. J Clin Endocrinol Metab 2006; 91: 1698–704
   PubMed Web of Science ®Google Scholar
• Staiger H., Tschritter O., Machann J., Thamer C., Fritsche A., Maerker E., et al. Relationship of serum adiponectin and leptin concentrations with body fat distribution in humans. Obes Res 2003; 11: 368–72
   PubMedGoogle Scholar
• Marette A., Mauriege P., Marcotte B., Atgie C., Bouchard C., Theriault C., et al. Regional variations in adipose tissue insulin action and GLUT4 transporter expression in severely obese premenopausal women. Diabetologia 1997; 40: 590–8
   PubMedGoogle Scholar
• Bos G., Snijder M. B., Nijpels G., Dekker J. M., Stehouwer C. D. A., Bouter L. M., et al. Opposite contributions of trunk and leg fat mass with plasma lipase activities: the Hoorn Study. Obes Res 2005; 13: 1817–23
   PubMedGoogle Scholar
• Hanley A. J. G., Williams K., Stern M. P., Haffner S. M. Homeostasis model assessment of insulin resistance of cardiovascular disease. The San Antonio Heart Study. Diabetes Care 2002; 25: 1177–84
   PubMed Web of Science ®Google Scholar
• Huptas S., Geiss H. C., Otto C., Parhofer K. G. Effect of atorvastatin (10 mg/day) on glucose metabolism in patients with the metabolic syndrome. Am J Cardiol 2006; 1: 66–9
   Google Scholar