miR-192 suppresses T follicular helper cell differentiation by targeting CXCR5 in childhood asthma

References

• Duijts L. Fetal and infant origins of asthma. Eur J Epidemiol. 2012;27:5–14.
   PubMed Web of Science ®Google Scholar
• Trivedi MK, Sharma S, Rifas-Shiman SL, et al. Folic acid in pregnancy and childhood asthma: a US cohort. Clin Immunol. 2017;9922817729482.
   Google Scholar
• Schmudde I, Laumonnier Y, Kohl J. Anaphylatoxins coordinate innate and adaptive immune responses in allergic asthma. Semin Immunol. 2013;25:2–11.
   PubMed Web of Science ®Google Scholar
• Wu LC, Scheerens H. Targeting IgE production in mice and humans. Curr Opin Immunol. 2014;31:8–15.
   PubMed Web of Science ®Google Scholar
• Hot topics from the Assemblies. Breathe. 2015;11:307–308.
   Web of Science ®Google Scholar
• Ferkol T, Schraufnagel D. The global burden of respiratory disease. Ann Am Thorac Soc. 2014;11:404–406.
   PubMedGoogle Scholar
• Wong GWK, Tingfan L, Ko FWS. Changing prevalence of allergic diseases in the Asia-Pacific region. Allergy Asthma Immunol Res. 2013;5:251–257.
   PubMed Web of Science ®Google Scholar
• King C, Tangye SG, Mackay CR. T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu Rev Immunol. 2008;26:741–766.
   PubMed Web of Science ®Google Scholar
• Wang Z, Ding L, Wang Z, et al. Circulating CD4(+)CXCR5(+) T cells exacerbate B cell antibody production in Crohn's disease through IL-21 secretion. Immunol Investig. 2015;44:665–677.
   PubMed Web of Science ®Google Scholar
• King C. A fine romance: T follicular helper cells and B cells. Immunity. 2011;34:827.
   PubMed Web of Science ®Google Scholar
• Xu H, Liu J, Cui X, et al. Increased frequency of circulating follicular helper T cells in lupus patients is associated with autoantibody production in a CD40L-dependent manner. Cell Immunol. 2015;295:46.
   PubMed Web of Science ®Google Scholar
• Morita R, Schmitt N, Bentebibel SE, et al. Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity. 2011;34:108–121.
   PubMed Web of Science ®Google Scholar
• Luo C, Li Y, Liu W, et al. Expansion of circulating counterparts of follicular helper T cells in patients with myasthenia gravis. J Neuroimmunol. 2013;256:55–61.
   PubMed Web of Science ®Google Scholar
• Simpson N, Gatenby PA, Wilson A, et al. Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum. 2010;62:234–244.
   PubMed Web of Science ®Google Scholar
• Arroyovilla I, Bautistacaro M, Balsa A, et al. Constitutively altered frequencies of circulating follicullar helper T cell counterparts and their subsets in rheumatoid arthritis. Arthritis Res Ther. 2014;16:500.
   PubMed Web of Science ®Google Scholar
• Gong F, Qian C, Zhu H, et al. Circulating follicular T-helper cell subset distribution in patients with asthma. Allergy Asthma Proc. 2016;37:154–161.
   PubMed Web of Science ®Google Scholar
• Gong F, Su Q, Jiang D, et al. High frequency of circulating follicular helper T cells in patients with bronchial asthma. Clin Lab. 2014;60:963–968.
   PubMed Web of Science ®Google Scholar
• Ma X, Sun Z, Zhai P, et al. Effect of follicular helper T cells on the pathogenesis of asthma. Exp Ther Med. 2017;14:967–972.
   PubMed Web of Science ®Google Scholar
• Fasanaro P, D'Alessandra Y, Magenta A, et al. microRNAs: promising biomarkers and therapeutic targets of acute myocardial ischemia. Curr Vasc Pharmacol. 2015;13:305–315.
   PubMed Web of Science ®Google Scholar
• Kam SH, Singh A, He JQ, et al. Peripheral blood gene expression changes during allergen inhalation challenge in atopic asthmatic individuals. J Asthma. 2012;49:219–226.
   PubMed Web of Science ®Google Scholar
• Yamamoto M, Singh A, Ruan J, et al. Decreased miR-192 expression in peripheral blood of asthmatic individuals undergoing an allergen inhalation challenge. BMC Genomics. 2012;13:655.
   PubMed Web of Science ®Google Scholar
• Garbacki N, Valentin ED, Huynhthu VA, et al. MicroRNAs profiling in murine models of acute and chronic asthma: a relationship with mRNAs targets. PloS One. 2011;6:e16509.
   PubMed Web of Science ®Google Scholar
• Cui YJ, Chen GH, Wang JL, et al. [Alterations of CD4 + CXCR5 + Tfh cells and its transcription regulatory factors in children with asthma]. Zhongguo Dang Dai Er Ke Za Zhi. 2014;16:1215–1219.
   PubMedGoogle Scholar
• Lazic N, Roberts G, Custovic A, et al. Multiple atopy phenotypes and their associations with asthma: similar findings from two birth cohorts. Allergy. 2013;68:764–770.
   PubMed Web of Science ®Google Scholar
• Rø AD, Simpson MR, Storrø O, et al. The predictive value of allergen skin prick tests and IgE tests at pre‐school age: The PACT study. Pediatr Allergy Immunol. 2015;25:691–698.
   Web of Science ®Google Scholar
• Tumes DJ, Papadopoulos M, Endo Y, et al. Epigenetic regulation of T‐helper cell differentiation, memory, and plasticity in allergic asthma. Immunol Rev. 2017;278:8–19.
   PubMed Web of Science ®Google Scholar
• O’Connell EJ. The burden of atopy and asthma in children. Allergy. 2004;59 Suppl 78:7–11.
   PubMed Web of Science ®Google Scholar
• Ferreira de Magalhaes MJ, Amaral RDS, Pereira AM, et al. Cost of asthma in children: a nationwide, population-based, cost-of-illness study. Pediatr Allergy Immunol. 2017;28:683–691.
   PubMed Web of Science ®Google Scholar
• Esteller M. Non-coding RNAs in human disease. Nat Rev Genet. 2011;12:861–874.
   PubMed Web of Science ®Google Scholar
• Alexandrova E, Miglino N, Hashim A, et al. Small RNA profiling reveals deregulated phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase (PI3K)/Akt pathway in bronchial smooth muscle cells from asthmatic patients. J Allergy Clin Immunol. 2016;137:58–67.
   PubMed Web of Science ®Google Scholar
• Heffler E, Allegra A, Pioggia G, et al. MicroRnas profiling in asthma: potential biomarkers and therapeutic targets. Am J Respir Cell Mol Biol. 2017;57:642–650.
   PubMed Web of Science ®Google Scholar
• Yamamoto M, Singh A, Jian R, et al. Decreased miR-192 expression in peripheral blood of asthmatic individuals undergoing an allergen inhalation challenge. BMC Genomics. 2012;13:1–9.
   PubMed Web of Science ®Google Scholar
• He J, Tsai L, Leong YA, et al. Circulating precursor CCR7 lo PD-1 hi CXCR5 + CD4 + T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity. 2013;39:770–781.
   PubMed Web of Science ®Google Scholar
• Cook KD, Shpargel KB, Starmer J, et al. T follicular helper cell-dependent clearance of a persistent virus infection requires T cell expression of the histone demethylase UTX. Immunity. 2015;43:703.
   PubMed Web of Science ®Google Scholar
• Craft JE. Follicular helper T cells in immunity and systemic autoimmunity. Nat Rev Rheumatol. 2012;8:337–347.
   PubMed Web of Science ®Google Scholar
• Zhang X, Ing S, Fraser A, Chen M, Khan O, Zakem J, Davis W, Quinet R. Follicular helper T cells: new insights into mechanisms of autoimmune diseases. Ochsner J. 2013;13:131.
   PubMedGoogle Scholar
• Feng J, Lu L, Hua C, et al. Correction: high frequency of CD4 + CXCR5+ TFH cells in patients with immune-active chronic hepatitis B. PLoS One. 2011;6:e21698.
   PubMed Web of Science ®Google Scholar
• Tangye SG, Ma CS, Brink R, et al. The good, the bad and the ugly – TFH cells in human health and disease. Nat Rev Immunol. 2013;13:412
   PubMed Web of Science ®Google Scholar
• Schmitt N, Ueno H. Blood Tfh cells come with colors. Immunity. 2013;39:629–630.
   PubMed Web of Science ®Google Scholar
• Schmitt N, Bentebibel SE, Ueno H. Phenotype and functions of memory Tfh cells in human blood. Trends Immunol. 2014;35:436–442.
   PubMed Web of Science ®Google Scholar
• Lim LP, Lau NC, Garrettengele P, et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 2005;433:769.
   PubMed Web of Science ®Google Scholar
• Feinberggorenshtein G, Guedj A, Shichrur K, et al. MiR-192 directly binds and regulates Dicer1 expression in neuroblastoma. PloS One. 2013;8:e78713.
   PubMed Web of Science ®Google Scholar
• Zhang S, Hao J, Xie F, et al. Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development. Carcinogenesis. 2011;32:1183.
   PubMed Web of Science ®Google Scholar
• Lagosquintana M, Rauhut R, Meyer J, et al. New microRNAs from mouse and human. RNA. 2003;9:175
   PubMed Web of Science ®Google Scholar
• Zhao C, Zhang J, Zhang S, et al. Diagnostic and biological significance of microRNA-192 in pancreatic ductal adenocarcinoma. Oncol Rep. 2013;30:276.
   PubMed Web of Science ®Google Scholar