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Research Article

A Critical Review of Epidemiological Studies in Inflammatory Bowel Disease

Pages 2-15 | Published online: 08 Jul 2009

References

  • Last J. Dictionary of epidemiology. 2nd ed. New York: Oxford University Press; 1988.
  • Gilat T, Hacohen D, Lilos P, Langman MJS. Childhood factors in ulcerative colitis and Crohn’s disease. Scand J Gastroenterol 1987;22:1009–24.
  • Orholm M, Munkholm P, Langholz E, Nielsen OH, Sorensen TIA, Binder V. Familial occurrence of inflammatory bowel disease. N Engl J Med 1991;324:84–8.
  • Meucci G, Vecchi M, Torgano G, Arrigoni M, Prada A, Rocca F, et al. Familial aggregation of IBD: a multi-centre study. Gastroenterology 1992;103:514–9.
  • Kitahora T, Utsunormiya T, Yokota A. Epidemiological study of ulcerative colitis in Japan: incidence and familial occurrence. The Epidemiology Group of the Research Committee of Inflammatory Bowel Disease in Japan. J Gastroenterol 1995; 30 Suppl 8:5–8.
  • Polito II JM, Rees RC, Childs B, Mendeloff AI, Harris ML, Bayles TM. Preliminary evidence for genetic anticipation in Crohn’s disease. Lancet 1996;347:798–800.
  • Thompson NP, Driscoll R, Pounder RE, Wakefield AJ. Genetics versus environment in IBD: results of a British twin study. BMJ 1996;312:95–6.
  • Satsangi J, Jewell DP, Rosenberg WMC, Bell JI. Genetics of inflammatory bowel disease. Gut 1994;35:696–700.
  • Satsangi J, Rosenberg WMC, Jewell DP. The prevalence of inflammatory bowel disease in relatives of patients with Crohn’s disease. Eur J Gastroenterol Hepatol 1994;6:413–6.
  • Binder V. Genetic epidemiology in inflammatory bowel disease. Dig Dis 1999;16(6):351–5.
  • Satsangi J, Jewell D, Parkes M, Bell J. Genetics of inflammatory bowel disease. A personal view on progress and prospects. Dig Dis 1999;16(6):370–4.
  • Satsangi J, Parkes M, Jewell DP, Bell JI. Genetics of inflammatory bowel disease. Clin Sci 1998;94(5):473–8.
  • Pena AS, Crusius JB. Genetics of inflammatory bowel disease: implications for the future. World J Surg 1998;22(4):390–3.
  • Satsangi J, Jewell DP. The genetics of inflammatory bowel disease. Gut 1997;40:572–4.
  • Mayberry JF, Rhodes J, Allan R, Newcombe RG, Regan GM, Chamberlain LM, et al. Diet in Crohn’s disease: two studies of current and previous habits in newly diagnosed patients. Dig Dis Sci 1981;26:444–8.
  • Persson PG, Ahlbom A, Hellers G. Diet and IBD: a case–control study. Epidemiology 1992;3:47–52.
  • Tragnone A, Hanau C, Bazzocchi G, Lanfranchi GA. Epidemiological characteristics of inflammatory bowel disease in Bologna, Italy—incidence and risk factors. Digestion 1993; 54(3):183–8.
  • Thornton TR, Emmett PM, Heaton KW. Diet and Crohn’s disease: characteristics of the pre-illness habit. BMJ 1979;2: 762–4.
  • Katschinski B, Logan RF, Edmond M, Langman MJ. Smoking and sugar intake are separate but interactive risk factors in Crohn’s disease. Gut 1988;29:1202–6.
  • Lashner BA, Shaheen NJ, Hanauer SB, Kirschner BS. Passive smoking is associated with an increased risk of developing inflammatory bowel disease in children. Am J Gastroenterol 1993;88:356–9.
  • Calkins BM. A meta-analysis of the role of smoking in inflammatory bowel disease. Dig Dis Sci 1989;34:1841–54.
  • Lindberg E, Huitfeldt JB. Smoking in Crohn’s disease: effect on localization and clinical course. Gut 1992;33:779–82.
  • Logan RF, Edmond M, Somerville KW, Langman MJ. Smoking and ulcerative colitis. BMJ Clin Res Ed 1984;288: 751–3.
  • Logan RFA, Kay CR. Oral contraception, smoking and inflammatory bowel disease—findings in the Royal College of General Practitioners oral contraception study. Int J Epidemiol 1989;18:105–7.
  • Katschinski B, Fingerle D, Scherbaum B, Goebell H. Oral contraceptive use and cigarette smoking in Crohn’s disease. Dig Dis Sci 1993;38:1596–600.
  • Jick H, Walker AM. Cigarette smoking and ulcerative colitis. N Engl J Med 1983;308:261–3.
  • Boyko EJ, Keopsell TD, Perera DR, Inui TS. Risk of ulcerative colitis among former and current cigarette smokers. N Engl J Med 1987;316:707–10.
  • Roberts CJ, Diggle R. Non smoking: a feature of ulcerative colitis. BMJ 1982;285:440.
  • Persson PG, Ahlbom A, Hellers G. Inflammatory bowel disease and tobacco smoke—a case–control study. Gut 1990;31:1377–81.
  • Lorusso D, Leo S, Misciagna G, Guerra V. Cigarette smoking and ulcerative colitis. A case–control study. Hepatogastroenterology 1989;36:202–4.
  • Sandler RS, Sandler DP, McDonnell CW, Wurzelmann JI. Childhood exposure to environmental tobacco smoke and the risk of ulcerative colitis. Am J Epidemiol 1992;135:603–8.
  • Lindberg E, Tysk C, Andersson K, Jarnerot G. Smoking and inflammatory bowel disease. A case control study. Gut 1988; 29:352–7.
  • Silverstein MD, Lashner BA, Hanauer SB, Evans AA, Kirsner JB. Cigarette smoking in Crohn’s disease. Am J Gastroenterol 1989;84:31–3.
  • Srivastava ED, Rhodes J, Avramidis P, Mayberry JF. Smoking and ulcerative colitis: a community study. Int J Colorectal Dis 1993;8:71–4.
  • Benoni C, Nilsson A. Smoking habits in patients with inflammatory bowel disease. A case control study. Scand J Gastroenterol 1984;19:824–30.
  • Vessey M, Jewell D, Smith A, Yeates D, McPherson K. Chronic inflammatory bowel disease, cigarette smoking, and use of oral contraceptives: findings in a large cohort study of women of childbearing age. BMJ 1986;292:1101–3.
  • Bustamante M, Nos P, Hoyos M, Hinojosa J, Moles JR, Garcia-Herola A, et al. Relationship between smoking and colonic involvement in inflammatory bowel disease. Esp Enferm Dig 1998;90(12):833–40.
  • Corra G, Tragnone A, Caprilli R, Trallori G, Papi C, Andreoli A, et al. Risk of inflammatory bowel disease attributable to smoking, oral contraceptive and breastfeeding in Italy: a nationwide case–control study. Int J Epidemiol 1998;27:397–404.
  • Persson PG, Leijonmarck CE, Bernell O, Hellers G, Ahlbom A. Risk indicators for inflammatory bowel disease. Int J Epidemiol 1993;22:268–72.
  • Sandler RS, Wurzelmann JI, Lyles CM. Oral contraceptive use and the risk of inflammatory bowel disease. Epidemiology 1992; 3(4):374–8.
  • Rhodes JM, Cockel R, Allan RM, Hawkes PC, Dawson J, Elias E. Colonic Crohn’s disease and use of oral contraception. BMJ 1984;288:595–6.
  • Wakefield AJ, Sawyerr AM, Hudson M, Dhillon AP, Pounder RE. Smoking, the oral contraceptive pill, and Crohn’s disease. Dig Dis Sci 1991;36:1147–50.
  • Lesko SM, Kaufman DW, Rosenberg L, Helmich SP, Miller DR, Stolley PD, et al. Evidence for an increased risk of Crohn’s disease in oral contraceptive users. Gastroenterology 1985;89: 1046–9.
  • Wurzelmann JI, Sandler RS, McDonnel CM. Oral contraceptive use and the risk of inflammatory bowel disease. Gastroenterology 1990;100:A263.
  • Acheson ED, Truelove SC. Early weaning in the aetiology of ulcerative colitis: a study of feeding in infancy in cases and controls. BMJ 1981;2:923–9.
  • Bergstrom O, Hellers G. Breast feeding during infancy in patients who later develop Crohn’s disease. Scand J Gastroenterol 1983;18:903–6.
  • Rigas A, Rigas B, Glassman M, Yen YY, Lan SJ, Petriduo E, et al. Breast-feeding and maternal smoking in the etiology of Crohn’s disease and ulcerative colitis in childhood. Ann Epidemiol 1993;3(4):387–92.
  • Koletzko S, Sherman P, Corey M, Griffiths A, Smith C. Role of infant feeding practices in development of Crohn’s disease in childhood. BMJ 1989;298:1617–8.
  • Koletzko S, Griffiths A, Corey M, Smith C, Sherman P. Infant feeding practices and ulcerative colitis in childhood. BMJ 1991;302:1580–1.
  • Thompson NP, Pounder RE, Wakefield AJ. Perinatal and childhood risk factors for inflammatory bowel disease: a case–control study. Eur J Gastroenterol Hepatol 1995;7:385–95.
  • Ekbom A, Adami H-O, Helmick CG, Jonzon A, Zack MM. Perinatal risk factors for inflammatory bowel disease: a case control study. Am J Epidemiol 1990;132:1111–9.
  • Whorwell PJ, Holdstock G, Whorwell GM, Wright R. Bottle feeding, early gastroenteritis, and inflammatory bowel disease. BMJ 1979;1:382.
  • Thompson NP, Montgomery SM, Pounder RE, Wakefield AJ. Is measles vaccination a risk factor for inflammatory bowel disease? Lancet 1995;345:1071–4.
  • Ekbom A, Wakefield AJ, Zack M, Adami HO. The role of perinatal measles infection in the aetiology of Crohn’s disease: a population-based epidemiological study. Lancet 1994;334: 508–10.
  • Sanderson JD, Moss MT, Tizard ML, Hermon-Taylor J. Mycobacterium paratuberculosis DNA in Crohn’s disease tissue. Gut 1992;33:890–6.
  • Sanderson JD, Hermon-Taylor J. Mycobacterial disease of the gut: some impact from molecular biology. Gut 1992;33:145–7.
  • Wakefield AJ, Pittilo RM, Sim R. Evidence of persistent measles virus infection in Crohn’s disease. J Med Virol 1993; 39: 345–53.
  • Wurzelmann JI, Lyles CM, Sandler RS. Childhood infections and the risk of inflammatory bowel disease. Dig Dis Sci 1994; 39:555–60.
  • Gent AE, Hellier MD, Grace RH, Swarbrick ET, Coggon D. Inflammatory bowel disease and domestic hygiene in infancy. Lancet 1994;343:766–7.
  • Allan RN, Pease P, Ibbotson JP. Clustering of Crohn’s disease in a Cotswold village. Q J Med 1986;59:473–8.
  • Bennett RA, Rubin PH, Present DH. Frequency of inflammatory bowel disease in offspring of couples both presenting with inflammatory bowel disease. Gastroenterology 1991;100: 1638–43.
  • Ekbom A, Zack M, Adami H-O, Hemick C. Is there clustering of inflammatory bowel disease at birth? Am J Epidemiol 1991;134: 876–86.
  • Miller DS, Keighley A, Smith PG, Hughes AO, Langman MJ. Crohn’s disease in Nottingham: a search for time–space clustering. Gut 1975;16:454–7.
  • Cave DR, Freedman LS. Seasonal variation in clinical presentation of Crohn’s disease and ulcerative colitis. Int J Epidemiol 1975;4:317–20.
  • Sonnenberg A. Occupational distribution of inflammatory bowel disease among German employees. Gut 1990;31:1037–40.
  • Sonnenberg A. Occupational mortality of inflammatory bowel disease. Digestion 1990;46:10–8.
  • Aabakken L, Osnes M. Non-steroidal anti-infl ammatory drug-induced disease in the distal ileum and large bowel. Scand J Gastroenterol 1989;24 Suppl 163:48–55.
  • Stewart THM, Hetenyi C, Rowsell H, Orizaga M. Ulcerative enterocolitis in dogs induced by drugs. J Pathol 1980;131:363–78.
  • Hall RI, Petty AH, Cobden I, Lendrum R. Enteritis and colitis associated with mefanamic acid. BMJ 1983;287:1182.
  • Philips MS, Fehilly B, Stewart S, Dronfield MW. Enteritis and colitis associated with mefanamic acid. BMJ 1983;287:1626.
  • Edwards AL, Heagerty AM, Bing RF. Enteritis and colitis associated with mefanamic acid. BMJ 1983;287:1626–7.
  • Bjarnason I, Zanelli G, Smith T, Prouse P, Williams P, Smethurst P, et al. Nonsteroidal anti-infl ammatory drug-induced intestinal inflammation in humans. Gastroenterology 1987;93: 480–9.
  • Tanner AR, Raghunath AS. Colonic inflammation and nonsteroidal anti-inflammatory drug administration: an assessment of the frequency of the problem. Digestion 1988;41:116–20.
  • Rutgeerts P, D’Haens G, Hiele M, Geboes K, Vantrappen G. Appendectomy protects against ulcerative colitis. Gastroenterology 1994;106:1251–3.
  • Scott IS, Sheaff M, Coumbe A, Feakins RM, Rampton DS. Appendiceal inflammation in ulcerative colitis. Histology 1998; 33(2):168–73.
  • Duggan AE, Usmani I, Neal KR, Logan RFA. Appendicectomy, childhood hygiene, Helicobacter pylori status, and risk of inflammatory bowel disease: a case–control study. Gut 1998;43: 494–8.
  • Derby LE, Jick H. Appendectomy protects against ulcerative colitis. Epidemiology 1997;9(2):205–7.
  • Dijkstra B, Bagshaw PF, Frizella FA. Protective effect of appendectomy on the development of ulcerative colitis: matched, case–control study. Dis Colon Rectum 1999;42(3): 334–6.
  • Parrello T, Pavia M, Angelillo IF, Monteleone G, Riegler G, Papi G, et al. Appendectomy is an independent protective factor for ulcerative colitis: results of a multi-centre case control study. The Italian Group for the Study of the Colon and Rectum. Ital J Gastroenterol Hepatol 1997;29(3):208–11.
  • Smithson JE, Radford-Smith G, Jewell GP. Appendectomy and tonsillectomy in patients with inflammatory bowel disease. J Clin Gastroenterol 1995;21(4):283–6.
  • Russel MG, Dorant E, Brummer RJ, van de Kruijs MA, Muris JW, Bergers JM, et al. Appendectomy and the risk of developing ulcerative colitis or Crohn’s disease: results of a large case control study. South Limberg Inflammatory Bowel Disease Study Group. Gastroenterology 1997;113(2):377–82.
  • Koutroubakis IE, Vlachonikolis IG, Kapsoritakis A, Spanoudakis S, Roussomoustakaki M, Mouzas IA, et al. Appendectomy, tonsillectomy, and risk of inflammatory bowel disease: case–controlled study in Crete. Dis Colon Rectum 1999;42(2): 225–30.
  • Sullivan SN. Hypothesis revisited: toothpaste and the cause of Crohn’s disease. Lancet 1990;336:1096–7.
  • Levine J. Exogenous factors in Crohn’s disease. A critical review. J Clin Gastroenterol 1992;14:216–26.
  • Russel MGVM, Stockerugger RW. Epidemiology of inflammatory bowel disease: an update. Scand J Gastroenterol 1996;31: 417–27.
  • Mayberry JF, Ballantyne KC, Hardcastle JD, Mangham C, Pye G. Epidemiological study of symptomatic inflammatory bowel disease: the identification of cases during a screening programme for colorectal cancer. Gut 1989;30:481–3.
  • Sandler RS. Epidemiology of inflammatory bowel disease. In: Targan SR, Shanahan F, editors. Inflammatory bowel disease; from bench to bedside. Baltimore, MD: Williams & Wilkins; 1994. p. 5–32.
  • Shivananda S, Lennard-Jones J, Logan R, Fear N, Price A, Carpenter L, et al. Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European collaboration study on inflammatory bowel disease (EC-IBD). Gut 1996;39:690–7.
  • Lennard-Jones JE. Classification of inflammatory bowel disease. Scand J Gastroenterol 1989;24 Suppl 170:2–6.
  • Probert CSJ, Jayanthi V, Pinder D, Wicks AC, Mayberry JF. Epidemiological study of ulcerative proctocolitis in Indian migrants and the indigenous population of Leicestershire. Gut 1992;33:687–93.
  • Mayberry JF. Crohn’s disease in developing countries. Ital J Gastroenterol 1980;12:324–6.
  • Mayberry JF, Mann R. Inflammatory bowel disease in rural sub-Saharan Africa: rarity of diagnosis in patients attending mission hospitals. Digestion 1989;44:172–6.
  • ICD-9 International Classification of Diseases. 9th Version, 3rd Edition Clinical Modification. Vol. 1, 2, 3. Practice Management Information Corporation; 1989.
  • ICD-10 International Classification of Diseases and Related Health Problems. 10th Version, Vol. 3. World Health Organization; 1994.
  • Ekbom A, Helmick C, Zack M, Adami HO. The epidemiology of inflammatory bowel disease: a large, population-based study in Sweden. Gastroenterology 1991;100:350–8.
  • Fonager K, Sorensen HT, Olsen O. Change in incidence of Crohn’s disease and ulcerative colitis in Denmark. A study based on the National Registry of patients, 1981–1992. Int J Epidemiol 1997;26: 1003–8.
  • Bernstein CN, Blanchard JF, Rawsthorne P, Wajda A. Epidemiology of Crohn’s disease and ulcerative colitis in a central Canadian province: a population-based study. Am J Epidemiol 1999;149(10):916–24.
  • Jenicek M. Epidemiology. The logic of modern medicine. EPIMED International; 1995.
  • Wright JP, Marks IN, Jameson C, Garish JAM, Kottler RE. Inflammatory bowel disease in Cape Town, 1975–1980. part II. Crohn’s disease. South Afr Med J 1983;63: 226–9.
  • Wright JP, Froggatt J, O’Keefe EA, Ackerman S, Watermeyer S, Louw J, et al. The epidemiology of inflammatory bowel disease in Cape Town 1980–1984. South Afr Med J 1986;70: 10–5.
  • Brahme F, Lindstrom C, Wenckert A. Crohn’s disease in a defined population. An epidemiological study of incidence, prevalence, mortality, and secular trends in the city of Malmo, Sweden. Gastroenterology 1975;69:342–51.
  • Stewenius J, Adnerhill I, Ekelund G, Floren CH, Fork FT, Janzon L, et al. Ulcerative colitis and indeterminate colitis in the city of Malmo, Sweden. A 25-year incidence study. Scand J Gastroenterol 1995;30:38–43.
  • Colombel JF, Salomez JL, Cortot A, Marti R, Lemaire B, Beuscart R, et al. Incidence of inflammatory bowel disease in north-western France. Scand J Gastroenterol 1989;24:22–4.
  • Cottone M, Cipolla C, Orlando A, Olivia L, Salerno G, Pagliaro L. Hospital incidence of Crohn’s disease in the Province of Palermo. A preliminary report. Scand J Gastroenterol 1989;24 Suppl 170:27–8.
  • Tsianos EV, Masalas CN, Merkouropoulos M, Dalekos GN, Logan RFA. Incidence of inflammatory bowel disease in north west Greece: rarity of Crohn’s disease in an area where ulcerative colitis is common. Gut 1994;35:369–72.
  • Manousos ON, Giannadaki E, Mouzas IA, Tzardi M, Koutroubakis I, Skordilis P, et al. Ulcerative colitis is as common in Crete as in Northern Europe: a 5-year prospective study. Eur J Gastroenterol Hepatol 1996;8:893–8.
  • Manousos ON, Koutroubakis I, Potamianos S, Roussomoustakaki M, Gourtsoyianniss N, Vlachonikolis IG. A prospective epidemiologic study of Crohn’s disease in Heraklion, Crete. Incidence over a 5-year period. Scand J Gastroenterol 1996;31: 599–603.
  • Devlin HB, Datta D, Dellipiani AW. The incidence and prevalence of inflammatory bowel disease in North Tees Health District. World J Surg 1980;4:183–93.
  • Rubin GP, Hungin AS, Kelly P, Ling J. Epidemiological features of inflammatory bowel disease in the North of England. Gastroenterology 1996;110(4):A1004.
  • Kyle J. Crohn’s disease in the North-eastern and Northern Isles of Scotland: an epidemiological review. Gastroenterology 1992;103:392–9.
  • Lee FI, Costello FT. Crohn’s disease in Blackpool—incidence and prevalence 1968–80. Gut 1985;26:274–8.
  • Fellows IW, Freeman JG, Holmes GK. Crohn’s disease in the city of Derby, 1951–85. Gut 1990;31: 1262–5.
  • Rose JDR, Roberts GM, Williams G, Mayberry JF, Rhodes J. Cardiff Crohn’s disease jubilee: the incidence over 50 years. Gut 1988;29: 346–51.
  • Srivastava ED, Mayberry JF, Morris TJ, Smith PM, Williams GT, Roberts GM, et al. Incidence of ulcerative colitis in Cardiff over 20 years: 1968–87. Gut 1992;33:256–8.
  • Haug K, Schrumpf E, Barstad S, Halvorsen JF. Epidemiology of ulcerative colitis in Western Norway. Scand J Gastroenterol 1988;23:517–22.
  • Morris D, Kyle J, Montgomery SM, Wakefield AJ, Pounder RE. Crohn’s disease in North-east Scotland: a real rise in incidence. Gut 1999;44 Suppl 1:T112.
  • Farrokhyar F, Swarbrick ET, Grace RH, Hellier MD, Gent AT, Irvine EJ. Incidence of Crohn’s disease and ulcerative colitis in three regional centres in England. Gastroenterology 1999; 116(4):A710, G3087.
  • Haug K, Schrumpf E, Halvorsen JF, Fluge E, Hamre E, Hamre T, et al. Epidemiology of Crohn’s disease in Western Norway. Scand J Gastroenterol 1989;24:1271–5.
  • Moum B, Vatn MH, Ekbom A, Fausa O, Lygren I, Sauar J. Incidence of inflammatory bowel disease in South-eastern Norway: evaluation of methods after 1 year of registration. Digestion 1995;56:377–81.
  • Moum B, Vatn A, Ekbom A, Aadland E, Faesa O, Lygren I, et al. Incidence of ulcerative colitis and indeterminate colitis in four counties of South-eastern Norway, 1990–93. Scand J Gastroenterol 1996;31:362–6.
  • Roin F, Roin J. Inflammatory bowel disease of the Faroe Islands. Scand J Gastroenterol 1989;24:44–6.
  • Binder V, Both H, Hansen PK, Hendriksen C, Kreiner S, Trop-Pedersen K. Incidence and prevalence of ulcerative colitis and Crohn’s disease in the county of Copenhagen, 1962–1978. Gastroenterology 1982;83: 563–8.
  • Lindberg E, Jarnerot G. The incidence of Crohn’s disease is not decreasing in Sweden. Scand J Gastroenterol 1991;26:495–500.
  • Lapidus A, Bernell O, Hellers G, Persson P-G, Lofberg R. Incidence of Crohn’s disease in Stockholm County 1955–1989. Gut 1997;41: 480–6.
  • Shivananda S, Pena AS, Nap M, Weterman IT, Mayberry JF, Ruitenberg EJ, et al. Epidemiology of Crohn’s disease in Regio Leiden, the Netherlands. A population study from 1979–1983. Gastroenterology 1987;93:966–74.
  • Tysk C, Jarnerot G. Ulcerative proctocolitis in Orebro, Sweden. A retrospective epidemiologic study, 1963–1987. Scand J Gastroenterol 1992;27: 945–50.
  • Bjornsson S, Johannsson JH, Oddsson E. Inflammatory bowel disease in Iceland, 1980–89. A retrospective nation-wide epidemiologic study. Scand J Gastroenterol 1998;33: 71–7.
  • Russel MGVM, Dorant E, Volovics A, Brummer RJ, Pop P, Muris JWM, et al. High incidence of inflammatory bowel disease in the Netherlands. Results of a prospective study. Dis Colon Rectum 1998;41:33–40.
  • Halme L, von Smitten K, Husa A. The incidence of Crohn’s disease in the Helsinki metropolitan area during 1975–1985. Ann Chir Gynaecol 1989;78(2):115–9.
  • Kurata JH, Kantor Fish S, Frankl H, Godby P, Vadheim CM. Crohn’s disease among ethnic groups in a large health maintenance organization. Gastroenterology 1992;102:1940–8.
  • Garland CF, Lilienfeld AM, Mendeloff AI, Markowitz JA, Terrell KB, Garland FC. Incidence rates of ulcerative colitis and Crohn’s disease in fifteen areas of the United States. Gastroenterology 1981;81:1115–24.
  • Loftus EV, Sandborn WJ, Tremaine WJ, Harmsen WS, Zinsmeister AR. Incidence and prevalence of Crohn’s disease in Olmsted county, Minnesota, 1970–1993. Gastroenterology 1997;112(4):A1027.
  • Stonnington CM, Philips SF, Melton III LJ, Zinsmeister AR. Chronic ulcerative colitis: incidence and prevalence in a community. Gut 1987;28:402–9.
  • Loftus EV, Sandborn WJ, Tremaine WJ, Harmsen WS, Zinsmeister AR. Incidence and prevalence of ulcerative colitis in Olmsted county, Minnesota, 1970–1993. Gastroenterology 1997;112(4):A1027.
  • Gollop JH, Philips SF, Melton III LJ, Zinsmeister AR. Epidemiologic aspects of Crohn’s disease: a population based study in Olmsted county, Minnesota, 1943–82. Gut 1988;29: 49–56.
  • Pinchbeck BR, Kirdeikis J, Thomson ABR. Inflammatory bowel disease in Northern Alberta. An epidemiologic study. J Clin Gastroenterol 1988;10(5):505–15.
  • Daiss W, Scheurlen M, Malchow H. Epidemiology of inflammatory bowel disease in the county of Tubingen (West Germany). Scand J Gastroenterol 1989;24:39–43.
  • Gossum VA, Alder M, de Reuck M, Devis G, Fiasse R, Vanheuverzwijin R, et al. Epidemiology of IBD in Brussels’ area (1992–93). Acta Gastroenterol Belg 1996;59(1):7–9.
  • Gower-Rousseau C, Salomez JL, Marti R, Nuttens MC, Votte A, Lemahieu M, et al. Incidence of inflammatory bowel disease in northern France. Gut 1994;35:1433–8.
  • Latour P, Belaiche J, Louis E, Fontaire F, Deflandre J, Loly J, et al. Incidence of IBD in the Province of Liege (Belgium). Acta Gastroenterol Belg 1996;59(1):3–6.
  • Martinez-Salmeron JF, Rodrigo M, de Teresa J, Nogueras F, Garcia-Montero M, de Sola C, et al. Epidemiology of inflammatory bowel disease in Province of Granada, Spain: a retrospective study from 1979–88. Gut 1993;34: 1207–9.
  • Mate-Jimenez J, Munoz S, Vicent D, Pajares JM. Incidence and prevalence of ulcerative colitis and Crohn’s disease in urban and rural areas of Spain from 1981–88. J Clin Gastroenterol 1994;18: 27–31.
  • Vucelic B, Korac B, Sentic M, Milicic D, Hadzic N, Juresa V, et al. Epidemiology of Crohn’s disease in Zagreb, Yugoslavia: a ten-year prospective study. Int J Epidemiol 1991;20:216–20.
  • Vucelic B, Korac B, Sentic M, Milicic D, Hadzic N, Juresa V, et al. Ulcerative colitis in Zagreb, Yugoslavia: incidence and prevalence 1980–89. Int J Epidemiol 1991;20:1043–7.
  • Flamenbaum M, Zenut M, Aublet-Cuvelier B, Larpent JL, Fabre P, Abergel A, et al. Incidence of inflammatory bowel diseases in the department of Puy-de-Dome in 1993–94. Gastroenterol Clin Biol 1997;21(6–7):491–6.
  • Pagenault M, Tron I, Alexandre JL, Cruchant E, Dabadie A, Chaperon J, et al. Incidence of inflammatory bowel disease in Bretagne (1994–1995). Gastroenterol Clin Biol 1997;21(6–7):483–90.
  • Latour P, Louis E, Belaiche J. Incidence of inflammatory bowel disease in the area of Liege: a 3 years prospective study (1993–1996). Acta Gastroenterol Belg 1998;61(4):410–3.
  • Timmer A, Breuer-Katschinski B, Goebell H. Time trends in the incidence and disease location of Crohn’s disease 19801995: a prospective analysis in an urban population in Germany. Inflamm Bowel Dis 1999;5(2):79–84.
  • Hinojosa J, Primo J, Lledo S, Lopez A, Roig JV, Fernandez J. Incidence of inflammatory bowel disease in Sagunto. Rev Esp Enferm Dig 1990;78(5):283–7.
  • Ranzi T, Bodini P, Zambelli A, Politi P, Lupinacci G, Campanini MC, et al. Epidemiological aspects of inflammatory bowel disease in a north Italian population: a 4-year prospective study. Eur J Gastroenterol Hepatol 1996;8(7): 657–61.
  • Monferrer Guardiola R, Martin Jimenez JA, Pedraza Sanz RG, Moreno Sanchez I, Soler Bahilo E, Hinojosa del Val J. Incidence of inflammatory bowel disease in the 02 health area of Castellon (1992–1996). Rev Esp Enferm Dig 1999;91(1): 33–46.
  • Tragnone A, Corrao G, Miglio F, Caprilli R, Lanfranchi GA, Studio GI. Incidence of inflammatory bowel disease in Italy: a nation-wide population-based study. Int J Epidemiol 1996;25: 1044–52.
  • Eason RJ, Lee SP, Tasman-Jones C. Inflammatory bowel disease in Auckland, New Zealand. Aust N Z J Med 1982;12: 125–31.
  • Morita N, Toki S, Hirohashi T, Minoda T, Ogawa K, Kono S, et al. Incidence and prevalence of inflammatory bowel disease in Japan: nation-wide epidemiological survey during the year 1991. J Gastroenterol 1995;8:1–4.
  • Yoshida Y, Murata Y. Inflammatory bowel disease in Japan: studies of epidemiology and etiopathogenesis. Med Clin North Am 1990;74:67–86.
  • Acheson ED, Nefzger D. Ulcerative colitis in the United States Army in 1944. Epidemiology: comparisons between patients and controls. Gastroenterology 1963;44: 7–19.
  • Evans JG, Acheson ED. An epidemiological study of ulcerative colitis and regional enteritis in the Oxford area. Gut 1965;6: 311–24.
  • Kyle J, Stark G. Fall in the incidence of Crohn’s disease. Gut 1980;21:340–3.
  • Jayanthi V, Probert CSJ, Pinder D, Wicks ACB, Mayberry JF. Epidemiology of Crohn’s disease in Indian migrants and the indigenous population in Leicestershire. Q J Med 1992;82: 125–38.
  • Sonnenberg A, McCarthy DJ, Jacobsen SJ. Geographic variation of inflammatory bowel disease within the United States. Gastroenterology 1991;100:143–9.
  • Trallori G, Palli D, Saieva C, Bradazzi G, Bonanomi AG, d’Albasio G, et al. A population-based study of inflammatory bowel disease in Florence over 15 years (1978–92). Scand J Gastroenterol 1996;31: 892–9.
  • Brullet E, Bonfill X, Urrutia G, Ruiz Ochoa V, Cueto M, Clofent J, et al. Epidemiological study on the incidence of inflammatory bowel disease in 4 Spanish areas. Spanish Group on the Epidemiological Study of Inflammatory Bowel Disease. Med Clin (Barc) 1998;110(17):651—6.
  • Bjornsson S. Inflammatory bowel disease in Iceland during a 30-year period, 1950–79. Scand J Gastroenterol 1989;24 Suppl 170:47–9.
  • Langholz E, Munkholm P, Nielsen OH, Kreiner S, Binder V. Incidence and prevalence of ulcerative colitis in Copenhagen county from 1962 to 1987. Scand J Gastroenterol 1991;26: 1247–56.
  • Nordenvall B, Brostrom O, Berglund M, Monsen U, Nordenstrom J, Sorstad J, et al. Incidence of ulcerative colitis in Stockholm county 1955–1979. Scand J Gastroenterol 1985;20: 783–90.
  • Berner J, Kiaer T. Ulcerative colitis and Crohn’s disease on the Faroe Islands 1964–83. Scand J Gastroenterol 1986;21:188–92.
  • Odes HS, Fraser GM, Krawiec J. Ulcerative colitis in the Jewish population of Southern Israel 1961–1985: epidemiological and clinical study. Gut 1987;28: 1630–6.
  • Stowe SP, Redmond SR, Stortmont JA, Shah AN, Chessin LN, Segal HL, et al. An epidemiological study of inflammatory bowel disease in Rochester, New York. Hospital incidence. Gastroenterology 1990;98:104–10.
  • Bergman L, Krause U. The incidence of Crohn’s disease in Central Sweden. Scand J Gastroenterol 1975;10:725–9.
  • Munkholm P, Langholz E, Nielsen OH, Kreiner S, Binder V. Incidence and prevalence of Crohn’s disease in the county of Copenhagen, 1962 to 1987: a sixfold increase in incidence. Scand J Gastroenterol 1992;27: 609–14.
  • Kildebo S, Breckan R, Nordgaard K, Burhol PG, Jorde R, and members of the Northern Norway Gastroenterology Society. The incidence of Crohn’s disease in Northern Norway from 1983 to 1986. Scand J Gastroenterol 1986;24: 1265–70.
  • Logan RF. Inflammatory bowel disease incidence: up, down or unchanged? Gut 1998;42:309–11.
  • Probert CSJ, Jayanthi V, Hughes AO, Thompson JR, Wicks ACB, Mayberry JF. Prevalence and family risk of ulcerative colitis and Crohn’s disease: an epidemiological study among Europeans and South Asians in Leicestershire. Gut 1993;34: 1547–51.
  • Keshavarzian A, Gupto S, Saverymuttu SH, Hodgson HJF. Are there ethnic differences in inflammatory bowel disease in England? Gut 1984;25:A1144.
  • Ahmed WIU, Kernohan EEM, Baker MR. Alcohol and cigarette consumption among white and Asian general practice patients. Health Educ J 1988;47:128–9.
  • Gilat T, Ribak J, Benaroya Y, Zemishlany Z, Weissman I. Ulcerative colitis in Jewish population of Tel-Aviv Jafo. I. Epidemiology. Gastroenterology 1974;66:335–42.
  • Odes HS, Fraser D, Krawiec J. Ulcerative colitis in migrant and native Jewish populations in southern Israel. Scand J Gastroenterol 1989;24 Suppl 170:36–8.
  • Shapira P, Tamir A. Ulcerative colitis in the Kinneret Sub District, Israel 1965–1994. Incidence and prevalence in different subgroups. J Clin Gastroenterol 1998;27(2):134–7.
  • Odes HS, Locker C, Neumann L, Zirkin HJ, Weizman Z, Sperber AD, et al. Epidemiology of Crohn’s disease in southern Israel. Am J Gastroenterol 1994;89:1859–62.
  • Yang H, McFlee C, Roth MP, Shanahan F, Targan SR, Rotter JI. Familial empirical risks for inflammatory bowel disease: differences between Jews and non-Jews. Gut 1993;34(4):517–24.
  • Lee WCJ, Bridger S, McGregor C, Macpherson AJS, Lennard-Jones JE. Why children with inflammatory bowel disease are diagnosed at a younger age than their affected parent. Gut 1999;44:808–11.
  • Acheson ED. On the mortality ascribed to regional enteritis. J Chronic Dis 1959;10:469–80.
  • Acheson ED. On the mortality ascribed to ulcerative colitis. J Chronic Dis 1959;10:481–7.
  • Sonnenberg A. Mortality from Crohn’s disease and ulcerative colitis in England-Wales and the US from 1950–1983. Dis Colon Rectum 1986;29:624–9.
  • Gollop JH, Phillips SF, Melton LJ, Zinsmeister AR. Epidemiologic aspects of Crohn’s disease: a population-based study in Olmsted County, Minnesota, 1943–82. Gut 1988;29:49–56.
  • Stonnington CM, Phillips SF, Zinsmeister AR, Melton LJ. Prognosis of chronic ulcerative colitis in a community. Gut 1987;28:1261–6.
  • Langholz E, Munkholm P, Davidson M, Binder V. Colorectal cancer risk and mortality in patients with ulcerative colitis. Gastroenterology 1992;103:1444–51.
  • Munkholm P, Langholz E, Davidson M, Binder V. Intestinal cancer risk and mortality in patients with Crohn’s disease. Gastroenterology 1993;105:1716–23.
  • Gyde SN, Prior P, Dew MJ, Saunders V, Waterhouse JAH, Allan RN. Mortality in ulcerative colitis. Gastroenterology 1982;83:36–43.
  • Prior P, Gyde W, Cooke WT, Waterhouse JAH, Allan RN. Mortality in Crohn’s disease. Gastroenterology 1981;80:307–12.
  • Probert CS, Jayanthi V, Wicks AC, Mayberry JF. Mortality from Crohn’s disease in Leicestershire 1972–1989: an epidemiological community-based study. Gut 1992;33:1226–8.
  • Probert CS, Jayanthi V, Wicks AC, Mayberry JF. Mortality in patients with ulcerative colitis in Leicestershire 1972–1989. An epidemiological study. Dig Dis Sci 1993;38:538–41.
  • Ekbom A, Helmick CG, Zack M, Holmberg L, Adami H-O. Survival and causes of death in patients with inflammatory bowel disease: a population-based study. Gastroenterology 1992;103:954–60.
  • Persson P-G, Bernell O, Lejionmarck C-E, Farahmand BY, Hellers G, Ahlbom A. Survival and cause-specific mortality in inflammatory bowel disease: a population-based cohort study. Gastroenterology 1996;110:1339–45.
  • Palli D, Trallori G, Saieva C, Tarantino O, Edili E, D’Albasio G, et al. General and cancer specific mortality of a population based cohort of patients with inflammatory bowel disease: the Florence study. Gut 1998;42:175–9.
  • Cottone M, Magliocco A, Rosselli M, Pinzone F, Oliva L, Orlando A, et al. Mortality in patients with Crohn’s disease. Scand J Gastroenterol 1996;31:372–5.
  • Farrokhyar F, Swarbrick ET, Grace RH, Hellier MD, Gent AE, Irvine EJ. Low mortality of Crohn’s disease (CD) and ulcerative colitis (UC) in three regional centres in England. Gastroenterology 1999;116(4):A710.
  • Langholz E, Munkholm P, Krasilnikoff A, Binder V. Inflammatory bowel disease with onset in childhood. Clinical features, morbidity, and mortality in a regional cohort. Scand J Gastroenterol 1997;32:139–47.
  • Jayanthi V, Probert CSJ, Mayberry JF. Epidemiology of inflammatory bowel disease. Q J Med 1991;78(285):5–12.
  • Sinclair TS, Brunt PW, Ashley N, Morwat G. Non-specific proctocolitis in Northern Eastern Scotland: a community study. Gastroenterology 1983;85:1–11.

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