64
Views
36
CrossRef citations to date
0
Altmetric
Research Article

Cellular Markers of Systemic Inflammation and Immune Suppression in Patients with Organ Failure Due to Severe Acute Pancreatitis

Pages 1100-1107 | Published online: 08 Jul 2009

References

  • Davies M, Hagen P. Systemic inflammatory response syndrome. Br J Surg 1997;84:920–35.
  • Heath D, Alexander D, Wilson C, Larvin M, Imrie C, McMahon M, et al. Which complications of acute pancreatitis are most lethal? A prospective multicentre clinical study of 719 episodes. Gut 1995;36:A478.
  • Deitch E. Multiple organ failure. Ann Surg 1992;216:117–34.
  • Debeaux A, Palmer K, Carter D. Factors influencing morbidity and mortality in acute pancreatitis; an analysis of 279 cases. Gut 1995;37: 121–6.
  • Tenner S, Sica G, Hughes M, Noordhoek E, Feng S, Zinner M, et al. Relationship of necrosis to organ failure in severe acute pancreatitis. Gastroenterology 1997;113:899–903.
  • Bradley III E. A clinically based classification system for acute pancreatitis. Arch Surg 1992;128:586–90.
  • Lankisch P, Pflichthofer D, Lehnick D. No strict correlation between necrosis and organ failure in acute pancreatitis. Pancreas 2000;20:319–22.
  • Bone R. Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome: What we do and do not know about cytokine regulation. Crit Care Med 1996;24:163–72.
  • Kingsnorth A, Galloway S, Formela L. Randomized, doubleblind phase II trial of Lexipafant, a platelet-activating factor antagonist, in human acute pancreatitis. Br J Surg 1995;82:1414–20.
  • McKay C, Curran F, Sharples C, Baxter J, Imrie C. Prospective placebo-controlled randomized trial of lexipafant in predicted severe acute pancreatitis. Br J Surg 1997;84:1239–43.
  • Norman J. The role of cytokines in the pathogenesis of acute pancreatitis. Am J Surg 1998;175:76–83.
  • Bhatia M, Brady M, Shokuhi S, Christmas S, Neoptolemos JP, Slavin J. Inflammatory mediators in acute pancreatitis. J Pathol 2000;190:117–25.
  • Deitch EA, Goodman ER. Prevention of multiple organ failure. Surg Clin North Am 1999;79:1471–88.
  • Modlin R, Brightbill H, Godowski P. The toll of innate immunity on microbial pathogens. N Engl J Med 1999;340:1834–5.
  • Schwandner R, Dziarski R, Wesche H, Rothe M, Kirsching C. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem 1999;274: 17406–9.
  • Vuorte J, Lindsberg P, Kaste M, Meri S, Jansson S-E, Rothlein R, et al. Anti-ICAM-1 monoclonal antibody R6.5 (Enlimomab) promotes activation of neutrophils in whole blood. J Immunol 1999;162: 2353–7.
  • Repo H, Jansson S-E, Leirisalo-Repo M. Flow cytometric determination of CD11b upregulation in vivo. J Immunol Meth 1993;164: 193–202.
  • Bevilacqua MP, Nelson MR. Selectins. J Clin Invest 1993;91: 379–87.
  • Repo H, Rochon Y, Schwartz B, Sharar S, Winn R, Harlan J. Binding of human peripheral blood polymorphonuclear leukocytes to E-selectin (CD62E) does not promote their activation. J Immunol 1997;159:943–51.
  • Ahmed N, McGill S, Yee J, Hu F, Michel R, Christou N. Mechanisms for the diminished neutrophil exudation to secondary inflammatory sites in infected patients with a systemic inflammatory response (sepsis). Crit Care Med 1999; 27:2459–68.
  • Takala A, Jousela I, Jansson S-E, Olkkola K, Takkunen O, Orpana A. Markers of systemic inflammation predicting organ failure in community-acquired septic shock. Clin Sci 1999;97:529–38.
  • Repo H, Harlan J. Mechanisms and consequences of phagocyte adhesion to endothelium. Ann Med 1999;31:156–65.
  • Takala A, Lähdevirta J, Jansson S-E, Vapalahti O, Orpana A, Karonen S-L, et al. Systemic inflammation in hemorrhagic fever with renal syndrome correlates with hypotension and thrombocytopenia but not with renal injury. J Inf Dis 2000;181:1964–70.
  • Harris E, Shigeoka A, Li W, Adams R, Prescott S, McIntyre T, et al. A novel syndrome of variant leukocyte adhesion deficiency involving defects in adhesion mediated by β1 and β2 integrins. Blood 2001;97:767–76.
  • Luhn K, Marquardt T, Harms E, Vestweber D. Discontinuation of fucose therapy in LADH causes rapid loss of selectin ligands and rise of leukocyte counts. Blood 2001;97:330–2.
  • Van der Poll T, de Waal Malefyt R, Coyle S, Lowry S. Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Inf Dis 1997;175:118–22.
  • Ditschkowski M, Kreuzfelder E, Rebmann V, Ferencik S, Majetschak M, Schmid E, et al. HLA-DR expression and soluble HLA-DR levels in septic patients after trauma. Ann Surg 1999;229:246–54.
  • Volk H-D, Reinke P, Krausch D, Zuckermann H, Asadullah K, Mulle JM, et al. Monocyte deactivation—rationale for a new therapeutic strategy in sepsis. Int Care Med 1996;22 Suppl 4:S474–81.
  • Heumann D, Glause MP, Calandra T. Monocyte deactivation in septic shock. Curr Opin Infect Dis 1998;11:279–83.
  • Döcke W, Randow F, Syrbe U, Krausch D, Zuckermann H, Asadullah K, et al. Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nature Med 1997;3:678–81.
  • Marshall J, Cook D, Christnou N, Bernard G, Sprung C, Sibbald W. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 1995;23:1638–52.
  • Fearon D, Collins L. Increased expression of C3b receptors on polymorphonuclear leukocytes induced by chemotactic factors and by purification procedures. J Immunol 1983;130:370–5.
  • Giannoudis P, Smith R, Windsor A, Bellamy M, Guillou P. Monocyte human leukocyte antigen-DR expression correlates with intrapulmonary shunting after major trauma. Am J Surg 1999;177:454–9.
  • Hommel G. A stagewise rejective multiple test procedure based on a modified Bonferroni test. Biometrika 1988;75:383–6.
  • Garcia-Sabrido JL, Valdecantos E, Bastida E, Tellado JM. The anergic state as a predictor of pancreatic sepsis. Zentralbl Chir 1989;114:114–20.
  • Pezzilli R, Billi P, Beltrandi E, Casadei Maldini M, Mancini R. Impaired lymphocyte proliferation in human acute pancreatitis. Digestion 1997;58:431–6.
  • Brivet F, Emilie D, Galanaud P, Parisian Study Group on Acute Pancreatitis. Pro- and anti-inflammatory cytokines during acute severe pancreatitis: an early and sustained response, although unpredictive of death. Crit Care Med 1999;27:749–55.
  • Chen C-C, Wang S-S, Lu R-H, Chang F-Y, Lee S-D. Serum interleukin 10 and interleukin 11 in patients with acute pancreatitis. Gut 1999;45: 895–9.
  • Richter A, Nebe T, Wendl K, Schuster K, Klaebish G, Quintel M, et al. HLA-DR expression in acute pancreatitis. Eur J Surg 1999;165:947–51.
  • Imrie CW, McKay CJ. The scientifi c basis of medical therapy of acute pancreatitis. Could it work, and is there a role for lexipafant? Gastroenterol Clin North Am 1999;28:591–9.
  • Johnson C, Kingsnorth A, Imrie C, McMahon M, Neoptolemos J, McKay C, et al. Double blind, randomized, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis. Gut 2001;48:62–9.
  • Wolk K, Döcke W, von Baehr V, Volk H, Sabat R. Impaired antigen presentation by human monocytes during endotoxin tolerance. Blood 2001; 96:218–23.
  • Balakrishnan V, Philip M. Cytokines as predictors of severity in acute pancreatitis. J Gastroenterol Hepatol 1998;13:1177–9.
  • Dominguez-Munoz JE, Carballo F, Garcia MJ, de Diego JM, Rabago L, Simon MA, et al. Clinical usefulness of polymorphonuclear elastase in predicting the severity of acute pancreatitis: results of a multicentre study. Br J Surg 1991;78:1230–4.
  • Widdison A, Cunningham S. Immune function early in acute pancreatitis. Br J Surg 1996;83:633–6.
  • Rinder CS, Bonan JL, Rinder HM, Mathew J, Hines R, Smith BR. Cardiopulmonary bypass induces leukocyte-platelet adhesion. Blood 1992;79:1201–5.
  • Calafat J, Kuijpers TW, Janssen H, Borregaard N, Verhoeven JA, Roos D. Evidence for small intracellular vesicles in human blood phagocytes containing cytochrome b558 and the adhesion molecule CD11b/CD18. Blood 1993;81:3122–9.
  • Rosenbloom A, Pinsky M, Bryant J, Shin A, Tran T, Whiteside T. Leukocyte activation in the peripheral blood of patients with cirrhosis of the liver and SIRS. JAMA 1995;274:58–65.
  • Philips M, Buyon J, Winchester R, Weissmann G, Abramson S. Up-regulation of the iC3b receptor (CR3) is neither necessary nor sufficient to promote neutrophil aggregation. J Clin Invest 1988;82: 495–501.
  • Diamond M, Springer T. A subpopulation of Mac-1 (CD11b/ CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen. J Cell Biol 1993;120:545–56.
  • Hensel M, Volk T, Döcke W, Kern F, Tschirna D, Egerer K, et al. Hyperprocalcitonemia in patients with noninfectious SIRS and pulmonary dysfunction associated with cardiopulmonary bypass. Anesthesiology 1998;89:93–104.
  • Kylänpää-Bäck M-L, Takala A, Kemppainen E, Puolakkainen P, Leppaniemi A, Haapiainen R, et al. Plasma level of procalcitonin determined on admission to hospital predicts the severity of acute pancreatitis. Crit Care Med 2001;29:63–9.
  • Hubacek J, Pit’ha J, Skodová Z, Stanek V, Poledne R. C(-260)-T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction. Circulation 1999;99:3218–20.
  • Fearon D. Innate immunity and the biological relevance of the acquired immune response. Q J Med 1999;92:235–7.
  • Eubanks J, Sabek O, Kotb M, Gaber L, Henry J, Hijiya N, et al. Acute pancreatitis induces cytokine production in endotoxinresistant mice. Ann Surg 1998;227:904–11.
  • Van Eeden S, Miyagashima R, Haley L, Hogg J. L-selectin expression increases on peripheral blood polymorphonuclear leukocytes during active marrow release. Am J Respir Crit Care Med 1995;151:500–7.
  • Maekawa K, Futami S, Nishida M, Terada T, Inagawa H, Suzuki S, et al. Effects of trauma and sepsis on soluble L-selectin and cell surface expression of L-selectin and CD11b. J Trauma 1998;44:460–8.
  • Skubitz K, Campbell K, Skubitz A. Synthetic peptides of CD66a stimulate neutrophil adhesion to endothelial cells. J Immunol 2000;164: 4257–64.
  • Nopp A, Lundahl J, Hallden G. Quantitative, rather than qualitative, differences in CD69 upregulation in human blood eosinophils upon activation with selected stimuli. Allergy 2000; 55:148–56.
  • Neoptolemos JP, Rarty M, Finch M, Sutton R. Acute pancreatitis: the substantial human and financial cases. Gut 1998;42:886–91.
  • Ranson J, Rifkind K, Roses D, Fink S, Eng K, Spencer F. Prognostic signs and the role of operative management in acute pancreatitis. Surg Gynecol Obstet 1974;139:69–81.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.