Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines

References

• Trier JS. Diagnosis of celiac sprue. Gastroenterology 1998; 115: 211–6
   PubMed Web of Science ®Google Scholar
• Schuppan D. Current concepts of celiac disease pathogenesis. Gastroenterology 2000; 119: 234–42
   PubMed Web of Science ®Google Scholar
• Sollid LM, Thorsby E. HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis. Gastroenterology 1993; 105: 910–22
   PubMed Web of Science ®Google Scholar
• Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 1997; 3: 797–801
   PubMed Web of Science ®Google Scholar
• Molberg O, McAdam SN, Sollid LM. Role of tissue transglutaminase in celiac disease. J Pediatr Gastroenterol Nutr 2000; 30: 232–40
   PubMed Web of Science ®Google Scholar
• Molberg O, Mcadam SN, Korner R, Quarsten H, Kristiansen C, Madsen L, et al. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in coeliac disease. Nat Med 1998; 4: 713–7
   PubMed Web of Science ®Google Scholar
• Pender SL, Tickle SP, Docherty AJ, Howie D, Wathen NC, MacDonald TT. A major role for matrix metalloproteinases in T cell injury in the gut. J Immunol 1997; 158: 1582–90
   PubMed Web of Science ®Google Scholar
• Fasano A. Modulation of intestinal permeability: an innovative method of oral drug delivery for the treatment of inherited and acquired human diseases. Molec Genet Metab 1998; 64: 12–8
   PubMed Web of Science ®Google Scholar
• Madara JL, Trier JS. Structural abnormalities of jejunal epithelial cell membranes in celiac sprue. Lab Invest 1980; 43: 254–61
   PubMed Web of Science ®Google Scholar
• Schulzke JD, Bentzel CJ, Schulzke I, Riecken EO, Fromm M. Epithelial tight junction structure in the jejunum of children with acute and treated celiac sprue. Pediatr Res 1998; 43: 435–41
   PubMed Web of Science ®Google Scholar
• Wang W, Uzzau S, Goldblum SE, Fasano A. Human zonulin, a potential modulator of intestinal tight junctions. J Cell Sci 2000; 113: 4435–40
   PubMed Web of Science ®Google Scholar
• Fasano A, Not T, Wang W, Uzzau S, Berti I, Tommasini A, et al. Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet 2000; 355: 1518–9
   PubMed Web of Science ®Google Scholar
• Clemente MG, De Virgiliis S, Kang JS, Macatagney R, Musu MP, Di Pierro MR, et al. Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut 2003; 52: 218–23
   PubMed Web of Science ®Google Scholar
• Leach L, Firth JA. Structure and permeability of human placental microvasculature. Microsc Res Tech 1997; 38: 137–44
   PubMed Web of Science ®Google Scholar
• Madsen KL, Lewis SA, Tavernini MM, Hibbard J, Fedorak RN. Interleukin 10 prevents cytokine-induced disruption of T84 monolayer barrier integrity and limits chloride secretion. Gastroenterology 1997; 113: 151–9
   PubMed Web of Science ®Google Scholar
• De Ritis G, Occorsio P, Auricchio S, Gramenzi F, Morisi G, Silano V. Toxicity of wheat flour proteins and protein-derived peptides for in vitro developing intestine from rat fetus. Pediatr Res 1979; 13: 1255–61
   PubMed Web of Science ®Google Scholar
• Shan L, Molberg O, Parrot I, Hausch F, Filiz F, Gray GM, et al. Structural basis for gluten intolerance in celiac sprue. Science 2002; 297: 2275–9
   PubMed Web of Science ®Google Scholar
• Di Pierro M, Lu R, Uzzau S, Wang W, Margaretten K, Pazzani C, et al. Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain. J Biol Chem 2001; 276: 19160–5
   PubMed Web of Science ®Google Scholar
• Fasano A, Uzzau S, Fiore C, Margaretten K. The enterotoxic effect of zonula occludens toxin on rabbit small intestine involves the paracellular pathway. Gastroenterology 1997; 112: 839–46
   PubMed Web of Science ®Google Scholar
• El Asmar R, Panigrahi P, Bamford P, berti I, Not T, Coppa GV, et al. Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure. Gastroenterology 2002; 123: 1607–15
   PubMed Web of Science ®Google Scholar
• Livak KJ, Flood SJ, Marmaro J, Giusti W, Deetz K. Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization. PCR Methods Appl 1995; 4: 357–62
   PubMedGoogle Scholar
• Uzzau S, Lu R, Wang W, Fiore C, Fasano A. Purification and preliminary characterization of the zonula occludens toxin receptor from human (CaCo2) and murine (IEC6) intestinal cell lines. FEMS Microbiol Lett 2001; 194: 1–5
   PubMed Web of Science ®Google Scholar
• Mitic LL, Anderson JM. Molecular architecture of tight junctions. Annu Rev Physiol 1998; 60: 121–42
   PubMed Web of Science ®Google Scholar
• Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S. Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol 1999; 147: 1351–63
   PubMed Web of Science ®Google Scholar
• Koning F. The molecular basis of celiac disease. J Mol Recog 2003; 16: 333–6
   PubMed Web of Science ®Google Scholar
• Daniel H. Molecular and integrative physiology of intestinal peptide transport. Annu Rev Physiol 2004; 66: 361–84
   PubMed Web of Science ®Google Scholar
• Walker WA. Antigen handling by the small intestine. Clin Gastroenterol 1986; 15: 1–20
   PubMedGoogle Scholar
• Matysiak-Budnik T, Candalh C, Dugave C, Namane A, Cellier C, Cerf-Bensussan, et al. Alterations of the intestinal transport and processing of gliadin peptides in celiac disease. Gastroenterology 2003; 125: 696–707
   PubMed Web of Science ®Google Scholar
• Catassi C, Pierani P, Natalini G, Gabrielli O, Coppa GV, Giorgi PL. Clinical application of a simple HPLC method for the sugar intestinal permeability test. J Pediatr Gastroenterol Nutr 1991; 12: 209–12
   PubMed Web of Science ®Google Scholar
• Hall EJ, Batt RM. Abnormal permeability precedes the development of a gluten sensitive enteropathy in Irish setter dogs. Gut 1991; 32: 749–53
   PubMed Web of Science ®Google Scholar
• van Elburg RM, Uil JJ, Mulder CJ, Heymans HS. Intestinal permeability in patients with celiac disease and relatives of patients with celiac disease. Gut 1993; 34: 354–7
   PubMed Web of Science ®Google Scholar
• Di Cagno R, De Angelis M, Auricchio S, Greco L, Clarke C, De Vincenzi M, et al. Sourdough bread made from wheat and nontoxic flours and started with selected lactobacilli is tolerated in celiac sprue patients. Appl Environ Microbiol 2004; 70: 1088–96
   PubMed Web of Science ®Google Scholar
• Sapone, A, Watts, T, Counts, D, Zielke, R, Bizzari, Fasano, A. Inhibition of the zonulin-dependent increased intestinal permeability prevents the onset of type 1 diabetes in BB/wor rats. Gastroenterology 2004;126A–518.
   Google Scholar
• Watts T, Berti I, Sapone A, Gerarduzzi T, Not T, Zielke R, et al. Role of the intestinal tight junction modulator zonulin in the pathogenesis of type-I diabetes in BB diabetic prone rats. Proc Natl Acad Sci USA 2005; 102: 2916–21
   PubMed Web of Science ®Google Scholar
• Fasano A, Fiorentini C, Donelli G, Uzzau S, Kaper JB, Margaretten K, et al. Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro. J Clin Invest 1995; 96: 710–20
   PubMed Web of Science ®Google Scholar
• Fleckenstein JM, Kopecko DJ. Breaching the mucosal barrier by stealth: an emerging pathogenic mechanism for enteroadherent bacterial pathogens. J Clin Invest 2001; 107: 27–30
   PubMed Web of Science ®Google Scholar
• Wittig BM, Zeitz M. The gut as an organ of immunology. Int J Colorectal Dis 2003; 18: 181–7
   PubMed Web of Science ®Google Scholar
• Mowat AM. Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol 2003; 3: 331–41
   PubMed Web of Science ®Google Scholar
• Fasano A. Pathological and therapeutical implications of macromolecules passage through the tight junction. Tight functions, M Cereijido, J Anderson. CRC Press, Boca Raton 2001; 697–722
   Google Scholar
• Fasano A, Berti I, Gerarduzzi T, Not T, Colletti RB, Drago S, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med 2003; 163: 286–92
   PubMed Web of Science ®Google Scholar
• Maki M, Mustalahti K, Kokkonen J, Kulmala P, Haapalahti M, Karttunen TJ, et al. Prevalence of celiac disease among children in Finland. N Engl J Med 2003; 348: 2517–24
   PubMed Web of Science ®Google Scholar
• Norris JM, Barriga K, Klingensmith G, Hoffman M, Eisenbarth GS, Erlich HA, et al. Timing of initial cereal exposure in infancy and risk of islet autoimmunity. JAMA 2003; 290: 1713–20
   PubMed Web of Science ®Google Scholar
• Ziegler AG, Schmid S, Huber D, Hummel M, Bonifacio E. Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. JAMA 2003; 290: 1721–8
   PubMed Web of Science ®Google Scholar