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Celiac Disease

Inhibition of epithelial growth factor receptor signalling does not preserve epithelial barrier function after in vitro gliadin insult

, , , , & , PhD , MD
Pages 820-825 | Received 17 Dec 2008, Published online: 21 Jul 2009

References

  • Mäki M, Collin P. Coeliac disease. Lancet 1997; 349: 1755–9
  • Schulzke JD, Schulzke I, Fromm M, Riecken EO. Epithelial barrier and ion transport in coeliac sprue: electrical measurements on intestinal aspiration biopsy specimens. Gut 1995; 37: 777–82
  • Montalto M, Cuoco L, Ricci R, Maggiano N, Vecchio FM, Gasbarrini G. Immunohistochemical analysis of ZO-1 in the duodenal mucosa of patients with untreated and treated celiac disease. Digestion 2002; 65: 227–33
  • Pizzuti D, Bortolami M, Mazzon E, Buda A, Guariso G, D'Odorico A, et al. Transcriptional downregulation of tight junctional protein ZO-1 in active coeliac disease is reversed after a gluten-free diet. Dig Liver Dis 2004; 36: 337–41
  • Green PH, Cellier C. Celiac disease. N Engl J Med 2007; 357: 1731–43
  • Drago S, El Asmar R, Di Pierro M, Grazia Clemente M, Tripathi A, Sapone A, et al. Gliadin, zonulin and gut permeability. Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scand J Gastroenterol 2006; 41: 408–19
  • Barone MV, Gimigliano A, Castoria G, Paolella G, Maurano F, Paparo F, et al. Growth factor-like activity of gliadin, an alimentary protein: implications for coeliac disease. Gut 2007; 56: 480–8
  • Juuti-Uusitalo K, Mäki M, Kainulainen H, Isola J, Kaukinen K. Gluten affects epithelial differentiation-associated genes in small intestinal mucosa of coeliac patients. Clin Exp Immunol 2007; 150: 294–305
  • Bracken S, Byrne G, Kelly J, Jackson J, Feighery C. Altered gene expression in highly purified enterocytes from patients with active coeliac disease. BMC Genomics 2008; 9: 377
  • Forsyth CB, Banan A, Farhadi A, Fields JZ, Tang Y, Shaikh M, et al. Regulation of oxidant-induced intestinal permeability by metalloprotease-dependent epidermal growth factor receptor signaling. J Pharmacol Exp Ther 2007; 321: 84–97
  • Chen Y, Lu Q, Schneeberger EE, Goodenough DA. Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in ras-transformed Madin-Darby canine kidney cells. Mol Biol Cell 2000; 11: 849–62
  • Sander GR, Cummins AG, Henshall T, Powell BC. Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins. FEBS Lett 2005; 579: 4851–5
  • Lindfors K, Blomqvist T, Juuti-Uusitalo K, Stenman S, Venälainen J, Mäki M, et al. Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture. Clin Exp Immunol 2008; 152: 552–8
  • Casalini P, Iorio MV, Galmozzi E, Ménard S. Role of HER receptor family in development and differentiation. J Cell Physiol 2004; 200: 343–50
  • Basuroy S, Seth A, Elias B, Naren AP, Rao R. MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxide. Biochem J 2006; 393: 69–77
  • Singh AB, Harris RC. Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells. J Biol Chem 2004; 279: 3543–52
  • Flores-Benítez D, Ruiz-Cabrera A, Flores-Maldonado C, Shoshani L, Cereijido M, Contreras RG. Control of tight junctional sealing: role of epidermal growth factor. Am J Physiol Renal Physiol 2007; 292: F828–36
  • Jung K, Kang B-K, Kim J-Y, Shin K-S, Lee C-S, Song D-S. Effects of epidermal growth factor on atrophic enteritis in piglets induced by experimental porcine epidemic diarrhoea virus. Vet J 2008; 177: 231–5
  • Lammers KM, Lu R, Brownley J, Lu B, Gerard C, Thomas K, et al. Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology 2008; 135: 194–204

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