Colonic paracellular permeability and circulating zonulin-related proteins

References

• Oświęcimska J, Szymlak A, Roczniak W, et al. New insights into the pathogenesis and treatment of irritable bowel syndrome. Adv Med Sci. 2017;62(1):17–30.
   PubMed Web of Science ®Google Scholar
• Barbara G. Mucosal barrier defects in irritable bowel syndrome. Who left the door open? Am J Gastroenterol. 2006;101(6):1295–1298.
   PubMed Web of Science ®Google Scholar
• Camilleri M, Gorman H. Intestinal permeability and irritable bowel syndrome. Neurogastroenterol Motil. 2007;19(7):545–552.
   PubMed Web of Science ®Google Scholar
• Del Valle-Pinero AY, Van Deventer HE, Fourie NH, et al. Gastrointestinal permeability in patients with irritable bowel syndrome assessed using a four probe permeability solution. Clin Chim Acta. 2013;418:97–101.
   PubMed Web of Science ®Google Scholar
• Dunlop SP, Hebden J, Campbell E, et al. Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes. Am J Gastroenterol. 2006;101(6):1288–1294.
   PubMed Web of Science ®Google Scholar
• Gecse K, Roka R, Sera T, et al. Leaky gut in patients with diarrhea-predominant irritable bowel syndrome and inactive ulcerative colitis. Digestion. 2012;85(1):40–46.
   PubMed Web of Science ®Google Scholar
• Piche T, Barbara G, Aubert P, et al. Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators. Gut. 2009;58(2):196–201.
   PubMed Web of Science ®Google Scholar
• Quigley E. Gut permeability in irritable bowel syndrome: more leaks add to slightly inflamed bowel syndrome conspiracy theory. Gastroenterology. 2009;137(2):728–730.
   PubMedGoogle Scholar
• Turcotte JF, Kao D, Mah SJ, et al. Breaks in the wall: increased gaps in the intestinal epithelium of irritable bowel syndrome patients identified by confocal laser endomicroscopy (with videos). Gastrointest Endosc. 2013;77(4):624–630.
   PubMed Web of Science ®Google Scholar
• Bednarska O, Walter SA, Casado-Bedmar M, et al. Vasoactive intestinal polypeptide and mast cells regulate increased passage of colonic bacteria in patients with irritable bowel syndrome. Gastroenterology. 2017;153(4):948–960.
   PubMed Web of Science ®Google Scholar
• Marshall JK, Thabane M, Garg AX, et al. Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkerton, Ontario. Aliment Pharmacol Ther. 2004;20(11–12):1317–1322.
   PubMed Web of Science ®Google Scholar
• Spiller RC, Jenkins D, Thornley JP, et al. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut. 2000;47(6):804–811.
   PubMed Web of Science ®Google Scholar
• Sturgeon C, Fasano A. Zonulin, a regulator of epithelial and endothelial barrier functions, and its involvement in chronic inflammatory diseases. Tissue Barriers. 2016;4(4):e1251384.
   PubMed Web of Science ®Google Scholar
• Fasano A. Intestinal zonulin: open sesame! Gut. 2001;49(2):159–162.
   PubMed Web of Science ®Google Scholar
• Suzuki T. Regulation of intestinal epithelial permeability by tight junctions. Cell Mol Life Sci. 2013;70(4):631–659.
   PubMed Web of Science ®Google Scholar
• Stevens BR, Goel R, Seungbum K, et al. Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression. Gut. 2018;67(8):1555–1557.
   PubMed Web of Science ®Google Scholar
• Fasano A, Not T, Wang W, et al. Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet. 2000;355(9214):1518–1519.
   PubMed Web of Science ®Google Scholar
• El Asmar R, Panigrahi P, Bamford P, et al. Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure. Gastroenterology. 2002;123(5):1607–1615.
   PubMed Web of Science ®Google Scholar
• Smecuol E, Sugai E, Niveloni S, et al. Permeability, zonulin production, and enteropathy in dermatitis herpetiformis. Clin Gastroenterol Hepatol. 2005;3(4):335–341.
   PubMed Web of Science ®Google Scholar
• Arrieta MC, Bistritz L, Meddings JB. Alterations in intestinal permeability. Gut. 2006;55(10):1512–1520.
   PubMed Web of Science ®Google Scholar
• Tripathi A, Lammers KM, Goldblum S, et al. Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc Natl Acad Sci USA. 2009;106(39):16799–16804.
   PubMed Web of Science ®Google Scholar
• Koch W, Latz W, Eichinger M, et al. Haptoglobin gene subtyping by restriction enzyme analysis. Clin Chem. 2003;49(11):1937–1940.
   PubMed Web of Science ®Google Scholar
• Vanuytsel T, Vermeire S, Cleynen I. The role of Haptoglobin and its related protein, Zonulin, in inflammatory bowel disease. Tissue Barriers. 2013;1(5):e27321.
   PubMedGoogle Scholar
• Scheffler L, Crane A, Heyne H, et al. Widely used commercial ELISA does not detect precursor of haptoglobin2, but recognizes properdin as a potential second member of the zonulin family. Front Endocrinol. 2018;9:22.
   PubMed Web of Science ®Google Scholar
• Ajamian M, Steer D, Rosella G, et al. Serum zonulin as a marker of intestinal mucosal barrier function: may not be what it seems. PLoS One. 2019;14(1):e0210728.
   PubMed Web of Science ®Google Scholar
• Talley NJ, Holtmann GJ, Jones M, et al. Zonulin in serum as a biomarker fails to identify the IBS, functional dyspepsia and non-coeliac wheat sensitivity. Gut. 2020;69(9):1–3.
   PubMed Web of Science ®Google Scholar
• Witt ST, Bednarska O, Keita AV, et al. Interactions between gut permeability and brain structure and function in health and irritable bowel syndrome. Neuroimage Clin. 2019;21:101602.
   PubMed Web of Science ®Google Scholar
• Longstreth GF, Thompson WG, Chey WD, et al. Functional bowel disorders. Gastroenterology. 2006;130(5):1480–1491.
   PubMed Web of Science ®Google Scholar
• Keita AV, Gullberg E, Ericson AC, et al. Characterization of antigen and bacterial transport in the follicle-associated epithelium of human ileum. Lab Invest. 2006;86(5):504–516.
   PubMed Web of Science ®Google Scholar
• Koch W, Latz W, Eichinger M, et al. Genotyping of the common haptoglobin Hp 1/2 polymorphism based on PCR. Clin Chem. 2002;48(9):1377–1382.
   PubMed Web of Science ®Google Scholar
• Flanagan JJ, Arjomandi A, Delanoy ML, et al. Development of monoclonal antibodies to pre-haptoglobin 2 and their use in an enzyme-linked immunosorbent assay (ELISA). J Immunol Methods. 2014;406:34–42.
   PubMed Web of Science ®Google Scholar
• Duerksen DR, Wilhelm-Boyles C, Veitch R, et al. A comparison of antibody testing, permeability testing, and zonulin levels with small-bowel biopsy in celiac disease patients on a gluten-free diet. Dig Dis Sci. 2010;55(4):1026–1031.
   PubMed Web of Science ®Google Scholar
• Fasano A. Regulation of intercellular tight junctions by zonula occludens toxin and its eukaryotic analogue zonulin. Ann NY Acad Sci. 2000;915:214–222.
   PubMed Web of Science ®Google Scholar
• Ganda Mall JP, Ostlund-Lagerstrom L, Lindqvist CM, et al. Are self-reported gastrointestinal symptoms among older adults associated with increased intestinal permeability and psychological distress? BMC Geriatr. 2018;18(1):75.
   PubMed Web of Science ®Google Scholar
• Langlois MR, Delanghe JR. Biological and clinical significance of haptoglobin polymorphism in humans. Clin Chem. 1996;42(10):1589–1600.
   PubMed Web of Science ®Google Scholar
• Wang W, Uzzau S, Goldblum SE, et al. Human zonulin, a potential modulator of intestinal tight junctions. J Cell Sci. 2000;113(24):4435–4440.
   PubMed Web of Science ®Google Scholar
• Paterson BM, Lammers KM, Arrieta MC, et al. The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: a proof of concept study. Aliment Pharmacol Ther. 2007;26(5):757–766.
   PubMed Web of Science ®Google Scholar
• Clemente MG, De Virgiliis S, Kang JS, et al. Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut. 2003;52(2):218–223.
   PubMed Web of Science ®Google Scholar
• Barbaro MR, Cremon C, Caio G, et al. 247 zonulin serum levels are increased in non-celiac gluten sensitivity and irritable bowel syndrome with diarrhea. Gastroenterology. 2015;148(4):S56.
   Google Scholar
• Barbaro MR, Cremon C, Morselli-Labate AM, et al. Serum zonulin and its diagnostic performance in non-coeliac gluten sensitivity. Gut. 2020;69(11):1966–1974.
   PubMed Web of Science ®Google Scholar
• Fasano A, Uzzau S, Fiore C, et al. The enterotoxic effect of zonula occludens toxin on rabbit small intestine involves the paracellular pathway. Gastroenterology. 1997;112(3):839–846.
   PubMed Web of Science ®Google Scholar
• Drago S, El Asmar R, Di Pierro M, et al. Gliadin, zonulin and gut permeability: effects on celiac and non-celiac intestinal mucosa and intestinal cell lines. Scand J Gastroenterol. 2006;41(4):408–419.
   PubMed Web of Science ®Google Scholar
• Cenac N, Chin AC, Garcia-Villar R, et al. PAR2 activation alters colonic paracellular permeability in mice via IFN-gamma-dependent and -independent pathways. J Physiol. 2004;558(3):913–925.
   PubMed Web of Science ®Google Scholar
• Pontarollo G, Mann A, Brandao I, et al. Protease-activated receptor signaling in intestinal permeability regulation. FEBS J. 2020;287(4):645–658.
   PubMed Web of Science ®Google Scholar
• Fasano A, Shea-Donohue T. Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nat Clin Pract Gastroenterol Hepatol. 2005;2(9):416–422.
   PubMedGoogle Scholar
• Leffler DA, Kelly CP, Abdallah HZ, et al. A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge. Am J Gastroenterol. 2012;107(10):1554–1562.
   PubMed Web of Science ®Google Scholar
• Kelly CP, Green PH, Murray JA, et al. Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo-controlled study. Aliment Pharmacol Ther. 2013;37(2):252–262.
   PubMed Web of Science ®Google Scholar
• Tajik N, Frech M, Schulz O, et al. Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis. Nat Commun. 2020;11(1):1995.
   PubMed Web of Science ®Google Scholar