Chronic constipation is negatively associated with colonic diverticula

References

• Martel J, Raskin JB, NDSG. History, incidence, and epidemiology of diverticulosis. J Clin Gastroenterol. 2008;42(10):1125–1127.
   PubMed Web of Science ®Google Scholar
• Nakaji S, Danjo K, Munakata A, et al. Comparison of etiology of right-sided diverticula in Japan with that of left-sided diverticula in the west. Int J Colorectal Dis. 2002;17(6):365–373.
   PubMed Web of Science ®Google Scholar
• Yamamichi N, Shimamoto T, Takahashi Y, et al. Trend and risk factors of diverticulosis in Japan: age, gender, and lifestyle/metabolic-related factors may cooperatively affect on the colorectal diverticula formation. PLOS One. 2015;10(4):e0123688.
   PubMed Web of Science ®Google Scholar
• Wheat CL, Strate LL. Trends in hospitalization for diverticulitis and diverticular bleeding in the United States from 2000 to 2010. Clin Gastroenterol Hepatol. 2016;14(1):96–103.e1.
   PubMed Web of Science ®Google Scholar
• Strate LL, Morris AM. Epidemiology, pathophysiology, and treatment of diverticulitis. Gastroenterology. 2019;156(5):1282–1298.e1.
   PubMed Web of Science ®Google Scholar
• Sandler RS, Everhart JE, Donowitz M, et al. The burden of selected digestive diseases in the United States. Gastroenterology. 2002;122(5):1500–1511.
   PubMed Web of Science ®Google Scholar
• Everhart JE, Ruhl CE. Burden of digestive diseases in the United States part II: lower gastrointestinal diseases. Gastroenterology. 2009;136(3):741–754.
   PubMed Web of Science ®Google Scholar
• Painter NS, Burkitt DP. Diverticular disease of the colon: a deficiency disease of Western civilization. Br Med J. 1971;2(5759):450–454.
   PubMed Web of Science ®Google Scholar
• Gear JS, Ware A, Fursdon P, et al. Symptomless diverticular disease and intake of dietary fibre. Lancet. 1979;1(8115):511–514.
   PubMed Web of Science ®Google Scholar
• Peery AF, Barrett PR, Park D, et al. A high-fiber diet does not protect against asymptomatic diverticulosis. Gastroenterology. 2012;142(2):266–272.e1.
   PubMed Web of Science ®Google Scholar
• Peery AF, Sandler RS, Ahnen DJ, et al. Constipation and a low-fiber diet are not associated with diverticulosis. Clinical gastroenterology and hepatology: the official clinical practice journal of the. Am Gastroenterol Assoc. 2013;11(12):1622–1627.
   Web of Science ®Google Scholar
• Yamada E, Inamori M, Watanabe S, et al. Constipation is not associated with colonic diverticula: a multicenter study in Japan. Neurogastroenterology and motility: the official journal of the. Neurogastroenterol Motil. 2015;27(3):333–338.
   PubMed Web of Science ®Google Scholar
• Yamada E, Kuriyama H, Uchida E, et al. Association between endoscopic findings related to colonic diverticula and bowel habits: a multicenter study in Japan. J Gastroenterol Hepatol. 2017;32(12):1938–1942.
   PubMed Web of Science ®Google Scholar
• Järbrink-Sehgal ME, Andreasson A, Talley NJ, et al. Symptomatic diverticulosis is characterized by loose stools. Clinical gastroenterology and hepatology: the official clinical practice journal of the. Am Gastroenterol Assoc. 2016;14(12):1763–1770.e1.
   Web of Science ®Google Scholar
• Jovani M, Ma W, Staller K, et al. Frequency of bowel movements and risk of diverticulitis. Clin Gastroenterol Hepatol. 2021;S1542-3565(21)00005-7. DOI:https://doi.org/10.1016/j.cgh.2021.01.003.
   Web of Science ®Google Scholar
• Peery AF, Keil A, Jicha K, et al. Association of obesity with colonic diverticulosis in women. Clin Gastroenterol Hepatol. 2020;18(1):107–114.e1.
   PubMed Web of Science ®Google Scholar
• Strate LL, Liu YL, Aldoori WH, Syngal S, et al. Obesity increases the risks of diverticulitis and diverticular bleeding. Gastroenterology. 2009;136(1):115–122.e1.
   PubMed Web of Science ®Google Scholar
• Nagata N, Niikura R, Shimbo T, et al. Alcohol and smoking affect risk of uncomplicated colonic diverticulosis in Japan. PLOS One. 2013;8(12):e81137.
   PubMed Web of Science ®Google Scholar
• Hjern F, Wolk A, Håkansson N. Smoking and the risk of diverticular disease in women. Br J Surg. 2011;98(7):997–1002.
   PubMed Web of Science ®Google Scholar
• Sharara AI, El-Halabi MM, Mansour NM, et al. Alcohol consumption is a risk factor for colonic diverticulosis. J Clin Gastroenterol. 2013;47(5):420–425.
   PubMed Web of Science ®Google Scholar
• Azzam N, Aljebreen AM, Alharbi O, Almadi MA. Prevalence and clinical features of colonic diverticulosis in a Middle Eastern population. WJGE. 2013;5(8):391–397.
   Google Scholar
• Yeo LX, Tseng TH, Chen WL, et al. Hypertension control and risk of colonic diverticulosis. Therap Adv Gastroenterol. 2019;12:1756284819855734.
   Web of Science ®Google Scholar
• Lai EJ, Calderwood AH, Doros G, et al. The boston bowel preparation scale: a valid and reliable instrument for colonoscopy-oriented research. Gastrointest Endosc. 2009;69(3):620–625.
   PubMed Web of Science ®Google Scholar
• Drossman DA. Functional gastrointestinal disorders: history, pathophysiology, clinical features and Rome IV. Gastroenterology. 2016;150(6):1262–1279.e2.
   Web of Science ®Google Scholar
• Agachan F, Chen T, Pfeifer J, et al. A constipation scoring system to simplify evaluation and management of constipated patients. Dis Colon Rectum. 1996;39(6):681–685.
   PubMed Web of Science ®Google Scholar
• Lewis SJ, Heaton KW. Stool form scale as a useful guide to intestinal transit time. Scan J Gastroenterol. 1997;32(9):920–924.
   PubMed Web of Science ®Google Scholar
• Jetté M, Sidney K, Blümchen G. Metabolic equivalents (METS) in exercise testing, exercise prescription, and evaluation of functional capacity. Clin Cardiol. 1990;13(8):555–565.
   PubMed Web of Science ®Google Scholar
• Milner P, Crowe R, Kamm MA, et al. Vasoactive intestinal polypeptide levels in sigmoid colon in idiopathic constipation and diverticular disease. Gastroenterology. 1990;99(3):666–675.
   PubMed Web of Science ®Google Scholar
• Shin JE. Are there any association between colonic diverticula and bowel symptoms? (neurogastroenterol motil 2015;27:333-338). J Neurogastroenterol Motil. 2015;21(2):290–291.
   PubMed Web of Science ®Google Scholar
• Böttner M, Barrenschee M, Hellwig I, et al. The enteric serotonergic system is altered in patients with diverticular disease. Gut. 2013;62(12):1753–1762.
   PubMed Web of Science ®Google Scholar
• Spiller RC. Changing views on diverticular disease: impact of aging, obesity, diet, and microbiota. Neurogastroenterol Motil. 2015;27(3):305–312.
   PubMed Web of Science ®Google Scholar
• Elisei W, Tursi A. The pathophysiology of colonic diverticulosis: Inflammation versus constipation? Inflamm Intest Dis. 2018;3(2):55–60.
   PubMedGoogle Scholar
• Lasisi F, Rex DK. Improving protection against proximal colon cancer by colonoscopy. Expert Rev Gastroenterol Hepatol. 2011;5(6):745–754.
   PubMed Web of Science ®Google Scholar
• Sugihara K, Muto T, Morioka Y. Motility study in right sided diverticular disease of the colon. Gut. 1983;24(12):1130–1134.
   PubMed Web of Science ®Google Scholar
• Sadahiro S, Ohmura T, Yamada Y, et al. Analysis of length and surface area of each segment of the large intestine according to age, sex and physique. Surg Radiol Anat. 1992;14(3):251–257.
   PubMed Web of Science ®Google Scholar
• Blackshaw LA, Brookes SJ, Grundy D, et al. Sensory transmission in the gastrointestinal tract. Neurogastroenterol Motil. 2007;19(1 Suppl):1–19.
   PubMed Web of Science ®Google Scholar
• Camilleri M, Ford MJ. Review article: colonic sensorimotor physiology in health, and its alteration in constipation and diarrhoeal disorders. Aliment Pharmacol Ther. 1998;12(4):287–302.
   PubMed Web of Science ®Google Scholar