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Editorial

Modelling and simulation in prediction of human xenobiotic absorption, distribution, metabolism and excretion (ADME): in vitro–in vivo extrapolations (IVIVE)

Pages 1013-1014 | Published online: 22 Sep 2008

References

  • Buckman S, Huang S-M, Murphy S. Medical product development and regulatory science for the 21st century: the critical path vision and its impact on health care. Clinical Pharmacology and Therapy 2007; 81: 141–144
  • Rostami-Hodjegan A, Tucker GT. ‘In silico’ simulations to assess the ‘in vivo’ consequences of ‘in vitro’ metabolic drug–drug interactions. Drug Discovery Today Technology 2004; 9: 441–448
  • Rostami-Hodjegan A, Tucker GT. Simulation and prediction of in vivo drug metabolism in human populations from in vitro data. Nature Reviews in Drug Discovery 2007; 6: 140–148

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