Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 37, 2007 - Issue 12
91
Views
12
CrossRef citations to date
0
Altmetric
Research Article

Metabolism of 2-fluoro-4-iodoaniline in earthworm Eisenia veneta using 19F-NMR spectroscopy, HPLC-MS, and HPLC-ICPMS (127I)

, , , , , & show all
Pages 1378-1393 | Received 21 Aug 2007, Accepted 13 Sep 2007, Published online: 22 Sep 2008

References

  • Axelsson BO, Jorten-Karlsson M, Michelson P, Abou-Shakra F. The potential of inductively coupled plasma mass spectrometry detection for high-performance liquid chromatography combined with accurate mass measurement of organic pharmaceutical compounds. Rapid Communications in Mass Spectrometry 2001; 15: 375–385
  • Bundy JG, Lenz EM, Osborn D, Weeks JM, Lindon JC, Nicholson JK. Metabolism of 4-fluoroaniline and 4-fluorobiphenyl in the earthworm Eisenia veneta characterized by high-resolution NMR spectroscopy with directly coupled HPLC-NMR and HPLC-MS. Xenobiotica 2002; 32: 479–490
  • Bundy JG, Osborn D, Weeks JM, Lindon JC, Nicholson JK. An NMR-based metabonomic approach to the investigation of coelomic fluid biochemistry in earthworms under toxic stress. FEBS Letters 2001; 500: 31–35
  • Duckett CJ, Wilson ID, Walker H, Abou-Shakra F, Lindon JC, Nicholson JK. High-performance liquid chromatography/inductively coupled plasma mass spectrometry with iodine-specific detection for profiling the metabolites produced in the earthworm Eisenia veneta by exposure to 2-fluoro-4-iodoaniline. Rapid Communications in Mass Spectrometry 2003; 17: 1855–1858
  • Jensen BP, Smith CJ, Bailey C, Rodgers C, Wilson ID, Nicholson JK. Application of inductively coupled plasma mass spectrometry and high-performance liquid chromatography-with parallel electrospray mass spectrometry to the investigation of the disposition and metabolic fate of 2-, 3- and 4-iodobenzoic acids in the rat. Journal of Chromatography B 2004; 809: 279–285
  • Lenz EM, Lindon JC, Nicholson JK, Weeks JM. 19F-NMR spectroscopic investigation into the absorption and metabolism of 3-trifluoromethylaniline in Eisenia veneta. Ecotoxicology and Environmental Safety 2003; 54: 157–168
  • Lenz EM, Lindon JC, Nicholson JK, Weeks JM, Osborn D. 19F-NMR and directly coupled 19F/1H-HPLC-NMR spectroscopic investigations of the metabolism of the model ecotoxin 3-trifluoromethylaniline in the earthworm species Eisenia veneta. Xenobiotica 2002; 32: 535–546
  • Michalke B, Witte H, Schramel P. Method developments for iodine speciation by reversed-phase liquid chromatography-ICP-mass spectrometry. Biological Trace Element Research 2000a; 78: 67–80
  • Michalke B, Witte H, Schramel P. Iodine speciation in human serum by reversed-phase liquid chromatography-ICP-mass spectrometry. Biological Trace Element Research 2000b; 78: 81–92
  • Organization for Economic Co-operation and Deveopment (OECD). Earthworm, acute toxicity tests. Guideline for Testing of Chemicals No. 207. OECD, Paris 1984
  • Sloley BD. Glutamyl conjugation of 5-hydroxytryptamine (serotonin) in the earthworm (Lumbricus terrestris). Neurochemical Research 1994; 19: 217–222
  • Stenersen J. Uptake and metabolism of xenobiotics by earthworms. Ecotoxicology of earthworms, PW Greig-Smith, H Becker, PJ Edwards, F Heimbach. Intercept, Andover 1992; 129–138
  • Takatera K, Watanabe T. Speciation of iodo amino acids by high-performance liquid chromatography with inductively coupled plasma mass spectrometric detection. Analytical Chemistry 1993; 65: 759–762

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.