Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 1
16
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Different pharmacokinetic s of (4R)-hexahydro-7,7- dimethyl-6-oxo-1,2,5-(3-14C)dithiazocine-4-carboxylic acid between the fasting and non-fasting rat: role of intestinal microorganisms

, &
Pages 53-62 | Published online: 22 Sep 2008

References

  • BARTH, C., SLADEK, M. and DECKER, K.,1971, The subcellulardistributionof short-chain fatty acyl-CoA synthetase activity in rat tissues. Biochimka et Biophysica Acta, 248, 24–33.
  • CUMMINGS, J. H., 1981, Short chain fatty acids in the human colon. Gut, 22, 763–779.
  • GissoN, S. A. W., MCFARLAN, C., HAY, S. and MACFARLANE, G. T., 1989, Significanceof microflorain proteolysis in the colon. Applied and Environmental Microbiology, 55, 679–683.
  • HARAGUCHI, Y., SASAKI, H., NAKAMURA, J. and SHIBASAKI, J., 1989, Formation of salicylic acid from salicyluric acid by intestinal microflora—effect of fasting and pretreatment with antibiotics. Journal of Pharmacobio -Dynamics, 12, S72.
  • ISHIDA, N., NAKATA, K., TANAKA, M., TAKASE, K. and MITA, S., 1991, The protective effects of (4R)-hexahydro-7,7-dimethy1-6-oxo-1,2,5-dithiazocine-4-carboxylic acid (5A3443), a novel cyclic disulfide, on chemically-induced acute liver injury. Japanese Journal of Pharmacology, 55, 275–278.
  • LARSEN, G. L. and BAKKE, J. E.,1983, Metabolism of mercapturicacid-pathwaymetabolitesof 2-chloro-N-isopropylacetanilide (propachlor) by gastrointestinal bacteria. Xenobiotka, 13, 115–126.
  • NAKATA, K., SASANO, M., MATSUNAGA, K., TANAKA, M. and MITA, S., 1991, Protective effect of (4R)-hexahydro-7,7-dimethy1-6-oxo-1,2,5-dithiazocine-4-carboxylic acid (5A3443), a novel cyclic disulfide compound, on immunology induced liver injuries in mice. Archives Internationales de Pharmacodynamie et de Therapie, 309, 170–184.
  • PERRETT, D., SNEDDON W. and STEPHENS, A. D., 1976, Studies on D-penicillamine metabolism in cystinuria and rheumatoid arthritis: isolation of S-methyl-D-pencillamine. Biochemical Phar-macology, 25, 259–264.
  • ROWLAND, I. R., MALLETT, A. K. and WISE, A., 1985, The effect of diet on the mammaliangut flora and its metabolic activities. CRC Critical Reviews in Toxicology, 16, 31–103.
  • SASANO, M., NAKATA, K. and MITA, S., 1991, Modulatory effects of 5A3443 on interleukin-2 and interferon-y production in human peripheral blood mononuclear cells. International Journal of Immunotherapy, 7, 117–122.
  • SAWAMOTO, T., KUROSAKI, Y., KIMURA, T. and NAKAYAMA, T., 1996. Pharmacokineties of aceta-minophen sulfate after oral administration in rats: analysis of plasma profiles exhibiting a non-linear second peak. Biological and Pharmaceutical Bulletin, 19, 77–82.
  • Smmizu, K., AMAGAYA, S. and OGIHARA, Y.,1985, Structuraltransform ationof saikosaponinsby gastric juice and intestinal flora. Journal of Pharmacobio -Dynamics, 8, 718–725.
  • STRUGALA, G. J., RAUWS, A. G. and ELBERS R.,1986, Intestinalfirst pass metabolism of amygdalinin the rat in vitro. Biochemical Pharmacology, 35, 2123–2128.
  • SUZUKI, S., TOMISAWA, H., ICHIHARA, S., FUKAZAWA, H. and TATEISHI, M., 1982,A CS bond cleavage enzyme of cysteine conjugates in intestinal microorganisms. Biochemical Pharmacology, 31, 2137–2140.
  • TAKEDA, S., I SHIHARA, K., WAKUI, Y., AMAGAYA S MARUNO M., AKAO, T. and KOBASHI, K., 1996, Bioavailability study of glycyrrhetic acid after oral administration of glycyrrhizin in rats: relevance to the intestinal bacterial hydrolysis. Journal of Pharmacy and Pharmacology, 48, 902–905.
  • TANAKA, M.,NAKATA, K., TAKASE, K. and MITA, S., 1991, The protective effects of (4R)-hexahydro-7,7-dim ethyl-6-oxo-1,2,5-dithioazocine4-carboxylic acid (5A3443), a novel cyclic disulfide com-pound, on acetaminophen-induced liver injury. Folia Pharmacologica Japonica, 97, 191–198.
  • TATEISHI, M., SUZUKI, S. and Snninzu, H., 1978, Cysteine conjugate fl-lyase in rat liver. Journal of Biological Chemistry, 253, 8854–8859.
  • TOMISAWA, H., SUZUKI, S., ICHIHARA, S., FUKAZAWA, H. and TATEISHI, M., 1984, Purification and characterization of C-S lyase from Fusobacterium varium . Journal of Biological Chemistry, 259, 2588–2593.
  • TOZAKI, H., EMI, Y., HORISAKA, E., FUJITA, T., YAMAMOTO, A. and MURANISHI, S., 1995, Metabolism of peptide drugs by the microorganisms in rat cecal contents. Biological and Pharmaceutical Bulletin, 18, 929–931.
  • WATANABE, K., YAMASHITA, S., FURUNO, K., KAWASAKI, H. and GOMITA, Y., 1995, Metabolism of omeprazole by gut flora in rats. Journal of Pharmaceutical Sciences, 84, 516–517.
  • YANG, M. G., MANOHARAN, K. and MICICELSEN, 0., 1970, Nutrition contribution of volatile fatty acids from the cecum of rats. Journal of Nutrition, 100, 545–550.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.