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Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 11
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Research Article

Metabolism of ethyl methyl sulphide and sulphoxide in rat microsomal fractions

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Pages 1101-1113 | Published online: 22 Sep 2008

References

  • DAHL, S. G., HYORTH, M. and HOUGH, E., 1982, Chlorpromazine, methotrimeprazine and metabolites. Structural changes accompanying the loss of neuroleptic potency by ring sulfoxidation. Molecular Pharmacology, 21, 409–414.
  • DAMANI, L. A. (ed.), 1989, Sulphur-containing Drugs and Related Organic Compounds, vol. 1, part A (Chichester: Ellis Horwood).
  • DAMANI, L. A. and NN, I. P., 1996, The assessment of the fiavin-containing monooxygenase activity in intact animals. Drug Metabolism and Drug Interaction, 13, 1–28.
  • GIBSON, G. G. and SKETT, P., 1986, Introduction to Drug Metabolism (London: Chapman & Hall). GONZALEZ, F. J., 1990, Molecular genetics of the P-450 superfamily. Pharmacology and Therapeutics, 45, 1–38.
  • HOODI, A. A. and DAMANI, L. A., 1984, Cytochrome P-450 and non-cytochrome P-450 sulphoxidations. Journal of Pharmacy and Pharmacology, 36 (suppl.), 629.
  • KOBAYASHI, S., MURRAY, S., WATSON, D., SESARDIC, D., DAVIS, D. S. and Booms, A. R., 1989, The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man. Biochemical Pharmacology, 38, 2795–2799.
  • LAwroN, M. and PHILPOT, R. M., 1995, Emergence of the flavin-containing monooxygenases gene family. In J. R. Hodgson, J. R. Bend and R. M. Philpot (eds), Biochemical Toxicology. Toxicology Communications, vol. 11 Rayleigh Institute (Raleigh, NC), pp. 1–27.
  • LEMOINE, A., JoHANN, M. and CRESTEIL, T.,1990, Evidence for the presence of distinct flavin-containing monooxygenase in human tissues. Archives in Biochemistry and Biophysics, 276, 336–342.
  • LOWRY, O. H., ROSEBOROUGH, N. S., FARR, A. L. and RANDALL, R. S., 1951, Protein measurement with Folin phenol reagent. Journal of Biological Chemistry, 193, 265–275.
  • MADESCLAIRE, M., 1986, Oxidation of sulphides. Tetrahedron, 42, 5459–5495.
  • MITCHELL, S. C., 1988, Biological consequences of drug sulphoxidation. Drug Metabolism and Drug Interaction, 6, 245–252.
  • MURRAY, M. and REIDY, G. F., 1990, Selectivity in the inhibition of mammalian cytochrome P-450 by chemical agents. Pharmacology Reviews, 42, 85–101.
  • NN, I. P. and DAMANI, L. A., 1992, Ethyl methyl Sulphide. A potential probe for monitoring the activity of the flavin-containing monooxygenase in vivo. British Journal of Clinical Pharmacology, 34, 160–161.
  • NN, I. P. and DAMANI, L. A., 1997, Gas—liquid chromatographic assay for the sulphoxide and sulphone metabolites of ethyl methyl Sulphide in rat microsomal fractions. Pharmaceutical Research, 14, S551.
  • OAE, S., 1977, Organic Chemistry of Sulphur (New York: Plenum).
  • RENWICK, A. G., EVANS, S. P., SWEATMAN, T. W., CUMBERLAND, J. and GEORGE, C. F., 1982, The role of the gut flora in the reduction of sulphinpyrazone in the rat. Biochemical Pharmacology, 31, 2649–2656.
  • SHRINER, R. L., STRUCK, H. C. and JoiusoN, W. J., 1930, The preparation and properties of certain sulphoxides and sulphones. Journal of the American Chemical Society, 52, 2060–2090.
  • TRAFICANTE, L. J. SIEKIERSKI, J., SAKALIS, G. and GERSHON, S., 1979, Sulfoxidation of chlorpromazine and thioridazine by bovine liver—preferential metabolic pathways. Biochemical Pharmacology, 28, 621–626.
  • ZIEGLER, D. M., 1980, Microsomal flavin-containing monooxygenases: oxygenation of nucleophilic nitrogen and sulphur compounds. In W. B. Jacoby (ed.), Enzymatic Basis of Detoxification, vol. 1 (New York: Academic Press), pp. 201–227.
  • ZIEGLER, D. M., 1990, Flavin-containing monooxygenases: enzymes adapted for multisubstrate specificity. TIPS, 11, 321–324.

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