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The use of metformin in the management of polycystic ovary syndrome and associated anovulatory infertility: The current evidence

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Pages 467-472 | Published online: 06 Apr 2010

References

  • Al-Inany H, Johnson N. Drugs for anovulatory infertility in polycystic ovary syndrome. British Medical Journal 2006; 332: 1461–1462
  • Balen A, Michelmore K. What is polycystic ovary syndrome. Human Reproduction 2002; 17: 2219–2227
  • P Braude, Taylor, A. ABC of subfertility. British Medical Journal Publishing, London 2004
  • Casper R F, Mitwally M F. Review: aromatase inhibitors for ovulation induction. Journal of Clinical Endocrinology and Metabolism 2006; 91: 760–771
  • Dale M M, Haylett D G. Pharmacology condensed. Churchill Livingstone, London 2004
  • De Leo V, La Marca A, Petraglia F. Insulin-lowering agents in the management of polycystic ovary syndrome. Endocrine Reviews 2003; 24: 633–667
  • Dunaif A, Segal K R, Futterweit W, Dobrjansky A. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 1989; 38: 1165–1174
  • Ehrmann D A. Polycystic ovary syndrome. New England Journal of Medicine 2005; 352: 1223–1236
  • Ehrmann D A, Cavaghan M K, Imperial J, Sturis J, Rosenfield R L, Polonsky K S. Effects of metformin on insulin secretion, insulin action, and ovarian steroidogenesis in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 1997; 82: 524–530
  • Fleming R, Hopkinson Z E, Wallace M, Greer I A, Sattar N. Ovarian function and metabolic factors in women with oligomenorrhoea treated with metformin in a randomised double blind placebo-controlled trial. Journal of Clinical Endocrinology and Metabolism 2002; 87: 569–574
  • Guzick D S. Treating the polycystic ovary syndrome the old-fashioned way. New England Journal of Medicine 2007; 356: 622–624
  • Homburg R. The management of infertility associated with polycystic ovary syndrome. Reproductive Biology and Endocrinology 2003; 1: 109
  • Hopkinson Z EC, Sattar N, Fleming R, Greer I A. Polycystic ovarian syndrome: the metabolic syndrome comes to gynaecology. British Medical Journal 1998; 317: 329–332
  • Jakubowicz D J, Iuorno M J, Jakubowicz S, Roberts K A, Nestler J E. Effects of metformin on early pregnancy loss in polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 2002; 87: 524–529
  • Kashyap S, Wells G A, Rosenwaks Z. Insulin-sensitizing agents as primary therapy for patients with polycystic ovarian syndrome. Human Reproduction 2004; 19: 2474–2483
  • Kumari A S, Haq A, Jayasundaram R, Abdel-Wareth L O, al Hai Alvares S A. Metformin monotherapy in lean women with polycystic ovary syndrome. Reproductive BioMedicine Online 2005; 10: 100–104
  • Ledger W L, Clark T. Long-term consequences of polycystic ovary syndrome. 2003, RCOG Guidelines No. 33. Available at: http://www.rcog.org.uk/resources/Public/pdf/Polys_Ovary_Syndrome_No33.pdf (Accessed 15 March 2007)
  • Legro R S, Myers E. Surrogate end-points or primary outcomes in clinical trials in women with polycystic ovary syndrome. Human Reproduction 2004; 19: 1697–1704
  • Legro R S, Barnhart H X, Schlaff W D, Carr B R, Diamond M P, Carson S A, et al. Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. New England Journal of Medicine 2007; 356: 551–566
  • Lord J M, Flight I HK, Norman R J. Metformin in polycystic ovary syndrome: systematic review and meta-analysis. British Medical Journal 2003a; 327: 951
  • Lord J M, Flight I HK, Norman R J. Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome. Cochrane Database of Systematic Reviews 2003b; 3: CD003053
  • Moghetti P, Castello R, Negri C, Tosi F, Perrone F, Caputo M, et al. Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomised, double-blind, placebo-controlled 6 month trial, followed by open, long-term clinical evaluation. Journal of Clinical Endocrinology and Metabolism 2000; 85: 139–146
  • Moll E, Bossuyt P MM, Korevaar J C, Lambalk C B, van der Veen F. Effect of clomiphene citrate plus metformin and clomiphene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial. British Medical Journal 2006; 332: 1485–1509
  • Nawrocka J, Starczewski A. Effects of metformin treatment in women with polycystic ovary syndrome depends on insulin resistance. Gynecological Endocrinology 2007; 23: 231–237
  • Nestler J E, Jakubowicz D J, Evans W S, Pasquali R. Effects of metformin and clomiphene-induced ovulation in the polycystic ovary syndrome. New England Journal of Medicine 1998; 338: 1876–1880
  • Neveu N, Granger L, St-Michel P, Lavoie H B. Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction and achievement in 154 women with polycystic ovary syndrome. Fertility and Sterility 2007; 87: 113–120
  • Norman R J. Metformin – comparison with other therapies in ovulation induction in polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 2004; 89: 4797–4800
  • Norman R J, Masters L, Milner C R, Wang J X, Davies M J. Relative risk of conversion from normoglycaemia to impaired glucose tolerance or non-insulin dependent diabetes mellitus in polycystic ovarian syndrome. Human Reproduction 2001; 16: 1995–1998
  • Norman R J, Davies M J, Lord J, Moran L J. The role of lifestyle modification in polycystic ovary syndrome. Trends in Endocrinology and Metabolism 2002; 13: 251–257
  • Norman R, Wu R, Stankiewicz M T. Polycystic ovary syndrome. MJA Practice Essentials-Endocrinology 2004; 180: 132–137
  • Palomba S, Orio F, Nardo L G, Falbo A, Russo T, Corea D, et al. Metformin administration versus laparoscopic ovarian diathermy in clomiphene citrate-resistant women with polycystic ovary syndrome: a prospective parallel randomized double-blind placebo-controlled trial. Journal of Clinical Endocrinology and Metabolism 2004; 89: 4801–4809
  • Palomba S, Orio F, Falbo A, Manguso F, Russo T, Cascella T, et al. Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 2005; 90: 4068–4074
  • Palomba S, Falbo A, Orio F, Tolino A, Zullo F. Efficacy predictors for metformin and clomiphene citrate in anovulatory infertile patients with polycystic ovary syndrome. Fertility and Sterility 2008a, Published online April 26, 2008
  • Palomba S, Oppedisana R, Tolino A, Orio F, Zullo F. Metformin use in infertile patients with polycystic ovary syndrome: an evidence-based overview. Reproductive BioMedicine Online 2008b; 16: 327–335
  • Pasquali R, Gambineri A. Insulin-sensitizing agents in polycystic ovary syndrome. European Journal of Endocrinology 2006; 154: 763–775
  • Richardson M R. Current perspectives in polycystic ovary syndrome. American Family Physician 68. 2003
  • Rodriguez G, Faundes-Latham A, Atkinson L E. An approach to the analysis of menstrual patterns in the critical evaluation of contraceptives. Studies in Family Planning 1976; 7: 42–51
  • Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Working Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Human Reproduction 2004; 19: 41–47
  • Siebert T I, Kruger T F, Steyn D W, Nosarka S. Is the addition of metformin efficacious in the treatment of clomiphene citrate-resistant patients with polycystic ovary syndrome? A structured literature review. Fertility and Sterility 2006; 86: 1432–1437
  • Sinawat S, Buppasiri P, Lumbiganon P, Pattanittum P. Long versus short-course treatment with metformin plus clomiphene citrate for ovulation induction in women with polycystic ovary syndrome. Cochrane Database of Systematic Reviews 2007; 1: CD006226
  • Sorensen M B, Franks S, Robertson C, Pennell D J, Collins P. Severe endothelial dysfunction in young women with polycystic ovary syndrome is only partially explained by known cardiovascular risk factors. Clinical Endocrinology 2006; 65: 655–659
  • Thessaloniki ESHRE/ASRM-sponsored PCOS Consensus Workshop Group. Consensus on infertility treatment related to polycystic ovary syndrome. Human Reproduction 2008; 23: 462–477

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