Halofuginone has a Beneficial Effect on Gentamicin-induced Acute Nephrotoxicity in Rats

References

• Abramovitch R, Dafni H, Neman M, Nagler A, Pines M. (1999). Inhibition of neovascularization and tumor growth and facilitation of wound repair, by halofuginone, an inhibitor of collagen type I synthesis. Neoplasia 1:321–329.
   PubMedGoogle Scholar
• Aykaç G, Uysal M, Yalçin AS, Koçak-Toker N, Sivas A, öz H. (1985). The effect of chronic ethanol ingestion on hepatic lipid peroxide, glutathione peroxidase, and glutathione transferase in rats. Toxicology 36:71–76.
   PubMed Web of Science ®Google Scholar
• Baliga R, Ueda N, Walker PD, Shah SV. (1999). Oxidant mechanisms in toxic acute renal failure. Drug Metab Rev 31:971–997.
   PubMed Web of Science ®Google Scholar
• Bradley PP, Preibat D, Christerser RD, Rothstein G. (1982). Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78:206–209.
   PubMed Web of Science ®Google Scholar
• Bruck R, Genina O, Aeed H, Alexiev R, Nagler A, Avni Y, Pines M. (2001). Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats. Hepatology 33:379–386.
   PubMed Web of Science ®Google Scholar
• Casini A, Ferrali M, Pompella AS, Maellaro E, Comporti M. (1986). Lipid peroxidation and cellular damage in extrahepatic tissues of bromobenzene-intoxicated mice. Am J Pathol 123:520–531.
   PubMed Web of Science ®Google Scholar
• Conner EM, Grisham MB. (1996). Inflammation, free radicals, and antioxidants. Nutrition 12:274–277.
   PubMed Web of Science ®Google Scholar
• Cuzzocrea S, Mazzon E, Dugo L, Serraino I, Di Paola R, Britti D, et al. (2002). A role for superoxide in gentamicin-mediated nephropathy in rats. Eur J Pharmacol 450:67–76.
   PubMed Web of Science ®Google Scholar
• Davies GR, Simmonds NJ, Stevens TR, Grandison A, Blake DR, Rampton DS. (1992). Mucosal reactive oxygen metabolite production in duodenal ulcer disease. Gut 33:1467–1472.
   PubMed Web of Science ®Google Scholar
• Eisenberg JM, Koffer H, Glick HA, Connell ML, Loss LE, Talbot GH, et al. (1987). What is the cost of nephrotoxicity associated with aminoglycosides? Ann Intern Med 107:900–909.
   PubMed Web of Science ®Google Scholar
• Elkin M, Ariel I, Miao HQ, Nagler A, Pines M, de Groot N, et al. (1999a). Inhibition of bladder carcinoma angiogenesis, stromal support, and tumor growth by halofuginone. Cancer Res 59:4111–4118.
   PubMed Web of Science ®Google Scholar
• Elkin M, Reich R, Nagler A, Aingorn E, Pines M, de Groot N, et al. (1999b). Inhibition of matrix metalloproteinase-2 expression and bladder carcinoma metastasis by halofuginone. Clin Cancer Res 5:1982–1988.
   PubMed Web of Science ®Google Scholar
• Farag MM, Mikhail M, Schata R, Abdel-Meguid E, Abdel-Tawab S. (1996). Assessment of gentamicin-induced nephrotoxicity in rats treated with low doses of ibuprofen and diclofenac sodium. Clin Sci (Lond) 91:187–191.
   PubMed Web of Science ®Google Scholar
• Granot I, Bartov I, Plavnik I, Wax E, Hurwitz S, Pines M. (1991). Increased skin tearing in broilers and reduced collagen synthesis in skin in vivo and in vitro in response to the coccidiostat halofuginone. Poult Sci 70:1559–1563.
   PubMed Web of Science ®Google Scholar
• Granot I, Halevy O, Hurwitz S, Pines M. (1993). Halofuginone: an inhibitor of collagen type I synthesis. Biochim Biophys Acta 1156:107–112.
   PubMed Web of Science ®Google Scholar
• Halevy O, Nagler A, Levi-Schaffer F, Genina O, Pines M. (1996). Inhibition of collagen type I synthesis by skin fibroblasts of graft versus host disease and scleroderma patients: effect of halofuginone. Biochem Pharmacol 52:1057–1063.
   PubMed Web of Science ®Google Scholar
• Karatas A, Paksoy M, Erzin Y, Carkman S, Gonenc M, Ayan F, et al. (2008). The effect of halofuginone, a specific inhibitor of collagen type 1 synthesis, in the prevention of pancreatic fibrosis in an experimental model of severe hyperstimulation and obstruction pancreatitis. J Surg Res 148:7–12.
   PubMed Web of Science ®Google Scholar
• Levi-Schaffer F, Nagler A, Slavin S, Knopov V, Pines M. (1996). Inhibition of collagen synthesis and changes in skin morphology in murine graft-versus-host disease and tight skin mice: effect of halofuginone. J Invest Dermatol 106:84–88.
   PubMed Web of Science ®Google Scholar
• Nagler A, Firman N, Feferman R, Cotev S, Pines M, Shoshan S. (1996). Reduction in pulmonary fibrosis in vivo by halofuginone. Am J Respir Crit Care Med 154:1082–1086.
   PubMed Web of Science ®Google Scholar
• Nagler A, Katz A, Aingorn H, Miao HQ, Condiotti R, Genina O, et al. (1997a). Inhibition of glomerular mesangial cell proliferation and extracellular matrix deposition by halofuginone. Kidney Int 52:1561–1569.
   PubMed Web of Science ®Google Scholar
• Nagler A, Miao HQ, Aingorn H, Pines M, Genina O, Vlodavsky I. (1997b). Inhibition of collagen synthesis, smooth muscle cell proliferation, and injury-induced intimal hyperplasia by halofuginone. Arterioscler Thromb Vasc Biol 17:194–202.
   PubMed Web of Science ®Google Scholar
• Nyska M, Nyska A, Rivlin E, Porat S, Pines M, Shoshan S, et al. (1996). Topically applied halofuginone, an inhibitor of collagen type I transcription, reduces peritendinous fibrous adhesions following surgery. Connect Tissue Res 34:97–103.
   PubMed Web of Science ®Google Scholar
• Pedraza-Chaverri J, Gonzalez-Orozco AE, Maldonado PD, Barrera D, Medina-Campos ON, Hernandez-Pando R. (2003). Dialyl disulfide ameliorates gentamicin-induced oxidative stress and nephropathy in rats. Eur J Pharmacol 473:71–78.
   PubMed Web of Science ®Google Scholar
• Pines M, Knopov V, Genina O, Lavelin I, Nagler A. (1997). Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis. J Hepatol 27:391–398.
   PubMed Web of Science ®Google Scholar
• Pines M, Nagler A. (1998). Halofuginone: a novel antifibrotic therapy. Gen Pharmacol 30:445–450.
   PubMedGoogle Scholar
• Priuska EM, Schacht J. (1995). Formation of free radicals by gentamicin and iron and evidence for an iron/gentamicin complex. Biochem Pharmacol 50:1749–1752.
   PubMed Web of Science ®Google Scholar
• Samadian T, Dehpour AR, Amini S, Nouhnejad P. (1993). Inhibition of gentamicin-induced nephrotoxicity by lithium in rat. Histol Histopathol 8:139–147.
   PubMed Web of Science ®Google Scholar
• Taras D, Blanc JF, Rullier A, Dugot-Senant N, Laurendeau I, Bièche I, et al. (2006). Halofuginone suppresses the lung metastasis of chemically induced hepatocellular carcinoma in rats through MMP inhibition. Neoplasia 8:312–318.
   PubMed Web of Science ®Google Scholar
• Walker PD, Shah SV. (1988). Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats. J Clin Invest 81:334–341.
   PubMed Web of Science ®Google Scholar
• Yanagida C, Ito K, Komiya I, Horie T. (2004). Protective effect of fosfomycin on gentamicin-induced lipid peroxidation of rat renal tissue. Chem Biol Interact 148:139–147.
   PubMed Web of Science ®Google Scholar