35
Views
7
CrossRef citations to date
0
Altmetric
Research Article

Effect of tocotrienols on iron-induced renal dysfunction and oxidative stress in rats

&
Pages 319-325 | Received 06 Oct 2008, Accepted 17 Apr 2009, Published online: 01 Oct 2009

References

  • Ahmad, N. S., Khalid, B. A., Luke, D. A., Ima Nirwana, S., (2005). Tocotrienol offers better protection than tocopherol from free radical–induced damage of rat bone. Clin Exp Pharmacol Physiol 32:761–770.
  • Awai, M., Narasaki, M., Yamanoi, Y., Seno, S. (1979). Induction of diabetes in animals by parenteral administration of ferric nitrilotriacetate. A model of experimental hemochromatosis. Am J Pathol 95:663–673.
  • Azlina, M. F., Nafeeza, M. I., Khalid, B. A. (2005). A comparison between tocopherol and tocotrienol effects on gastric parameters in rats exposed to stress. Asia Pac J Clin Nutr 14:358–365.
  • Baker, M. S., Gebicki, J. M. (1986). The effect of pH on yields of hydroxyl radicals produced from superoxide by potential biological iron chelators. Arch Biochem Biophys 246:581–588.
  • Bates, G. W., Wernicke, J. (1971). The kinetics and mechanism of iron(3) exchange between chelates and transferrin. IV. The reaction of transferrin with iron(3) nitrilotriacetate. J Biol Chem 246:3679–3685.
  • Baud, L., Ardaillou, R. (1993). Involvement of reactive oxygen species in kidney damage. Br Med Bull 49:621–629.
  • Bomzon, A., Holt, S., Moore, K. (1997). Bile acids, oxidative stress, and renal function in biliary obstruction. Semin Nephrol 17:549–562.
  • Goddard, J. G., Sweeney, G. D. (1983). Ferric nitrilotriacetate: a potent stimulant of in vivo lipid peroxidation in mice. Biochem Pharmacol 32:3879–3882.
  • Gupta, A., Chander, V., Sharma, S., Chopra, K. (2007). Sodium nitroprusside and L-arginine attenuates ferric nitrilotriacetate–induced oxidative renal injury in rats. Toxicology 232:183–191.
  • Gupta, A., Sharma, S., Chopra, K. (2008). Reversal of iron-induced nephrotoxicity in rats by molsidomine, a nitric oxide donor. Food Chem Toxicol 46:537–543.
  • Hamazaki, S., Okada, S., Ebina, Y., Fujioka, M., Midorikawa, O. (1986). Nephrotoxicity of ferric nitrilotriacetate. An electron-microscopic and metabolic study. Am J Pathol 123:343–350.
  • Jollow, D. J., Mitchell, J. R., Zampaglione, N., Gillette, J. R. (1974). Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 11:151–169.
  • Kamat, J. P., Devasagayam, T. P. (1995). Tocotrienols from palm oil as potent inhibitors of lipid peroxidation and protein oxidation in rat brain mitochondria. Neurosci Lett 195:179–182.
  • Kamat, J. P., Sarma, H. D., Devasagayam, T. P., Nesaretnam, K., Basiron, Y. (1997). Tocotrienols from palm oil as effective inhibitors of protein oxidation and lipid peroxidation in rat liver microsomes. Mol Cell Biochem 170:131–137.
  • Khanna, S., Roy, S., Ryu, H., Bahadduri, P., Swaan, P. W., Ratan, R. R., et al. (2003). Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. J Biol Chem 278:43508–43515.
  • Kono, Y. (1978). Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys 186:189–195.
  • Kubo, K., Saito, M., Tadokoro, T., Maekawa, A. (1997). Changes in susceptibility of tissues to lipid peroxidation after ingestion of various levels of docosahexanoic acid and vitamin E. Br J Nutr 78:655–669.
  • Liu, M., Okada, S., Kawabata, T. (1991). Radical-promoting “free” iron level in the serum of rats treated with ferric nitrilotriacetate: comparison with other iron-chelate complexes. Acta Med Okayama 45:401–408.
  • Markewitz, B. A., Michael, J. R., Kohan, D. E. (1993). Cytokine-induced expression of a nitric oxide synthatase in rat renal tubule cells. J Clin Invest 91:2138–2143.
  • Matsuura, R. (1983). Uptake of iron and nitrilotriacetate (NTA) in rat liver and the toxic effect of Fe-NTA. Acta Med Okayama 37:393–400.
  • McIntyre, M., Bohr, D. F., Dominiczak, A. F. (1999). Endothelial function in hypertension: the role of superoxide anion. Hypertension 34:539–545.
  • Min, K. S., Morishita, F., Tetsuchikawahara, N., Onosaka, S. (2005). Induction of hepatic and renal metallothionein synthesis by ferric nitrilotriacetate in mice: the role of MT as an antioxidant. Toxicol Appl Pharmacol 204:9–17.
  • Minhajuddin, M., Beg, Z. H., Iqbal, J. (2005). Hypolipidemic and antioxidant properties of tocotrienol-rich fraction isolated from rice bran oil in experimentally induced hyperlipidemic rats. Food Chem Toxicol 43:747–753.
  • Nesaretnam, K., Stephen, R., Dils, R., Darbre, P. (1998). Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status. Lipids 33:461–469.
  • Norazlina, M., Lee, P. L., Lukman, H. I., Nazrun, A. S., Ima-Nirwana, S. (2007). Effects of vitamin E supplementation on bone metabolism in nicotine-treated rats. Singapore Med J 48:195–199.
  • Ohkawa, H., Ohishi, N., Yagi, K. (1979). Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351–358.
  • Okada, S. (1996). Iron-induced tissue damage and cancer: the role of reactive oxygen species–free radicals. Pathol Int 46:311–332.
  • Paller, M. S., Hedlund, B. E. (1994). Extracellular iron chelators protect kidney cells from hypoxia/reoxygenation. Free Radic Biol Med 17:597–603.
  • Preece, N. E., Evans, P. F., Howarth, J. A., King, L. J., Parke, D. V. (1988). The induction of autoxidative tissue damage by iron nitrilotriacetate in rats and mice. Toxicol Appl Pharmacol 93:89–100.
  • Salahudeen, A. K. (1995). Role of lipid peroxidation in H2O2-induced renal epithelial (LLC-PK1) cell injury. Am J Physiol 268:F30–F38.
  • Schaffer, S., Muller, W. E., Eckert, G. P. (2005). Tocotrienols: constitutional effects in aging and disease. J Nutr 135:151–154.
  • Sen, C. K., Khanna, S., Roy, S. (2006). Tocotrienols: vitamin E beyond tocopherols. Life Sci 78:2088–2098.
  • Sen, C. K., Khanna, S., Roy, S., Packer, L. (2000). Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced PP60(C-SRC) kinase activation and death of HT4 neuronal cells. J Biol Chem 275:13049–13055.
  • Sheridan, A. M., Fitzpatrick, S., Wang, C., Wheeler, D. C., Lieberthal, W. (1996). Lipid peroxidation contributes to hydrogen peroxide–induced cytotoxicity in renal epithelial cells. Kidney Int 49:88–93.
  • Shimoi, K., Shen, B., Toyokuni, S., Mochizuki, R., Furugori, M., Kinae, N. (1997). Protection by alpha G-rutin, a water-soluble antioxidant flavonoid, against renal damage in mice treated with ferric nitrilotriacetate. Jpn J Cancer Res 88:453–460.
  • Suzuki, Y. J., Tsuchiya, M., Packer, L. (1993). Antioxidant activities of dihydrolipoic acid and its structural homologues. Free Radic Res Commun 18:115–122.
  • Tak, P. P., Firestein, G. S. (2001). NF-kappaB: a key role in inflammatory diseases. J Clin Invest 107:7–11.
  • Theriault, A., Chao, J. T., Wang, Q., Gapor, A., Adeli, K. (1999). Tocotrienol: a review of its therapeutic potential. Clin Biochem 32:309–319.
  • Toyokuni, S. (2002). Iron and carcinogenesis: from Fenton reaction to target genes. Redox Rep 7:189–197.
  • Toyokuni, S., Uchida, K., Okamoto, K., Hattori-Nakakuki, Y., Hiai, H., Stadtman, E. R. (1994). Formation of 4-hydroxy-2-nonenal–modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate. Proc Natl Acad Sci U S A 91:2616–2620.
  • Uchida, T. (1995). Overview of iron metabolism. Int J Hematol 62:193–202.
  • Umemura, T., Sai, K., Takagi, A., Hasegawa, R., Kurokawa, Y. (1990). Oxidative DNA damage, lipid peroxidation, and nephrotoxicity induced in the rat kidney after ferric nitrilotriacetate administration. Cancer Lett 54:95–100.
  • Wada, S., Satomi, Y., Murakoshi, M., Noguchi, N., Yoshikawa, T., Nishino, H. (2005). Tumor-suppressive effects of tocotrienol in vivo and in vitro. Cancer Lett 229:181–191.
  • Yoshida, Y., Saito, Y., Jones, L. S., Shigeri, Y. (2007). Chemical reactivities and physical effects in comparison between tocopherols and tocotrienols: physiological significance and prospects as antioxidants. J Biosci Bioeng 104:439–445.
  • Zhang, D., Okada, S., Kawabata, T., Yasuda, T. (1995). An improved simple colorimetric method for quantitation of non-transferrin-bound iron in serum. Biochem. Mol Biol Int 35:635–641.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.