597
Views
57
CrossRef citations to date
0
Altmetric
Review Article

Cinnamon (Cinnamomum zeylanicum) as an antidote or a protective agent against natural or chemical toxicities: a review

ORCID Icon, ORCID Icon & ORCID Icon
Pages 338-351 | Received 03 Oct 2017, Accepted 12 Dec 2017, Published online: 10 Jan 2018

References

  • Abd El-Aziz, A.R., et al., 2015. Use of selected essential oils to control aflatoxin contaminated stored cashew and detection of aflatoxin biosynthesis gene. The Scientific World Journal, 2015, 958192.
  • Abdeen, A., et al., 2017. Protective effect of cinnamon against cadmium-induced hepatorenal oxidative damage in rats. International Journal of Pharmacology and Toxicology, 5 (1), 17–22.
  • Al‐Anati, L. and Petzinger, E., 2006. Immunotoxic activity of ochratoxin A. Journal of Veterinary Pharmacology and Therapeutics, 29 (2), 79–90.
  • Amalaradjou, M.A.R., Kim, K.S., and Venkitanarayanan, K., 2014. Sub-inhibitory concentrations of trans-cinnamaldehyde attenuate virulence in Cronobacter sakazakii in vitro. International Journal of Molecular Sciences, 15 (5), 8639–8655.
  • Azumi, S. and Tanamoto, K.-I., 1999. Anti-endotoxin properties of a cinnamon bark-derived compound and its effect on the endotoxin shock model. Journal of Endotoxin Research, 5 (3), 109–117.
  • Azumi, S., Tanimura, A., and Tanamoto, K.-I., 1997. A novel inhibitor of bacterial endotoxin derived from cinnamon bark. Biochemical and Biophysical Research Communications, 234 (2), 506–510.
  • Beutin, L., et al., 1993. Prevalence and some properties of verotoxin (Shiga-like toxin)-producing Escherichia coli in seven different species of healthy domestic animals. Journal of Clinical Microbiology, 31 (9), 2483–2488.
  • Blevins, S.M., et al., 2007. Effect of cinnamon on glucose and lipid levels in non insulin-dependent type 2 diabetes. Diabetes Care, 30 (9), 2236–2237.
  • Brr, A.-A.H. and Mahmoud, Y.A.-G., 2005. Anti-yeast effects of some plant extracts on yeasts contaminating processed poultry products in Egypt. Czech Journal of Food Sciences, 23, 12–19.
  • Chung, J.-W., Kim, J.-J., and Kim, S.-J., 2011. Antioxidative effects of cinnamomi cortex: a potential role of iNOS and COX-II. Pharmacognosy Magazine, 7 (28), 314.
  • Connell, B.J., et al., 2016. A cinnamon-derived procyanidin compound displays anti-HIV-1 activity by blocking heparan sulfate-and co-receptor-binding sites on gp120 and reverses T cell exhaustion via impeding tim-3 and PD-1 upregulation. PLoS One, 11 (10), e0165386.
  • Eidi, A., et al., 2012. Hepatoprotective activity of cinnamon ethanolic extract against CCI4-induced liver injury in rats. Excli Journal, 11, 495.
  • El‐Raouf, A., et al., 2015. Cinnamic acid and cinnamaldehyde ameliorate cisplatin‐induced splenotoxicity in rats. Journal of Biochemical and Molecular Toxicology, 29 (9), 426–431.
  • El‐Sayed, E.S.M., et al., 2013. Comparative study of the possible protective effects of cinnamic acid and cinnamaldehyde on cisplatin‐induced nephrotoxicity in rats. Journal of Biochemical and Molecular Toxicology, 27 (12), 508–514.
  • Elgawish, R.A.R. and Abdelrazek, H.M., 2014. Effects of lead acetate on testicular function and caspase-3 expression with respect to the protective effect of cinnamon in albino rats. Toxicology Reports, 1, 795–801.
  • Elhassaneen, Y., et al., 2009. Dibutylnitrosamine induces histopathological changes in rat: possible protective effects of cinnamon flavonoid extract. Journal of Pharmacology and Toxicology, 4 (2), 58–69.
  • ElKady, A.I. and Ramadan, W.S., 2016. The aqueous extract of cinnamon bark ameliorated cisplatin-induced cytotoxicity in vero cells without compromising the anticancer efficiency of cisplatin. Biomedical Papers, 160 (3), 363–371.
  • Farag, M.R., Alagawany, M., and Tufarelli, V., 2017. In vitro antioxidant activities of resveratrol, cinnamaldehyde and their synergistic effect against cyadox-induced cytotoxicity in rabbit erythrocytes. Drug and Chemical Toxicology, 40 (2), 196–205.
  • Hamidpour, R., et al., 2015. Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer’s disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities. Journal of Traditional and Complementary Medicine, 5 (2), 66–70.
  • Hariri, A.T., et al., 2011. The effect of crocin and safranal, constituents of saffron, against subacute effect of diazinon on hematological and genotoxicity indices in rats. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 18 (6), 499–504.
  • Hassani, F.V., et al., 2017. Protective effect of crocin on BPA-induced liver toxicity in rats through inhibition of oxidative stress and downregulation of MAPK and MAPKAP signaling pathway and miRNA-122 expression. Food and Chemical Toxicology, 107 (Pt A), 395–405.
  • Ho, S.-C., Chang, K.-S., and Chang, P.-W., 2013. Inhibition of neuroinflammation by cinnamon and its main components. Food Chemistry, 138 (4), 2275–2282.
  • Hong, J.-W., et al., 2012. Anti-inflammatory activity of cinnamon water extract in vivo and in vitro LPS-induced models. BMC Complementary and Alternative Medicine, 12 (1), 237.
  • Hori, M., et al., 2007. A search for the plant ingredients that protect cells from air pollutants and benz[a]pyrene phototoxicity. Drug and Chemical Toxicology, 30 (2), 105–116.
  • Hosseini, S.M., et al., 2017. Protective effect of thymoquinone, the active constituent of Nigella sativa fixed oil, against ethanol toxicity in rats. Iranian Journal of Basic Medical Sciences, 20 (8), 927–939.
  • Hua, H., et al., 2014. Inhibitory effect of essential oils on Aspergillus ochraceus growth and ochratoxin a production. PLoS One, 9 (9), e108285.
  • Ismail, H.F., et al., 2017. Comparative study of herbal plants on the phenolic and flavonoid content, antioxidant activities and toxicity on cells and zebrafish embryo. Journal of Traditional and Complementary Medicine, 7 (4), 452–465.
  • Jeon, W.-Y., et al., 2012. Protective effects of the traditional herbal formula oryeongsan water extract on ethanol-induced acute gastric mucosal injury in rats. Evidence-Based Complementary and Alternative Medicine, 2012, 438191.
  • Kanuri, G., et al., 2009. Cinnamon extract protects against acute alcohol-induced liver steatosis in mice. The Journal of Nutrition, 139 (3), 482–487.
  • Khasnavis, S. and Pahan, K., 2012. Sodium benzoate, a metabolite of cinnamon and a food additive, upregulates neuroprotective Parkinson disease protein DJ-1 in astrocytes and neurons. Journal of Neuroimmune Pharmacology, 7 (2), 424–435.
  • Khasnavis, S. and Pahan, K., 2014. Cinnamon treatment upregulates neuroprotective proteins Parkin and DJ-1 and protects dopaminergic neurons in a mouse model of Parkinson’s disease. Journal of Neuroimmune Pharmacology, 9 (4), 569–581.
  • Kim, Y.-G., et al., 2015. Cinnamon bark oil and its components inhibit biofilm formation and toxin production. International Journal of Food Microbiology, 195, 30–39.
  • Koehler, P., Hanlin, R., and Beraha, L., 1975. Production of aflatoxins B1 and G1 by Aspergillus flavus and Aspergillus parasiticus isolated from market pecans. Applied Microbiology, 30 (4), 581–583.
  • Kosegarten, C.E., et al., 2017. Description of Aspergillus flavus growth under the influence of different factors (water activity, incubation temperature, protein and fat concentration, pH, and cinnamon essential oil concentration) by kinetic, probability of growth, and time-to-detection models. International Journal of Food Microbiology, 240, 115–123.
  • Kwon, J.-Y., et al., 2012. 2′-Benzoyloxycinnamaldehyde inhibits nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells via regulation of AP-1 pathway. European Journal of Pharmacology, 696 (1), 179–186.
  • Lari, P., et al., 2015. Evaluation of diazinon-induced hepatotoxicity and protective effects of crocin. Toxicology and Industrial Health, 31 (4), 367–376.
  • Lee, J., et al., 2011. Protective effect of Ssanghwa-tang fermented by Lactobacillus fermentum against carbon tetrachloride-induced acute hepatotoxicity. African Journal of Traditional, Complementary and Alternative Medicines, 8 (3), 312–321.
  • Lee, J.-W., et al., 2016. Effect of an herbal mixture of Cinnamon Cortex, Persicae Semen, and Natril Sulfas on collagen-induced arthritis and lipopolysaccharides-induced nuclear factor-κ B signaling. Chinese Journal of Integrative Medicine. Available from: https://doi.org/10.1007/s11655-016-2517-y
  • Lee, S.-C., et al., 2017. Anti-inflammatory effect of cinnamaldehyde and linalool from the leaf essential oil of Cinnamomum osmophloeum Kanehira in endotoxin-induced mice. Journal of Food and Drug Analysis. Available from: https://doi.org/10.1016/j.jfda.2017.03.006
  • Lv, C., et al., 2017. Protective effect of cinnamaldehyde against glutamate-induced oxidative stress and apoptosis in PC12 cells. European Journal of Pharmacology, 815, 487–494.
  • Mahmood, N., et al., 2014. Pathological changes of gentamicin in liver tissue and antioxidant property of cinnamon extract on wistar rats. Biomedical & Pharmacology Journal, 7, 341–347.
  • Malik, J., Munjal, K., and Deshmukh, R., 2015. Attenuating effect of standardized lyophilized Cinnamomum zeylanicum bark extract against streptozotocin-induced experimental dementia of Alzheimer’s type. Journal of Basic and Clinical Physiology and Pharmacology, 26 (3), 275–285.
  • Manso, S., et al., 2014. Diminution of aflatoxin B1 production caused by an active packaging containing cinnamon essential oil. Food Control, 45, 101–108.
  • Mathew, S. and Abraham, T.E., 2006. Studies on the antioxidant activities of cinnamon (Cinnamomum verum) bark extracts, through various in vitro models. Food Chemistry, 94 (4), 520–528.
  • Mehri, S., Meshki, M.A., and Hosseinzadeh, H., 2015. Linalool as a neuroprotective agent against acrylamide-induced neurotoxicity in Wistar rats. Drug and Chemical Toxicology, 38 (2), 162–166.
  • Mehri, S., et al., 2014. Neuroprotective effect of thymoquinone in acrylamide-induced neurotoxicity in Wistar rats. Iranian Journal of Basic Medical Sciences, 17 (12), 1007.
  • Mendes, S.J., et al., 2016. Cinnamaldehyde modulates LPS-induced systemic inflammatory response syndrome through TRPA1-dependent and independent mechanisms. International Immunopharmacology, 34, 60–70.
  • Moallem, S.A., et al., 2014. Effect of aqueous extract of Crocus sativus L. (saffron) stigma against subacute effect of diazinon on specific biomarkers in rats. Toxicology and Industrial Health, 30 (2), 141–146.
  • Mohamed, I.K., 2017. Ameliorative effect of an aqueous mixture of cinnamon and ginger tea against hepatotoxicity induced in rats by the insecticide diazinon: a histopathological and ultrastructural study. International Journal of Pure & Applied Bioscience, 5 (2), 56–71.
  • Mohammadzadeh, N., Mehri, S., and Hosseinzadeh, H., 2017. Berberis vulgaris and its constituent berberine as antidotes and protective agents against natural or chemical toxicities. Iranian Journal of Basic Medical Sciences, 20 (5), 538.
  • Mollazadeh, H. and Hosseinzadeh, H., 2016. Cinnamon effects on metabolic syndrome: a review based on its mechanisms. Iranian Journal of Basic Medical Sciences, 19 (12), 1258.
  • Morales, G., et al., 2014. Effect of natural extracts on the formation of acrylamide in fried potatoes. LWT-Food Science and Technology, 58 (2), 587–593.
  • Morgan, A.M., et al., 2014. Studies on the potential protective effect of cinnamon against bisphenol A- and octylphenol-induced oxidative stress in male albino rats. Toxicology Reports, 1, 92–101.
  • Moselhy, S.S. and Ali, H.K., 2009. Hepatoprotective effect of cinnamon extracts against carbon tetrachloride induced oxidative stress and liver injury in rats. Biological Research, 42 (1), 93–98.
  • Moselhy, S.S. and Junbi, H.H., 2010. Antioxidant properties of ethanolic and aqueous Cinnamon extracts against liver injury in rats. International Journal of Advances in Pharmaceutical Sciences, 1 (2), 151–155.
  • Nesic, K., Ivanovic, S., and Nesic, V., 2014. Fusarial toxins: secondary metabolites of Fusarium fungi. Reviews of Environmental Contamination and Toxicology, 228, 101–120.
  • Noori, S., Azmat, M., and Mahboob, T., 2012. Study on antioxidant effects of cinnamon and garlic extract in liver, kidney and heart tissue of rat. Bioscience Research, 9 (1), 17–22.
  • Ozbayer, C., et al., 2014. Gastroprotective, cytoprotective and antioxidant effects of Oleum cinnamomi on ethanol induced damage. Cytotechnology, 66 (3), 431–441.
  • Paranagama, P., et al., 2010. A comparison of essential oil constituents of bark, leaf, root and fruit of cinnamon (Cinnamomum zeylanicum Blum) grown in Sri Lanka. Journal of the National Science Foundation of Sri Lanka, 29 (3–4), 147–153.
  • Patra, K., et al., 2012. Amelioration of cyclophosphamide induced myelosuppression and oxidative stress by cinnamic acid. Chemico-Biological Interactions, 195 (3), 231–239.
  • Pourbakhsh, H., et al., 2014. Effect of Nigella sativa fixed oil on ethanol toxicity in rats. Iranian Journal of Basic Medical Sciences, 17 (12), 1020–1031.
  • Przedborski, S. and Jackson-Lewis, V., 1998. Mechanisms of MPTP toxicity. Movement Disorders, 13, 35–38.
  • Rameshrad, M., Razavi, B.M., and Hosseinzadeh, H., 2017. Protective effects of green tea and its main constituents against natural and chemical toxins: a comprehensive review. Food and Chemical Toxicology, 100, 115–137.
  • Ranasinghe, P., et al., 2012. Effects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model. Pharmacognosy Research, 4 (2), 73.
  • Ranasinghe, P., et al., 2013. Medicinal properties of ‘true’ cinnamon (Cinnamomum zeylanicum): a systematic review. BMC Complementary and Alternative Medicine, 13 (1), 275.
  • Razavi, B.M. and Hosseinzadeh, H., 2015. Saffron as an antidote or a protective agent against natural or chemical toxicities. DARU Journal of Pharmaceutical Sciences, 23 (1), 31.
  • Sariözkan, S., et al., 2016. Effects of cinnamon (C. zeylanicum) bark oil against taxanes-induced damages in sperm quality, testicular and epididymal oxidant/antioxidant balance, testicular apoptosis, and sperm DNA integrity. Nutrition and Cancer, 68 (3), 481–494.
  • Schriner, S.E., et al., 2014. Extension of Drosophila lifespan by cinnamon through a sex-specific dependence on the insulin receptor substrate chico. Experimental Gerontology, 60, 220–230.
  • Shakeel, M., et al., 2016. Toxic effects of titanium dioxide nanoparticles and titanium dioxide bulk salt in the liver and blood of male Sprague-Dawley rats assessed by different assays. Biological Trace Element Research, 173 (2), 405–426.
  • Shakeel, M., et al., 2017. Assessment of titanium dioxide nanoparticles (TiO2-NPs) induced hepatotoxicity and ameliorative effects of cinnamomum cassia in Sprague-Dawley rats. Biological Trace Element Research, 1–13. doi: 10.1007/s12011-017-1074-3. [Epub ahead of print]
  • Song, F., et al., 2013. Protective effects of cinnamic acid and cinnamic aldehyde on isoproterenol-induced acute myocardial ischemia in rats. Journal of Ethnopharmacology, 150 (1), 125–130.
  • Sun, Q., et al., 2015. In vitro anti-aflatoxigenic effect and mode of action of cinnamaldehyde against aflatoxin B 1. International Biodeterioration & Biodegradation, 104, 419–425.
  • Taner, G., et al., 2017. Use of in vitro assays to assess the potential cytotoxic, genotoxic and antigenotoxic effects of vanillic and cinnamic acid. Drug and Chemical Toxicology, 40 (2), 183–190.
  • Tanomand, S. and Najafian, M., 2013. Inhibitory effects of cinnamon extract on gentamicin-induced nephrotoxicity in mail adult Wistar rats. Advances in Environmental Biology, 7, 2100–2105.
  • Tavakkoli, A., et al., 2017. Black seed (Nigella sativa) and its constituent thymoquinone as an antidote or a protective agent against natural or chemical toxicities. Iranian Journal of Pharmaceutical Research, 16, 2–23.
  • Tolba, R., et al., 2015. Diethylnitrosamine (DEN)-induced carcinogenic liver injury in mice. Laboratory Animals, 49, 59–69.
  • Tung, Y.-T., et al., 2010. Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves. Pharmaceutical Biology, 48 (10), 1130–1136.
  • Ullah, N., et al., 2017. Nephroprotective property of Cinnamomum zeylanicum and its antibacterial activity in combination with gantamicin. Pakistan Journal of Pharmaceutical Sciences, 30 (1), 55–60.
  • Velluti, A., et al., 2004a. Impact of essential oils on growth rate, zearalenone and deoxynivalenol production by Fusarium graminearum under different temperature and water activity conditions in maize grain. Journal of Applied Microbiology, 96 (4), 716–724.
  • Velluti, A., et al., 2004b. Effect of essential oils of cinnamon, clove, lemon grass, oregano and palmarosa on growth of and fumonisin B1 production by Fusarium verticillioides in maize. Journal of the Science of Food and Agriculture, 84 (10), 1141–1146.
  • Wang, H.-F., Wang, Y.-K., and Yih, K.-H., 2007. DPPH free-radical scavenging ability, total phenolic content, and chemical composition analysis of forty-five kinds of essential oils. Journal of Cosmetic Science, 59 (6), 509–522.
  • Wang, H., et al., 2015. Therapeutic efficacy and mechanism of Zhenrenyangzang decoction in rats with experimental ulcerative colitis. International Journal of Clinical and Experimental Medicine, 8 (9), 15254.
  • Wang, L., et al., 2014. Beneficial roles of dietary Oleum cinnamomi in alleviating intestinal injury. Frontiers in Bioscience (Landmark Edition), 20, 814–828.
  • Xing, F., et al., 2014. Growth inhibition and morphological alterations of Fusarium verticillioides by cinnamon oil and cinnamaldehyde. Food Control, 46, 343–350.
  • Yuan, H.D., Huang, B., and Chung, S.H., 2011. Protective effect of cinnamaldehyde on streptozotocin-induced damage in rat pancreatic β-cells. Food Science and Biotechnology, 20 (5), 1271–1276.
  • Yüce, A., et al., 2014. Effectiveness of cinnamon (Cinnamomum zeylanicum) bark oil in the prevention of carbon tetrachloride-induced damages on the male reproductive system. Andrologia, 46 (3), 263–272.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.