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Research Articles

Hepatic susceptibility to oxidative damage after repeated concomitant exposure to aspartame and aflatoxin B1 in rats

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Pages 2780-2785 | Received 28 May 2021, Accepted 07 Aug 2021, Published online: 28 Oct 2021

References

  • Abhilash, M., et al., 2011. Effect of long term intake of aspartame on antioxidant defense status in liver. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 49 (6), 1203–1207.
  • Adaramoye, O.A., and Akanni, O.O., 2016. Effects of long-term administration of aspartame on biochemical indices, lipid profile and redox status of cellular system of male rats. Journal of Basic and Clinical Physiology and Pharmacology, 27 (1), 10–1515.
  • Aebi, H., 1984. Catalase in vitro. Methods in Enzymology, 105, 121–126.
  • Almazroo, O.A., Miah, M.K., and Venkataramanan, R., 2017. Drug metabolism in the liver. Clinics in Liver Disease, 21 (1), 1–20.
  • Alm-Eldeen, A.A., et al., 2015. Synergistic effect of black tea and curcumin in improving the hepatotoxicity induced by aflatoxin B1 in rats. Toxicology and Industrial Health, 31 (12), 1269–1280.
  • Andrade, P.D., et al., 2013. Aflatoxins in food products consumed in Brazil: a preliminary dietary risk assessment. Food Additives & Contaminants: Part A, 30 (1), 127–136.
  • Ashok, I., and Sheeladevi, R., 2015. Oxidant stress evoked damage in rat hepatocyte leading to triggered nitric oxide synthase (NOS) levels on long term consumption of aspartame. Journal of Food and Drug Analysis, 23 (4), 679–691.
  • Ashok, I., et al., 2017. Oxidative stress evoked damages on rat sperm and attenuated antioxidant status on consumption of aspartame. International Journal of Impotence Research, 29 (4), 164–170.
  • Ashok, I., Sheeladevi, R., and Wankhar, D., 2014. Effect of long-term aspartame (artificial sweetener) on anxiety, locomotor activity and emotionality behavior in Wistar Albino rats. Biomedicine & Preventive Nutrition, 4 (1), 39–43.
  • Benderitter, M., et al., 1998. Studies by electron paramagnetic resonance of the importance of iron in the hydroxyl scavenging properties of ascorbic acid in plasma: effects of iron chelators. Fundamental & Clinical Pharmacology, 12 (5), 510–516.
  • Benzie, I.F.F., and Strain, J.J., 1996. The Ferric Reducing Ability of Plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Analytical Biochemistry, 239 (1), 70–76.
  • Bradford, M.M., 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72, 248–254.
  • Butchko, H.H., and Stargel, W.W., 2001. Aspartame: scientific evaluation in the postmarketing period. Regulatory Toxicology and Pharmacology : RTP, 34 (3), 221–233.
  • Coulombe, R.A., and Sharma, R.P., 1985. Clearance and excretion of intratracheally and orally administered aflatoxin B1 in the rat. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, 23 (9), 827–830.
  • Di Simplicio, P., et al., 2003. Thiolation and nitrosation of cysteines in biological fluids and cells. Amino Acids, 25 (3–4), 323–339.
  • Ellman, G.L., 1959. Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics, 82 (1), 70–77.
  • El-Nekeety, A.A., et al., 2011. Antioxidant properties of Thymus vulgaris oil against aflatoxin-induce oxidative stress in male rats. Toxicon : Official Journal of the International Society on Toxinology, 57 (7-8), 984–991.
  • Figlewicz, D.P., et al., 2009. Effect of moderate intake of sweeteners on metabolic health in the rat. Physiology & Behavior, 98 (5), 618–624.
  • Finamor, I.A., et al., 2014. The protective effect of N-acetylcysteine on oxidative stress in the brain caused by the long-term intake of aspartame by rats. Neurochemical Research, 39 (9), 1681–1690.
  • Habig, W.H., Pabst, M.J., and Jakoby, W.B., 1974. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. The Journal of Biological Chemistry, 249 (22), 7130–7139.
  • Hamza, R.Z., et al., 2019. Effect of l-carnitine on aspartame-induced oxidative stress, histopathological changes, and genotoxicity in liver of male rats. Journal of Basic and Clinical Physiology and Pharmacology, 30 (2), 219–232.
  • Humphries, P., Pretorius, E., and Naudé, H., 2008. Direct and indirect cellular effects of aspartame on the brain. European Journal of Clinical Nutrition, 62 (4), 451–462.
  • Jumah, M.B., and Otman, S.I., 2019. Histopathological effect of aspartame on liver and kidney of mice. International Journal of Pharmacology, 15, 336–342.
  • Lee, H.J., and Ryu, D., 2017. Worldwide occurrence of mycotoxins in cereals and cereal-derived food products: public health perspectives of their co-occurrence. Journal of Agricultural and Food Chemistry, 65 (33), 7034–7051.
  • Li, H., et al., 2018. The toxic effects of aflatoxin B1 and aflatoxin M1 on kidney through regulating L-proline and downstream apoptosis. BioMed Research International, 2018, 1–11.
  • Liu, Y., and Wu, F., 2010. Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environmental Health Perspectives, 118 (6), 818–824.
  • Magnuson, B.A., et al., 2007. Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. Critical Reviews in Toxicology, 37 (8), 629–727.
  • Marin, D.E., and Taranu, I., 2012. Overview on aflatoxins and oxidative stress. Toxin Reviews, 31 (3-4), 32–43.
  • Marin, S., et al., 2013. Mycotoxins: occurrence, toxicology, and exposure assessment. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 60, 218–237.
  • Marinovich, M., et al., 2013. Aspartame, low-calorie sweeteners and disease: regulatory safety and epidemiological issues. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 60, 109–115.
  • Naaz, F., Abdin, M.Z., and Javed, S., 2014. Protective effect of esculin against prooxidant aflatoxin B1-induced nephrotoxicity in mice. Mycotoxin Research, 30 (1), 25–32.
  • Ohkawa, H., Ohishi, N., and Yagi, K., 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry, 95 (2), 351–358.
  • Orina, I., Manley, M., and Williams, P.J., 2017. Non-destructive techniques for the detection of fungal infection in cereal grains. Food Research International (Ottawa, Ont.), 100 (Pt 1), 74–86.
  • Ostry, V., et al., 2017. Mycotoxins as human carcinogens-the IARC Monographs classification. Mycotoxin Research, 33 (1), 65–73.
  • Peters, J., et al., 2017. Mycotoxin profiling of 1000 beer samples with a special focus on craft beer. PLoS One, 12 (10), e0185887–1371.
  • Qian, G., et al., 2013. Integrative Toxicopathological Evaluation of Aflatoxin B1Exposure in F344 Rats. Toxicologic Pathology, 41 (8), 1093–1105.
  • Reagan-Shaw, S., et al., 2008. Dose translation from animal to human studies revisited. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 22 (3), 659–661.
  • Rencüzoğullari, E., et al., 2004. Genotoxicity of aspartame. Drug and Chemical Toxicology, 27 (3), 257–268.
  • Rotimi, O.A., et al., 2018. Oxidative stress in extrahepatic tissues of rats co-exposed to aflatoxin B1 and low protein diet. Toxicological Research, 34 (3), 211–220.
  • Rushing, B.R., and Selim, M.I., 2019. Aflatoxin B1: a review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 124, 81–100.
  • Sadhasivam, S., et al., 2017. Rapid detection and identification of mycotoxigenic fungi and mycotoxins in stored wheat grain. Toxins (Basel), 9, 302. 10.3390/toxins9100302
  • Simintzi, I., et al., 2007. The effect of aspartame metabolites on the suckling rat frontal cortex acetylcholinesterase. An in vitro study. Food and Chemical Toxicology, 45 (12), 2397–2401.
  • Singh, S.D., and Chuturgoon, A.A., 2017. A comparative analysis of mycotoxin contamination of supermarket and premium brand pelleted dog food in Durban, South Africa. Journal of the South African Veterinary Association, 88 (0), e1–e6.
  • Souto, N.S., et al., 2018. Aflatoxin B1 reduces non-enzymatic antioxidant defenses and increases protein kinase C activation in the cerebral cortex of young rats. Nutritional Neuroscience, 21 (4), 268–275.
  • Souto, N.S., et al., 2019. Behavioural and biochemical effects of one-week exposure to aflatoxin B1 and aspartame in male Wistar rats. World Mycotoxin Journal, 12 (3), 293–305.
  • Stoev, S.D., 2015. Foodborne mycotoxicoses, risk assessment and underestimated hazard of masked mycotoxins and joint mycotoxin effects or interaction. Environmental Toxicology and Pharmacology, 39 (2), 794–809.
  • Trebak, F., et al., 2015. Impact of aflatoxin B1 on hypothalamic neuropeptides regulating feeding behavior. Neurotoxicology, 49, 165–173.
  • Williams, J.H., et al., 2004. Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions. The American Journal of Clinical Nutrition, 80 (5), 1106–1122.
  • Wogan, G.N., Kensler, T.W., and Groopman, J.D., 2012. Present and future directions of translational research on aflatoxin and hepatocellular carcinoma. A review. Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment, 29 (2), 249–257.
  • Yılmaz, S., Kaya, E., and Comakli, S., 2017. Vitamin E (α tocopherol) attenuates toxicity and oxidative stress induced by aflatoxin in rats. Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University, 26 (6), 907–917.

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