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Research Articles

Exogenous glutathione protects against gentamicin-induced acute kidney injury by inhibiting NF-κB pathway, oxidative stress, and apoptosis and regulating PCNA

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Pages 441-450 | Received 23 Dec 2021, Accepted 27 Feb 2022, Published online: 10 Mar 2022

References

  • Abd-Elhamid, T.H., et al., 2018. Reno-protective effects of ursodeoxycholic acid against gentamicin-induced nephrotoxicity through modulation of NF-κB, eNOS and caspase-3 expressions. Cell and Tissue Research, 374 (2), 367–387.
  • Adil, M., et al., 2016. Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction. Renal Failure, 38 (6), 996–1006.
  • Ahmad, S.H., et al., 2017. Toll-like receptors, NF-κB, and IL-27 mediate adenosine A2A receptor signaling in BTBR T + Itpr3tf/J mice. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 79 (Pt B), 184–191.
  • Ahmadvand, H., et al., 2019a. Glutathione ameliorates liver markers, oxidative stress and inflammatory indices in rats with renal ischemia reperfusion injury. Journal of Renal Injury Prevention, 8 (2), 91–97.
  • Ahmadvand, H., et al., 2019b. Selenium effects on antioxidant and inflammatory indices in renal ischemia-reperfusion injury in rats. Journal of Renal Injury Prevention, 8 (2), 71–77.
  • Ahmadvand, H., et al., 2020. Renoprotective effects of gallic acid against gentamicin nephrotoxicity through amelioration of oxidative stress in rats. Brazilian Archives of Biology and Technology, 63, e20200131.
  • Al-Harbi, N.O., et al., 2018. Short chain fatty acid, acetate ameliorates sepsis-induced acute kidney injury by inhibition of NADPH oxidase signaling in T cells. International Immunopharmacology, 58, 24–31.
  • Al-Harbi, N.O., et al., 2019. Amelioration of sepsis-induced acute kidney injury through inhibition of inflammatory cytokines and oxidative stress in dendritic cells and neutrophils respectively in mice: role of spleen tyrosine kinase signaling. Biochimie, 158, 102–110.
  • Ali, F.E.M., et al., 2020. Ursodeoxycholic acid abrogates gentamicin-induced hepatotoxicity in rats: Role of NF-κB-p65/TNF-α, Bax/Bcl-xl/Caspase-3, and eNOS/iNOS pathways. Life Sciences, 254, 117760.
  • Anderson, M.E., 1998. Glutathione: an overview of biosynthesis and modulation. Chemico-Biological Interactions, 111–112, 1–14.
  • Babaeenezhad, E., et al., 2021. D-Limonene alleviates acute kidney injury following gentamicin administration in rats: role of NF-κB pathway, mitochondrial apoptosis, oxidative stress, and PCNA. Oxidative Medicine and Cellular Longevity, 2021, 6670007.
  • Ballatori, N., et al., 2009. Glutathione dysregulation and the etiology and progression of human diseases. Biological Chemistry, 390 (3), 191–214.
  • Beshay, O.N., et al., 2020. Resveratrol reduces gentamicin-induced EMT in the kidney via inhibition of reactive oxygen species and involving TGF-β/Smad pathway. Life Sciences, 258, 118178.
  • Bledsoe, G., et al., 2008. Role of tissue kallikrein in prevention and recovery of gentamicin-induced renal injury. Toxicological Sciences : An Official Journal of the Society of Toxicology, 102 (2), 433–443.
  • Borges, I., et al., 2007. Proinflammatory and oxidative stress markers in patients with periodontal disease. Mediators of Inflammation, 2007, 45794.
  • Cazzalini, O., et al., 2010. p21CDKN1A participates in base excision repair by regulating the activity of poly(ADP-ribose) polymerase-1. DNA Repair, 9 (6), 627–635.
  • Chen, J., et al., 2015. Glutathione supplementation attenuates oxidative stress and improves vascular hyporesponsiveness in experimental obstructive jaundice. Oxidative Medicine and Cellular Longevity, 2015, 486148.
  • Chen, X.L., et al., 2004. Superoxide, H2O2, and iron are required for TNF-alpha-induced MCP-1 gene expression in endothelial cells: role of Rac1 and NADPH oxidase . American Journal of Physiology. Heart and Circulatory Physiology, 286 (3), H1001–H1007.
  • Chen, Y.C., et al., 2011. Leptin reduces gentamicin-induced apoptosis in rat renal tubular cells via the PI3K-Akt signaling pathway. European Journal of Pharmacology, 658 (2-3), 213–218.
  • Choi, K.H., et al., 2000. Gentamicin induced apoptosis of renal tubular epithelial (LLC-PK1) cells. The Korean Journal of Internal Medicine, 15 (3), 218–223.
  • Dalvi, R.R., 1988. Involvement of glutathione in the reduction of captan-induced in vivo inhibition of monooxygenases and liver toxicity in the rat. Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes, 23 (2), 171–178.
  • Denamur, S., et al., 2016. Subcellular mechanisms involved in apoptosis induced by aminoglycoside antibiotics: insights on p53, proteasome and endoplasmic reticulum. Toxicology and Applied Pharmacology, 309, 24–36.
  • Ellman, G.L., 1959. Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics, 82 (1), 70–77.
  • Giustarini, D., et al., 2008. Nitrite and nitrate measurement by griess reagent in human plasma: Evaluation of interferences and standardization. Methods in Enzymology, 440, 361–380.
  • Gong, X., et al., 2012. Protective effects of N-acetylcysteine amide (NACA) on gentamicin-induced apoptosis in LLC-PK1 cells. Renal Failure, 34 (4), 487–494.
  • IWATA‏, S., 2016. Effect of chronic glutathione administration on striatal dopaminergic terminals in intrastriatal 6-hydroxydopamine-treated rats. Core.Ac.Uk‏, 20, 7–10.
  • Jado, J.C., et al., 2020. Nephroprotective effect of cilastatin against gentamicin-induced renal injury in vitro and in vivo without altering its bactericidal efficiency. Antioxidants, 9 (9), 821.
  • Josepovitz, C., et al., 1982. Inhibition of gentamicin uptake in rat renal cortex in vivo by aminoglycosides and organic polycations. Journal of Pharmacology and Experimental Therapeutics, 223 (2), 314–321.
  • Kang, C., et al., 2013. Protective effects of Houttuynia cordata Thunb. on gentamicin-induced oxidative stress and nephrotoxicity in rats. Toxicological Research, 29 (1), 61–67.
  • Kuthan, H., et al., 1986. A spectrophotometric assay for superoxide dismutase activities in crude tissue fractions. The Biochemical Journal, 237 (1), 175–180.
  • Kwon, D.H., et al., 2019. Protective effect of glutathione against oxidative stress-induced cytotoxicity in RAW 264.7 macrophages through activating the nuclear factor erythroid 2-related factor-2/heme oxygenase-1 pathway. Antioxidants, 8 (4), 82.
  • Lee, I.C., et al., 2012. Melatonin attenuates gentamicin-induced nephrotoxicity and oxidative stress in rats. Archives of Toxicology, 86 (10), 1527–1536.
  • Lee, J.U., 2008. Nitric oxide in the kidney : its physiological role and pathophysiological implications. Electrolyte & Blood Pressure : E & BP, 6 (1), 27–34.
  • Lee, K.E., et al., 2013. Macrophage-stimulating protein attenuates gentamicin-induced inflammation and apoptosis in human renal proximal tubular epithelial cells. Biochemical and Biophysical Research Communications, 434 (3), 527–533.
  • Lopez-Novoa, J.M., et al., 2011. New insights into the mechanism of aminoglycoside nephrotoxicity: An integrative point of view. Kidney International, 79 (1), 33–45.
  • Meister, A., and Anderson, M.E., 1983. Glutathione. Annual Review of Biochemistry, 52, 711–760.
  • Mishra, V., et al., 2018. Oxidative stress and cellular pathways of asthma and inflammation: Therapeutic strategies and pharmacological targets. Pharmacology & Therapeutics, 181, 169–182.
  • Mocquet, V., et al., 2008. Sequential recruitment of the repair factors during NER: The role of XPG in initiating the resynthesis step. The EMBO Journal, 27 (1), 155–167.
  • Mullane, K., 1989. Neutrophil-platelet interactions and post-ischemic myocardial injury. Progress in Clinical and Biological Research, 301, 39–51.
  • Nadeem, A., et al., 2021a. Role of ITK signaling in acute kidney injury in mice: Amelioration of acute kidney injury associated clinical parameters and attenuation of inflammatory transcription factor signaling in CD4+ T cells by ITK inhibition. International Immunopharmacology, 99, 108028.
  • Nadeem, A., et al., 2021b. Bruton’s tyrosine kinase inhibition attenuates oxidative stress in systemic immune cells and renal compartment during sepsis-induced acute kidney injury in mice. International Immunopharmacology, 90, 107123.
  • Ohkawa, H., et al., 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry, 95 (2), 351–358.
  • Ozbek, E., et al., 2009. Atorvastatin prevents gentamicin-induced renal damage in rats through the inhibition of p38-MAPK and NF-kappaB pathways. Renal Failure, 31 (5), 382–392.
  • Potočnjak, I., and Domitrović, R., 2016. Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association, 98 (Pt B), 251–261.
  • Radermacher, J., et al., 1992. Importance of NO/EDRF for glomerular and tubular function: Studies in the isolated perfused rat kidney. Kidney International, 41 (6), 1549–1559.
  • Rotman, G., and Shiloh, Y., 1997. The ATM gene protein: possible roles in genome surveillance, checkpoint controls cellular defence against oxidative stress. Cancer Surveys, 29, 285–304.
  • Rotruck, J.T., et al., 1973. Selenium: biochemical role as a component of glutathione peroxidase. Science (New York, N.Y.), 179 (4073), 588–590.
  • Sai, K., et al., 1992. The protective role of glutathione, cysteine and vitamin C against oxidative DNA damage induced in rat kidney by potassium bromate. Japanese Journal of Cancer Research : Gann, 83 (1), 45–51.
  • Salama, S.A., et al., 2018. Troxerutin down-regulates KIM-1, modulates p38 MAPK signaling, and enhances renal regenerative capacity in a rat model of gentamycin-induced acute kidney injury. Food & Function, 9 (12), 6632–6642.
  • Schmitz, C., et al., 2002. Megalin deficiency offers protection from renal aminoglycoside accumulation. The Journal of Biological Chemistry, 277 (1), 618–622.
  • Segerer, S., et al., 2000. Chemokines, chemokine receptors, and renal disease: From basic science to pathophysiologic and therapeutic studies. Journal of the American Society of Nephrology : JASN, 11 (1), 152–176.
  • Servais, H., et al., 2006. Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation . Antimicrobial Agents and Chemotherapy, 50 (4), 1213–1221.
  • Sies, H., et al., 1997. Glutathione peroxidase protects against peroxynitrite-mediated oxidations. A new function for selenoproteins as peroxynitrite reductase. The Journal of Biological Chemistry, 272 (44), 27812–27817.
  • Silan, C., et al., 2007. Gentamicin-induced nephrotoxicity in rats ameliorated and healing effects of resveratrol. Biological & Pharmaceutical Bulletin, 30 (1), 79–83.
  • Sinha, A.K., 1972. Colorimetric assay of catalase. Analytical Biochemistry, 47 (2), 389–394.
  • Soares, T.J., et al., 2002. Long-term evolution of the acute tubular necrosis (ATN) induced by glycerol: Role of myofibroblasts and macrophages. International Journal of Experimental Pathology, 83 (4), 165–172.
  • Spiecker, M., et al., 1998. Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants. Journal of Leukocyte Biology, 63 (6), 732–739.
  • Stambe, C., et al., 2003. Blockade of p38alpha MAPK ameliorates acute inflammatory renal injury in rat anti-GBM glomerulonephritis. Journal of the American Society of Nephrology : JASN, 14 (2), 338–351.
  • Sun, S., et al., 2006. Protective effect of glutathione against lipopolysaccharide-induced inflammation and mortality in rats. Inflammation Research : Official Journal of the European Histamine Research Society, 55 (11), 504–510.
  • Tillhon, M., et al., 2013. p21CDKN1A and DNA repair systems: recent findings and future perspectives. In: DNA repair—new research directions. Rijeka: InTech, 249–279.
  • Tugcu, V., et al., 2006. Selective nuclear factor κ-B inhibitors, pyrolidium dithiocarbamate and sulfasalazine, prevent the nephrotoxicity induced by gentamicin. BJU International, 98 (3), 680–686.
  • Ueno, Y., et al., 2002. Dietary glutathione protects rats from diabetic nephropathy and neuropathy. The Journal of Nutrition, 132 (5), 897–900.
  • Wang, L., et al., 2020. Sexual dimorphism in glutathione metabolism and glutathione-dependent responses. Redox Biology, 31, 101410.
  • Xu, Y.Y., et al., 2012. Evaluation of the effect of glutathione on cisplatin antitumor activity and kidney injury at different administration inistration times. Molecular Medicine Reports, 6 (5), 1075–1080.

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