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Research Articles

The protective effect of N-acetyl cysteine against selenium toxicity and gamma irradiation in rats

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Pages 482-490 | Received 11 Nov 2021, Accepted 16 Mar 2022, Published online: 31 Mar 2022

References

  • Alkhalf, M.I., Khalifa, F.K., 2018. Blueberry extract attenuates γ-radiation-induced hepatocyte damage by modulating oxidative stress and suppressing NF-κB in male rats. Saudi Journal of Biological Sciences, 25 (7), 1272–1277.
  • Alnahdi, A., John, A., Raza, H., 2019. N-acetyl cysteine attenuates oxidative stress and glutathione-dependent redox imbalance caused by high glucose/high palmitic acid treatment in pancreatic Rin-5F cells. PLoS One, 14, e0226696.
  • Al-Shaqha, W.M., et al., 2015. Anti-diabetic potential of Catharanthus roseus Linn. and its effect on the glucose transport gene (GLUT-2 and GLUT-4) in streptozotocin induced diabetic wistar rats. BMC Complementary and Alternative Medicine, 15, 379.
  • Astiz, M., de Alaniz, M.J., Marra, C.A., 2012. The oxidative damage and inflammation caused by pesticides are reverted by lipoic acid in rat brain. Neurochemistry International, 61 (7), 1231–1241.
  • Azab, K.S., et al., 2017. Response of COX2/PGE2 inflammatory pathway to brown seaweed extract in rats exposed to gamma radiation. World Journal of Nuclear Science and Technology, 7, 189–205.
  • Bostancı, M.E., Hepokur, C., Kisli, E., 2021. The effects of sildenafil and N-acetylcysteine the zone of stasis in burns. Ulusal Travma ve Acil Cerrahi Dergisi = Turkish Journal of Trauma & Emergency Surgery: TJTES, 27 ( 1), 9–16.
  • Cai, Z., et al., 2018. Protective effect of N-acetylcysteine activated carbon release microcapsule on myocardial ischemia-reperfusion injury in rats. Experimental and Therapeutic Medicine, 15 ( 2), 1809–1818.
  • Ceylan, B., et al., 2018. N-acetylcysteine suppresses colistimethate sodium-induced nephrotoxicity via activation of SOD2, eNOS, and MMP3 protein expressions. Renal Failure, 40 (1), 423–434.
  • Chaves Cayuela, N., et al., 2020. N-acetylcysteine reduced ischemia and reperfusion damage associated with steatohepatitis in mice. International Journal of Molecular Science, 21 (11), 4106.
  • Chung, Y.H., et al., 2021. Radiation-induced metabolic shifts in the hepatic parenchyma: findings from 18F-FDG PET imaging and tissue NMR metabolomics in a mouse model for hepatocellular carcinoma. Molecules, 26, 2573.
  • De Pinto, M.C., Locato, V., De Gara, L., 2012. Redox regulation in plant programmed cell death. Plant, Cell & Environment, 35, 234–244.
  • Dodd, S., et al., 2008. N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility. Expert Opinion on Biological Therapy, 8 (12), 1955–1962.
  • Dominari, A., et al., 2021. Bottom-up analysis of emergent properties of N-acetylcysteine as an adjuvant therapy for COVID-19. World Journal of Virology, 10 (2), 34–52.
  • Duan, Y., et al., 2013. Variations of energy metabolism and adenosine triphosphatase activity in gastric mucosa in chronic atrophic gastritis rats with Qi deficiency and blood stasis syndrome and effect of zhiweifangbian capsule. Journal of Traditional Chinese Medicine, 33 (4), 500–504.
  • Gandhi, S., et al., 2020. Contribution of immune cells to glucocorticoid receptor expression in breast cancer. International Journal of Molecular Science, 21 (13), 4635.
  • Gupta, M., Gupta, S., 2016. An overview of selenium uptake, metabolism, and toxicity in plants. Frontiers in Plant Science, 7, 2074.
  • Hasanuzzaman, M., et al. 2020. Selenium toxicity in plants and environment: biogeochemistry and remediation possibilities. Plants (Basel), 9 (12), 1711.
  • Hugouvieux, V., et al., 2009. Arabidopsis putative selenium-binding protein1 expression is tightly linked to cellular sulfur demand and can reduce sensitivity to stresses requiring glutathione for tolerance. Plant Physiology, 151 (2), 768–781.
  • Iftimovici, A., et al., 2020. Stress, cortisol and NR3C1 in at-risk individuals for psychosis: a Mendelian randomization study. Frontiers in Psychiatry, 11, 680.
  • Komolafe, O. et al., 2017. Serum C-reactive protein, procalcitonin, and lactate dehydrogenase for the diagnosis of pancreatic necrosis. The Cochrane Database of Systematic Reviews, 4 (4), CD012645.
  • Lafin, J.T., et al., 2019. Methylseleninic acid induces lipid peroxidation and radiation sensitivity in head and neck cancer cells. International Journal of Molecular Science, 20 (1), 225.
  • Lei, G., et al., 2020. The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression. Cell Research, 30 (2), 146–162.
  • Li, Q., et al., 2018. Inhibition of autophagy promoted high glucose/ROS-mediated apoptosis in ADSCs. Stem Cell Research & Therapy, 9 (1), 289.
  • Livak, K.J., Schmittgen, T.D., 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) Method. Methods, 25, 402–408.
  • Lu ,C.W., et al., 2019. Gender differences with dose-response relationship between serum selenium levels and metabolic syndrome-a case-control study. Nutrients, 11, 477.
  • Mercantepe, F., et al., 2019. The effects of N-acetylcysteine on radiotherapy-induced small intestinal damage in rats. Experimental Biology & Medicine (Maywood), 244 (5), 372–379.
  • Mézes, M., Balogh, K., 2009. Prooxidant mechanisms of selenium toxicity – a review. Acta Biologica Szegediensis, 53, 15–18.
  • Mohanty, R.R., et al., 2021. Therapeutic potential of N-acetyl cysteine (NAC) in preventing cytokine storm in COVID-19: review of current evidence. European Review for Medical and Pharmacological Sciences, 25 (6), 2802–2807.
  • Mroczek-Zdyrska, M., Wójcik, M., 2012. The influence of selenium on root growth and oxidative stress induced by lead in Vicia faba L. minor plants. Biological Trace Element Research, 147 (1-3), 320–328.
  • Nogueira, C.W., Barbosa, N.V., Rocha, J.B.T., 2021. Toxicology and pharmacology of synthetic organoselenium compounds: an update. Archives of Toxicology, 95 (4), 1179–1226.
  • Nuszkiewicz, J., Woźniak, A., Szewczyk-Golec, K., 2020. Ionizing radiation as a source of oxidative stress-the protective role of melatonin and vitamin D. International Journal of Molecular Science, 21 (16), 5804.
  • Paintlia, M.K., et al., 2008. Lipopolysaccharide-induced peroxisomal dysfunction exacerbates cerebral white matter injury: attenuation by N-acetyl cysteine. Experimental Neurology, 210 (2), 560–576.
  • Pei, Y., et al., 2018. Biological activities and potential oral applications of N-acetylcysteine: progress and prospects. Oxidative Medicine and Cellular Longevity, 2018, 2835787.
  • Prevatto, J.P., et al., 2017. Antioxidant treatment induces hyperactivation of the HPA axis by upregulating ACTH receptor in the adrenal and downregulating glucocorticoid receptors in the pituitary. Oxidative Medicine and Cellular Longevity, 2017, 4156361.
  • Raff, H., Cort, B., 2016. CORT, Cort, B, corticosterone, and now cortistatin: enough already!. Endocrinology, 157, 3307–3308.
  • Samuni, Y., et al., 2013. The chemistry and biological activities of N-acetylcysteine. Biochimica et Biophysica Acta, 1830 (8), 4117–4129.
  • Settas, N., Faucz, F.R., Stratakis, C.A., 2018. Succinate dehydrogenase (SDH) deficiency, Carney triad and the epigenome. Molecular and Cellular Endocrinology, 469, 107–111.
  • Sevilla, L.M., Pérez, P., 2018. Roles of the glucocorticoid and mineralocorticoid receptors in skin pathophysiology. International Journal of Molecular Science, 19, 1906.
  • Shin, J.H., et al., 2019. Synergistic effects of N-acetylcysteine and mesenchymal stem cell in a lipopolysaccharide-induced interstitial cystitis rat model. Cells, 9, 86.
  • Sinha, M., et al., 2012. Amelioration of ionizing radiation induced lipid peroxidation in mouse liver by Moringa oleifera Lam. leaf extract. Indian Journal of Experimental Biology, 50 (3), 209–215.
  • Sokół, R., Koziatek-Sadłowska, S., 2020. Changes in the corticosterone level in tooting male black grouse (Tetrao tetrix) infected with Eimeria spp. Poultry Science, 99 (3), 1306–1310.
  • Sulaiman, S., et al., 2020. Hepatoprotective effect of prazosin is comparable to N-acetylcysteine in acetaminophen induced hepatotoxicity in mice. Journal of Ayub Medical College, Abbottabad, 32 (1), 28–32.
  • Verma, A.S., et al., 2019. Exogenous supplementation of N-acetylcysteine can reduce hepatotoxicity induced by ascites fluid (cell-free) adsorbed over protein-A-containing Staphylococcus aureus Cowan-I without compromising its antitumor effect. Journal of Pharmacy & Bioallied Sciences, 11 (3), 205–215.
  • Wang, B., Li, H.L., Yang, W.Y., 2007. [N-acetyl-l-cysteine improves function of islet beta cell in hyperlipidemic rats and its mechanism]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical Sciences, 36 (6), 575–580.
  • Wang, H., et al., 2018. Pathogenesis of abnormal hepatic lipid metabolism induced by chronic intermittent hypoxia in rats and the therapeutic effect of N-acetylcysteine. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 24, 4583–4591.
  • Wei, G., et al., 2021. A meta-analysis of the efficacy of L-carnitine/L-acetyl-carnitine or N-acetyl-cysteine in men with idiopathic asthenozoospermia. American Journal of Men;s Health, 15 (2), 15579883211011371.
  • Wills, E.D., 1966. Mechanisms of lipid peroxide formation in animal tissues. The Biochemical Journal, 99 (3), 667–676.
  • Zhang, J., et al., 2005. Comparison of short-term toxicity between Nano-Se and selenite in mice. Life Sciences, 76 (10), 1099–1109.
  • Zhitkovich, A., 2019. N-acetylcysteine: antioxidant, aldehyde scavenger, and more. Chemical Research in Toxicology, 32 (7), 1318–1319.

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