Investigation of the phytochemical composition and remedial effects of southern grape hyacinth (Muscari neglectum Guss. ex Ten.) plant extract against carbon tetrachloride-induced oxidative stress in rats

References

• Agirman, E., Celik, I., and Dogan, A., 2020. Consumption of the Syrian mesquite plant (Prosopis farcta) fruit and seed lyophilized extracts may have both protective and toxic effects in STZ-induced diabetic rats. Archives of Physiology and Biochemistry.doi:10.1080/13813455.2020.1734844
   PubMedGoogle Scholar
• Alkan, E.E. and Celik, I., 2018. The therapeutics effects and toxic risk of Heracleum persicum Desf. extract on streptozotocin-induced diabetic rats. Toxicology Reports, 5, 919–926.
   PubMed Web of Science ®Google Scholar
• Alpers, D.H. and Isselbacher, K.J., 1968. Biochemical effects of CCl4 on rat intestinal mucosa. Biochimica et Biophysica Acta, 158 (3), 414–424.
   PubMedGoogle Scholar
• Baba, E., et al., 2014. Effects of Muscari comosum extract on nonspecific immune parameters in gilthead seabream, Sparus aurata (L. 1758). Journal of the World Aquaculture Society, 45 (2), 173–182.
   Web of Science ®Google Scholar
• Beutler, E., 1963. Improved method for the determination of blood glutathione. Journal of Laboratory and Clinical Medicine, 61, 882–888.
   PubMed Web of Science ®Google Scholar
• Bouayed, J., et al., 2011. Total phenolics, flavonoids, anthocyanins and antioxidant activity following simulated gastro-intestinal digestion and dialysis of apple varieties:Bioaccessibility and potential uptake. Food Chemistry, 128 (1), 14–21.
   PubMed Web of Science ®Google Scholar
• Bradford, M.M., 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72 (1-2), 248–254.
   PubMed Web of Science ®Google Scholar
• Buege, J.A. and Aust, S. D., 1978. Microsomal lipid peroxidation. In: J. Abelson, M.I. Simon, G.L. Verdine, and A.M. Pyle, eds. Methods in enzymology. USA: Academic Press, 302–310.
   Google Scholar
• Bulbena, O., et al., 1997. Cytoprotective activity in the gastric mucosa of rats exposed to carbon tetrachloride-induced liver injury. Inflammation, 21 (5), 475–488.
   PubMed Web of Science ®Google Scholar
• Cadirci, E., et al., 2007. Effects of Onosma armeniacum root extract on ethanol-induced oxidative stress in stomach tissue of rats. Chemico-Biological Interactions, 170 (1), 40–48.,
   PubMed Web of Science ®Google Scholar
• Campos-Vidal, Y., et al., 2021. Gastroprotective activity of kaempferol glycosides from Malvaviscus arboreus Cav. Journal of Ethnopharmacology, 268, 113633.
   PubMed Web of Science ®Google Scholar
• Çetin, E., et al., 2011. Hepatoprotective effect of ghrelin on carbon tetrachloride-induced acute liver injury in rats. Regulatory Peptides, 171 (1-3), 1–5.
   PubMedGoogle Scholar
• Cheng, Y.T., Lu, C.C., and Yen, G.C., 2017. Phytochemicals enhance antioxidant enzyme expression to protect against NSAID‐induced oxidative damage of the gastrointestinal mucosa. Molecular Nutrition & Food Research, 61 (6), 1600659.
   Web of Science ®Google Scholar
• de Lira Mota, K.S., et al., 2009. Flavonoids with gastroprotective activity. Molecules (Basel, Switzerland), 14 (3), 979–1012.
   PubMed Web of Science ®Google Scholar
• Dogan, A., et al., 2018. Investigation of the protective effects of horse mushroom (Agaricus arvensis Schaeff.) against carbon tetrachloride-induced oxidative stress in rats. Molecular Biology Reports, 45 (5), 787–797.
   PubMed Web of Science ®Google Scholar
• Dogan, A., et al., 2022. The protective effects of the Lactarius deliciosus and Agrocybe cylindracea mushrooms on histopathology  of carbon tetrachloride induced oxidative stress in rats. Biotechnic and Histochemistry, 97 (2), 143–151.
   Web of Science ®Google Scholar
• Eker, I., 2021. What is Muscari massayanum and what is not? Second species born of confusion:Muscari erzincanicum (Asparagaceae, Scilloideae), a new species from Turkey. Phytotaxa, 487 (1), 41–55.
   Web of Science ®Google Scholar
• El-bakry, K., et al., 2016. Hepatoprotective effect of Moringa oleifera leaves extract against carbon tetrachloride-induced liver damage in rats. World Journal of Pharmaceutical Sciences, 5 (5), 76–89.
   Google Scholar
• El-Hadary, A.E. and Ramadan Hassanien, M.F., 2016. Hepatoprotective effect of cold-pressed Syzygium aromaticum oil against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Pharmaceutical Biology, 54 (8), 1364–1372.
   PubMed Web of Science ®Google Scholar
• Eroğlu, H., et al., 2021. Seed micromorphology and anatomy of 36 Muscari (Asparagaceae) taxa from Turkey with notes on their systematic importance. Acta Botanica Croatica, 80 (2), 146–157.
   Web of Science ®Google Scholar
• Eroglu-Ozkan, E., et al., 2018. Identification of volatile compounds and antimicrobial activities of Muscari neglectum growing in Turkey. Fresenius Environmental Bulletin, 27 (7), 4674–4678.
   Web of Science ®Google Scholar
• Eroğlu-Ozkan, E., Demirci-Kayiran, S., and Taşkın, T., 2017. Abudayyak M. In vitro antioxidant and cytotoxic activity of Muscari neglectum growing in Turkey. Marmara Pharmaceutical Journal, 22 (1), 74–79.
   Google Scholar
• Garg, S. K., et al., 2019. Polyphenols and flavonoids. In: R. Gupta, et al., eds. Nutraceuticals in Veterinary Medicine. Switzerland, Cham: Springer, 187–204.
   Google Scholar
• Giglio, F., et al., 2021. Muscari comosum L. Bulb extracts modulate oxidative stress and redox signaling in HepG2 cells. Molecules, 26 (2), 416.
   PubMed Web of Science ®Google Scholar
• Gomez-Hurtado, I., et al., 2011. Gut microbiota dysbiosis is associated with inflammation and bacterial translocation in mice with CCl4-induced fibrosis. PLoS One., 6 (7), e23037.
   PubMed Web of Science ®Google Scholar
• Gonthier, M.P., et al., 2003. Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats. The Journal of Nutrition, 133 (6), 1853–1859.
   PubMed Web of Science ®Google Scholar
• Hiruma-Lima, C.A., et al., 2001. Gastroprotective effect of aparisthman, a diterpene isolated from Aparisthmium cordatum on experimental gastric ulcer models in rats and mice. Phytomedicine, 8, 94–100.
   PubMed Web of Science ®Google Scholar
• Hsouna, A., et al., 2019c. Potential anti‐inflammatory and antioxidant effects of Citrus aurantium essential oil against carbon tetrachloride‐mediated hepatotoxicity: A biochemical, molecular and histopathological changes in adult rats. Environmental Toxicology, 34 (4), 388–400.
   PubMed Web of Science ®Google Scholar
• Hsouna, A.B., et al., 2019a. Essential oil from halophyte Lobularia maritima: protective effects against CCl4-induced hepatic oxidative damage in rats and inhibition of the production of proinflammatory gene expression by lipopolysaccharide-stimulated RAW 264.7 macrophages. RSC Advances, 9 (63), 36758–36770.
   PubMed Web of Science ®Google Scholar
• Hsouna, A.B., et al., 2019b. Chemical composition and hepatoprotective effect of essential oil from Myrtus communis L. flowers against CCL 4-induced acute hepatotoxicity in rats. RSC Advances, 9 (7), 3777–3787.
   PubMed Web of Science ®Google Scholar
• Hsouna, B.A., et al., 2020. Lobularia maritima leave extract, a nutraceutical agent with antioxidant activity, protects against CCl4-induced liver injury in mice. Drug and Chemical Toxicology, 45 (2), 604–616.
   PubMed Web of Science ®Google Scholar
• İstifli, E.S., et al., 2019. Alpha-linolenic acid confers protection on mice renal cells against cisplatin-induced nephrotoxicity. Cytotechnology, 71 (5), 905–914.
   PubMed Web of Science ®Google Scholar
• Jafari, A., and Maassoumi, A.A., 2011. Synopsis of Leopoldia, Muscari and Pseudomuscari (Hyacinthaceae) in Iran, with Leopoldia ghouschtchiensis sp. nova. Annales Botanici Fennici, 48 (5), 396–400.
   Web of Science ®Google Scholar
• Jahedsani, A., et al., 2020. Apigenin attenuates aluminum phosphide-induced cytotoxicity via reducing mitochondrial/lysosomal damages and oxidative stress in rat cardiomyocytes. Pesticide Biochemistry and Physiology, 167, 104585.
   PubMed Web of Science ®Google Scholar
• Joshi, R., et al., 2012. Antioxidant activity and free radical scavenging reactions of gentisic acid: in-vitro and pulse radiolysis studies. Free Radical Research, 46 (1), 11–20.
   PubMed Web of Science ®Google Scholar
• Jovanović, A.A., et al., 2019. Effect of gentisic acid on the structural-functional properties of liposomes incorporating β-sitosterol. Colloids and Surfaces. B, Biointerfaces, 183, 110422.
   PubMed Web of Science ®Google Scholar
• Kahle, K., et al., 2007. Polyphenols are intensively metabolized in the human gastrointestinal tract after apple juice consumption. Journal of Agricultural and Food Chemistry, 55 (26), 10605–10614.
   PubMed Web of Science ®Google Scholar
• Karaköse, M., and Karaköse, G.Ç., 2017. Medicinal and aromatic plants of Esenli (Giresun) forest planning unit. International Journal of Secondary Metabolite, 4 (3), 285–305.
   Google Scholar
• Karlén, T., 1984. Karyotpes and chromosome numbers of five species of Muscari (Liliaceae). Willdenowia, 14 (3), 13–20.
   Google Scholar
• Kayıran, S.D., and Özkan, E.E., 2017. The ethnobotanical uses of Hyacinthaceae species growing in Turkey and a review of pharmacological activities. Indian Journal of Traditional Knowledge, 16 (2), 243–250.
   Web of Science ®Google Scholar
• Kazemnezhad, M., et al., 2021. Phytochemical and biological studies on Muscari inconstrictum seeds distributed in Iran. Journal of Reports in Pharmaceutical Sciences, 10 (1), 1–4.
   Google Scholar
• Kolgazi, M., et al., 2021. Caffeic acid attenuates gastric mucosal damage induced by ethanol in rats via nitric oxide modulation. Chemico-Biological Interactions, 334, 109351.
   PubMed Web of Science ®Google Scholar
• Kuroda, K., and Akao, M., 1977. Inhibitory effect of fumaric acid and dicarboxylic acids on gastric ulceration in rats. Archives Internationales de Pharmacodynamie et de. Therapie, 226 (2), 324–330.
   Web of Science ®Google Scholar
• Li, Q., et al., 2018. Kaempferol protects ethanol-induced gastric ulcers in mice via pro-inflammatory cytokines and NO. Acta Biochimica et Biophysica Sinica, 50 (3), 246–253.
   PubMed Web of Science ®Google Scholar
• Lin, L.G., et al., 2014. Naturally occurring homoisoflavonoids and their pharmacological activities. Planta Medica, 80 (13), 1053–1066.
   PubMed Web of Science ®Google Scholar
• Liu, L., et al., 2020. Neuroprotective effects of D-(-)-quinic acid on aluminum chloride-induced dementia in rats. Evidence-Based Complementary and Alternative Medicine, 2020, 1–10.
   Web of Science ®Google Scholar
• Liu, S., Mizu, H., and Yamauchi, H., 2010. Photoinflammatory responses to UV-irradiated ketoprofen mediated by the induction of ROS generation, enhancement of cyclooxygenase-2 expression, and regulation of multiple signaling pathways. Free Radical Biology & Medicine, 48 (6), 772–780.
   PubMed Web of Science ®Google Scholar
• Loewer, H. P., 2004. Jefferson's Garden. NC, USA: Sylva.
   Google Scholar
• Loizzo, M.R., et al., 2010. Chelating, antioxidant and hypoglycaemic potential of Muscari comosum (L.) Mill. bulb extracts. International Journal of Food Sciences and Nutrition, 61 (8), 780–791.
   PubMed Web of Science ®Google Scholar
• Mahboubi, M., and Taghizadeh, M., 2016. The antimicrobial and antioxidant activity of Muscari neglectum flower ethanol extract. Herba Polonica, 62 (4), 39–48.
   Google Scholar
• Mahomoodally, M.F., et al., 2021. A comprehensive evaluation of the chemical profiles and biological properties of six geophytes from Turkey: Sources of bioactive compounds for novel nutraceuticals. International Food Research Journal, 140, 110068.
   PubMedGoogle Scholar
• Mannervik, B., and Guthenberg, C., 1981. Glutathione transferase (human placenta). Methods in Enzymology, 77, 231–235.
   PubMedGoogle Scholar
• McCord, J.M., and Fridovich, I., 1969. Superoxide dismutase: an enzymic function for erythrocuprein (hemocuprein). Journal of Biological Chemistry, 244 (22), 6049–6055.
   PubMed Web of Science ®Google Scholar
• Moreno, M.I.N., et al., 2000. Comparison of the free radical-scavenging activity of propolis from several regions of Argentina. Journal of Ethnopharmacology, 71 (1-2), 109–114.
   PubMed Web of Science ®Google Scholar
• Mulholland, D.A., Schwikkard, S.L., and Crouch, N.R., 2013. The chemistry and biological activity of the Hyacinthaceae. Natural Product Research, 30 (9), 1165–1210.
   Google Scholar
• Nasrabadi, M., Halimi, M., and Nadaf, M., 2013. Phytochemical screeningand chemical composition of extract of Muscari neglectum. Middle-East Journal of Scientific Research, 14 (4), 566–569.
   Google Scholar
• Olaleye, O.O., et al., 2019. Protective effect of the fruit of Dialum guineense Willd (Fabaceae) against oxidative stress. West African Journal of Pharmacy, 30 (2), 104–113.
   Google Scholar
• Özcan, M.M., et al., 2018. Effect of species on total phenol, antioxidant activity and phenolic compounds of different wild onion bulbs. Journal of Food Measurement and Characterization, 12 (2), 902–905.
   Web of Science ®Google Scholar
• Paglia, D.E., and Valentine, W.N., 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. Journal of Laboratory and Clinical Medicine, 70 (1), 158–169.
   PubMed Web of Science ®Google Scholar
• Palanivel, M.G., et al., 2008. Hepatoprotective and antioxidant effect of Pisonia aculeata L. against CCl4-induced hepatic damage in rats. Scientia Pharmaceutica, 76 (2), 203–216.
   Google Scholar
• Pero, R.W., et al., 2009. Antioxidant metabolism induced by quinic acid. Increased urinary excretion of tryptophan and nicotinamide. Phytotherapy Research, 23 (3), 335–346.
   PubMed Web of Science ®Google Scholar
• Pirgozliev, V., et al., 2008. Fumaric and sorbic acid as additives in broiler feed. Research in Veterinary Science, 84 (3), 387–394.
   PubMed Web of Science ®Google Scholar
• Sánchez-Rodríguez, E., et al., 2012. Phenolic profiles of cherry tomatoes as influenced by hydric stres and rootstock technique. Food Chemistry, 134 (2), 775–782.
   PubMed Web of Science ®Google Scholar
• Slinkard, K., and Singleton, V.L., 1977. Total phenol analysis: automation and comparison with manual methods. American Journal of Enology and Viticulture, 28 (1), 49–55.
   Web of Science ®Google Scholar
• Smith, J.W., et al., 2013. Socioeconomic disparities in the operative management of peptic ulcer disease. Surgery, 154 (4), 672–679.
   PubMed Web of Science ®Google Scholar
• Speta, F., 1998. Hyacinthaceae. In: Flowering Plants Monocotyledons. Berlin, Heidelberg.
   Google Scholar
• Suzek, H., et al., 2016. Protective effect and antioxidant role of sweetgum (Liquidambar orientalis) oil against carbon tetrachloride-induced hepatotoxicity and oxidative stress in rats. Pharmaceutical Biology, 54 (3), 451–457.
   PubMed Web of Science ®Google Scholar
• Teschke, R., 2018. Liver injury by carbon tetrachloride intoxication in 16 patients treated with forced ventilation to accelerate toxin removal via the lungs: A clinical report. Toxics, 6 (2), 25.
   PubMed Web of Science ®Google Scholar
• Tong, J., et al., 2015. Hepatoprotective activity of flavonoids from Cichorium glandulosum seeds in vitro and in vivo carbon tetrachloride-induced hepatotoxicity. Journal of Ethnopharmacology, 174, 355–363.
   PubMed Web of Science ®Google Scholar
• Tüfekçi, A.R., et al., 2018. Determination of Phenolic Profile of Cirsium arvense (L.) Scop. Subsp. vestitum (Wimmer et Grab.) Petrak Plant. Eurasian Journal of Biological and Chemical Sciences, 1 (2), 33–36.
   Google Scholar
• Turker, A.U., and Usta, C., 2008. Biological screening of some Turkish medicinal plant extracts for antimicrobial and toxicity activities. Natural Product Research, 22 (2), 136–146.
   PubMed Web of Science ®Google Scholar
• Weber, L.W., et al., 2003. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Critical Reviews in Toxicology, 33 (2), 105–136.
   PubMed Web of Science ®Google Scholar
• Werdenberg, D., et al., 2003. Presystemic metabolism and intestinal absorption of antipsoriatic fumaric acid esters. Biopharmaceutics & Drug Disposition, 24 (6), 259–273.
   PubMed Web of Science ®Google Scholar
• Winczura, A., et al., 2012. Damage of DNA and proteins by major lipid peroxidation products in genome stability. Free Radical Research, 46 (4), 442–459.
   PubMed Web of Science ®Google Scholar
• Yilmaz, M.A., 2020. Simultaneous quantitative screening of 53 phytochemicals in 33 species of medicinal and aromatic plants: A detailed, robust and comprehensive LC–MS/MS method validation. Industrial Crops and Products, 149, 112347.
   Web of Science ®Google Scholar