270
Views
28
CrossRef citations to date
0
Altmetric
Review Articles

Enhancing Cytotoxic Therapies for Breast and Prostate Cancers With Polyunsaturated Fatty Acids

, , &
Pages 284-296 | Received 18 Feb 2009, Accepted 03 Aug 2009, Published online: 31 Mar 2010

REFERENCES

  • Doll , R . 1992 . The lessons of life: keynote address to the nutrition and cancer conference . Cancer Res , 52 : 2024s – 2029s .
  • Berquin , I M , Edwards , I J and Chen , Y Q . 2008 . Multi-targeted therapy of cancer by omega-3 fatty acids . Cancer Lett , 269 : 363 – 377 .
  • Simopoulos , A P . 2001 . The Mediterranean diets: what is so special about the diet of Greece? The scientific evidence . J Nutr , 131 : 3065S – 3073S .
  • Gago-Dominguez , M , Yuan , J M , Sun , C L , Lee , H P and Yu , M C . 2003 . Opposing effects of dietary n-3 and n-6 fatty acids on mammary carcinogenesis: the Singapore Chinese Health Study . Br J Cancer , 89 : 1686 – 1692 .
  • Cowing , B E and Saker , K E . 2001 . Polyunsaturated fatty acids and epidermal growth factor receptor/mitogen-activated protein kinase signaling in mammary cancer . J Nutr , 131 : 1125 – 1128 .
  • Terry , P , Lichtenstein , P , Feychting , M , Ahlbom , A and Wolk , A . 2001 . Fatty fish consumption and risk of prostate cancer . Lancet , 357 : 1764 – 1766 .
  • Biondo , P D , Brindley , D N , Sawyer , M B and Field , C J . 2008 . The potential for treatment with dietary long-chain polyunsaturated n-3 fatty acids during chemotherapy . J Nutr Biochem , 19 : 787 – 796 .
  • Germain , E , Chajes , V , Cognault , S , Lhuillery , C and Bougnoux , P . 1998 . Enhancement of doxorubicin cytotoxicity by polyunsaturated fatty acids in the human breast tumor cell line MDA-MB-231: relationship to lipid peroxidation . Int J Cancer , 75 : 578 – 583 .
  • Plumb , J A , Luo , W and Kerr , D J . 1993 . Effect of polyunsaturated fatty acids on the drug sensitivity of human tumour cell lines resistant to either cisplatin or doxorubicin . Br J Cancer , 67 : 728 – 733 .
  • Shao , Y , Pardini , L and Pardini , R S . 1995 . Dietary menhaden oil enhances mitomycin C antitumor activity toward human mammary carcinoma MX-1 . Lipids , 30 : 1035 – 1045 .
  • Menendez , J A , Del Mar Barbacid , M , Montero , S , Sevilla , E Escrich , E . 2001 . Effects of gamma-linolenic acid and oleic acid on paclitaxel cytotoxicity in human breast cancer cells . Eur J Cancer , 37 : 402 – 413 .
  • Menendez , J A , Lupu , R and Colomer , R . 2005 . Exogenous supplementation with omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA; 22:6n-3) synergistically enhances taxane cytotoxicity and downregulates Her-2/neu (c-erbB-2) oncogene expression in human breast cancer cells . Eur J Cancer Prev , 14 : 263 – 270 .
  • Shaikh , I A , Brown , I , Schofield , A C , Wahle , K W and Heys , S D . 2008 . Docosahexaenoic acid enhances the efficacy of docetaxel in prostate cancer cells by modulation of apoptosis: the role of genes associated with the NF-kappaB pathway . Prostate , 68 : 1635 – 1646 .
  • Wolff , A C , Donehower , R C , Carducci , M K , Carducci , M A Brahmer , J R . 2003 . Phase I study of docosahexaenoic acid-paclitaxel: a taxane-fatty acid conjugate with a unique pharmacology and toxicity profile . Clin Cancer Res , 9 : 3589 – 3597 .
  • Kenny , F S , Pinder , S E , Ellis , I O , Gee , J M Nicholson , R I . 2000 . Gamma linolenic acid with tamoxifen as primary therapy in breast cancer . Int J Cancer , 85 : 643 – 648 .
  • Calviello , G , Serini , S , Piccioni , E and Pessina , G . 2009 . Antineoplastic effects of n-3 polyunsaturated fatty acids in combination with drugs and radiotherapy: preventive and therapeutic strategies . Nutr Cancer , 61 : 287 – 301 .
  • de Gomez Dumm , I N and Brenner , R R . 1975 . Oxidative desaturation of alpha-linoleic, linoleic, and stearic acids by human liver microsomes . Lipids , 10 : 315 – 317 .
  • Mackler , N J and Pienta , K J . 2005 . Drug insight: Use of docetaxel in prostate and urothelial cancers . Nat Clin Pract Urol , 2 : 92 – 100 . 112
  • Szulawska , A and Czyz , M . 2006 . Molecular mechanisms of anthracyclines action . Postepy Hig Med Dosw [serial online] , 60 : 78 – 100 . Available at: http://www.phmd.pl/pub/phmd/vol_60/8745.pdfAccessed January 1, 2009
  • Mano , M . 2006 . Vinorelbine in the management of breast cancer: new perspectives, revived role in the era of targeted therapy . Cancer Treat Rev , 32 : 106 – 118 .
  • Leveque , D and Jehl , F . 1996 . Clinical pharmacokinetics of vinorelbine . Clin Pharmacokinet , 31 : 184 – 197 .
  • Gradishar , W J . 2006 . Albumin-bound paclitaxel: a next-generation taxane . Expert Opin Pharmacother , 7 : 1041 – 1053 .
  • Menendez , J A , Ropero , S , Lupu , R and Colomer , R . 2004 . Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) enhances docetaxel (Taxotere) cytotoxicity in human breast carcinoma cells: relationship to lipid peroxidation and HER-2/neu expression . Oncol Rep , 11 : 1241 – 1252 .
  • Wang , Z , Butt , K , Wang , L and Liu , H . 2007 . The effect of seal oil on paclitaxel induced cytotoxicity and apoptosis in breast carcinoma MCF-7 and MDA-MB-231 cell lines . Nutr Cancer , 58 : 230 – 238 .
  • Wahle , K WJ , Heys , S D and Rotondo , D . 2004 . Conjugated linoleic acids: are they beneficial or detrimental to health? . Prog Lipid Res , 43 : 553 – 587 .
  • Fite , A , Goua , M , Wahle , K J , Schofield , A Hutcheon , A . 2007 . Potentiation of the anti-tumour effect of docetaxel by conjugated linoleic acids (CLAs) in breast cancer cells in vitro . Prostaglandins Leukot Essent Fatty Acids , 77 : 87 – 96 .
  • Maheo , K , Vibet , S , Steghens , J P , Dartigeas , C Lehman , M . 2005 . Differential sensitization of cancer cells to doxorubicin by DHA: a role for lipoperoxidation . Free Radic Biol Med , 39 : 742 – 751 .
  • Vibet , S , Goupille , C , Bougnoux , P , Steghens , J P Gore , J . 2008 . Sensitization by docosahexaenoic acid (DHA) of breast cancer cells to anthracyclines through loss of glutathione peroxidase (GPx1) response . Free Radic Biol Med , 44 : 1483 – 1491 .
  • Davies , C L , Loizidou , M , Cooper , A J and Taylor , I . 1999 . Effect of gamma-linolenic acid on cellular uptake of structurally related anthracyclines in human drug sensitive and multidrug resistant bladder and breast cancer cell lines . Eur J Cancer , 35 : 1534 – 1540 .
  • Vibet , S , Maheo , K , Gore , J , Dubois , P Bougnoux , P . 2007 . Differential subcellular distribution of mitoxantrone in relation to chemosensitization in two human breast cancer cell lines . Drug Metab Dispos , 35 : 822 – 828 .
  • Menendez , J A , Ropero , S , del Barbacid , M M , Montero , S Solanas , M . 2002 . Synergistic interaction between vinorelbine and gamma-linolenic acid in breast cancer cells . Breast Cancer Res Treat , 72 : 203 – 219 .
  • DeGraffenried , L A , Friedrichs , W E , Fulcher , L , Fernandes , G Silva , J M . 2003 . Eicosapentaenoic acid restores tamoxifen sensitivity in breast cancer cells with high Akt activity . Ann Oncol , 14 : 1051 – 1056 .
  • Horia , E and Watkins , B A . 2007 . Complementary actions of docosahexaenoic acid and genistein on COX-2, PGE2 and invasiveness in MDA-MB-231 breast cancer cells . Carcinogenesis , 28 : 809 – 815 .
  • Menendez , J A , Colomer , R and Lupu , R . 2004 . Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) is a selective estrogen-response modulator in human breast cancer cells: gamma-linolenic acid antagonizes estrogen receptor-dependent transcriptional activity, transcriptionally represses estrogen receptor expression and synergistically enhances tamoxifen and ICI 182,780 (Faslodex) efficacy in human breast cancer cells . Int J Cancer , 109 : 949 – 954 .
  • Nakagawa , H , Yamamoto , D , Kiyozuka , Y , Tsuta , K Uemura , Y . 2000 . Effects of genistein and synergistic action in combination with eicosapentaenoic acid on the growth of breast cancer cell lines . J Cancer Res Clin Oncol , 126 : 448 – 454 .
  • Chen , J , Power , K A , Mann , J , Cheng , A and Thompson , L U . 2007 . Flaxseed alone or in combination with tamoxifen inhibits MCF-7 breast tumor growth in ovariectomized athymic mice with high circulating levels of estrogen . Exp Biol Med (Maywood) , 232 : 1071 – 1080 .
  • Menendez , J A , Vellon , L , Colomer , R and Lupu , R . 2005 . Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her-2/neu oncogene amplification . Ann Oncol , 16 : 359 – 371 .
  • Flowers , M and Thompson , P A . 2009 . t10c12 conjugated linoleic acid suppresses HER2 protein and enhances apoptosis in SKBr3 breast cancer cells: possible role of COX2 . PLoS One , 4 : e5342
  • Narayanan , N K , Narayanan , B A and Reddy , B S . 2005 . A combination of docosahexaenoic acid and celecoxib prevents prostate cancer cell growth in vitro and is associated with modulation of nuclear factor-kappaB, and steroid hormone receptors . Int J Oncol , 26 : 785 – 792 .
  • Narayanan , N K , Narayanan , B A , Bosland , M , Condon , M S and Nargi , D . 2006 . Docosahexaenoic acid in combination with celecoxib modulates HSP70 and p53 proteins in prostate cancer cells . Int J Cancer , 119 : 1586 – 1598 .
  • Hardman , W E , Avula , C P , Fernandes , G and Cameron , I L . 2001 . Three percent dietary fish oil concentrate increased efficacy of doxorubicin against MDA-MB 231 breast cancer xenografts . Clin Cancer Res , 7 : 2041 – 2049 .
  • Hardman , W E , Moyer , M P and Cameron , I L . 1999 . Fish oil supplementation enhanced CPT-11 (irinotecan) efficacy against MCF7 breast carcinoma xenografts and ameliorated intestinal side-effects . Br J Cancer , 81 : 440 – 448 .
  • Norman , H A , Butrum , R R , Feldman , E , Heber , D Nixon , D . 2003 . The role of dietary supplements during cancer therapy . J Nutr , 133 : 3794S – 3799S .
  • Colas , S , Germain , E , Arab , K , Maheo , K Goupille , C . 2005 . Alpha-tocopherol suppresses mammary tumor sensitivity to anthracyclines in fish oil-fed rats . Nutr Cancer , 51 : 178 – 183 .
  • Shao , Y , Pardini , L and Pardini , R S . 1997 . Intervention of transplantable human mammary carcinoma MX-1 chemotherapy with dietary menhaden oil in athymic mice: increased therapeutic effects and decreased toxicity of cyclophosphamide . Nutr Cancer , 28 : 63 – 73 .
  • Connolly , J M , Coleman , M and Rose , D P . 1997 . Effects of dietary fatty acids on DU145 human prostate cancer cell growth in athymic nude mice . Nutr Cancer , 29 : 114 – 119 .
  • Colas , S , Maheo , K , Denis , F , Goupille , C Hoinard , C . 2006 . Sensitization by dietary docosahexaenoic acid of rat mammary carcinoma to anthracycline: a role for tumor vascularization . Clin Cancer Res , 12 : 5879 – 5886 .
  • Harries , M , O'Donnell , A , Scurr , M , Reade , S Cole , C . 2004 . Phase I/II study of DHA-paclitaxel in combination with carboplatin in patients with advanced malignant solid tumours . Br J Cancer , 91 : 1651 – 1655 .
  • Guminski , A D , Harnett , P R and deFazio , A . 2001 . Carboplatin and paclitaxel interact antagonistically in a megakaryoblast cell line—a potential mechanism for paclitaxel-mediated sparing of carboplatin-induced thrombocytopenia . Cancer Chemother Pharmacol , 48 : 229 – 234 .
  • Bougnoux , P , Hajjaji , N , Baucher , M A , Jourdan , M Goupille , C . . Docosahexaenoic acid (DHA) intake during first-line chemotherapy improves survival in metastatic breast cancer . AACR Meeting Abstracts . 2006 . pp. 1237-a Available at http://aacrmeetingabstracts.org/cgi/content/abstract/2006/1/1237-aAccessed January 8, 2009
  • Kenny , F S , Gee , J M , Nicholson , R I , Ellis , I O Morris , T M . 2001 . Effect of dietary GLA+/-tamoxifen on the growth, ER expression and fatty acid profile of ER positive human breast cancer xenografts . Int J Cancer , 92 : 342 – 347 .
  • Simopoulos , A P . 2004 . The traditional diet of Greece and cancer . Eur J Cancer Prev , 13 : 219 – 230 .
  • Bradley , M O , Webb , N L , Anthony , F H , Devanesan , P Witman , P A . 2001 . Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel . Clin Cancer Res , 7 : 3229 – 3238 .
  • Siddiqui , R A , Zerouga , M , Wu , M , Castillo , A Harvey , K . 2005 . Anticancer properties of propofol-docosahexaenoate and propofol-eicosapentaenoate on breast cancer cells . Breast Cancer Res , 7 : R645 – R654 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.