Effects of Phytoestrogen Extracts Isolated from Pumpkin Seeds on Estradiol Production and ER/PR Expression in Breast Cancer and Trophoblast Tumor Cells

REFERENCES

• Velentzis , L S , Woodside , J V , Cantwell , M M , Leathem , A J and Keshtgar , M R . 2008 . Do phytoestrogens reduce the risk of breast cancer and breast cancer recurrence? What clinicians need to know . Eur J Cancer , 44 : 1799 – 1806 .
   PubMed Web of Science ®Google Scholar
• Fletcher , R J . 2003 . Food sources of phyto-oestrogens and their precursors in Europe . Br J Nutr , 89 ( Suppl 1 ) : S39 – S43 .
   PubMed Web of Science ®Google Scholar
• Ward , H A and Kuhnle , G G . 2010 . Phytoestrogen consumption and association with breast, prostate and colorectal cancer in EPIC Norfolk . Arch Biochem Biophys , 501 : 170 – 175 .
   PubMed Web of Science ®Google Scholar
• Duffy , C , Perez , K and Partridge , A . 2007 . Implications of phytoestrogen intake for breast cancer . CA Cancer J Clin , 57 : 260 – 277 .
   PubMed Web of Science ®Google Scholar
• Saarinen , N M , Warri , A , Airio , M , Smeds , A and Makela , S . 2007 . Role of dietary lignans in the reduction of breast cancer risk . Mol Nutr Food Res , 51 : 857 – 866 .
   PubMed Web of Science ®Google Scholar
• Usui , T . 2006 . Pharmaceutical prospects of phytoestrogens . Endocr J , 53 : 7 – 20 .
   PubMed Web of Science ®Google Scholar
• Abarzua , S , Drechsler , S , Fischer , K , Pietschmann , N Stapel , J . 2010 . Online monitoring of cellular metabolism in the MCF-7 carcinoma cell line treated with phytoestrogen extracts . Anticancer Res , 30 : 1587 – 1592 .
   PubMed Web of Science ®Google Scholar
• Abarzua , S , Szewczyk , M , Gailus , S , Richter , D U Ruth , W . 2007 . Effects of phytoestrogen extracts from Linum usitatissimum on the Jeg3 human trophoblast tumour cell line . Anticancer Res , 27 : 2053 – 2058 .
   PubMed Web of Science ®Google Scholar
• Richter , D U , Mylonas , I , Toth , B , Scholz , C Briese , V . 2009 . Effects of phytoestrogens genistein and daidzein on progesterone and estrogen (estradiol) production of human term trophoblast cells in vitro . Gynecol Endocrinol , 25 : 32 – 38 .
   PubMed Web of Science ®Google Scholar
• Luyengi , L , Suh , N , Fong , H H , Pezzuto , J M and Kinghorn , A D . 1996 . A lignan and four terpenoids from Brucea javanica that induce differentiation with cultured HL-60 promyelocytic leukemia cells . Phytochemistry , 43 : 409 – 412 .
   PubMed Web of Science ®Google Scholar
• Sicilia , T , Niemeyer , H B , Honig , D M and Metzler , M . 2003 . Identification and stereochemical characterization of lignans in flaxseed and pumpkin seeds . J Agric Food Chem , 51 : 1181 – 1188 .
   PubMed Web of Science ®Google Scholar
• Adlercreutz , H and Mazur , W . 1997 . Phyto-oestrogens and Western diseases . Ann Med , 29 : 95 – 120 .
   PubMed Web of Science ®Google Scholar
• Matscheski , A , Richter , D U , Hartmann , A M , Effmert , U Jeschke , U . 2006 . Effects of phytoestrogen extracts isolated from rye, green and yellow pea seeds on hormone production and proliferation of trophoblast tumor cells Jeg3 . Horm Res , 65 : 276 – 288 .
   PubMed Web of Science ®Google Scholar
• Remmele , W and Stegner , H E . 1987 . Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue . Pathologe , 8 : 138 – 140 .
   PubMed Web of Science ®Google Scholar
• Theil , C , Briese , V , Gerber , B and Richter , D U . 2010 . The effects of different lignans and isoflavones, tested as aglycones and glycosides, on hormone receptor-positive and -negative breast carcinoma cells in vitro . Arch Gynecol Obstet , 284 : 459 – 465 .
   PubMed Web of Science ®Google Scholar
• Gossell-Williams , M , Lyttle , K , Clarke , T , Gardner , M and Simon , O . 2008 . Supplementation with pumpkin seed oil improves plasma lipid profile and cardiovascular outcomes of female non-ovariectomized and ovariectomized Sprague-Dawley rats . Phytother Res , 22 : 873 – 877 .
   PubMed Web of Science ®Google Scholar
• Allred , C D , Allred , K F , Ju , Y H , Goeppinger , T S Doerge , D R . 2004 . Soy processing influences growth of estrogen-dependent breast cancer tumors . Carcinogenesis , 25 : 1649 – 1657 .
   PubMed Web of Science ®Google Scholar
• Allred , C D , Twaddle , N C , Allred , K F , Goeppinger , T S Churchwell , M I . 2005 . Soy processing affects metabolism and disposition of dietary isoflavones in ovariectomized BALB/c mice . J Agric Food Chem , 53 : 8542 – 8550 .
   PubMed Web of Science ®Google Scholar
• Bolca , S , Urpi-Sarda , M , Blondeel , P , Roche , N Vanhaecke , L . 2010 . Disposition of soy isoflavones in normal human breast tissue . Am J Clin Nutr , 91 : 976 – 984 .
   PubMed Web of Science ®Google Scholar
• Bonagura , T W , Pepe , G J , Enders , A C and Albrecht , E D . 2008 . Suppression of extravillous trophoblast vascular endothelial growth factor expression and uterine spiral artery invasion by estrogen during early baboon pregnancy . Endocrinology , 149 : 5078 – 5087 .
   PubMed Web of Science ®Google Scholar
• van Duursen , M B , Nijmeijer , S M , de Morree , E S , de Jong , P C and van den Berg , M . 2011 . Genistein induces breast cancer-associated aromatase and stimulates estrogen-dependent tumor cell growth in in vitro breast cancer model . Toxicology , 289 : 67 – 73 .
   PubMed Web of Science ®Google Scholar
• Ju , Y H , Doerge , D R , Woodling , K A , Hartman , J A Kwak , J . 2008 . Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) in vivo . Carcinogenesis , 29 : 2162 – 2168 .
   PubMed Web of Science ®Google Scholar
• Aka , J A , Mazumdar , M and Lin , S X . 2009 . Reductive 17beta-hydroxysteroid dehydrogenases in the sulfatase pathway: critical in the cell proliferation of breast cancer . Mol Cell Endocrinol , 301 : 183 – 190 .
   PubMed Web of Science ®Google Scholar
• Rice , S and Whitehead , S A . 2006 . Phytoestrogens and breast cancer—promoters or protectors? . Endocr Relat Cancer , 13 : 995 – 1015 .
   PubMed Web of Science ®Google Scholar
• An , J , Tzagarakis-Foster , C , Scharschmidt , T C , Lomri , N and Leitman , D C . 2001 . Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens . J Biol Chem , 276 : 17808 – 17814 .
   PubMed Web of Science ®Google Scholar
• Strom , A , Hartman , J , Foster , J S , Kietz , S Wimalasena , J . 2004 . Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D . Proc Natl Acad Sci U S A , 101 : 1566 – 1571 .
   PubMed Web of Science ®Google Scholar
• Richter , D U , Abarzua , S , Chrobak , M , Scholz , C Kuhn , C . 2010 . Effects of phytoestrogen extracts isolated from flax on estradiol production and ER/PR expression in MCF7 breast cancer cells . Anticancer Res , 30 : 1695 – 1699 .
   PubMed Web of Science ®Google Scholar
• Taxvig , C , Elleby , A , Sonne-Hansen , K , Bonefeld-Jorgensen , E C Vinggaard , A M . 2010 . Effects of nutrition relevant mixtures of phytoestrogens on steroidogenesis, aromatase, estrogen, and androgen activity . Nutr Cancer , 62 : 122 – 131 .
   PubMed Web of Science ®Google Scholar
• Saggar , J K , Chen , J , Corey , P and Thompson , L U . 2010 . The effect of secoisolariciresinol diglucoside and flaxseed oil, alone and in combination, on MCF-7 tumor growth and signaling pathways . Nutr Cancer , 62 : 533 – 542 .
   PubMed Web of Science ®Google Scholar
• Dave , B , Wynne , R , Su , Y , Korourian , S Chang , J C . 2010 . Enhanced mammary progesterone receptor-A isoform activity in the promotion of mammary tumor progression by dietary soy in rats . Nutr Cancer , 62 : 774 – 782 .
   PubMed Web of Science ®Google Scholar
• Moore , M R , Spence , J B , Kiningham , K K and Dillon , J L . 2006 . Progestin inhibition of cell death in human breast cancer cell lines . J Steroid Biochem Mol Biol , 98 : 218 – 227 .
   PubMed Web of Science ®Google Scholar
• Seeger , H , Rakov , V and Mueck , A O . 2005 . Dose-dependent changes of the ratio of apoptosis to proliferation by norethisterone and medroxyprogesterone acetate in human breast epithelial cells . Horm Metab Res , 37 : 468 – 473 .
   PubMed Web of Science ®Google Scholar
• Thompson , L U , Chen , J M , Li , T , Strasser-Weippl , K and Goss , P E . 2005 . Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer . Clin Cancer Res , 11 : 3828 – 3835 .
   PubMed Web of Science ®Google Scholar