Pomegranate Intake Protects Against Genomic Instability Induced by Medical X-rays In Vivo in Mice

References

• Schauer DA, and Linton OW: National council on radiation protection and measurements report shows substantial medical exposure increase. Radiology 253, 293–296, 2009.
   Google Scholar
• Little JB: Radiation carcinogenesis. Carcinogenesis 21, 397–404, 2000.
   PubMed Web of Science ®Google Scholar
• Mettler FA: Medical effects and risks of exposure to ionising radiation. J Radiol Prot 32, N9–N13, 2012.
   PubMed Web of Science ®Google Scholar
• Ron E: Cancer risks from medical radiation. Health Phys 85, 47–59, 2003.
   PubMed Web of Science ®Google Scholar
• Nyandoto P, Muhonen T, and Joensuu H: Second cancer among long-term survivors from Hodgkin's disease. Int J Radiat Oncol Biol Phys 42, 373–378, 1998.
   PubMed Web of Science ®Google Scholar
• Brenner DJ, Curtis RE, Hall EJ, and Ron E: Second malignancies in prostate carcinoma patients after radiotherapy compared with surgery. Cancer 88, 398–406, 2000.
   PubMed Web of Science ®Google Scholar
• Barcellos-Hoff MH: New biological insights on the link between radiation exposure and breast cancer risk. J Mammary Gland Biol Neoplasia 18, 3–13, 2013.
   PubMed Web of Science ®Google Scholar
• Pearce MS, Salotti JA, Little MP, McHugh K, Lee C, et al.: Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Lancet 380, 499–505, 2012.
   PubMed Web of Science ®Google Scholar
• Miglioretti DL, Johnson E, Williams A, Greenlee RT, Weinmann S, et al.: The use of computed tomography in pediatrics and the associated radiation exposure and estimated cancer risk. JAMA Pediatr 167, 700–707, 2013.
   PubMed Web of Science ®Google Scholar
• Mathews JD, Forsythe AV, Brady Z, Butler MW, Goergen SK, et al.: Cancer risk in 680,000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians. BMJ 346, f2360, 2013.
   PubMed Web of Science ®Google Scholar
• Riley PA: Free radicals in biology: oxidative stress and the effects of ionizing radiation. Int J Radiat Biol 65, 27–33, 1994.
   PubMed Web of Science ®Google Scholar
• Weiss JF, and Landauer MR: Protection against ionizing radiation by antioxidant nutrients and phytochemicals. Toxicology 189, 1–20, 2003.
   PubMed Web of Science ®Google Scholar
• Sun J, Chen Y, Li M, and Ge Z: Role of antioxidant enzymes on ionizing radiation resistance. Free Radic Biol Med 24, 586–593, 1998.
   PubMed Web of Science ®Google Scholar
• Chatterjee A: Reduced glutathione: a radioprotector or a modulator of DNA-repair activity? Nutrients 5, 525–542, 2013.
   PubMed Web of Science ®Google Scholar
• Scott MD, Meshnick SR, and Eaton JW: Superoxide dismutase amplifies organismal sensitivity to ionizing radiation. J Biol Chem 264, 2498–2501, 1989.
   PubMed Web of Science ®Google Scholar
• Jagetia GC, and Reddy TK: The grapefruit flavanone naringin protects against the radiation-induced genomic instability in the mice bone marrow: a micronucleus study. Mutat Res 519, 37–48, 2002.
   PubMed Web of Science ®Google Scholar
• Jagetia GC: Radioprotection and radiosensitization by curcumin. Adv Exp Med Biol 595, 301–320, 2007.
   PubMed Web of Science ®Google Scholar
• Toklu HZ, Sehirli O, Ozyurt H, Mayadagli AA, Eksioglu-Demiralp E, et al.: Punica granatum peel extract protects against ionizing radiation-induced enteritis and leukocyte apoptosis in rats. J Radiat Res 50, 345–353, 2009.
   PubMed Web of Science ®Google Scholar
• Gil MI, Tomas-Barberan FA, Hess-Pierce B, Holcroft DM, and Kader AA: Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem 48, 4581–4589, 2000.
   PubMed Web of Science ®Google Scholar
• Lansky EP, and Newman RA: Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. J Ethnopharmacol 109, 177–206, 2007.
   PubMed Web of Science ®Google Scholar
• Heber D: Pomegranate ellagitannins. In: Herbal Medicine: Biomolecular and Clinical Aspects, Benzie IFF, and Wachtel-Galor S (eds.), 2nd ed. Boca Raton: CRC Press, 2011, pp. 201–210.
   Google Scholar
• Seeram NP, Aviram M, Zhang Y, Henning SM, Feng L, et al.: Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States. J Agric Food Chem 56, 1415–1422, 2008.
   PubMed Web of Science ®Google Scholar
• Dai J, and Mumper RJ: Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules 15, 7313–7352, 2010.
   PubMed Web of Science ®Google Scholar
• Danesi F, Kroon PA, Saha S, de Biase D, D'Antuono LF, et al.: Mixed pro- and anti-oxidative effects of pomegranate polyphenols in cultured cells. Int J Mol Sci 15, 19458–19471, 2014.
   PubMed Web of Science ®Google Scholar
• Cerda B, Espin JC, Parra S, Martinez P, and Tomas-Barberan FA: The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans. Eur J Nutr 43, 205–220, 2004.
   PubMed Web of Science ®Google Scholar
• Seeram NP, Henning SM, Zhang Y, Suchard M, Li Z, et al.: Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. J Nutr 136, 2481–2485, 2006.
   PubMed Web of Science ®Google Scholar
• Larrosa M, Garcia-Conesa MT, Espin JC, and Tomas-Barberan FA: Ellagitannins, ellagic acid and vascular health. Mol Aspects Med 31, 513–539, 2010.
   PubMed Web of Science ®Google Scholar
• Whitley AC, Stoner GD, Darby MV, and Walle T: Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid—extensive binding to protein and DNA. Biochem Pharmacol 66, 907–915, 2003.
   PubMed Web of Science ®Google Scholar
• Stevenson DE, and Hurst RD: Polyphenolic phytochemicals—just antioxidants or much more? Cell Mol Life Sci 64, 2900–2916, 2007.
   PubMed Web of Science ®Google Scholar
• Matthaiou CM, Goutzourelas N, Stagos D, Sarafoglou E, Jamurtas A, et al.: Pomegranate juice consumption increases GSH levels and reduces lipid and protein oxidation in human blood. Food Chem Toxicol 73, 1–6, 2014.
   PubMed Web of Science ®Google Scholar
• Bishayee A, Bhatia D, Thoppil RJ, Darvesh AS, Nevo E, et al.: Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms. Carcinogenesis 32, 888–896, 2011.
   PubMed Web of Science ®Google Scholar
• Mukherjee S, Ghosh S, Choudhury S, Adhikary A, Manna K, et al.: Pomegranate reverses methotrexate-induced oxidative stress and apoptosis in hepatocytes by modulating Nrf2-NF-kappaB pathways. J Nutr Biochem 24, 2040–2050, 2013.
   PubMed Web of Science ®Google Scholar
• Bishayee A, Thoppil RJ, Darvesh AS, Ohanyan V, Meszaros JG, et al.: Pomegranate phytoconstituents blunt the inflammatory cascade in a chemically induced rodent model of hepatocellular carcinogenesis. J Nutr Biochem 24, 178–187, 2013.
   PubMed Web of Science ®Google Scholar
• Afaq F, Khan N, Syed DN, and Mukhtar H: Oral feeding of pomegranate fruit extract inhibits early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis. Photochem Photobiol 86, 1318–1326, 2010.
   PubMed Web of Science ®Google Scholar
• Seeram NP, Aronson WJ, Zhang Y, Henning SM, Moro A, et al.: Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland. J Agric Food Chem 55, 7732–7737, 2007.
   PubMed Web of Science ®Google Scholar
• Reagan-Shaw S, Nihal M, and Ahmad N: Dose translation from animal to human studies revisited. FASEB J 22, 659–661, 2008.
   PubMed Web of Science ®Google Scholar
• Kovvuru P, Mancilla PE, Shirode AB, Murray TM, Begley TJ, et al.: Oral ingestion of silver nanoparticles induces genomic instability and DNA damage in multiple tissues. Nanotoxicology 9, 162–171, 2015.
   PubMed Web of Science ®Google Scholar
• Rogakou EP, Boon C, Redon C, and Bonner WM: Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 146, 905–916, 1999.
   PubMed Web of Science ®Google Scholar
• Kuo LJ, and Yang LX: Gamma-H2AX—a novel biomarker for DNA double-strand breaks. In Vivo 22, 305–309, 2008.
   PubMed Web of Science ®Google Scholar
• Hayashi M, MacGregor JT, Gatehouse DG, Adler ID, Blakey DH, et al.: In vivo rodent erythrocyte micronucleus assay. II. Some aspects of protocol design including repeated treatments, integration with toxicity testing, and automated scoring. Environ Mol Mutagen 35, 234–252, 2000.
   PubMed Web of Science ®Google Scholar
• Karran P: DNA double strand break repair in mammalian cells. Curr Opin Genet Dev 10, 144–150, 2000.
   PubMed Web of Science ®Google Scholar
• Khanna KK, and Jackson SP: DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 27, 247–254, 2001.
   PubMed Web of Science ®Google Scholar
• Thompson LH, and Schild D: Homologous recombinational repair of DNA ensures mammalian chromosome stability. Mutat Res 477, 131–153, 2001.
   PubMed Web of Science ®Google Scholar
• Zha S, Boboila C, and Alt FW: Mre11: roles in DNA repair beyond homologous recombination. Nat Struct Mol Biol 16, 798–800, 2009.
   PubMed Web of Science ®Google Scholar
• Anderson ME: Glutathione: an overview of biosynthesis and modulation. Chem Biol Interact 111–112, 1–14, 1998.
   PubMed Web of Science ®Google Scholar
• Forman HJ, Davies KJ, and Ursini F: How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo. Free Radic Biol Med 66, 24–35, 2014.
   PubMed Web of Science ®Google Scholar
• Aiyer HS, Vadhanam MV, Stoyanova R, Caprio GD, Clapper ML, et al.: Dietary berries and ellagic acid prevent oxidative DNA damage and modulate expression of DNA repair genes. Int J Mol Sci 9, 327–341, 2008.
   PubMed Web of Science ®Google Scholar
• Lieber MR, Gu J, Lu H, Shimazaki N, and Tsai AG: Nonhomologous DNA end joining (NHEJ) and chromosomal translocations in humans. Subcell Biochem 50, 279–296, 2010.
   PubMedGoogle Scholar
• Rothkamm K, Kuhne M, Jeggo PA, and Lobrich M: Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks. Cancer Res 61, 3886–3893, 2001.
   PubMed Web of Science ®Google Scholar
• Reliene R, Bishop AJ, and Schiestl RH: Involvement of homologous recombination in carcinogenesis. Adv Genet 58, 67–87, 2007.
   PubMed Web of Science ®Google Scholar
• Mao Z, Bozzella M, Seluanov A, and Gorbunova V: DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle 7, 2902–2906, 2008.
   PubMed Web of Science ®Google Scholar
• Faria A, Monteiro R, Mateus N, Azevedo I, and Calhau C: Effect of pomegranate (Punica granatum) juice intake on hepatic oxidative stress. Eur J Nutr 46, 271–278, 2007.
   PubMed Web of Science ®Google Scholar
• Guo C, Wei J, Yang J, Xu J, Pang W, et al.: Pomegranate juice is potentially better than apple juice in improving antioxidant function in elderly subjects. Nutr Res 28, 72–77, 2008.
   PubMed Web of Science ®Google Scholar
• Gueritat J, Lefeuvre-Orfila L, Vincent S, Cretual A, Ravanat JL, et al.: Exercise training combined with antioxidant supplementation prevents the antiproliferative activity of their single treatment in prostate cancer through inhibition of redox adaptation. Free Radic Biol Med 77, 95–105, 2014.
   PubMed Web of Science ®Google Scholar
• Rosenblat M, Hayek T, and Aviram M: Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages. Atherosclerosis 187, 363–371, 2006.
   PubMed Web of Science ®Google Scholar
• Rosenblat M, Volkova N, Coleman R, and Aviram M: Pomegranate byproduct administration to apolipoprotein e-deficient mice attenuates atherosclerosis development as a result of decreased macrophage oxidative stress and reduced cellular uptake of oxidized low-density lipoprotein. J Agric Food Chem 54, 1928–1935, 2006.
   PubMed Web of Science ®Google Scholar
• Moskaug JO, Carlsen H, Myhrstad MC, and Blomhoff R: Polyphenols and glutathione synthesis regulation. Am J Clin Nutr 81, 277S–283S, 2005.
   PubMed Web of Science ®Google Scholar
• Garcia-Villalba R, Espin JC, Aaby K, Alasalvar C, Heinonen M, et al.: Validated method for the characterization and quantification of extractable and nonextractable ellagitannins after acid hydrolysis in pomegranate fruits, juices, and extracts. J Agric Food Chem 63, 6555–6566, 2015.
   PubMed Web of Science ®Google Scholar