Rising Cancer Incidence and Role of the Evolving Diet in Kenya

References

• Korir A, Okerosi N, Ronoh V, Mutuma G, and Parkin M: Incidence of cancer in Nairobi, Kenya (2004-2008). Int J Cancer 137, 2053–2059, 2015.
   PubMed Web of Science ®Google Scholar
• Topazian H, Cira M, Dawsey SM, Kibachio J, Kocholla L, et al.: Joining forces to overcome cancer: the Kenya cancer research and control stakeholder program. J Cancer Policy 7,36–41, 2016.
   PubMed Web of Science ®Google Scholar
• Rodin D, Grover S, Elmore SN, Knaul FM, Atun R, et al.: The power of integration: radiotherapy and global palliative care. Ann Palliat Med 5,209–217, 2016.
   PubMed Web of Science ®Google Scholar
• Nieminen MT, Novak-Frazer L, Collins R, Dawsey SP, Dawsey SM, et al.: Alcohol and acetaldehyde in African fermented milk mursik–a possible etiologic factor for high incidence of esophageal cancer in western Kenya." Cancer Epidemiol Biomarkers Prev 22,69–75, 2013.
   Web of Science ®Google Scholar
• Alibek K, Baiken Y, Kakpenova A, Mussabekova A, Zhussupbekova S, et al.: Implication of human herpesviruses in oncogenesis through immune evasion and suppression. Infect Agents Cancer 9,3, 2014.
   PubMed Web of Science ®Google Scholar
• Lippi G, Mattiuzzi C, and Cervellin G: Meat consumption and cancer risk: a critical review of published meta-analyses. Crit Rev Oncol/Hematol 97, 1–14, 2016.
   PubMed Web of Science ®Google Scholar
• Larsson SC and Wolk A: Meat consumption and risk of colorectal cancer: a meta‐analysis of prospective studies. Int J Cancer 119, 2657–2664, 2006.
   PubMed Web of Science ®Google Scholar
• Aune D, Chan DS, Lau R, Vieira R, Greenwood DC, et al.: Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose-response meta-analysis of prospective studies. BMJ 343,d6617, 2011.
   PubMed Web of Science ®Google Scholar
• Pan P, Yu J, and Wang LS: Colon cancer: what we eat. Surg Oncol Clin N Am 27, 243–267, 2018.
   PubMed Web of Science ®Google Scholar
• D’Elia L, Rossi G, Ippolito R, Cappuccio FP, and Strazzullo P: Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 31, 489–498, 2012.
   PubMed Web of Science ®Google Scholar
• Tramacere I, Negri E, Pelucchi C, Bagnardi V, Rota M, et al.: A meta-analysis on alcohol drinking and gastric cancer risk. Ann Oncol 23,28–36, 2012.
   PubMed Web of Science ®Google Scholar
• Castello A, Fernandez de Larrea N, Martin V, Davila-Batista V, Boldo E, et al.: High adherence to the Western, Prudent, and Mediterranean dietary patterns and risk of gastric adenocarcinoma: MCC-Spain study. Gastric Cancer 21, 372–382, 2018.
   Google Scholar
• Stott-Miller M, Neuhouser ML, and Stanford JL: Consumption of deep-fried foods and risk of prostate cancer. Prostate 73, 960–969, 2013.
   PubMed Web of Science ®Google Scholar
• Labbé DP, Zadra G, Ebot EM, Mucci LA, Kantoff PW, et al.: Role of diet in prostate cancer: the epigenetic link. Oncogene 34,4683–4691, 2015.
   Web of Science ®Google Scholar
• Sonn GA, Aronson W, and Litwin MS: Impact of diet on prostate cancer: a review. Prostate Cancer Prostatic Dis 8,304–310, 2005.
   Web of Science ®Google Scholar
• Blackburn GL, Copeland T, Khaodhiar L, and Buckley RB: Diet and breast cancer. J Womens Health (Larchmt) 12, 183–192, 2003.
   PubMed Web of Science ®Google Scholar
• Brennan SF, Cantwell MM, Cardwell CR, Velentzis LS, and Woodside JV: Dietary patterns and breast cancer risk: a systematic review and meta-analysis. Am J Clin Nutr 91, 1294–1302, 2010.
   PubMed Web of Science ®Google Scholar
• Castello A, Pollan M, Buijsse B, Ruiz A, Casas AM, et al.: Spanish Mediterranean diet and other dietary patterns and breast cancer risk: case-control EpiGEICAM study. Br J Cancer 111,1454–1462, 2014.
   PubMed Web of Science ®Google Scholar
• Toden S and Goel A: The importance of diets and epigenetics in cancer prevention: a hope and promise for the future? Altern Ther Health Med 20 Suppl 2, 6–11, 2014.
   PubMed Web of Science ®Google Scholar
• Zhong S, Ma T, Chen L, Chen W, Lv M, et al.: Physical activity and risk of lung cancer: a meta-analysis. Clin J Sport Med 26, 173–181, 2016.
   Web of Science ®Google Scholar
• C, W. C. R. F. A. I. f. Third expert report. Diet, nutrition, physical activity and cancer: a global perspective world cancer research fund/American Institute for Cancer Research. Continuous Update Project Expert Report 2018. The American Institute for Cancer Research, Washington, DC, 2018.
   Google Scholar
• Slattery ML, Potter JD, Ma KN, Caan BJ, Leppert M, and Samowitz W: Western diet, family history of colorectal cancer, NAT2, GSTM-1 and risk of colon cancer. Cancer Causes Control 11, 1–8, 2000.
   PubMed Web of Science ®Google Scholar
• Tenge CN, Kuremu RT, Buziba NG, Patel K, and Were PA: Burden and pattern of cancer in Western Kenya. East Afr Med J 86, 7–10, 2009.
   PubMedGoogle Scholar
• Mostert S, Njuguna F, Kemps L, Strother M, Aluoch L, et al.: Epidemiology of diagnosed childhood cancer in Western Kenya. Arch Dis Child 97,508–512, 2012.
   PubMed Web of Science ®Google Scholar
• Rogena EA, Simbiri KO, De Falco G, Leoncini L, Ayers L, and Nyagol J: A review of the pattern of AIDS defining, HIV associated neoplasms and premalignant lesions diagnosed from 2000-2011 at Kenyatta National Hospital, Kenya. Infect Agent Cancer 10, 28, 2015.
   PubMed Web of Science ®Google Scholar
• Askari F, Parizi MK, Jessri M, and Rashidkhani B: Dietary patterns in relation to prostate cancer in Iranian men: a case-control study. Asian Pac J Cancer Prev 15, 2159–2163, 2014.
   PubMedGoogle Scholar
• Somi MH, Mousavi SM, Naghashi S, Faramarzi E, Jafarabadi MA, et al.: Is there any relationship between food habits in the last two decades and gastric cancer in North-western Iran? Asian Pac J Cancer Prev 16,283–290, 2015.
   PubMedGoogle Scholar
• Heidemann C, Schulze MB, Franco OH, van Dam RM, Mantzoros CS, and Hu FB: Dietary patterns and risk of mortality from cardiovascular disease, cancer, and all causes in a prospective cohort of women. Circulation 118, 230–237, 2008.
   PubMed Web of Science ®Google Scholar
• Karagulle M, Fidan E, Kavgaci H, and Ozdemir F: The effects of environmental and dietary factors on the development of gastric cancer. J BUON 19, 1076–1082, 2014.
   PubMed Web of Science ®Google Scholar
• Ollberding NJ, Aschebrook-Kilfoy B, Caces DB, Smith SM, Weisenburger DD, et al.: Dietary patterns and the risk of non-Hodgkin lymphoma. Public Health Nutr 17,1531–1537, 2014.
   PubMed Web of Science ®Google Scholar
• Kilonzo RM, Imungi JK, Muiru WM, Lamuka PO, and Njage PM: Household dietary exposure to aflatoxins from maize and maize products in Kenya. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 31, 2055–2062, 2014.
   PubMed Web of Science ®Google Scholar
• Mota OM, Curado MP, Oliveira JC, Martins E, and Cardoso DM: Risk factors for esophageal cancer in a low-incidence area of Brazil. Sao Paulo Med J 131, 27–34, 2013.
   PubMed Web of Science ®Google Scholar
• Patel K, Wakhisi J, Mining S, Mwangi A, and Patel R: Esophageal cancer, the topmost cancer at MTRH in the Rift Valley, Kenya, and its potential risk factors. ISRN Oncol 2013, 503249, 2013.
   PubMedGoogle Scholar
• Raschke V and Cheema B: Colonisation, the New World Order, and the eradication of traditional food habits in East Africa: historical perspective on the nutrition transition. Public Health Nutr 11, 662–674, 2008.
   PubMed Web of Science ®Google Scholar
• Gonzales JF, Barnard ND, Jenkins DJ, Lanou AJ, Davis B, et al.: Applying the precautionary principle to nutrition and cancer. J Am Coll Nutr 33,239–246, 2014.
   PubMed Web of Science ®Google Scholar
• Lippi G and Mattiuzzi C: Fried food and prostate cancer risk: systematic review and meta-analysis. Int J Food Sci Nutr 66, 587–589, 2015.
   PubMed Web of Science ®Google Scholar
• Kasdagly M, Radhakrishnan S, Reddivari L, Veeramachaneni DN, and Vanamala J: Colon carcinogenesis: influence of Western diet-induced obesity and targeting stem cells using dietary bioactive compounds. Nutrition 30, 1242–1256, 2014.
   PubMed Web of Science ®Google Scholar
• Bishop KS and Ferguson LR: The interaction between epigenetics, nutrition and the development of cancer. Nutrients 7, 922–947, 2015.
   PubMed Web of Science ®Google Scholar
• Latino-Martel P, Cottet V, Druesne-Pecollo N, Pierre FH, Touillaud M, et al.: Alcoholic beverages, obesity, physical activity and other nutritional factors, and cancer risk: a review of the evidence. Crit Rev Oncol Hematol 99,308–323, 2016.
   PubMed Web of Science ®Google Scholar
• Sutandyo N: Nutritional carcinogenesis. Acta Med Indones 42, 36–42, 2010.
   PubMedGoogle Scholar
• Kampschulte M, Stockl C, Langheinrich AC, Althohn U, Bohle RM, et al.: Western diet in ApoE-LDLR double-deficient mouse model of atherosclerosis leads to hepatic steatosis, fibrosis, and tumorigenesis. Lab Invest 94,1273–1282, 2014.
   PubMed Web of Science ®Google Scholar
• Gorski I, Chung W-C, Herr K, and Mehta K: Nyama choma culture: implications of increased red meat and alcohol consumption in east Africa. JSD 9, 96, 2016.
   Google Scholar
• Strnad M: [Salt and cancer]. Acta Med Croatica 64, 159–161, 2010.
   PubMedGoogle Scholar
• Rhead JL, Letley DP, Mohammadi M, Hussein N, Mohagheghi MA, et al.: A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer. Gastroenterology 133,926–936, 2007.
   PubMed Web of Science ®Google Scholar
• Gnagnarella P, Gandini S, La Vecchia C, and Maisonneuve P: Glycemic index, glycemic load, and cancer risk: a meta-analysis–. Am J Clin Nutr 87, 1793–1801, 2008.
   PubMed Web of Science ®Google Scholar
• Rapp K, Schroeder J, Klenk J, Ulmer H, Concin H, et al.: Fasting blood glucose and cancer risk in a cohort of more than 140,000 adults in Austria. Diabetologia 49,945–952, 2006.
   PubMed Web of Science ®Google Scholar
• Schulz MD, Atay C, Heringer J, Romrig FK, Schwitalla S, et al.: High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity. Nature 514,508–512, 2014.
   PubMed Web of Science ®Google Scholar
• Stender S and Dyerberg J: Influence of trans fatty acids on health. Ann Nutr Metab 48, 61–66, 2004.
   PubMed Web of Science ®Google Scholar
• Abel S, Riedel S, and Gelderblom WC: Dietary PUFA and cancer. Proc Nutr Soc 73, 361–367, 2014.
   PubMed Web of Science ®Google Scholar
• Rosato V, Edefonti V, Bravi F, Bosetti C, Bertuccio P, et al.: Nutrient-based dietary patterns and prostate cancer risk: a case–control study from Italy. Cancer Causes & Control 25,525–532, 2014.
   PubMed Web of Science ®Google Scholar
• Tewari R, Chhabra M, Natu SM, Goel A, Dalela D, et al.: Significant association of metabolic indices, lipid profile, and androgen levels with prostate cancer. Asian Pac J Cancer Prev 15,9841–9846, 2014.
   PubMedGoogle Scholar
• Nelson ER, Wardell SE, Jasper JS, Park S, Suchindran S, et al.: 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. Science 342,1094–1098, 2013.
   PubMed Web of Science ®Google Scholar
• Yang CS and Newmark HL: The role of micronutrient deficiency in carcinogenesis. Crit Rev Oncol Hematol 7, 267–287, 1987.
   PubMed Web of Science ®Google Scholar
• Newmark HL, Yang K, Lipkin M, Kopelovich L, Liu Y, et al.: A Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice. Carcinogenesis 22,1871–1875, 2001.
   PubMed Web of Science ®Google Scholar
• Tjonneland A, Christensen J, Olsen A, Stripp C, Nissen SB, et al.: Folate intake, alcohol and risk of breast cancer among postmenopausal women in Denmark. Eur J Clin Nutr 60,280–286, 2006.
   PubMed Web of Science ®Google Scholar
• Gichuhi S, Ohnuma S, Sagoo MS, and Burton MJ: Pathophysiology of ocular surface squamous neoplasia. Exp Eye Res 129, 172–182, 2014.
   PubMed Web of Science ®Google Scholar
• Tajaddini A, Pourzand A, Sanaat Z, and Pirouzpanah S: Dietary resistant starch contained foods and breast cancer risk: a case-control study in northwest of Iran. Asian Pac J Cancer Prev 16, 4185–4192, 2015.
   PubMedGoogle Scholar
• Adeva MM and Souto G: Diet-induced metabolic acidosis. Clin Nutr 30, 416–421, 2011.
   PubMed Web of Science ®Google Scholar
• Swietach P, Vaughan-Jones RD, Harris AL, and Hulikova A: The chemistry, physiology and pathology of pH in cancer. Philos Trans R Soc Lond B Biol Sci 369, 20130099, 2014.
   PubMed Web of Science ®Google Scholar
• Wicki A and Hagmann J: Diet and cancer. Swiss Med Wkly 141, w13250, 2011.
   PubMed Web of Science ®Google Scholar
• Mavropoulos JC, Buschemeyer WC III, Tewari AK, Rokhfeld D, Pollak M, et al.: The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model. Cancer Prev Res (Phila) 2,557–565, 2009.
   PubMed Web of Science ®Google Scholar
• Klement RJ and Kammerer U: Is there a role for carbohydrate restriction in the treatment and prevention of cancer? Nutr Metab (Lond) 8, 75, 2011.
   PubMed Web of Science ®Google Scholar
• Spensley PC: Aflatoxin, the active principle in turkey 'X' disease. Endeavour 22, 75–79, 1963.
   PubMed Web of Science ®Google Scholar
• Kigen G, Busakhala N, Kamuren Z, Rono H, Kimalat W, and Njiru E: Factors associated with the high prevalence of oesophageal cancer in Western Kenya: a review. Infect Agent Cancer 12, 59, 2017.
   PubMed Web of Science ®Google Scholar
• Wogan GN: Dietary factors and special epidemiological situations of liver cancer in Thailand and Africa. Cancer Res 35, 3499–3502, 1975.
   PubMed Web of Science ®Google Scholar
• De Vries HR and Lamplugh SM: Aflatoxins in liver biopsies from Kenya. Trop Geogr Med 41, 26–30, 1989.
   PubMedGoogle Scholar
• Wild CP, Jiang YZ, Sabbioni G, Chapot B, and Montesano R: Evaluation of methods for quantitation of aflatoxin-albumin adducts and their application to human exposure assessment. Cancer Res 50, 245–251, 1990.
   PubMed Web of Science ®Google Scholar
• Aydin M, Aydin S, Bacanli M, and Basaran N: Aflatoxin levels in chronic hepatitis B patients with cirrhosis or hepatocellular carcinoma in Balikesir, Turkey. J Viral Hepat 22, 926–935, 2015.
   PubMed Web of Science ®Google Scholar
• Autrup H, Seremet T, Wakhisi J, and Wasunna A: Aflatoxin exposure measured by urinary excretion of aflatoxin B1-guanine adduct and hepatitis B virus infection in areas with different liver cancer incidence in Kenya. Cancer Res 47, 3430–3433, 1987.
   PubMed Web of Science ®Google Scholar
• Kang'ethe EK and Lang'a KA: Aflatoxin B1 and M1 contamination of animal feeds and milk from urban centers in Kenya. Afr Health Sci 9, 218–226, 2009.
   PubMed Web of Science ®Google Scholar
• Cotty PJ and Jaime-Garcia R: Influences of climate on aflatoxin producing fungi and aflatoxin contamination. Int J Food Microbiol 119, 109–115, 2007.
   PubMed Web of Science ®Google Scholar
• van der Fels-Klerx HJ, Olesen JE, Madsen MS, and Goedhart PW: Climate change increases deoxynivalenol contamination of wheat in north-western Europe. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 29, 1593–1604, 2012.
   PubMed Web of Science ®Google Scholar
• Yard EE, Daniel JH, Lewis LS, Rybak ME, Paliakov EM, et al.: Human aflatoxin exposure in Kenya, 2007: a cross-sectional study. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 30,1322–1331, 2013.
   PubMed Web of Science ®Google Scholar
• Mutiga SK, Were V, Hoffmann V, Harvey JW, Milgroom MG, and Nelson RJ: Extent and drivers of mycotoxin contamination: inferences from a survey of Kenyan maize mills. Phytopathology 104, 1221–1231, 2014.
   PubMed Web of Science ®Google Scholar
• Uehara Y and Kiyohara C: Alcohol consumption and lung cancer risk among Japanese: a meta-analysis. Fukuoka Igaku Zasshi 101, 101–108, 2010.
   PubMedGoogle Scholar
• Scoccianti C, Straif K, and Romieu I: Recent evidence on alcohol and cancer epidemiology. Future Oncol 9, 1315–1322, 2013.
   PubMed Web of Science ®Google Scholar
• Varela-Rey M, Woodhoo A, Martinez-Chantar ML, Mato JM, and Lu SC: Alcohol, DNA methylation, and cancer. Alcohol Res 35, 25–35, 2013.
   PubMed Web of Science ®Google Scholar
• Castro GD and Castro JA: Alcohol drinking and mammary cancer: Pathogenesis and potential dietary preventive alternatives. WJCO 5, 713–729, 2014.
   Google Scholar
• Vasiliou V, Pappa A, and Estey T: Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism. Drug Metab Rev 36, 279–299, 2004.
   PubMed Web of Science ®Google Scholar
• Liu Y, Chen H, Sun Z, and Chen X: Molecular mechanisms of ethanol-associated oro-esophageal squamous cell carcinoma. Cancer Lett 361, 164–173, 2015.
   PubMed Web of Science ®Google Scholar
• Seitz HK and Stickel F: Acetaldehyde as an underestimated risk factor for cancer development: role of genetics in ethanol metabolism. Genes Nutr 5, 121–128, 2010.
   PubMed Web of Science ®Google Scholar
• Matsuda T, Kawanishi M, Yagi T, Matsui S, and Takebe H: Specific tandem GG to TT base substitutions induced by acetaldehyde are due to intra-strand crosslinks between adjacent guanine bases. Nucleic Acids Res 26, 1769–1774, 1998.
   PubMed Web of Science ®Google Scholar
• Cogliano VJ, Baan R, Straif K, Grosse Y, Lauby-Secretan B, et al.: Preventable exposures associated with human cancers. J Natl Cancer Inst 103,1827–1839, 2011.
   PubMed Web of Science ®Google Scholar
• Wong AW, Paulson QX, Hong J, Stubbins RE, Poh K, et al.: Alcohol promotes breast cancer cell invasion by regulating the Nm23-ITGA5 pathway. J Exp Clin Cancer Res 30,75, 2011.
   PubMed Web of Science ®Google Scholar
• Leon-Buitimea A, Rodriguez-Fragoso L, Lauer FT, Bowles H, Thompson TA, et al.: Ethanol-induced oxidative stress is associated with EGF receptor phosphorylation in MCF-10A cells overexpressing CYP2E1. Toxicol Lett 209,161–165, 2012.
   PubMed Web of Science ®Google Scholar
• Odera JO, Odera E, Githang'a J, Walong EO, Li F, et al.: Esophageal cancer in Kenya. Am J Dig Dis (Madison) 4,23–33, 2017.
   PubMedGoogle Scholar
• Rostrup M, Edwards JK, Abukalish M, Ezzabi M, Some D, et al.: The methanol poisoning outbreaks in Libya 2013 and Kenya 2014. PLoS One 11,e0152676, 2016.
   PubMed Web of Science ®Google Scholar
• Mwachiro MM, Burgert SL, Lando J, Chepkwony R, Bett C, et al.: Esophageal squamous dysplasia is common in asymptomatic Kenyans: a prospective, community-based, cross-sectional study. Am J Gastroenterol 111, 500–507, 2016.
   Google Scholar
• Homann N, Karkkainen P, Koivisto T, Nosova T, Jokelainen K, and Salaspuro M: Effects of acetaldehyde on cell regeneration and differentiation of the upper gastrointestinal tract mucosa. J Natl Cancer Inst 89, 1692–1697, 1997.
   PubMedGoogle Scholar
• Derry MM, Raina K, Agarwal C, and Agarwal R: Identifying molecular targets of lifestyle modifications in colon cancer prevention. Front Oncol 3, 119, 2013.
   PubMedGoogle Scholar
• Singh S, Arcaroli J, Thompson DC, Messersmith W, and Vasiliou V: Acetaldehyde and retinaldehyde-metabolizing enzymes in colon and pancreatic cancers. Adv Exp Med Biol 815, 281–294, 2015.
   PubMed Web of Science ®Google Scholar
• Ngule CM, TAS, and Obey Jackie K: Phytochemical and bioactivity evaluation of senna didymobotrya fresen Irwin used by the Nandi community in Kenya. Int J Bioassay 2, 1037–1043, 2013.
   Google Scholar
• Gathirua-Mwangi WG and Zhang J: Dietary factors and risk for advanced prostate cancer. Eur J Cancer Prev 23, 96–109, 2014.
   PubMed Web of Science ®Google Scholar
• Kumar M, Kumar A, Nagpal R, Mohania D, Behare P, et al.: Cancer-preventing attributes of probiotics: an update. Int J Food Sci Nutr 61,473–496, 2010.
   PubMed Web of Science ®Google Scholar
• Mohammadi M: Probiotics and cancer. J Biol 2, 202–209, 2013.
   Google Scholar
• Karimi S, Wawire M, and Mathooko FM: Impact of frying practices and frying conditions on the quality and safety of frying oils used by street vendors and restaurants in Nairobi, Kenya. J Food Compos Anal 62, 239–244, 2017.
   Web of Science ®Google Scholar
• Purcaro G, Navas JA, Guardiola F, Conte LS, and Moret S: Polycyclic aromatic hydrocarbons in frying oils and snacks. J Food Prot 69, 199–204, 2006.
   PubMed Web of Science ®Google Scholar
• Duong VT, Duong V, Lien NT, Imasaka T, Tang Y, et al.: Detection of polychlorinated biphenyls in transformer oils in Vietnam by multiphoton ionization mass spectrometry using a far-ultraviolet femtosecond laser as an ionization source. Talanta 149,275–279, 2016.
   PubMed Web of Science ®Google Scholar
• Njoroge RW, Macharia BN, Sawe DJ, and Maiyoh GK: Effects of crude kerosene on testosterone levels, aggression and toxicity in rat. Toxicol Rep 2, 175–183, 2015.
   PubMed Web of Science ®Google Scholar
• Ritchie G, Still K, Rossi J III, Bekkedal M, Bobb A, et al.: Biological and health effects of exposure to kerosene-based jet fuels and performance additives. J Toxicol Environ Health B Crit Rev 6,357–451, 2003.
   PubMed Web of Science ®Google Scholar
• Lam NL, Smith KR, Gauthier A, and Bates MN: Kerosene: a review of household uses and their hazards in low- and middle-income countries. J Toxicol Environ Health B Crit Rev 15, 396–432, 2012.
   PubMed Web of Science ®Google Scholar
• Duarte-Davidson R, Courage C, Rushton L, and Levy L: Benzene in the environment: an assessment of the potential risks to the health of the population. Occup Environ Med 58, 2–13, 2001.
   PubMed Web of Science ®Google Scholar
• McHale CM, Zhang L, and Smith MT: Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment. Carcinogenesis 33, 240–252, 2012.
   PubMed Web of Science ®Google Scholar
• Blanton RH, Lyte M, Myers MJ, and Bick PH: Immunomodulation by polyaromatic hydrocarbons in mice and murine cells. Cancer Res 46, 2735–2739, 1986.
   PubMed Web of Science ®Google Scholar
• Krieger JA, Born JL, and Burchiel SW: Persistence of calcium elevation in the HPB-ALL human T cell line correlates with immunosuppressive properties of polycyclic aromatic hydrocarbons. Toxicol Appl Pharmacol 127, 268–274, 1994.
   PubMed Web of Science ®Google Scholar
• Arvas A: Vaccination in patients with immunosuppression. Turk Pediatri Ars 49, 181–185, 2014.
   PubMedGoogle Scholar
• Sekhotha MM, Monyeki KD, and Sibuyi ME: Exposure to agrochemicals and cardiovascular disease: a review. IJERPH 13, 229, 2016.
   Web of Science ®Google Scholar
• Lo AC, Soliman AS, Khaled HM, Aboelyazid A, and Greenson JK: Lifestyle, occupational, and reproductive factors and risk of colorectal cancer. Dis Colon Rectum 53, 830–837, 2010.
   PubMed Web of Science ®Google Scholar
• Clapp RW, Jacobs MM, and Loechler EL: Environmental and occupational causes of cancer: new evidence 2005-2007. Rev Environ Health 23, 1–37, 2008.
   PubMedGoogle Scholar
• Mosby TT, Cosgrove M, Sarkardei S, Platt KL, and Kaina B: Nutrition in adult and childhood cancer: role of carcinogens and anti-carcinogens. Anticancer Res 32, 4171–4192, 2012.
   PubMed Web of Science ®Google Scholar
• Abnet CC: Carcinogenic food contaminants. Cancer Invest 25, 189–196, 2007.
   PubMed Web of Science ®Google Scholar
• Cohn BA, La Merrill M, Krigbaum NY, Yeh G, Park JS, et al.: DDT exposure in utero and breast cancer. J Clin Endocrinol Metab 100,2865–2872, 2015.
   PubMed Web of Science ®Google Scholar
• Sobhani I, Tap J, Roudot-Thoraval F, Roperch JP, Letulle S, et al.: Microbial dysbiosis in colorectal cancer (CRC) patients. PLoS One 6,e16393, 2011.
   PubMed Web of Science ®Google Scholar
• Xuan C, Shamonki JM, Chung A, DiNome ML, Chung M, et al.: Microbial dysbiosis is associated with human breast cancer. PLoS One 9,e83744, 2014.
   PubMed Web of Science ®Google Scholar
• Boursi B, Mamtani R, Haynes K, and Yang YX: Recurrent antibiotic exposure may promote cancer formation - another step in understanding the role of the human microbiota? Eur J Cancer 51, 2655–2664, 2015.
   PubMed Web of Science ®Google Scholar
• Lewis JD, Chen EZ, Baldassano RN, Otley AR, Griffiths AM, et al.: Inflammation, antibiotics, and diet as environmental stressors of the gut microbiome in pediatric Crohn’s disease. Cell Host & Microbe 18,489–500, 2015.
   PubMed Web of Science ®Google Scholar
• Vangay P, Ward T, Gerber JS, and Knights D: Antibiotics, pediatric dysbiosis, and disease. Cell Host Microbe 17, 553–564, 2015.
   PubMed Web of Science ®Google Scholar
• Zitvogel L, Galluzzi L, Viaud S, Vétizou M, Daillère R, et al.: Cancer and the gut microbiota: an unexpected link. Sci Transl Med 7,271ps271–271ps271, 2015.
   Web of Science ®Google Scholar
• Kenya Veterinary Association. http://www.kenyavetassociation.com/project/advocacy-and-policy/ Accessed on March 8, 2018.
   Google Scholar
• Hogervorst JG, Baars BJ, Schouten LJ, Konings EJ, Goldbohm RA, et al.: The carcinogenicity of dietary acrylamide intake: a comparative discussion of epidemiological and experimental animal research. Crit Rev Toxicol 40,485–512, 2010.
   PubMed Web of Science ®Google Scholar
• Hogervorst JG, Schouten LJ, Konings EJ, Goldbohm RA, and van den Brandt PA: Dietary acrylamide intake is not associated with gastrointestinal cancer risk. J Nutr 138, 2229–2236, 2008.
   PubMed Web of Science ®Google Scholar
• Amadou A, Torres-Mejia G, Hainaut P, and Romieu I: Breast cancer in Latin America: global burden, patterns, and risk factors. Salud Publica Mex 56, 547–554, 2014.
   PubMed Web of Science ®Google Scholar
• Hogstedt C, Jansson C, Hugosson M, Tinnerberg H, and Gustavsson P: Cancer incidence in a cohort of Swedish chimney sweeps, 1958-2006. Am J Publ Health 103, 1708–1714, 2013.
   PubMed Web of Science ®Google Scholar
• Mir MM and Dar NA: Esophageal cancer in Kashmir (India): an enigma for researchers. Int J Health Sci (Qassim) 3, 71–85, 2009.
   PubMedGoogle Scholar
• Yassi A, Tate RB, and Routledge M: Cancer incidence and mortality in workers employed at a transformer manufacturing plant: update to a cohort study. Am J Ind Med 44, 58–62, 2003.
   PubMed Web of Science ®Google Scholar
• Wilson KM, Giovannucci E, Stampfer MJ, and Mucci LA: Dietary acrylamide and risk of prostate cancer. Int J Cancer 131, 479–487, 2012.
   PubMed Web of Science ®Google Scholar
• Aykan NF: Red meat and colorectal cancer. Oncol Rev 9, 288, 2015.
   PubMedGoogle Scholar
• Straif K, Baan R, Grosse Y, Secretan B, El Ghissassi F, et al.: Carcinogenicity of household solid fuel combustion and of high-temperature frying. Lancet Oncol 7,977–978, 2006.
   PubMedGoogle Scholar
• French SW, Oliva J, French BA, Li J, and Bardag-Gorce F: Alcohol, nutrition and liver cancer: role of Toll-like receptor signaling. World J Gastroenterol16, 1344–1348, 2010.
   PubMed Web of Science ®Google Scholar
• Liu Y, Nguyen N, and Colditz GA: Links between alcohol consumption and breast cancer: a look at the evidence. Womens Health (Lond Engl) 11, 65–77, 2015.
   PubMedGoogle Scholar
• Waihenya CG, and Mungai PN: Pattern of transitional cell carcinoma of the urinary bladder as seen at Kenyatta National Hospital, Nairobi. East Afr Med J 81, 114–119, 2004.
   PubMedGoogle Scholar
• Stattin P, Bjor O, Ferrari P, Lukanova A, Lenner P, et al.: Prospective study of hyperglycemia and cancer risk. Diabetes Care 30,561–567, 2007.
   PubMed Web of Science ®Google Scholar