Administration of a Nutraceutical Mixture Composed by Aloe arborescens, Annona muricata, Morinda citrifolia, Beta rubra, Scutellaria baicalensis, and Vaccinium myrtillus Reduces Doxorubicin-Induced Side Effects

References

• Minotti G, Menna P, Salvatorelli E, Cairo G, and Gianni L: Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56, 185–229, 2004. doi: 10.1124/pr.56.2.6
   PubMed Web of Science ®Google Scholar
• Wang J: DNA topoisomerases. Annu Rev Biochem 65, 635–692, 1996. doi: 10.1146/annurev.bi.65.070196.003223
   PubMed Web of Science ®Google Scholar
• Berthiaume J, and Wallace K: Adriamycin-induced oxidative mitochondrial cardiotoxicity. Cell Biol Toxicol 23, 15–25, 2007. doi: 10.1007/s10565-006-0140-y
   PubMed Web of Science ®Google Scholar
• Carvalho F, Burgeiro A, Garcia R, Moreno A, and Carvalho R: Doxorubicin-induced cardiotoxicity: from bioenergetic failure and cell death to cardiomyopathy. Med Res Rev 34, 106–135, 2014. doi: 10.1002/med.21280
   PubMed Web of Science ®Google Scholar
• Zhang S, Liu X, Bawa-Khalfe T, Lu L, Lyu Y, et al. Identification of the molecular basis of doxorubicin-induced cardiotoxicity. Nat Med 18, 1639–1642, 2012. doi: 10.1038/nm.2919
   PubMed Web of Science ®Google Scholar
• Fogli S, Nieri P, and Breschi M: The role of nitric oxide in anthracycline toxicity and prospects for pharmacologic prevention of cardiac damage. FASEB J 18, 664–675, 2004. doi: 10.1096/fj.03-0724rev
   PubMed Web of Science ®Google Scholar
• Octavia Y, Tocchetti C, Gabrielson K, Janssens S, Crijns H, et al. Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies. J Mol Cell Cardiol 52, 1213–1225, 2012. doi: 10.1016/j.yjmcc.2012.03.006
   PubMed Web of Science ®Google Scholar
• Stěrba M, Popelová O, Vávrová A, Jirkovský E, Kovaříková P, et al. Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection. Antioxid Redox Signal 18, 899–929, 2013. doi: 10.1089/ars.2012.4795
   PubMed Web of Science ®Google Scholar
• Licata S, Saponiero A, Mordente A, and Minotti G: Doxorubicin metabolism and toxicity in human myocardium: role of cytoplasmic deglycosidation and carbonyl reduction. Chem Res Toxicol 13, 414–420, 2000. doi: 10.1021/tx000013q
   PubMed Web of Science ®Google Scholar
• Carvalho C, Santos R, Cardoso S, Correia S, Oliveira P, et al. Doxorubicin: the good, the bad and the ugly effect. Curr Med Chem 16, 3267–3285, 2009. doi: 10.2174/092986709788803312
   PubMed Web of Science ®Google Scholar
• Zolfagharzadeh F, and Roshan V: Pre-treatment Hepatoprotective Effect of Regular Aerobic Training Against Hepatic Toxicity Induced by Doxorubicin in rats. Asian Pac J Cancer Prev 14, 2931–2936, 2013. doi: 10.7314/APJCP.2013.14.5.2931
   PubMedGoogle Scholar
• Zhang Q, Wang F, Jia K, and Kong L: Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects. Front Pharmacol 6, 1253, 2018.
   Google Scholar
• Huang C, Ju D, Chang C, Muralidhar Reddy P, and Velmurugan B: A review on the effects of current chemotherapy drugs and natural agents in treating non-small cell lung cancer. Biomedicine (Taipei) 7, 23, 2017. doi: 10.1051/bmdcn/2017070423
   PubMedGoogle Scholar
• Soeda M: Extract of Cape aloes inhibited sarcoma 180 and Ehrlich ascites tumours. J Med Soc Jpn 16, 365–369, 1969.
   Google Scholar
• Hart LA, van Enckevort PH, van Dijk H, Zaat R, de Silva KT, and Labadie RP: Two functionally and chemically distinct immunomodulatory compounds in the gel of Aloe vera. J Ethnopharmacol 23, 61–71, 1988. doi: 10.1016/0378-8741(88)90115-8
   PubMed Web of Science ®Google Scholar
• Winters WD, Benavides R, and Clouse WJ: Effects of aloe extracts on human normal and tumour cells in vitro. Econ Bot 35, 89–95, 1981. doi: 10.1007/BF02859219
   Web of Science ®Google Scholar
• Capasso F, Borrelli F, Capasso R, Di Carlo G, and Izzo A: Aloe and its therapeutic use. Phytother Res 12, 124–127, 1998.
   Web of Science ®Google Scholar
• Gavamukulya Y, Wamunyokoli F, and El-Shemy H: Annona muricata: is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med 10, 835–848, 2017. doi: 10.1016/j.apjtm.2017.08.009
   PubMed Web of Science ®Google Scholar
• Baskar R, Rajeswari V, and Kumar T: In vitro antioxidant studies in leaves of Annona species. Indian J Exp Biol 45, 480–485, 2007.
   PubMed Web of Science ®Google Scholar
• Liu C, Wu J, Gu J, Xiong Z, Wang F, et al. Baicalein improves cognitive deficits induced by chronic cerebral hypoperfusion in rats. Pharmacol Biochem Behav 86, 423–430, 2007. doi: 10.1016/j.pbb.2006.11.005
   PubMed Web of Science ®Google Scholar
• Sameer M, Sunil K, Ajay K, Surrinder K, Suri O, et al. A Review on Plants a useful source of anti-cancer drugs. J Pharm Res 4, 264–271, 2011.
   Google Scholar
• Hwang Y, Jinhua M, Choi B, Cui C, Jeon W, et al. Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion-induced memory impairments and chronic lipopolysaccharide infusion-induced memory impairments. J Ethnopharmacol 137, 681–689, 2011. doi: 10.1016/j.jep.2011.06.025
   PubMed Web of Science ®Google Scholar
• Luo H, Lv X, Wang G, Li Y, Kurihara H, et al. Anti-inflammatory effects of anthocyanins-rich extract from bilberry (Vaccinium myrtillus L.) on croton oil-induced ear edema and Propionibacterium acnes plus LPS-induced liver damage in mice. Int J Food Sci Nutr 65, 594–601, 2014. doi: 10.3109/09637486.2014.886184
   PubMed Web of Science ®Google Scholar
• Mohamad Shalan N, Mustapha N, and Mohamed S: Morinda citrifolia leaf enhanced performance by improving angiogenesis, mitochondrial biogenesis, antioxidant, anti-inflammatory & stress responses. Food Chem 212, 443–452, 2016. doi: 10.1016/j.foodchem.2016.05.179
   PubMed Web of Science ®Google Scholar
• Ninfali P, Antonini E, Frati A, and Scarpa E: C-Glycosyl flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, anticancer and antiinflammatory activities-A review. Phytother Res 31, 871–884, 2017. doi: 10.1002/ptr.5819
   PubMed Web of Science ®Google Scholar
• McGrath JC, Drummond GB, McLachlan EM, Kilkenny C, and Wainwright CL: Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160, 1573–1576, 2010. doi: 10.1111/j.1476-5381.2010.00873.x
   PubMed Web of Science ®Google Scholar
• Gibson-Corley KN, Olivier AK, and Meyerholz DK: Principles for valid histopathologic scoring in research. Vet Pathol 50, 1007–1015, 2013. doi: 10.1177/0300985813485099
   PubMed Web of Science ®Google Scholar
• Keizer G, Pinedo M, Schuurhuis J, and Joenje H: Doxorubicin (adriamycin): a critical review of free radical-dependent mechanisms of cytotoxicity. Pharmacol Ther 47, 219–231, 1990. doi: 10.1016/0163-7258(90)90088-J
   PubMed Web of Science ®Google Scholar
• Sayed-Ahmed M, Khattab M, Gad M, and Osman A: Increased plasma endothelin-1 and cardiac nitric oxide during doxorubicin-induced cardiomyopathy. Pharmacol Toxicol 89, 140–144, 2001. doi: 10.1034/j.1600-0773.2001.d01-148.x
   PubMedGoogle Scholar
• Pacher P, Liaudet L, Bai P, Mabley JG, Kaminski PM, et al. Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction. Circulation 107, 896–910, 2003. doi: 10.1161/01.CIR.0000048192.52098.DD
   PubMed Web of Science ®Google Scholar