The Genetic Basis of Emotional Behavior: Has the Time Come for a Drosophila Model?

References

• Acevedo S. F., Froudarakis E. I., Kanellopoulos A., Skoulakis E. M. Protection from premature habituation requires functional mushroom bodies in Drosophila. Learn Mem 2007; 14: 376–384
   PubMed Web of Science ®Google Scholar
• Angus J. Genetic control of activity, preening, and the response to a shadow stimulus in Drosophila melanogaster. Behav Gen 1974; 4: 317–329
   PubMed Web of Science ®Google Scholar
• Archer J. Tests for emotionality in rats and mice: a review. Anim Behav 1973; 21: 205–235
   PubMed Web of Science ®Google Scholar
• Arnold, M. B. 1960. Emotion and Personality (Vols. I, II). New York: Columbia University Press.
   Google Scholar
• Ayyub C., Paranjape J., Rodrigues V., Siddiqi O. Genetics of olfactory behavior in Drosophila melanogaster. J Neurogen 1990; 6: 243–262
   PubMed Web of Science ®Google Scholar
• Baier A., Wittek B., Brembs B. Drosophila as a new model organism for the neurobiology of aggression?. J Exp Biol 2002; 205: 1233–1240
   PubMedGoogle Scholar
• Bechara A., Damasio H., Damasio A. R. Emotion, decision making, and the orbitofrontal cortex. Cerebr Cort 2000; 10: 295–307
   PubMed Web of Science ®Google Scholar
• Belzung, C., & Philippot, P. 2007. Anxiety from a phylogenetic perspective: is there a qualitative difference between human and animal anxiety? Neur Plast, Article ID 59676, 17 pages.
   PubMedGoogle Scholar
• Besson M., Martin J. R. Centrophobism/thigmotaxis, a new role for the mushroom bodies in Drosophila. J Neurobiol 2005; 62: 386–396
   PubMedGoogle Scholar
• Bier E., Bodmer R. Drosophila, an emerging model for cardiac disease. Gene 2004; 342: 1–11
   PubMed Web of Science ®Google Scholar
• Bloch G., Borst D. W., Huang Z., Robinson G. E., Cnaani J., Hefetz A. Juvenile hormone titers, juvenile hormone biosynthesis, ovarian development, and social environment in Bombus terrestris. J Insect Physiol 2000; 46: 47–57
   PubMed Web of Science ®Google Scholar
• Bloch G., Hefetz A., Hartfelder K. Ecdysteroid titer, ovary status, and dominance in adult worker and queen bumble bees (Bombus terrestris). J Insect Physiol 2000; 46: 1033–1040
   PubMed Web of Science ®Google Scholar
• Bodmer R., Venkatesh T. V. Heart development in Drosophila and vertebrates: conservation of molecular mechanisms. Devel Genet 1998; 22: 181–186
   PubMedGoogle Scholar
• Brain, P. F. 1979. Hormones, Drugs, and Aggression (Vol. 3). Montreal, QuebecCanada: Eden Press.
   Google Scholar
• Burnet B., Burnet L., Connolly K., Williamson N. A genetic analysis of locomotor activity in Drosophila melanogaster. Heredity 1988; 61: 111–119
   Google Scholar
• Burrows A. M., Waller B. M., Parr L. A., Bonar C. J. Muscles of facial expression in the chimpanzee (Pan troglodytes): descriptive, comparative, and phylogenetic contexts. J Anat 2006; 208: 153–167
   PubMed Web of Science ®Google Scholar
• Chabaud M. A., Devaud J. M., Pham-Delegue M. H., Preat T., Kaiser L. Olfactory conditioning of proboscis activity in Drosophila melanogaster. J Compar Physiol A Sens Neural Behav Physiol 2006; 192: 1335–1348
   PubMed Web of Science ®Google Scholar
• Chan H. Y., Bonini N. M. Drosophila models of human neurodegenerative disease. Cell Death Differentiat 2000; 7: 1075–1080
   PubMed Web of Science ®Google Scholar
• Chen S., Lee A. Y., Bowens N. M., Huber R., Kravitz E. A. Fighting fruit flies: a model system for the study of aggression. Proc Natl Acad Sci U S A 2002; 99: 5664–5668
   PubMed Web of Science ®Google Scholar
• Cocroft R. B. Insect vibrational defense signals. Nature 1996; 382: 679–680
   Google Scholar
• Cocroft R. B. Parent-offspring communication in response to predators in a subsocial treehopper (Hemiptera: Membracidae: Umbonia crassicornis). Ethology 1999; 105: 553–568
   Web of Science ®Google Scholar
• Connolly K. Locomotor activity in Drosophila. II. Selection for active and inactive strains. Anim Behav 1966; 14: 444–449
   PubMed Web of Science ®Google Scholar
• Connolly K. The social facilitation of preening behaviour in Drosophila melanogaster. Anim Behav 1968; 16: 385–391
   PubMed Web of Science ®Google Scholar
• Damasio A. Fundamental feelings. Nature 2001; 413: 781
   PubMed Web of Science ®Google Scholar
• Darwin, C. 1871. The Descent of Man, and Selection in Relation to Sex ( reprinted 1981 by Princeton University Press). London: John Murray.
   Google Scholar
• Darwin C. The Expression of the Emotions in Man and Animals3rd ed. University of Chicago Press, GlasgowUK 1872
   Google Scholar
• Davis R. L. Olfactory memory formation in Drosophila: from molecular to systems neuroscience. Annu Rev Neurosci 2005; 28: 275–302
   PubMed Web of Science ®Google Scholar
• Dawkins M. S. Animal minds and animal emotions. Am Zool 2000; 40: 883–888
   Google Scholar
• Denenberg V. H. Open-field behavior in the rat: what does it mean?. Ann N Y Acad Sci 1969; 159: 852–859
   PubMed Web of Science ®Google Scholar
• Dierick H. A., Greenspan R. J. Molecular analysis of flies selected for aggressive behavior. Nat Genet 2006; 38: 1023–1031
   PubMed Web of Science ®Google Scholar
• Dierick H. A., Greenspan R. J. Serotonin and neuropeptide F have opposite modulatory effects on fly aggression. Nat Genet 2007; 39: 678–682
   PubMed Web of Science ®Google Scholar
• Donegan J., Ewing A. W. Duetting in Drosophila and Zaprionus species. Anim Behav 1980; 28: 1289
   Google Scholar
• Dow M. A., von Schilcher F. Aggression and mating success in Drosophila melanogaster. Nature 1975; 254: 511–512
   PubMed Web of Science ®Google Scholar
• Duerr J. S., Quinn W. G. Three Drosophila mutations that block associative learning also affect habituation and sensitization. Proc Natl Acad Sci U S A 1982; 79: 3646–3650
   PubMed Web of Science ®Google Scholar
• Ebbs M. L., Amrein H. Taste and pheromone perception in the fruit fly Drosophila melanogaster. Pflugers Arch 2007; 454: 735–747
   PubMed Web of Science ®Google Scholar
• Edwards A. C., Rollmann S. M., Morgan T. J., Mackay T. F. Quantitative genomics of aggressive behavior in Drosophila melanogaster. PLoS Genet 2006; 2: e154
   PubMed Web of Science ®Google Scholar
• Ekman P. Expression and nature of emotion. Approaches to Emotion, K. Scherer, P. Ekman. Erlbaum, Hillsdale, New JerseyUSA 1984; 319–343
   Google Scholar
• Ewing A. W. Attempts to select for spontaneous activity in Drosophila melanogaster. Anim Behav 1963; 11: 369–378
   Google Scholar
• Feala J. D., Omens J. H., Paternostro G., McCulloch A. D. Discovering regulators of the Drosophila cardiac hypoxia response using automated phenotyping technology. Ann N Y Acad Sci 2008; 1123: 169–177
   PubMed Web of Science ®Google Scholar
• Finn D. A., Rutledge-Gorman M. T., Crabbe J. C. Genetic animal models of anxiety. Neurogenetics 2003; 4: 109–135
   PubMed Web of Science ®Google Scholar
• Flynn, J. P. 1976. Neural basis of threat and attack. In: Grenell, R. G., & Gabay, S. Biological Foundation of Psychiatry (pp 111–133). New York: Raven Press.
   Google Scholar
• Fox L. E., Soll D. R., Wu C. F. Coordination and modulation of locomotion pattern generators in Drosophila larvae: effects of altered biogenic amine levels by the tyramine beta hydroxlyase mutation. J Neurosci 2006; 26: 1486–1498
   PubMed Web of Science ®Google Scholar
• Gerber B., Stocker R. F. The Drosophila larva as a model for studying chemosensation and chemosensory learning: a review. Chem Senses 2007; 32: 65–89
   PubMed Web of Science ®Google Scholar
• Hall C. S. Emotional behavior in the rat. J Comparat Psychol 1934; 18: 385–403
   Google Scholar
• Hay D. A. Genetical and maternal determinants of the activity and preening behaviour of Drosophila melanogaster reared in different environments. Heredity 1972; 28: 311–336
   PubMed Web of Science ®Google Scholar
• Heisenberg M. Mushroom body memoir: from maps to models. Nat Rev Neurosci 2003; 4: 266–275
   PubMed Web of Science ®Google Scholar
• Heisenberg M., Wolf R., Brembs B. Flexibility in a single behavioral variable of Drosophila. Learn Mem 2001; 8: 1–10
   PubMed Web of Science ®Google Scholar
• Hirsch, J. (Ed.). 1967. Behavior-Genetic Analysis. New York: McGraw Hill.
   Google Scholar
• Hoffmann A. A. A laboratory study of male territoriality in the sibling species Drosophila melanogaster and Drosophila simulans. Anim Behav 1987; 35: 807–818
   Web of Science ®Google Scholar
• Hoffmann A. A. Geographic variation in the territorial success of Drosophila melanogaster males. Behav Genet 1989; 19: 241–255
   PubMedGoogle Scholar
• Hoyer S. C., Eckart A., Herrel A., Zars T., Fischer S. A., Hardie S. L., et al. Octopamine in male aggression of Drosophila. Curr Biol 2008; 18: 159–167
   PubMed Web of Science ®Google Scholar
• Jacobs M. E. Influence of light on mating of Drosophila melanogaster. Ecology 1960; 41: 182–188
   Google Scholar
• Jacobson L. H., Cryan J. F. Feeling strained? Influence of genetic background on depression-related behavior in mice: a review. Behav Genet 2007; 37: 171–213
   PubMed Web of Science ®Google Scholar
• Kalueff A. V., Wheaton M., Murphy D. L. What's wrong with my mouse model? Advances and strategies in animal modeling of anxiety and depression. Behav Brain Res 2007; 179: 1–18
   PubMed Web of Science ®Google Scholar
• Kamyshev N. G., Iliadi K. G., Bragina J. V. Drosophila conditioned courtship: two ways of testing memory. Learn Mem 1999; 6: 1–20
   PubMedGoogle Scholar
• Kamyshev N. G., Kamysheva E. A., Smirnova G. P., Parfeniuk I. V. The reciprocal training of Drosophila individuals in a group situation by the trial-and-error method. Zhurnal Obshchei Biologii 1994; 55: 737–748
   PubMed Web of Science ®Google Scholar
• Kamyshev N. G., Smirnova G. P., Kamysheva E. A., Nikiforov O. N., Parafenyuk I. V., Ponomarenko V. V. Plasticity of social behavior in Drosophila. Neurosci Behav Physiol 2002; 32: 401–408
   PubMedGoogle Scholar
• Kernan M. J. Mechanotransduction and auditory transduction in Drosophila. Pflugers Arch 2007; 454: 703–720
   PubMedGoogle Scholar
• LeDoux J. E. Emotion, memory, and the brain. Sci Am 1994; 270: 50–57
   PubMed Web of Science ®Google Scholar
• LeDoux J. E. The Emotional Brain. Touchstone, New York 1996
   Google Scholar
• LeDoux J. E. The emotional brain, fear, and the amygdala. Cell Mol Neurobiol 2003; 23: 727–738
   PubMed Web of Science ®Google Scholar
• Lester D. The effect of fear and anxiety on exploration and curiosity: toward a theory of exploration. J Gen Psychol 1968; 79: 105–120
   PubMed Web of Science ®Google Scholar
• Levine J. D., Funes P., Dowse H. B., Hall J. C. Resetting the circadian clock by social experience in Drosophila melanogaster. Science 2002; 298: 2010–2012
   PubMed Web of Science ®Google Scholar
• Lewis M., Haviland-Jones J. M. Handbook of Emotions. The Guilford Press, New York/London 2000
   Google Scholar
• Lipp H.-P.,  Wolfer D. P. Genetic background problems in the analysis of cognitive and neuronal changes in genetically modified mice. Clin Neurosci Res 2003; 3: 223–231
   Web of Science ®Google Scholar
• Liu L., Davis R. L., Roman G. Exploratory activity in Drosophila requires the kurtz nonvisual arrestin. Genetics 2007; 175: 1197–1212
   PubMed Web of Science ®Google Scholar
• Manev H., Dimitrijevic N. Fruit flies for antipain drug discovery. Life Sci 2005; 76: 2403–2407
   PubMed Web of Science ®Google Scholar
• Marks I. Fears, Phobias, and Rituals: Panic, Anxiety and their Disorders. Oxford University Press, New York 1987
   Google Scholar
• Martin J. R. Locomotor activity: a complex behavioural trait to unravel. Behav Proc 2003; 64: 145–160
   PubMed Web of Science ®Google Scholar
• Martin J. R., Ernst R., Heisenberg M. Mushroom bodies suppress locomotor activity in Drosophila melanogaster. Learn Mem 1998; 5: 179–191
   PubMed Web of Science ®Google Scholar
• Martin J. R., Raabe T., Heisenberg M. Central complex substructures are required for the maintenance of locomotor activity in Drosophila melanogaster. J Compar Physiol A Sens Neural Behav Physiol 1999; 185: 277–288
   PubMed Web of Science ®Google Scholar
• Moldin S. O. Neurobiology of anxiety and fear: challenges for genomic science of the new millennium. Biolog Psychiatry 2000; 48: 1144–1146
   PubMed Web of Science ®Google Scholar
• Moyer K. E. Kinds of aggression and their physiological basis. Comm Behav Biol 1968; 2: 65–87
   Google Scholar
• Nichols R. FMRFamide-related peptides and serotonin regulate Drosophila melanogaster heart rate: mechanisms and structure requirements. Peptides 2006; 27: 1130–1137
   PubMed Web of Science ®Google Scholar
• Nunez J., Almeida L., Balderrama N., Giurfa M. Alarm pheromone induces stress analgesia via an opioid system in the honeybee. Physiol Behav 1997; 63: 75–80
   PubMed Web of Science ®Google Scholar
• Oatley K., Jenkins J. M. Understanding Emotions. Blackwell, OxfordUK 1998
   Google Scholar
• Ocorr K., Akasaka T., Bodmer R. Age-related cardiac disease model of Drosophila. Mech Ageing Dev 2007; 128: 112–116
   PubMed Web of Science ®Google Scholar
• Paillete M., lkeda H., Jallon J.-M. A new acoustic signal of the fruit-flies Drosophila simulans and D. melanogaster. Bioacoustics 1991; 3: 247–254
   Google Scholar
• Panksepp J. Toward a general psychobiological theory of emotions. Behav Brain Sci 1982; 5: 407–467
   Web of Science ®Google Scholar
• Paternostro G., Vignola C., Bartsch D. U., Omens J. H., McCulloch A. D., Reed J. C. Age-associated cardiac dysfunction in Drosophila melanogaster. Circ Res 2001; 88: 1053–1058
   PubMed Web of Science ®Google Scholar
• Pavlov I. P., Anrep G. V. Conditioned Reflexes: An Investigation of the Physiological Activity of the Cerebral Cortex. Courier Dover, New York 2003
   Google Scholar
• Pearce A. N., Huang Z. Y., Breed M. D. Juvenile hormone and aggression in honey bees. J Insect Physiol 2001; 47: 1243–1247
   PubMed Web of Science ®Google Scholar
• Pessoa L. On the relationship between emotion and cognition. Nat Rev Neurosci 2008; 9: 148–158
   PubMed Web of Science ®Google Scholar
• Pick S., Strauss R. Goal-driven behavioral adaptations in gap-climbing Drosophila. Curr Biol 2005; 15: 1473–1478
   PubMedGoogle Scholar
• Plutchik R. Emotions: a general psychoevolutionary theory. Approaches to Emotion, K. Schere, P. Ekman. Erlbaum, Hillsdale, New JerseyUSA 1984; 197–219
   Google Scholar
• Popov A. V. Coevolution of sound-production and hearing in insects. Sensory Systems and Communication in Arthropods, F. G. Gribakin, K. Wiese, A. V. Popov. Basel/Boston/Berlin. Birkhäuser Verlag. 1990; 301–304
   Google Scholar
• Popov A. V., Peresleni A. I., Savateeva-Popova E. V., Wolf R., Heisenberg M. Role of mushroom bodies and the central complex of Drosophila melanogaster in the organization of courtship behavior and communicative vocalization. J Evol Biochem Physiol 2004; 40: 521–530
   Google Scholar
• Putz G., Heisenberg M. Memories in Drosophila heat-box learning. Learn Mem 2002; 9: 349–359
   PubMed Web of Science ®Google Scholar
• Ressler N. Rewards and punishments, goal-directed behavior, and consciousness. Neurosci Biobehav Rev 2004; 28: 27–39
   PubMed Web of Science ®Google Scholar
• Riemensperger T., Voller T., Stock P., Buchner E., Fiala A. Punishment prediction by dopaminergic neurons in Drosophila. Curr Biol 2005; 15: 1953–1960
   PubMed Web of Science ®Google Scholar
• Ringo J., Kananen M. K., Wood D. Aggression and mating success in 3 species of Drosophila. Z. Tierpsych- J Comparat Ethol 1983; 61: 341–350
   Google Scholar
• Rolls E. T. The Brain and Emotions. Oxford University Press, OxfordUK 1999
   Google Scholar
• Roth K. A., Katz R. J. Stress, behavioral arousal, and open field activity—a reexamination of emotionality in the rat. Neurosci Biobehav Rev 1979; 3: 247–263
   PubMed Web of Science ®Google Scholar
• Ruan H., Wu C. F. Social interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants. Proc Natl Acad Sci U S A 2008; 105: 7506–7510
   PubMed Web of Science ®Google Scholar
• Rubin G. M., Yandell M. D., Wortman J. R., Gabor Miklos G. L., Nelson C. R., Hariharan I. K., et al. Comparative genomics of the eukaryotes. Science 2000; 287: 2204–2215
   PubMed Web of Science ®Google Scholar
• Saraswati S., Fox L. E., Soll D. R., Wu C. F. Tyramine and octopamine have opposite effects on the locomotion of Drosophila larvae. J Neurobiol 2004; 58: 425–441
   PubMedGoogle Scholar
• Schapker H., Breithaupt T., Shuranova Z., Burmistrov Y., Cooper R. L. Heart and ventilatory measures in crayfish during environmental disturbances and social interactions. Comparat Biochem Physiol Part A Mol Integrat Physiol 2002; 131: 397–407
   PubMed Web of Science ®Google Scholar
• Schwaerzel M., Monastirioti M., Scholz H., Friggi-Grelin F., Birman S., Heisenberg M. Dopamine and octopamine differentiate between aversive and appetitive olfactory memories in Drosophila. J Neurosci 2003; 23: 10495–10502
   PubMed Web of Science ®Google Scholar
• Siegel R. W., Hall J. C. Conditioned responses in courtship behavior of normal and mutant Drosophila. Proc Natl Acad Sci U S A 1979; 76: 3430–3434
   PubMed Web of Science ®Google Scholar
• Sitaraman D., Zars M., Laferriere H., Chen Y. C., Sable-Smith A., Kitamoto T., et al. Serotonin is necessary for place memory in Drosophila. Proc Natl Acad Sci U S A 2008; 105: 5579–5584
   PubMed Web of Science ®Google Scholar
• Smith W. The Behavior of Communicating. Harvard University Press, Cambridge, MassachusettsUSA 1977
   Google Scholar
• Spruijt B. M., van Hooff J. A., Gispen W. H. Ethology and neurobiology of grooming behavior. Physiol Rev 1992; 72: 825–852
   PubMed Web of Science ®Google Scholar
• Stocker R. F. Taste perception: Drosophila—a model of good taste. Curr Biol 2004; 14: R560–R561
   PubMed Web of Science ®Google Scholar
• Strauss R., Heisenberg M. A higher control center of locomotor behavior in the Drosophila brain. J Neurosci 1993; 13: 1852–1861
   PubMed Web of Science ®Google Scholar
• Suh G. S., Wong A. M., Hergarden A. C., Wang J. W., Simon A. F., Benzer S., et al. A single population of olfactory sensory neurons mediates an innate avoidance behaviour in Drosophila. Nature 2004; 431: 854–859
   PubMed Web of Science ®Google Scholar
• Tarantino L. M., Bucan M. Dissection of behavior and psychiatric disorders using the mouse as a model. Hum Mol Genet 2000; 9: 953–965
   PubMed Web of Science ®Google Scholar
• Tempel B. L., Bonini N., Dawson D. R., Quinn W. G. Reward learning in normal and mutant Drosophila. Proc Natl Acad Sci U S A 1983; 80: 1482–1486
   PubMed Web of Science ®Google Scholar
• Tinette S., Zhang L., Robichon A. Cooperation between Drosophila flies in searching behavior. Genes Brain Behav 2004; 3: 39–50
   PubMed Web of Science ®Google Scholar
• Ting C. Y., Lee C. H. Visual circuit development in Drosophila. Curr Opin Neurobiol 2007; 17: 65–72
   PubMed Web of Science ®Google Scholar
• Tully T., Quinn W. G. Classical conditioning and retention in normal and mutant Drosophila melanogaster. J Comparat Physiol A Sens Neural Behav Physiol 1985; 157: 263–277
   PubMed Web of Science ®Google Scholar
• van Dijken F. R., Stolwijk H., Scharloo W. Locomotor activity in Drosophila melanogaster. Netherlands J Zool 1977; 35: 438–454
   Google Scholar
• van Dijken F. R., van Sambeek M. P., Scharloo W. Divergent selection on locomotor activity in Drosophila melanogaster. III. Genetic analysis. Behav Genet 1979; 9: 563–570
   PubMedGoogle Scholar
• van Swinderen B., Flores K. A. Attention-like processes underlying optomotor performance in a Drosophila choice maze. Dev Neurobiol 2007; 67: 129–145
   PubMed Web of Science ®Google Scholar
• Wang L., Dankert H., Perona P., Anderson D. J. A common genetic target for environmental and heritable influences on aggressiveness in Drosophila. Proc Natl Acad Sci U S A 2008; 105: 5657–5663
   PubMedGoogle Scholar
• Wessells R. J., Bodmer R. Screening assays for heart function mutants in Drosophila. Biotechniques 2004; 37: 58–66
   PubMed Web of Science ®Google Scholar
• Wilson E. O. Sociobiology: The New Synthesis. Harvard University Press, Cambridge, MassachusettsUSA 1975
   Google Scholar
• Wilson E. O. The sociogenesis of insect colonies. Science 1985; 228: 1489–1495
   PubMed Web of Science ®Google Scholar
• Wolf F. W., Rodan A. R., Tsai L. T., Heberlein U. High-resolution analysis of ethanol-induced locomotor stimulation in Drosophila. J Neurosci 2002; 22: 11035–11044
   PubMed Web of Science ®Google Scholar
• Wolf M. E. Cocaine addiction: clues from Drosophila on drugs. Curr Biol 1999; 9: R770–R772
   PubMedGoogle Scholar
• Wu Q., Wen T., Lee G., Park J. H., Cai H. N., Shen P. Developmental control of foraging and social behavior by the Drosophila neuropeptide Y-like system. Neuron 2003; 39: 147–161
   PubMed Web of Science ®Google Scholar
• Wustmann G., Heisenberg M. Behavioral manipulation of retrieval in a spatial memory task for Drosophila melanogaster. Learn Mem 1997; 4: 328–336
   PubMed Web of Science ®Google Scholar
• Wustmann G., Rein K., Wolf R., Heisenberg M. A new paradigm for operant conditioning of Drosophila melanogaster. J Comparat Physiol A Sens. Neural Behav Physiol 1996; 179: 429–436
   PubMed Web of Science ®Google Scholar
• Yurkovic A., Wang O., Basu A. C., Kravitz E. A. Learning and memory associated with aggression in Drosophila melanogaster. Proc Natl Acad Sci U S A 2006; 103: 17519–17524
   PubMedGoogle Scholar
• Zhang K., Guo J. Z., Peng Y., Xi W., Guo A. Dopamine–mushroom body circuit regulates saliency-based decision making in Drosophila. Science 2007; 316: 1901–1904
   PubMed Web of Science ®Google Scholar
• Zornik E., Paisley K., Nichols R. Neural transmitters and a peptide modulate Drosophila heart rate. Peptides 1999; 20: 45–51
   PubMed Web of Science ®Google Scholar