197
Views
11
CrossRef citations to date
0
Altmetric
SPECIAL ISSUE ARTICLES

Tobacco Addiction and Pharmacogenetics of Nicotine Metabolism

&
Pages 262-271 | Received 13 Aug 2008, Published online: 01 Sep 2009

References

  • Amos C. I., Wu X., Broderick P., Gorlov I. P., Gu J., Eisen T., et al. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Gen 2008; 40: 616–622
  • Aubin H. J., Bobak A., Britton J. R., Oncken C., Billing C. B., Jr., Gong J., et al. Varenicline versus transdermal nicotine patch for smoking cessation: results from a randomised open-label trial. Thorax 2008; 63: 717–724
  • Benowitz N. L., Jacob P., III. Individual differences in nicotine kinetics and metabolism in man. Pharmacokinetics, Metabolism, and Pharmaceutics of Drugs of Abuse, R. S. Rapaka, N. Chiang, B. R. Martin. United States Department of Health and Human Services: National Institute on Drug Abuse, Bethesda, MDUSA 1997; 48–64
  • Benowitz N. L., Lessov C. N., Swan G. E., Jacob P., III. Female sex and oral contraceptive use accelerate nicotine metabolism. Clin Pharmacol Ther 2006a; 79: 480–488
  • Benowitz N. L., Swan G. E., Jacob P., III, Lessov-Schlaggar C. N., Tyndale R. F. CYP2A6 genotype and the metabolism and disposition kinetics of nicotine. Clin Pharmacol Ther 2006b; 80: 457–467
  • Benowitz N. L., Lessov-Schlaggar C. N., Swan G. E. Genetic influences in the variation in renal clearance of nicotine and cotinine. Clin Pharmacol Ther 2008; 84: 243–247
  • Berrettini W., Yuan X., Tozzi F., Song K., Francks C., Chilcoat H., et al. Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking. Mol Psychiatry 2008; 13: 368–373
  • Bierut L. J., Madden P. A. F., Breslau N., Johnson E. O., Hatsukami D., Pomerleau O. F., et al. Novel genes identified in a high density genome-wide association study for nicotine dependence. Hum Mol Genet 2007; 16: 24–35
  • Bierut, L. J., Stitzel, J. A., Wang, J. C., Hinrichs, A. L., Bertelsen, S., Fox, L., , et al.in press. An amino acid change in the alpha 5 nicotinic receptor increases risk for nicotine dependence. Am J Psychiatry.
  • Cascorbi H. F., Vesell E. S., Blake D. A., Helrich M. Genetic and environmental influence on halothane in twins. Clin Pharmacol Ther 1971; 12: 50–55
  • Chanock S. J., Hunter D. J. Genomics: when the smoke clears. Nature 2008; 452: 537–538
  • David S. P., Brown R. A., Papandonatos G. D., Kahler C. W., Lloyd-Richardson E. E., Munafò M. R., et al. Pharmacogenetic clinical trial of sustained-release bupropion for smoking cessation. Nicotine Tobacco Res 2007; 9: 821–833
  • Dorus E., Pandey G. N., Davis J. M. Genetic determinants of lithium ion distribution. Arch Gen Psychiatry 1975; 32: 1097–1102
  • Evans W. E., Johnson J. A. Pharmacogenomics: the inherited basis for interindividual differences in drug response. Annu Rev Genomics Hum Genet 2001; 2: 9–39
  • Evans W. E., Relling M. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 1999; 286: 487–491
  • Frueh, F. W. 2006. Pharmacogenomics: patient selection for clinical trial participation and enrichment strategies. Available at: http://www.fda.gov/cder/genomics/presentations.htm. Accessed on August 12, 2008.
  • Grassi G., Seravalle G., Calhoun D. A., Bolla G. B., Giannattasio C., Marabini M., et al. Mechanisms responsible for sympathetic activation by cigarette smoking in humans. Circulation 1994; 90: 248–253
  • Hart M. N., Wang S., Nakamoto K., Wesselman C., Li Y., Zhong X. Genetic polymorphisms in cytochrome P450 oxidoreductase infleunce microsomal P450-catalyzed drug metabolism. Pharmacogenet Genomics 2008; 18: 11–24
  • Heatherton T. F., Kozlowski L. T., Frecker R. C., Fagerström K. O. The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. British Journal of Addiction 1991; 86: 1119–1127
  • Howard L. A., Ahluwalia J. S., Lin S. K., Sellers E. M., Tyndale R. F. CYP2E1*1D regulatory polymorphism: association with alcohol and nicotine dependence. Pharmacogenetics 2003; 13: 321–328
  • Huang S.-M., Goodsaid F., Rahman A., Frueh F., Lesko L. J. Application of pharmacogenomics in clinical pharmacology. Toxicol Mech Meth 2006; 16: 89–99
  • Hughes, J. R., Stead, L. F., Lancaster, T. 2007. Antidepressants for smoking cessation. Cochrane Database Syst Rev, CD000031.
  • Hung R. J., McKay J. D., Gaborieau V., Boffetta P., Hashibe M., Zaridze D., et al. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature 2008; 452: 633–637
  • Hukkanen J., Jacob P., III, Benowitz N. L. Metabolism and disposition kinetics of nicotine. Pharmacol Rev 2005; 57: 79–115
  • Itoh M., Nakajima M., Higashi E., Yoshida R., Nagata K., Yamazoe Y., et al. Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha. J Pharmacol Exp Ther 2006; 319: 693–702
  • Javitz H. S., Swan G. E., Zbikowski S. M., et al. Cost-effectiveness of different combinations of bupropion SR dose and behavioral treatment for smoking cessation: a societal perspective. Am J Manag Care 2004a; 10: 217–226
  • Javitz H. S., Swan G. E., Zbikowski S. M., et al. Return on investment of different combinations of bupropion SR dose and behavioral treatment for smoking cessation in a health care setting: an employer's perspective. Value Health 2004b; 7: 535–543
  • Lerman C., Shields P. G., Wileyto E. P., Audrain J., Hawk L. H., Jr, Pinto A., et al. Effects of dopamine transporter and receptor polymorphisms on smoking cessation in a bupropion clinical trial. Health Psychol 2003; 22: 541–548
  • Lerman C., Tyndale R., Patterson F., Wileyto E. P., Shields P. G., Pinto A., et al. Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation. Clin Pharmacol Ther 2006; 79: 600–608
  • Lessov-Schlaggar C. N., Pergadia M. L., Khroyan T. V., Swan G. E. Genetics of nicotine dependence and pharmacotherapy. Biochem Pharmacol 2008; 75: 178–195
  • Li G. H., Faulhaber H. D., Rosenthal M., Schuster H., Jordan J., Timmermann B., et al. Beta-2 adrenergic receptor gene variations and blood pressure under stress in normal twins. Psychophysiology 2001; 38: 485–489
  • Malaiyandi V., Goodz S. D., Sellers E. M., Tyndale R. F. CYP2A6 genotype, phenotype, and the use of nicotine metabolites as biomarkers during ad libitum smoking. Cancer Epidemiol Biomarkers Prev 2006; 15: 1812–1819
  • Mathers C. D., Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006; 3: 2011–2030
  • McCaffery J. M., Pogue-Geile M. F., Ferrell R. E., Petro N., Manuck S. B. Variability within alpha- and beta-adrenoreceptor genes as a predictor of cardiovascular function at rest and in response to mental challenge. J Hypertens 2002; 20: 1105–1114
  • McCaffery J. M., Bleil M., Pogue-Geile M. F., Ferrell R. E., Manuck S. B. Allelic variation in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cardiovascular reactivity in young adult male and female twins of European-American descent. Psychosom Med 2003; 65: 721–728
  • McClure J., Swan G. E. Tailoring nicotine replacement therapy: rationale and potential approaches. CNS Drugs 2006; 20: 281–291
  • Meyer U. A. Pharmacogenetics—five decades of therapeutic lessons from genetic diversity. Nat Rev Genet 2004; 5: 669–676
  • Moolchan E. T., Hudson D. L., Schroeder J. R., Sehnert S. S. Heart rate and blood pressure responses to tobacco smoking among African-American adolescents. J Natl Med Assoc 2004; 96: 767–771
  • Mwenifumbo J. C., Lessov-Schlaggar C. N., Zhou Q., Krassnow R. E., Swan G. E., Benowitz N. L., et al. Identification of novel CYP2A6*1B variants; the CYP2A6*1B allele is associated with faster in, vivo nicotine metabolism. Clin Pharmacol Ther 2008; 83: 115–121
  • Nakajima M., Tanaka E., Kwon J. T., Yokoi T. Characterization of nicotine and cotinine N-glucuronidations in human liver microsomes. Drug Metab Dispos 2002; 30: 1484–1490
  • Neale M. C., Cardon L. Methodology for Genetic Studies of Twins and Families. Kluwer Academic Publishers, Dordect/Boston/London 1992
  • Neale M. C., Boker S. M., Xie G., Maes H. H. Mx: Statistical Modeling6th ed. Department of Psychiatry, Virginia Commonwealth University, Richmond, VirginiaUSA 2002
  • Niaura R., Shadel W. G., Goldstein M. G., Hutchinson K. E., Abrams D. B. Individual differences in responses to the first cigarette following overnight abstinence in regular smokers. Nicotine Tobacco Res 2001; 3: 37–44
  • O'Loughlin J., Paradis G., Kim W., DiFranza J., Meshefedjian G., McMillan-Davey E., et al. Genetically decreased CYP2A6 and the risk of tobacco dependence: a prospective study of novice smokers. Tobacco Contr 2004; 13: 422–428
  • Pomerleau O. F., Collins A. C., Shiffman S., Pomerleau C. S. Why some people smoke and others do not: new perspectives. J Consult Clin Psychol 1993; 61: 723–731
  • Rieder M. J., Reiner A. P., Gage B. F., Nickerson D. A., Eby C. S., McLeod H. L., et al. Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose. N Engl J Med 2005; 352: 2285–2293
  • Rubin, D. 2002. PharmGKB: The Pharmacogenetics Knowledge Base. Available at: http://infolab.stanford.edu/infoseminar/Archive/WinterY2002/rubin.pdf. Accessed on August 12, 2008.
  • Saccone S. F., Hinrichs A. L., Saccone N. L., Chase G. A., Konvicka K., Madden P. A. F., et al. Cholinergic nicotinic receptor genes implicated in a nicotine-dependence association study targeting 348 candidate genes with 3,713 SNPs. Hum Mol Genet 2007; 16: 36–49
  • SAS Institute, SAS for Windows, version 9.1. Cary, North CarolinaUSA: SAS Institute, Inc., copyright 2002–2003.
  • Silagy, C., Lancaster, T., Stead, L., Mant, D., Fowler, G. 2004. Nicotine replacement therapy for smoking cessation. Cochrane Database Syst Rev, CD000146.
  • Snieder H., Harshfield G. A., Barbeau P., Pollock D. M., Pollock J. S., Treiber F. A. Dissecting the genetic architecture of the cardiovascular and renal stress response. Biolog Psychol 2002; 61: 73–95
  • Stolerman I. P., Jarvis M. J. The scientific case that nicotine is addictive. Psychopharmacology 1995; 117: 2–10
  • Swan G. E., Jack L. M., Ward M. M. Subgroups of smokers with different success rates after use of transdermal nicotine. Addiction 1997; 92: 207–218
  • Swan G. E., Benowitz N. L., Jacob P., III, Lessov C. N., Tyndale R. F., Wilhelmsen K., et al. Pharmacogenetics of nicotine metabolism in twins: methods and procedures. Twin Res 2004; 7: 435–448
  • Swan G. E., Benowitz N. L., Lessov C. N., Jacob P., III, Tyndale R. F., Wilhelmsen K. Nicotine metabolism: the impact of CYP2A6 on estimates of additive genetic influence. Pharmacogenet Genomics 2005a; 15: 115–125
  • Swan G. E., Valdes A. M., Ring H. Z., Khroyan T. V., Jack L. M., Ton C. C., et al. Dopamine receptor DRD2 genotype and smoking cessation outcome following treatment with bupropion SR. Pharmacogenomics J 2005b; 5: 21–29
  • Swan G. E., Hops H., Wilhelmsen K. C., Lessov C. N., Cheng L.S-C., Hudmon K. S., et al. A genome-wide screen for nicotine dependence susceptibility loci. Am J Med Genet B Neuropsychiatric Genet 2006; 141: 354–360
  • Swan G. E., Jack L. M., Valdes A. M., Ring H. Z., Ton C. C., Curry S. J., et al. Joint effect of dopaminergic genes on likelihood of smoking following treatment with bupropion SR. Health Psychol 2007a; 26: 361–368
  • Swan G. E., Lessov-Schlaggar C. N., Krasnow R. E., Wilhelmsen K. C., Jacob P., III, Benowitz N. L. Genetic and environmental sources of variation in heart rate response to infused nicotine in twins. Cancer Epidemiol Biomarkers Prev 2007b; 16: 1057–1064
  • Swan G. E., Jack L. M., Javitz H., McAfee T., McClure J. M. Predictors of 12-month outcome in smokers who received bupropion SR for smoking cessation. CNS Drugs 2008; 22: 239–256
  • Swan, G. E., Lessov-Schlaggar, C. N., Bergen, A. W., He, Y., Tyndale, R. F., Benowitz, N. L. in press. Genetic and environmental influences on the ratio of 3'hydroxycotinine to cotinine in plasma and urine. Pharmacogenet Genomics.
  • Thorgeirsson T. E., Geller F., Sulem P., Rafnar T., Wiste A., Magnusson K. P., et al. Variant associated with nicotine dependence, lung cancer, and peripheral arterial disease. Nature 2008; 452: 638–642
  • Uhl G. R., Drgon T., Johnson C., Fatusin O. O., Liu Q. R., Contoreggi C., et al. “Higher order” addiction molecular genetics: convergent data from genomewide association in humans and mice. Biochem Pharmacol 2008a; 75: 98–111
  • Uhl G. R., Liu Q. R., Drgon T., Johnson C., Walther D., Rose J. E., et al. Molecular genetics of successful smoking cessation: convergent genomewide association study results. Arch Gen Psychiatry 2008b; 65: 683–693
  • Vesell E. S., Page J. G., Passanti T. G. Genetic and environmental factors affecting ethanol metabolism in man. Clin Pharmacol Ther 1971; 12: 192–201
  • Vesell E. S. The influence of host factors on drug response. VII. Implications for interpretation of clinical trials and other published studies on drug response in man. Rational Drug Ther 1981; 15: 1–5
  • Weber W. W. Pharmacogenetics. Oxford University Press, New York 1997
  • Weinshilboum R. M., Wang L. Pharmacogenetics and pharmacogenomics: development, science, and translation. Annu Rev Genomics Human Genet 2006; 7: 223–245
  • Williams R. B., Marchuk D. A., Gadde K. M., Barefoot J. C., Grichnik K., Helms M. J., et al. Central nervous system serotonin function and cardiovascular responses to stress. Psychosom Med 2001; 63: 300–305
  • World Health Organization. The Tobacco Atlas . 2002. Available at: http://www.who.int/tobacco/statistics/tobacco_atlas. Accessed on December 17, 2008.
  • Yamanaka H., Nakajima M., Fukami T., Sakai H., Nakamura A., Katoh M., et al. CYP2A6 and CYP2B6 are involved in nornicotine formation from nicotine in humans: interindividual differences in these contributions. Drug Metab Dispos 2005; 33: 1811–1818
  • Yin T., Miyata T. Warfarin dose and the pharmacogenomics of CYP2C9 and VKORC1—rationale and perspectives. Thromb Res 2007; 120: 1–10
  • Zevin S., Schaner M. E., Giacomini K. M. Nicotine transport in a human choriocarcinoma cell line (JAR). J Pharmaceut Sci 1998; 87: 702–706
  • Zhang L., Rao F., Wessel J., Kennedy B. P., Rana B. K., Taupenot L., et al. Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins. Physiolog Genomics 2004; 19: 277–291

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.