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Basic Research

Comparative ultrastructural hepatic alterations induced by free and liposome-encapsulated mefenamic acid

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Pages 335-345 | Received 18 Nov 2016, Accepted 28 Jun 2017, Published online: 22 Aug 2017

References

  • Chaudhary A. Pharmaceutical Chemistry-VI, Medicinal Chemistry-II. First ed. India, Meerut: Krishna Prakashan Media (P) Ltd, 2010.
  • Gligore V, Bolosiu H. Mefenamic acid in the treatment of rheumatoid arthritis and related diseases. J Int Med Res. 1974;2(2):153–155.
  • Khubchandani RP, Ghatikar KN, Keny S, et al. Choice of antipyretic in children. J Assoc Physicians India 1995;43(9):614–616.
  • Moll R, Derry S, Moore RA, et al. Single dose oral mefenamic acid for acute postoperative pain in adults. Cochrane Database Syst Rev. 2011;16(3):CD007553.
  • Warner TD, Giuliano F, Vojnovic I, et al. Nonsteroid drug selectivity for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proc Natl Acad Sci. 1999;96(13):7563–7568.
  • Kliachkin BM, Basargin ST, Timofeev IV, et al. The effect of mefenamic acid on the immunity indices and hemostatic system in cancer patients and on the cathepsin D-like protease activity in the tissues in cancer of the large intestine. Vopr Onkol. 1992;38:792–797.
  • Bauman DR, Rudnick SI, Szewczuk LM, et al. Development of nonsteroidal anti-inflammatory drug analogs and steroid carboxylates selective for human aldo-keto reductase isoforms: Potential antineoplastic agents that work independently of cyclooxygenase isozymes. Mol Pharmacol. 2005;67:60–68.
  • Hashemipour MA, Honarmand HM, Falsafi F, et al. In vitro cytotoxic effects of celecoxib, mefenamic acid, aspirin and indomethacin on several cells lines. J Den (Shiraz). 2016;17:219–225.
  • Joo Y, Kim HS, Woo RS, et al. Mefenamic acid shows neuroprotective effects and improves cognitive impairment in vitro and in vivo Alzheimer’s disease models. Mol Pharmacol. 2006;69:76–84.
  • Khansari PS, Halliwell RF. Evidence for neuroprotection by the fenamate NSAID, mefenamic acid. Neurochem Int. 2009;55(7):683–688.
  • Armagan G, Seygili E, Turunc E, et al. Effect of mefenamic acid on some of the base excision repair enzymes against D-serine-induced neurotoxicity. Turk J Pharm Sci. 2016;13(1):103–114.
  • Cimolai, N. The potential and promise of mefenamic acid. Expert Rev Clin Pharmacol. 2013;6(3):289–305.
  • Myles AB, Bacon PA, Williams KA. Mefenamic acid in rheumatoid arthritis. Ann Rheum Dis. 1967;26:494–498.
  • Tafazoli S, Spehar DD, O’brien PJ. Oxidative stress mediated idiosyncratic drug toxicity. Drug Met Rev. 2005;37:311–325.
  • Rodríguez L, Williams R, Derby LE, et al. Acute liver injury associated with nonsteroidal anti-inflammatory drugs and the role of risk factors. Arch Int Med. 1994;154:311–316.
  • Masubuchi Y, Saito H, Horie T. Structural requirements for the hepatotoxicity of nonsteroidal anti-inflammatory drugs in isolated rat hepatocytes. J Pharmacol Exp Ther. 1998;287:208–213.
  • Somchit N, Sanat F, Gan EH, et al. Liver injury induced by the non-steroidal antiinflammatory drug mefenamic acid. Singapore Med J. 2004;45(11):530–532.
  • Derle DV, Bele M, Kasliwal N. In vitro and in vivo evaluation of mefenamic acid and its complexes with β-cyclodextrin and HP-β-cyclodextrin. Asian J Pharm. 2014;2:30–34.
  • Mudit D, Bhardwaj Y, Keshavarao P, et al. Enhancing solubility and dissolution of mefenamic acid by freeze drying using b-cyclodextrin. Int Res J Pharm. 2011;2:146–150.
  • Rao KS, Nagabhushanam M, Chowdary K. In vitro dissolution studies on solid dispersions of mefenamic acid. Indian J Pharm Sci. 2011;73(2):243–247.
  • Kulkarni PR, Yadav J, Vaidya K, et al. Liposomes: A novel drug delivery system. Int J Curr Pharm Res. 2011;3(2):10–18.
  • van Rooijen N, van Nieuwmegen R. Use of liposomes as biodegradable and harmless adjuvants. Methods Enzymol. 1983;9:83–95.
  • Chiong H, Hakim MN, Sulaiman MR, et al. Development and characterization study of liposomes-encapsulated piroxicam. Int J Drug Del. 2011;3(1):64–37.
  • Goh JZ, Chiong HS, Zuraini A, et al. Rapid spectrophotometric determination, characterization and anti-inflammatory efficacy evaluation of nanoencapsulated diclofenac sodium. J Drug Del Sci Technol. 2014;24(4):361–366.
  • Hayat MA. Principles and Techniques of Electron Microscopy, Biological Applications. Fourth ed. Cambridge: Cambridge University Press, 2000.
  • Uyemura SA, Santos AC, Mingatto FE, et al. Diclofenac sodium and mefenamic acid: Potent inducers of the membrane permeability transition in renal cortex mitochondria. Arch Biochem Biophys. 1997;342(2):231–235.
  • Suwalsky M, Manrique-Moreno M, Howe J, et al. Molecular interactions of mefenamic acid with lipid bilayers and red blood cells. J Braz Chem Soc. 2011;22(12):2243–2249.
  • Singh A, Bhat T, Sharma OP. Clinical biochemistry and hepatotoxicity. J Clin Toxicol. 2011;4:11–18.
  • Zhang X, Li C, Gong Z, et al. Development of a convenient in vivo hepatotoxin assay using a transgenic zebrafish line with liver-specific DsRed Expression. PLoS One 2014;9(3):e91874.
  • Tatematsu Y, Hayash H, Taguch R, et al. Effect of N-phenylanthranilic acid scaffold nonsteroidal anti-inflammatory drugs on the mitochondrial permeability transition. Biol Pharm Bull. 2016;39(2):278–284.
  • Shashi K, Satinder K, Bharat P. A complete review on: Liposomes. Int Res J Pharm. 2012;3(7):10–17.
  • Sailaja AK, Shashikala P. An overall review on liposomal drug delivery systems. Indian J Novel Drug Delivery 2014;6(2):112–119.
  • Allen TM, Cullis PR. Liposomal drug delivery systems: From concept to clinical applications. ADV Drug Deliver Rev. 2013;65(1):36–48.
  • Samad A, Sultana Y, Aqil M. Liposomal drug delivery systems: An update review. Curr Drug Deliv. 2007;4(4):297–305.
  • Szebeni J, Moghimi SM. Liposome triggering of innate immune responses: A perspective on benefits and adverse reactions. J Liposome Res. 2009;19:85–90.
  • Kegel V, Pfeiffer E, Burkhardt B, et al. Subtoxic concentrations of hepatotoxic drugs lead to Kupffer cell activation in a human in vitro liver model: An approach to study DILI. Mediat Inflamm. 2015; Article ID 640631:1–14.
  • Neyrinck A. Modulation of Kupffer cell activity: Physio-pathological consequences on hepatic metabolism. Bull Mem Acad R Med Belg. 2004;159(5–6):358–366.
  • Oligny LL, Lough J. Hepatic sinusoidal ectasia. Hum Pathol. 1992;23:953–956.
  • Buko V, Ergov A, Karput S, et al. Mitochondrial respiration and oxidative phosphorylation in thioacetamide-induced liver necrosis. Toxicol Lett. 1998;95:162–165.
  • Lenaz G. The mitochondrial production of reactive oxygen species: Mechanisms and implications in human pathology. IUBMB Life 2001;52(3–5):159–164.
  • El-Shenawy NS. Oxidative stress responses of rats exposed to roundup and its active ingredient glyphosate. Environ Toxicol Pharmacol. 2009;28:379–385.
  • Xia T, Kovochich M, Brant J, et al. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett. 2006;6(8):1794–1807.
  • Braydich-Stolle L, Hussain S, Schlager JJ, et al. In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol Sci. 2005;88:412–419.
  • Ahn T, Kim M, Yun CH, et al. Functional regulation of hepatic cytochrome p450 enzymes by physicochemical properties of phospholipids in biological membranes. Curr Protein Pept Sci. 2007;8(5):496–505.
  • Allen T. Toxicity of drug carriers to the mononuclear phagocyte system. ADV Drug Deliv Rev. 1988;2:55–67.
  • Yu HY, Lin CY. Uptake of charged liposomes by the rat liver. J Formos Med Assoc. 1997; 96:409–413.
  • Michaeli S, Galili G. Degradation of organelles or specific organelle components via selective autophagy in plant cells. Int J Mol Sci. 2014;15(5):7624–7638.
  • Bernales S, Schuck S, Walter P. ER-phagy: Selective autophagy of the endoplasmic reticulum. Autophagy 2007;3(3):285–287.
  • Eom E, Choi J. p38 MAPK activation, DNA damage, cell cycle arrest and apoptosis as mechanisms of toxicity of silver nanoparticles in Jurkat T cells. Environ Sci Technol. 2010;44(21):8337–8342.
  • Pandey G, Srivastava D, Madhuri S. Anatomical and histological study of the effect of lead on hepatocytes of Albino rats. Toxicol Int. 2008;15(1):69–70.

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