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Articles

A randomised trial comparing the efficacy and safety of topical ketoprofen in Transfersome® gel (IDEA-033) with oral ketoprofen and drug-free ultra-deformable Sequessome™ vesicles (TDT 064) for the treatment of muscle soreness following exercise

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Pages 88-95 | Accepted 26 Mar 2015, Published online: 20 Apr 2015

References

  • Al-Saeed, A. (2011). Gastrointestinal and cardiovascular risk of nonsteroidal anti-inflammatory drugs. Oman Medical Journal, 26, 385−391. doi:10.5001/omj.2011.101
  • Bagheri, H., Lhiaubet, V., Montastruc, J. L., & Chouini-Lalanne, N. (2000). Photosensitivity to ketoprofen: Mechanisms and pharmacoepidemiological data. Drug Safety, 22, 339–349. doi:10.2165/00002018-200022050-00002
  • Cevc, G., & Blume, G. (1992). Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1104, 226–232. doi:10.1016/0005-2736(92)90154-E
  • Cevc, G., & Gebauer, D. (2003). Hydration-driven transport of deformable lipid vesicles through fine pores and the skin barrier. Biophysical Journal, 84, 1010–1024. doi:10.1016/S0006-3495(03)74917-0
  • Conaghan, P. G. (2012). A turbulent decade for NSAIDs: Update on current concepts of classification, epidemiology, comparative efficacy, and toxicity. Rheumatology International, 32, 1491−1502. doi:10.1007/s00296-011-2263-6
  • Conaghan, P. G., Bijlsma, J. W., Kneer, W., Wise, E., Kvien, T. K., & Rother, M. (2014). Drug-free gel containing ultra-deformable phospholipid vesicles (TDT 064) as topical therapy for the treatment of pain associated with osteoarthritis: A review of clinical efficacy and safety. Current Medical Research and Opinion, 30, 599−611. doi:10.1185/03007995.2013.860018
  • Conaghan, P. G., Dickson, J., Bolten, W., Cevc, G., & Rother, M. (2013). A multicentre, randomized, placebo- and active-controlled trial comparing the efficacy and safety of topical ketoprofen in Transfersome gel (IDEA-033) with ketoprofen-free vehicle (TDT 064) and oral celecoxib for knee pain associated with osteoarthritis. Rheumatology, 52, 1303−1312. doi:10.1093/rheumatology/ket133
  • Elder, C. L., Dahners, L. E., & Weinhold, P. S. (2001). A cyclooxygenase-2 inhibitor impairs ligament healing in the rat. American Journal of Sports Medicine, 29, 801−805.
  • Ferry, S. T., Dahners, L. E., Afshari, H. M., & Weinhold, P. S. (2007). The effects of common anti-inflammatory drugs on the healing rat patellar tendon. American Journal of Sports Medicine, 35, 1326−1333. doi:10.1177/0363546507301584
  • Harirforoosh, S., & Jamali, F. (2009). Renal adverse effects of nonsteroidal anti-inflammatory drugs. Expert Opinion on Drug Safety, 8, 669−681. doi:10.1517/14740330903311023
  • Heyneman, C. A., Lawless-Liday, C., & Wall, G. C. (2000). Oral versus topical NSAIDs in rheumatic diseases. Drugs, 60, 555−574. doi:10.2165/00003495-200060030-00004
  • Hills, B. A. (1995). Remarkable anti-wear properties of joint surfactant. Annals of Biomedical Engineering, 23, 112–115. doi:10.1007/BF02368318
  • Hills, B. A., & Monds, M. K. (1998). Deficiency of lubricating surfactant lining the articular surfaces of replaced hips and knees. British Journal of Rheumatology, 37, 143−147. doi:10.1093/rheumatology/37.2.143
  • Klinge, S. A., & Sawyer, G. A. (2013). Effectiveness and safety of topical versus oral nonsteroidal anti-inflammatory drugs: A comprehensive review. The Physician and Sportsmedicine, 41, 64−74. doi:10.3810/psm.2013.05.2016
  • Kneer, W., Rother, I., Rother, M., & Seidel, E., IDEA-033-III-01 Study Group. (2009). A multiple-dose, open-label, safety, compliance, and usage evaluation study of epicutaneously applied Diractin (ketoprofen in Transfersome) in joint/musculoskeletal pain or soft tissue inflammation. Current Drug Safety, 4, 5−10. doi:10.2174/157488609787354468
  • Kneer, W., Rother, M., Mazgareanu, S., & Seidel, E. J. European IDEA-033 study group (2013) A 12-week randomized study of topical therapy with three dosages of ketoprofen in Transfersome® gel (IDEA-033) compared with the ketoprofen-free vehicle (TDT 064), in patients with osteoarthritis of the knee. Journal of Pain Research, 6, 743−753.
  • Nieman, D. C., Henson, D. A., Dumke, C. L., Oley, K., McAnulty, S. R., Davis, J. M., … Morrow, J. D. (2006). Ibuprofen use, endotoxemia, inflammation, and plasma cytokines during ultramarathon competition. Brain, Behavior and Immunity, 20, 578–584. doi:10.1016/j.bbi.2006.02.001
  • Nikanne, E., Kokki, H., Salo, J., & Linna, T. J. (2005). Celecoxib and ketoprofen for pain management during tonsillectomy: A placebo-controlled clinical trial. Otolaryngology – Head and Neck Surgery, 132, 287−294. doi:10.1016/j.otohns.2004.09.005
  • Rother, M., & Conaghan, P. G. (2013). A randomized, double-blind, phase III trial in moderate osteoarthritis knee pain comparing topical ketoprofen gel with ketoprofen-free gel. Journal of Rheumatology, 40, 1742−1748. doi:10.3899/jrheum.130192
  • Rother, M., Yeoman, G., & Ekman, E. (2012). A double-blind, placebo-controlled trial comparing the safety and efficacy of epicutaneously applied ketoprofen in Transfersome gel with naproxen for the treatment of pain associated with osteoarthritis (OA) of the knee. Poster session presented at EULAR. Berlin.
  • Shen, W., Li, Y., Tang, Y., Cummins, J., & Huard, J. (2005). NS-398, a cyclooxygenase-2-specific inhibitor, delays skeletal muscle healing by decreasing regeneration and promoting fibrosis. The American Journal of Pathology, 167, 1105−1117. doi:10.1016/S0002-9440(10)61199-6
  • Warden, S. J. (2009). Prophylactic misuse and recommended use of non-steroidal anti-inflammatory drugs by athletes. British Journal of Sports Medicine, 43, 548−549. doi:10.1136/bjsm.2008.056697
  • Warden, S. J. (2010). Prophylactic use of NSAIDs by athletes: A risk/benefit assessment. The Physician and Sportsmedicine, 38, 132−138. doi:10.3810/psm.2010.04.1770
  • Warner, D. C., Schnepf, G., Barrett, M. S., Dian, D., & Swigonski, N. L. (2002). Prevalence, attitudes, and behaviors related to the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in student athletes. Journal of Adolescent Health, 30, 150−153. doi:10.1016/S1054-139X(01)00325-1
  • Wilcox, C. M., Cryer, B., & Triadafilopoulos, G. (2005). Patterns of use and public perception of over-the-counter pain relievers: Focus on nonsteroidal antiinflammatory drugs. Journal of Rheumatology, 32, 2218−2224.

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