163
Views
8
CrossRef citations to date
0
Altmetric
Research Article

Design of PEG-grafted-PLA nanoparticles as oral permeability enhancer for P-gp substrate drug model Famotidine

, , &
Pages 91-103 | Received 11 Oct 2016, Accepted 30 Jan 2017, Published online: 10 Mar 2017

References

  • Akhtar N, Ahad A, Khar RK, Jaggi M, Aqil M, Iqbal Z, Ahmad FJ, Talegaonkar S. The emerging role of P-glycoprotein inhibitors in drug delivery: A patent review. Expert Opin Ther Pat, 2011;21:561–76.
  • Artursson P, Palm K, Luthman K. Caco-2 monolayers in experimental and theoretical predictions of drug transport. Adv Drug Deliv Rev, 2012;64(Supplement):280–9.
  • Ashiru-Oredope DAI, Patel N, Forbes B, Patel R, Basit AW. The effect of polyoxyethylene polymers on the transport of ranitidine in Caco-2 cell monolayers. Int J Pharm, 2011;409:164–8.
  • Aulton ME. Aulton’s pharmaceutics: the design and manufacture of medicines. 3rd ed. Edinburgh; New York: Churchill Livingstone; 2007.
  • Avgoustakis K, Beletsi A, Panagi Z, Klepetsanis P, Karydas AG, Ithakissios DS. PLGA-mPEG nanoparticles of cisplatin: In vitro nanoparticle degradation, in vitro drug release and in vivo drug residence in blood properties. J Control Release, 2002;79:123–35.
  • Bala I, Hariharan S, Kumar M. PLGA nanoparticles in drug delivery: The state of the art. Crit Rev Ther Drug Carrier Syst, 2004;21:387–422.
  • Baseer A, Hassan F, Hassan SF, Jabeen SJ, Israr F, Murtaza G, Haque N.. Physico-chemical comparison of famotidine tablets prepared via dry granulation and direct compression techniques. Pak J Pharm Sci, 2013;26:439–43.
  • Bhardwaj V, Hariharan S, Bala I, Lamprecht A, Kumar N, Panchagnula R, Kumar M. Pharmaceutical aspects of polymeric nanoparticles for oral drug delivery. J Biomed Nanotechnol, 2005;1:235–58.
  • Choi KM, Choi MC, Han DH, Park TS, Ha CS. Plasticization of poly(lactic acid) (PLA) through chemical grafting of poly(ethylene glycol) (PEG) via in situ reactive blending. Eur Polym J, 2013;49:2356–64.
  • Collnot EM, Baldes C, Wempe MF, Kappl R, Hüttermann J, Hyatt JA, Edgar KJ, Schaefer UF, Lehr CM. Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: Influence on ATPase activity and membrane fluidity. Mol Pharm, 2007;4:465–74.
  • Dahan A, Amidon GL. Segmental dependent transport of low permeability compounds along the small intestine due to P-glycoprotein: The role of efflux transport in the oral absorption of BCS class III drugs. Mol Pharm, 2008;6:19–28.
  • Elmowafy E, Awad G, Mansour S, El-Shamy A. Release mechanisms behind polysaccharides-based famotidine controlled release matrix tablets. AAPS PharmSciTech, 2008;9:1230–9.
  • Essa S, Rabanel JM, Hildgen P. Effect of polyethylene glycol (PEG) chain organization on the physicochemical properties of poly(d, l-lactide) (PLA) based nanoparticles. Eur J Pharm Biopharm, 2010;75:96–106.
  • Estudante M, Morais JG, Soveral G. a, Benet LZ. Intestinal drug transporters: An overview. Adv Drug Deliv Rev, 2013;65:1340–56.
  • Ferenczy GG, Parkanyi L, Angyan JG, Kalman A, Hegedus B. Crystal and electronic structure of two polymorphic modifications of famotidine. An experimental and theoretical study. J Mol Struct Theochem, 2000;503:73–9.
  • Gaumet M, Vargas A, Gurny R, Delie F. Nanoparticles for drug delivery: The need for precision in reporting particle size parameters. Eur J Pharm Biopharm, 2008;69:1–9.
  • Gorner T, Gref R, Michenot D, Sommer F, Tran MN, Dellacherie E. Lidocaine-loaded biodegradable nanospheres. I. Optimization of the drug incorporation into the polymer matrix. J Control Release, 1999;57:259–68.
  • Govender T, Stolnik S, Garnett MC, Illum L, Davis SS. PLGA nanoparticles prepared by nanoprecipitation: Drug loading and release studies of a water soluble drug. J Control Release, 1999;57:171–85.
  • Gref R, Miralles G, Dellacherie É. Polyoxyethylene-coated nanospheres: Effect of coating on zeta potential and phagocytosis. Polym Int, 1999;48:251–6.
  • Hassouna F, Raquez JM, Addiego F, Dubois P, Toniazzo V, Ruch D. New approach on the development of plasticized polylactide (PLA): Grafting of poly(ethylene glycol) (PEG) via reactive extrusion. Eur Polym J, 2011;47:2134–44.
  • Hawley A, Illum L, Davis S. Preparation of biodegradable, surface engineered PLGA nanospheres with enhanced lymphatic drainage and lymph node uptake. Pharm Res, 1997;14:657–61.
  • Hugger ED, Audus KL, Borchardt RT. Effects of poly(ethylene glycol) on efflux transporter activity in Caco-2 cell monolayers. J Pharm Sci, 2002a;91:1980–90.
  • Hugger ED, Novak BL, Burton PS, Audus KL, Borchardt RT. A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro. J Pharm Sci, 2002b;91:1991–2002.
  • Hugger ED, Cole CJ, Raub TJ, Burton PS, Borchardt RT. Automated analysis of polyethylene glycol-induced inhibition of P-glycoprotein activity in vitro. J Pharm Sci, 2003;92:21–6.
  • Hunter A, Elsom CJ, Wibroe PP, Moghimi SM. Polymeric particulate technologies for oral drug delivery and targeting: A pathophysiological perspective. Nanomed Nanotechnol Biol Med, 2012;8(Supplement 1):S5–20.
  • Iqbal J, Hombach J, Matuszczak B, Bernkop-Schnurch A. Design and in vitro evaluation of a novel polymeric P-glycoprotein (P-gp) inhibitor. J Control Release, 2010;147:62–9.
  • Jiang T, Han N, Zhao B, Xie Y, Wang S. Enhanced dissolution rate and oral bioavailability of simvastatin nanocrystal prepared by sonoprecipitation. Drug Dev Ind Pharm, 2012;38:1230–9.
  • Kiho Lee CN, Brouwer KLR, Thanker DR. Secretory transport of Rantidine and Famotidine across CaCo-2 cell monolayers. J Pharmacol Exp Ther, 2002;303:574–80.
  • Kin-Kai DH, Giesing GH, Hurst Aventis Pharmaceuticals, Inc. Method of enhancing bioavailability of fexofenadine and its derivatives. US6451815; 2002.
  • Lamprecht A, Ubrich N, Hombreiro Perez M, Lehr CM, Hoffman M, Maincent P. Influences of process parameters on nanoparticle preparation performed by a double emulsion pressure homogenization technique. Int J Pharm, 2000;196:177–82.
  • Lenhardt T, Vergnault G, Grenier P, Scherer D, Langguth P. Evaluation of nanosuspensions for absorption enhancement of poorly soluble drugs: in vitro transport studies across intestinal epithelial monolayers. AAPS J, 2008;10:435–8.
  • Li SD, Huang L. Pharmacokinetics and biodistribution of nanoparticles. Mol Pharm, 2008;5:496–504.
  • Lin SY, Cheng WT, Wang SL. Thermodynamic and kinetic characterization of polymorphic transformation of famotidine during grinding. Int J Pharm, 2006;318:86–91.
  • Liu P, Rong X, Laru J, van Veen B, Kiesvaara J, Hirvonen J, Laaksonen T, Peltonen L. Nanosuspensions of poorly soluble drugs: Preparation and development by wet milling. Int J Pharm, 2011;411:215–22.
  • Merisko-Liversidge E, Liversidge GG, Cooper ER. Nanosizing: A formulation approach for poorly-water-soluble compounds. Eur J Pharm Sci, 2003;18:113–20.
  • Mert O, Lai SK, Ensign L, Yang M, Wang YY, Wood J, Hanes J. A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles. J Control Release, 2012;157:455–60.
  • Mittal G, Sahana DK, Bhardwaj V, Ravi Kumar MNV. Estradiol loaded PLGA nanoparticles for oral administration: Effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo. J Control Release, 2007;119:77–85.
  • Monjed S, Gilles P, Elias F. Particle uptake by Peyer’s patches: A pathway for drug and vaccine delivery. Expert Opin Drug Deliv, 2004;1:141–63.
  • Morakul B, Suksiriworapong J, Leanpolchareanchai J, Junyaprasert VB. Precipitation-lyophilization-homogenization (PLH) for preparation of clarithromycin nanocrystals: Influencing factors on physicochemical properties and stability. Int J Pharm, 2013;457:187–96.
  • Nadeau V, Leclair G, Sant S, Rabanel JM, Quesnel R, Hildgen P. Synthesis of new versatile functionalized polyesters for biomedical applications. Polymer, 2005;46:11263–72.
  • Owens DE, Peppas NA. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm, 2006;307:93–102.
  • Panoyan A, Quesnel R, Hildgen P. Injectable nanospheres from a novel multiblock copolymer: Cytocompatibility, degradation and in vitro release studies. J Microencapsul, 2003;20:745–58.
  • Patravale VB, Date AA, Kulkarni RM. Nanosuspensions: A promising drug delivery strategy. J Pharm Pharmacol, 2004;56:827–40.
  • Ramachandran S, Nandhakumar S, Dhanaraju MD. Formulation and characterization of glutaraldehyde cross-linked chitosan biodegradable microspheres loaded with famotidine. Trop J Pharm Res, 2011;10:309–16.
  • Rabanel J-M, Aoun V, Hildgen P. Impact of polymer physico-chemical properties on PEG-grafted-PLA nanoparticles structure. CRS 37th annual meeting; 2012a.
  • Rabanel J-M, Aoun V, Elkin I, Mokhtar M, Hildgen P. Drug-loaded nanocarriers: Passive targeting and crossing of biological barriers. Curr Med Chem, 2012b;19:3070–102.
  • Redhead HM, Davis SS, Illum L. Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: In vitro characterisation and in vivo evaluation. J Control Release, 2001;70:353–63.
  • Rieux A, Fievez V, Garinot M, Schneider YJ, Preat V. Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach. J Control Release, 2006;116:1–27.
  • Rozehnal V, Nakai D, Hoepner U, Fischer T, Kamiyama E, Takahashi M, Yasuda S, Mueller J. Human small intestinal and colonic tissue mounted in the Ussing chamber as a tool for characterizing the intestinal absorption of drugs. Eur J Pharm Sci, 2012;46:367–73.
  • Rowe RC, Sheskey PJ, Quinn ME. Handbook of pharmaceutical excipients. London; Chicago : Washington, DC: Pharmaceutical Press; American Pharmacists Association; 2007.
  • Sahoo NG, Kakran M, Shaal LA, Li L, Muller RH, Pal M, Tan LP. Preparation and characterization of quercetin nanocrystals. J Pharm Sci, 2011;100:2379–90.
  • Sahoo SK, Panyam J, Prabha S, Labhasetwar V. Residual polyvinyl alcohol associated with poly (d,l-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake. J Control Release, 2002;82:105–14.
  • Sant S, Poulin S, Hildgen P. Effect of polymer architecture on surface properties, plasma protein adsorption, and cellular interactions of pegylated nanoparticles. J Biomed Mater Res Part A, 2008;87:885–95.
  • Sepassi S, Goodwin DJ, Drake AF, Holland S, Leonard G, Martini L, Lawrence MJ. Effect of polymer molecular weight on the production of drug nanoparticles. J Pharm Sci, 2007;96:2655–66.
  • Shah VJP, Bagchi T, Misra A. Role of Caco-2 cell monolayers in prediction of intestinal drug absorption. Biotechnol Prog, 2006;22:186–98.
  • Shen Q, Lin Y, Handa T, Doi M, Sugie M, Wakayama K, Okada N, Fujita T, et al. Modulation of intestinal P-glycoprotein function by polyethylene glycols and their derivatives by in vitro transport and in situ absorption studies. Int J Pharm, 2006;313:49–56.
  • Shilpa S, Ve´ronique N, Hildgen P. Effect of porosity on the release kinetics of propafenone-loaded PEG-g-PLA nanoparticles. J Control Release, 2005;107:203–14.
  • Shoaib M, Al Sabah Siddiqi S, Yousuf R, Zaheer K, Hanif M, Rehana S, Jabeen S. Development and evaluation of hydrophilic colloid matrix of Famotidine tablets. AAPS PharmSciTech, 2010;11:708–18.
  • Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE. Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release, 2001;70:1–20.
  • Tobio M, Gref R, Sanchez A, Langer R, Alonso MJ. Stealth PLA-PEG nanoparticles as protein carriers for nasal administration. Pharm Res, 1998;15:270–5.
  • Vila A, Gill H, McCallion O, Alonso MJ. Transport of PLA-PEG particles across the nasal mucosa: Effect of particle size and PEG coating density. J Control Release, 2004;98:231–44.
  • Yoncheva K, Lizarraga E, Irache JM. Pegylated nanoparticles based on poly(methyl vinyl ether-co-maleic anhydride): Preparation and evaluation of their bioadhesive properties. Eur J Pharm Sci, 2005;24:411–19.
  • Yu L. Amorphous pharmaceutical solids: Preparation, characterization and stabilization. Adv Drug Deliv Rev, 2001;48:27–42.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.