Mechanism of radiosensitization by hyperthermia (43°C) as derived from studies with DNA repair defective mutant cell lines

References

• Kampinga HH, Dikomey E. Hyperthermic radiosensitization: mode of action and clinical relevance. Int J Radiat Biol 2001; 77: 399–408.
   PubMed Web of Science ®Google Scholar
• Dewey WC, Sapareto SA, Betten DA. Hyperthermic radiosensitization of synchronous Chinese hamster cells: relationship between lethality and chromosomal aberrations. Radiat Res 1978; 76; 48–59.
   Google Scholar
• Dewey WC, Sapareto SA, Betten DA. Radiosensitization by hyperthermia occurs through an increase inchromosomal aberrations. In: Streffer C, ed. Cancer therapy by hyperthermia and radiation. Munich: Urban & Schwarzenberg, 1978; 149–50.
   Google Scholar
• Kim SH, Kim JR, Hahn EW. The enhanced killing of irradiated HeLa cells in synchro-nous culture by hyperthermia. Radiat Res 1976; 66: 337–45.
   Google Scholar
• Henderson SD, Kimler BF, Scanlan MF. Interaction of hyperthermia and radiation on the survival of synchronous 9L cells. Radiat Res 1982; 92: 146–59.
   Google Scholar
• Murthy AK, Harris JR, Belli JA. Hyperthermia and radiation response of plateau phase cells. Potentiation and radiation damage repair. Radiat Res 1977; 70: 241–7.
   Google Scholar
• Raaphorst GP, Azzam El. Ataxia-telangiectasia homo- and heterozygous cells show a normal repair and fixation response to anisotonic NaC1 treatment after irradiation. Radiat Res 1985; 101: 497–507.
   PubMed Web of Science ®Google Scholar
• Raaphorst GP, Azzam El, Vadasz JA. Ataxia telangiectasia cells exhibit the same radiosensitization response by incorporation of BrdUrd or IdUrd as do normal human cells. Radiat Res 1985; 103: 455–60.
   Google Scholar
• Mitchel RE, Smith BP, Wheatly N, Chan A, Child S, Paterson MC. Sensitivity of hyperthermia-treated human cells to killing by ultraviolet or gamma radiation. Radiat Res 1985; 104: 234–41.
   PubMed Web of Science ®Google Scholar
• Mitchel REJ, Chan A, Smith BP, Child SD, Paterson MC. The effects of hyperthermia and ionizing radiation in normal and ataxia telangiectasia human fibroblast lines. Radiat Res 1984; 99: 627–35.
   Google Scholar
• Larsson C, Ng CE. p21+/+ and p21-/- human colorectal carcinoma cells display equivalent amounts of thermal radiosensitization. Radiat Res 2003; 160; 205–209.
   PubMed Web of Science ®Google Scholar
• Warters RL, Roti Roti JL. Excision of X-ray-induced thymine damage in chromatin from heated cells. Radiat Res 1979; 79: 113–21.
   PubMed Web of Science ®Google Scholar
• Sakkers RJ, Filon AR, Brunsting JF, Kampinga HH, Konings AWT, Mullenders LHF. Selective inhibition of repair of active genes by hyperthermia is due to inhibition of global and transcription coupled repair pathways. Carcinogenesis 1995; 16: 743–8.
   PubMed Web of Science ®Google Scholar
• Sakkers RJ, Filon AR, Brunsting JF, Kampinga HH, Mullenders LH, Konings AW. Heat-shock treatment selectively affects induction and repair of cyclobutane pyrimidine dimers in transcriptionally active genes in ultraviolet-irradiated human fibroblasts. Radiat Res 1993; 135: 343–50.
   PubMed Web of Science ®Google Scholar
• Sakkers RJ, Filon AR, Kampinga HH, Konings AW, Mullenders LH. Repair of UV-induced pyrimidine(6-4)pyrimidone photoproducts is selectively inhibited in trans-criptionally active genes after heat treatment of human fibroblasts. Int J Radiat Biol 1995; 67: 495–9.
   Google Scholar
• Mullenders LHF, Sakkers RJ, Kampinga HH, Konings AWT. Chromatin structure, hyperthermia and repair of UV-induced photolesions in mammalian cells. In: Obe G, Natarajan AT, eds. Chromosomal Alterations: origin and significance. Berlin, Heidelberg, New York: Springler Verlag, 1994; 21–30.
   Google Scholar
• Sakkers R. Heat-induced alterations in chromatin structure and repair of DNA damage. PhD Thesis, RuG, Groningen, the Netherlands, 1995.
   Google Scholar
• Jeggo PA. DNA-PK: at the cross-roads of biochemistry and genetics. Mutat Res-DNA Repair 1997; 384: 1–14.
   PubMed Web of Science ®Google Scholar
• Pfeiffer P, Goedecke W, Obe G. Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations. Mutagenesis 2000; 15: 289–302.
   Google Scholar
• Takata M, Sasaki MS, Sonoda E, Morrison C, Hashimoto M, Utsumi H, Yamaguchi-Iwai Y, Shinohara A, Takeda S. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the main-tenance of chromosomal integrity in vertebrate cells. EMBO J 1998; 17: 5497–508.
   Google Scholar
• Iliakis G, Seaner R. A DNA double-strand break repair-deficient mutant of CHO cells shows reduced radiosensitization after exposure to hyperthermic temperatures in the plateau phase of growth. Int J Hypertherrnia 1990; 6: 801–12.
   PubMed Web of Science ®Google Scholar
• Woudstra EC, Konings AW, Jeggo PA, Kampinga HH. Role of DNA-PK subunits in radiosensitization by hyperthermia. Radiat Res 1999; 152: 214–8.
   PubMed Web of Science ®Google Scholar
• Dynlacht JR, Bittner ME, Bethel JA, Beck BD. The non-homologous end-joining pathway is not involved in the radiosensitization of mammalian cells by heat shock. J Cell Physiol 2003; 196: 557–64.
   PubMed Web of Science ®Google Scholar
• Kampinga HH, Kanon B, Konings AWT, Stackhouse MA, Bedford JS. Thermal radio-sensitization in heat- and radiation-sensitive mutants of CHO cells. Int J Radiat Biol 1993; 64: 225–30.
   Google Scholar
• Raaphorst GP, Thakar M, Ng CE. Thermal radiosensitization in two pairs of CHO wild-type and radiation-sensitive mutant cell lines. Int J Hypertherrnia 1993; 9: 383–91.
   Google Scholar
• Komatsu K, Kubota N, Gallo M, Okumura Y, Lieber MR. The scid factor on human chromosome 8 restores V(D)J recombination in addition to double-strand break repair. Cancer Res 1995; 55: 1774–9.
   Google Scholar
• Wachters FM, van Putten JWG, Maring JG, Zdzienicka MZ, Groen HJM, Kampinga HH. Selective targeting of homologous DNA recombination repair by Gemcitabine. Int j Radiat Biol Oncol Phys 2003; 57: 553–562.
   PubMed Web of Science ®Google Scholar
• Mitchel REJ, Smith BP, Wheatly N, Chan A, Child S, Paterson MC. Sensitivity of hyperthermia-treated human cells to killing by ultraviolet or gamma radiation. Radiat Res 1985; 104: 234–41.
   PubMed Web of Science ®Google Scholar
• Feldmann E, Schmiemann V, Goedecke W, Reichenberger S, Pfeiffer P. DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining. Nucl Acids Res 2000; 28: 2585–96.
   Google Scholar
• DiBiase Si, Zeng ZC, Chen R, Hyslop T, Curran WJ Jr, Maids G. DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining appara-tus. Cancer Res 2000; 60: 1245–53.
   PubMed Web of Science ®Google Scholar
• Boulton Si, Jackson SP. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J 1998; 17: 1819–28.
   PubMed Web of Science ®Google Scholar
• Gent van GD, Hoeijmakers JH, Kanaar R: Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet 2001; 2: 196–206.
   PubMed Web of Science ®Google Scholar
• O'Regan P, Wilson C, Townsend S, Thacker J. XRCC2 is a nuclear RAD51-like protein required for damage-dependent RAD51 focus formation without the need for ATP binding. J Biol Chem 2001; 276: 22148–53.
   PubMed Web of Science ®Google Scholar
• Wallace SS. DNA damages processed by base excision repair: biological consequences. Int J Radiat Biol 1994; 66: 579–89.
   PubMed Web of Science ®Google Scholar
• Anson RM, Croteau DL, Stierum RH, Filburn C, Parse11 R, Bohr VA. Homogenous repair of singlet oxygen-induced DNA damage in differentially transcribed regions and strands of human mitochondrial DNA. Nucl Acids Res 1998; 26: 662–8.
   Google Scholar
• Svejstrup JQ. Mechanisms of transcription-coupled DNA repair. Nat Rev Mol Cell Biol 2002; 3: 21–9.
   PubMed Web of Science ®Google Scholar
• Harrison L, Hatahet Z, Purmal AA, Wallace SS. Multiply damaged sites in DNA: inter-actions with Escherichia coli endonucleases III and VIII. Nucl Acids Res 1998; 26: 932–41.
   PubMed Web of Science ®Google Scholar
• Harrison L, Hatahet Z, Wallace SS. In vitro repair of synthetic ionizing radiation-induced multiply damaged DNA sites. J Mol Biol 1999; 290: 667–84.
   Google Scholar
• Blaisdell JO, Wallace SS. Abortive base-excision repair of radiation-induced clustered DNA lesions in Escherichia coli. Proc Natl Acad Sci USA 2001; 98: 7426–30.
   PubMed Web of Science ®Google Scholar
• Cappelli E, Taylor R, Cevasco M, Abbondandolo A, Caldecott K, Frosina G. Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair. J Biol Chem 1997; 272: 23970–5.
   PubMed Web of Science ®Google Scholar
• Zdzienicka MZ. Mammalian mutants defective in the response to ionizing radiation-induced DNA damage. Mutat Res-DNA Repair 1995; 336: 203–13.
   PubMed Web of Science ®Google Scholar
• Zdzienicka MZ. Mammalian X-ray sensitive mutants: a tool for the elucidation of the cellular response to ionizing radiation. Cancer Surv 1996; 28: 281–93.
   PubMedGoogle Scholar
• Spiro IJ, Denman DL, Dewey WC. Effect of hyperthermia on CHO DNA polymerases a and 13. Radiat Res 1982; 89: 134–49.
   PubMed Web of Science ®Google Scholar
• Warters RL, Roti Roti JL. Production and excision of 5',6'-dihydroxydihydrothymine type products in the DNA of preheated cells. Int J Radiat Biol 1978; 34: 381–4.
   Web of Science ®Google Scholar
• Dahm-Daphi J, Brammer I, Dikomey E. Heat effects on the repair of DNA double-strand breaks in CHO cells. Int J Radiat Biol 1997; 72: 171–9.
   Google Scholar
• Kampinga HH, Hiemstra YS, Konings AWT, Dikomey E. Correlation between slowly repairable double-strand breaks and thermal radiosensitization in the human HeLa S3 cell line. Int J Radiat Biol 1997; 72: 293–301.
   PubMed Web of Science ®Google Scholar