852
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Histological findings in resected leiomyomas following MR-HIFU treatment, single-institution data from seven patients with unfavorable focal therapy

, , , , , , , , & show all
Article: 2234666 | Received 10 Apr 2023, Accepted 04 Jul 2023, Published online: 24 Jul 2023

References

  • Kim Y-S, Trillaud H, Rhim H, et al. MR thermometry analysis of sonication accuracy and safety margin of volumetric MR imaging-guided high-intensity focused ultrasound ablation of symptomatic uterine fibroids. Radiology. 2012;265(2):627–637. doi: 10.1148/radiol.12111194.
  • Funaki K, Fukunishi H, Funaki T, et al. Mid-term outcome of magnetic resonance-guided focused ultrasound surgery for uterine myomas: from six to twelve months after volume reduction. J Minim Invasive Gynecol. 2007;14(5):616–621. doi: 10.1016/j.jmig.2007.04.009.
  • Kim HS, Baik J-H, Pham LD, et al. MR-guided high-intensity focused ultrasound treatment for symptomatic uterine leiomyomata: long-term outcomes. Acad Radiol. 2011;18(8):970–976. doi: 10.1016/j.acra.2011.03.008.
  • Leppert PC, Baginski T, Prupas C, et al. Comparative ultrastructure of collagen fibrils in uterine leiomyomas and normal myometrium. Fertil Steril. 2004;82:1182–1187. doi: 10.1016/j.fertnstert.2004.04.030.
  • Tinelli A, Malvasi A, Rahimi S, et al. Myoma pseudocapsule: a distinct endocrino-anatomical entity in gynecological surgery. Gynecol Endocrinol. 2009;25(10):661–667. doi: 10.1080/09513590903015502.
  • Wei J-J, Zhang X-M, Chiriboga L, et al. Spatial differences in biologic activity of large uterine leiomyomata. Fertil Steril. 2006;85(1):179–187. doi: 10.1016/j.fertnstert.2005.07.1294.
  • Bourlev V, Pavlovitch S, Stygar D, et al. Different proliferative and apoptotic activity in peripheral versus central parts of human uterine leiomyomas. Gynecol Obstet Invest. 2003;55(4):199–204. doi: 10.1159/000072074.
  • Fujita M. Histological and biochemical studies of collagen in human uterine leiomyomas. Hokkaido Igaku Zasshi. 1985;60(4):602–615.
  • Iwahashi M, Muragaki Y, Ikoma M, et al. Immunohistochemical analysis of collagen expression in uterine leiomyomata during the menstrual cycle. Exp Ther Med. 2011;2:287–290.
  • Wright NT, Humphrey JD. Denaturation of collagen via heating: an irreversible rate process. Annu Rev Biomed Eng. 2002;4:109–128. doi: 10.1146/annurev.bioeng.4.101001.131546.
  • Fujisawa C, Castellot JJ. Matrix production and remodeling as therapeutic targets for uterine leiomyoma. J Cell Commun Signal. 2014;8(3):179–194. doi: 10.1007/s12079-014-0234-x.
  • Leppert PC, Jayes FL, Segars JH. The extracellular matrix contributes to mechanotransduction in uterine fibroids. Obstet Gynecol Int. 2014;2014:1–12. doi: 10.1155/2014/783289.
  • Norian JM, Owen CM, Taboas J, et al. Characterization of tissue biomechanics and mechanical signaling in uterine leiomyoma. Matrix Biol. 2012;31(1):57–65. doi: 10.1016/j.matbio.2011.09.001.
  • Wolańska M, Sobolewski K, Bańkowski E, et al. Matrix metalloproteinases of human leiomyoma in various stages of tumor growth. Gynecol Obstet Invest. 2004;58(1):14–18. doi: 10.1159/000077177.
  • Stewart EA, Taran FA, Chen J, et al. Magnetic resonance elastography of uterine leiomyomas: a feasibility study. Fertil Steril. 2011;95(1):281–284. doi: 10.1016/j.fertnstert.2010.06.004.
  • Hricak H, Tscholakoff D, Heinrichs L, et al. Uterine leiomyomas: correlation of MR, histopathologic findings, and symptoms. Radiology. 1986;158(2):385–391. doi: 10.1148/radiology.158.2.3753623.
  • Ueda H, Togashi K, Konishi I, et al. Unusual appearances of uterine leiomyomas: MR imaging findings and their histopathologic backgrounds. RadioGraphics. 1999;19(Suppl. 1):S131–S145. doi: 10.1148/radiographics.19.suppl_1.g99oc04s131.
  • Arleo EK, Schwartz PE, Hui P, et al. Review of leiomyoma variants. AJR Am J Roentgenol. 2015;205(4):912–921. doi: 10.2214/AJR.14.13946.
  • Cramer SF, Marchetti C, Freedman J, et al. Relationship of myoma cell size and menopausal status in small uterine leiomyomas. Arch Pathol Lab Med. 2000;124(10):1448–1453. doi: 10.5858/2000-124-1448-ROMCSA.
  • Swe TT, Onitsuka H, Kawamoto K, et al. Uterine leiomyoma: correlation between signal intensity on magnetic resonance imaging and pathologic characteristics. Radiat Med. 1992;10:235–242.
  • Jondal DE, Wang J, Chen J, et al. Uterine fibroids: correlations between MRI appearance and stiffness via magnetic resonance elastography. Abdom Radiol. 2018;43(6):1456–1463. doi: 10.1007/s00261-017-1314-1.
  • Zhao W-P, Chen J-Y, Chen W-Z. Effect of biological characteristics of different types of uterine fibroids, as assessed with T2-weighted magnetic resonance imaging, on ultrasound-guided high-intensity focused ultrasound ablation. Ultrasound Med Biol. 2015;41(2):423–431. doi: 10.1016/j.ultrasmedbio.2014.09.022.
  • Yamashita Y, Torashima M, Takahashi M, et al. Hyperintense uterine leiomyoma at T2-weighted MR imaging: differentiation with dynamic enhanced MR imaging and clinical implications. Radiology. 1993;189(3):721–725. doi: 10.1148/radiology.189.3.8234695.
  • Oguchi O, Mori A, Kobayashi Y, et al. Prediction of histopathologic features and proliferative activity of uterine leiomyoma by magnetic resonance imaging prior to GnRH analogue therapy: correlation between T2-weighted images and effect of GnRH analogue. J Obstet Gynaecol (Tokyo 1995). 1995;21(2):107–117. doi: 10.1111/j.1447-0756.1995.tb01083.x.
  • Shimada K, Ohashi I, Kasahara I, et al. Differentiation between completely hyalinized uterine leiomyomas and ordinary leiomyomas: three-phase dynamic magnetic resonance imaging (MRI) vs. diffusion-weighted MRI with very small b-factors. J Magn Reson Imaging. 2004;20(1):97–104. doi: 10.1002/jmri.20063.
  • Venkatesan AM, Partanen A, Pulanic TK, et al. Magnetic resonance imaging-guided volumetric ablation of symptomatic leiomyomata: correlation of imaging with histology. J Vasc Interv Radiol. 2012;23(6):786–794.e4. doi: 10.1016/j.jvir.2012.02.015.
  • Stewart EA, Gedroyc WMW, Tempany CMC, et al. Focused ultrasound treatment of uterine fibroid tumors: safety and feasibility of a noninvasive thermoablative technique. Am J Obstet Gynecol. 2003;189(1):48–54. doi: 10.1067/mob.2003.345.
  • Anttinen M, Yli-Pietilä E, Suomi V, et al. Histopathological evaluation of prostate specimens after thermal ablation may be confounded by the presence of thermally-fixed cells. Int J Hyperthermia. 2019;36:915–925.
  • Coad JE, Kosari K, Humar A, et al. Radiofrequency ablation causes ‘thermal fixation’ of hepatocellular carcinoma: a post-liver transplant histopathologic study. Clin Transplant. 2003;17(4):377–384. doi: 10.1034/j.1399-0012.2003.00062.x.
  • Courivaud F, Kazaryan AM, Lund A, et al. Thermal fixation of swine liver tissue after magnetic resonance-guided high-intensity focused ultrasound ablation. Ultrasound Med Biol. 2014;40(7):1564–1577.
  • Hennings L, Kaufmann Y, Griffin R, et al. Dead or alive? Autofluorescence distinguishes heat-fixed from viable cells. Int J Hyperthermia. 2009;25(5):355–363. doi: 10.1080/02656730902964357.
  • Xiong X, Chen F, Chen J, et al. Pathologic evaluation of uterine fibroids ablated with high intensity focused ultrasound. Int J Clin Exp Pathol. 2016;9:6163–6170.
  • Funaki K, Fukunishi H, Funaki T, et al. Magnetic resonance-guided focused ultrasound surgery for uterine fibroids: relationship between the therapeutic effects and signal intensity of preexisting T2-weighted magnetic resonance images. Am J Obstet Gynecol. 2007;196(2):184.e1–184.e6. doi: 10.1016/j.ajog.2006.08.030.
  • Kroemer G, Galluzzi L, Vandenabeele P, et al. Classification of cell death. Cell Death Differ. 2009;16(1):3–11. doi: 10.1038/cdd.2008.150.
  • Coad JE. Thermal fixation: a central outcome of hyperthermic therapies. Proceedings of the Thermal Treatment of Tissue: Energy Delivery and Assessment III. Vol. 5698. International Society for Optics and Photonics; 2005. p. 15–22.
  • Wall MS, Deng XH, Torzilli PA, et al. Thermal modification of collagen. J Shoulder Elbow Surg. 1999;8(4):339–344. doi: 10.1016/s1058-2746(99)90157-x.
  • Miles CA, Bailey AJ. Thermal denaturation of collagen revisited. J Chem Sci. 1999;111:71–80.
  • Voogt MJ, van Stralen M, Ikink ME, et al. Targeted vessel ablation for more efficient magnetic resonance-guided high-intensity focused ultrasound ablation of uterine fibroids. Cardiovasc Intervent Radiol. 2012;35(5):1205–1210. doi: 10.1007/s00270-011-0313-9.
  • McCluggage WG, Ellis PK, McClure N, et al. Pathologic features of uterine leiomyomas following uterine artery embolization. Int J Gynecol Pathol. 2000;19(4):342–347. doi: 10.1097/00004347-200010000-00008.
  • Tempany CMC, Stewart EA, McDannold N, et al. MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study. Radiology. 2003;226(3):897–905. doi: 10.1148/radiol.2271020395.
  • Choe YS, Lee WM, Choi JS, et al. Clinical characteristics of patients with leiomyoma who undergo surgery after high intensity focused ultrasound (HIFU). Obstet Gynecol Sci. 2019;62(4):258–263. doi: 10.5468/ogs.2019.62.4.258.
  • Stewart EA, Gostout B, Rabinovici J, et al. Sustained relief of leiomyoma symptoms by using focused ultrasound surgery. Obstet Gynecol. 2007;110(2 Pt 1):279–287. doi: 10.1097/01.AOG.0000275283.39475.f6.
  • Bankhead P, Loughrey MB, Fernández JA, et al. QuPath: open source software for digital pathology image analysis. Sci Rep. 2017;7(1):16878. doi: 10.1038/s41598-017-17204-5.
  • Mindjuk I, Trumm CG, Herzog P, et al. MRI predictors of clinical success in MR-guided focused ultrasound (MRgFUS) treatments of uterine fibroids: results from a single centre. Eur Radiol. 2015;25(5):1317–1328. doi: 10.1007/s00330-014-3538-6.
  • Suomi V, Viitala A, Sainio T, et al. High-Intensity focused ultrasound therapy in the uterine fibroid: a clinical case study of poor heating efficacy. Annu Int Conf IEEE Eng Med Biol Soc. 2019;2019:2500–2503. doi: 10.1109/EMBC.2019.8857147.
  • Suomi V, Komar G, Sainio T, et al. Comprehensive feature selection for classifying the treatment outcome of high-intensity ultrasound therapy in uterine fibroids. Sci Rep. 2019;9(1):10907. doi: 10.1038/s41598-019-47484-y.