93
Views
0
CrossRef citations to date
0
Altmetric
Review Article

The safety of early pharmacological venous thromboembolism prophylaxis in patients with traumatic intracranial haemorrhage: a systematic review and meta-analysis

, &
Received 14 Oct 2022, Accepted 01 Apr 2024, Published online: 30 Apr 2024

References

  • Bryan-Hancock C, Harrison J. The global burden of traumatic brain injury: preliminary results from the Global Burden of Disease Project. Injury Prevention 2010;16:A17.
  • Perel P, Roberts I, Bouamra O, et al. Intracranial bleeding in patients with traumatic brain injury: A prognostic study. BMC Emerg Med 2009;9:15.
  • Goldstein JN, and Greenberg SM. Should anticoagulation be resumed after intracerebral hemorrhage? Cleve Clin J Med 2017;77;791–9.
  • Oertel M, Kelly DF, McArthur D, et al. Progressive hemorrhage after head trauma: predictors and consequences of the evolving injury. J Neurosurg 2002;96:109–16.
  • Kahn SR, Lim W, Dunn AS, et al. Prevention of VTE in nonsurgical patients. Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 2012;141:e195S–226S.
  • Sprügel MI, Sembill JA, Kuramatsu JB, et al. Heparin for prophylaxis of venous thromboembolism in intracerebral haemorrhage. J Neurol Neurosurg Psychiatry 2019;90:783–91.
  • Reiff DA, Haricharan RN, Bullington NM, et al. Traumatic brain injury is associated with the development of deep vein thrombosis independent of pharmacological prophylaxis. J Trauma 2009;66:1436–40.
  • Acosta JA, Yang JC, Winchell RJ, et al. Lethal injuries and time to death in a level I trauma center. J Am Coll Surg 1998;186:528–33.
  • Farr S, Toor H, Patchana T, et al. Risks, benefits, and the optimal time to resume deep vein thrombosis prophylaxis in patients with intracranial hemorrhage. Cureus 2019; 11:e5827.
  • Rabinstein AA, Gupta A. Restarting anticoagulation after intracranial hemorrhage: a risky decision with no recipe. Neurology 2014;82:1016–7.
  • Higgins JPT, Thomas J, Chandler J, et al. eds. Chapter 10: Analysing data and undertaking meta-analyses | Cochrane Training. In: Cochrane Handbook for Systematic Reviews of Interventions version 6.2 2021:1. Cochrane, 2021. Available from: www.training.cochrane.org/handbook
  • Lee KS, Zhang JJY, Nga VDW, et al. Tenets for the proper conduct and use of meta-analyses: a practical guide for neurosurgeons. World Neurosurg 2022;161:291–302.e1.
  • Frisoli FA, Shinseki M, Nwabuobi L, et al. Early venous thromboembolism chemoprophylaxis after traumatic intracranial hemorrhage. Clin Neurosurg 2017;81:1016–20.
  • Rivas L, Vella M, Ju T, et al. Early chemoprophylaxis against venous thromboembolism in patients with traumatic brain injury. Am Surg 2022;88:187–93.
  • Jakob DA, Lewis M, Benjamin ER, et al. Timing of venous thromboembolic pharmacological prophylaxis in traumatic combined subdural and subarachnoid hemorrhage. Am J Surg 2021;223:1194–9.
  • Meyer RM, Larkin MB, Szuflita NS, et al. Early venous thromboembolism chemoprophylaxis in combat-related penetrating brain injury. J Neurosurg 2017;126:1047–55.
  • Störmann P, Osinloye W, Freiman TM, et al. Early chemical thromboprophylaxis does not increase the risk of intracranial hematoma progression in patients with isolated severe traumatic brain injury. World J Surg 2019;43:2804–11.
  • Al-Dorzi HM, Al-Yami G, Al-Daker F, et al. The association of timing of pharmacological prophylaxis and venous thromboembolism in patients with moderate-to-severe traumatic brain injury: a retrospective cohort study. Ann Thorac Med 2022;17:102–9.
  • Byrne JP, Mason SA, Gomez D, et al. Timing of pharmacologic venous thromboembolism prophylaxis in severe traumatic brain injury: a propensity-matched cohort study. J Am Coll Surg 2016;223:621–31.e5.
  • Depew AJ, Hu CK, Nguyen AC, et al. Thromboembolic prophylaxis in blunt traumatic intracranial hemorrhage: A retrospective review. Am Surg 2008;74:906–11.
  • Hachem LD, Mansouri A, Scales DC, et al. Anticoagulant prophylaxis against venous thromboembolism following severe traumatic brain injury: a prospective observational study and systematic review of the literature. Clin Neurol Neurosurg 2018;175:68–73.
  • Kim J, Gearhart MM, Zurick A, et al. Preliminary report on the safety of heparin for deep venous thrombosis prophylaxis after severe head injury. J Trauma 2002;53:38–42.
  • Kim L, Schuster J, Holena DN, et al. Early initiation of prophylactic heparin in severe traumatic brain injury is associated with accelerated improvement on brain imaging. J Emerg Trauma Shock 2014;7:141–8.
  • Koehler DM, Shipman J, Davidson MA, et al. Is early venous thromboembolism prophylaxis safe in trauma patients with intracranial hemorrhage. J Trauma 2011;70:324–9.
  • Levy AS, Salottolo K, Bar-Or R, et al. Pharmacologic thromboprophylaxis is a risk factor for hemorrhage progression in a subset of patients with traumatic brain injury. J Trauma 2010;68:886–94.
  • Salottolo K, Offner P, Levy AS, et al. Interrupted pharmocologic thromboprophylaxis increases venous thromboembolism in traumatic brain injury. J Trauma 2011;70:19–26.
  • Carney N, Totten AM, O'Reilly C, et al. Guidelines for the management of severe traumatic brain injury, fourth edition. Neurosurgery 2017;80:6–15.
  • Strollo BP, Bennett GJ, Chopko MS, et al. Timing of venous thromboembolism chemoprophylaxis after traumatic brain injury. J Crit Care 2018;43:75–80.
  • Khan NR, Patel PG, Sharpe JP, Lee SL, Sorenson J. Chemical venous thromboembolism prophylaxis in neurosurgical patients: an updated systematic review and meta-analysis. J Neurosurg, 2017;129:906–15.
  • Homnick A, Sifri Z, Yonclas P, et al. The temporal course of intracranial haemorrhage progression: how long is observation necessary? Injury 2012;43:2122–5.
  • Chang EF, Meeker M, Holland MC. Acute traumatic intraparenchymal hemorrhage: risk factors for progression in the early post-injury period. Neurosurgery 2006;58:647–56.
  • Kempny A, McCabe C, Dimopoulos K, et al. Incidence, mortality and bleeding rates associated with pulmonary embolism in England between 1997 and 2015. Int J Cardiol 2019;277:229–34.
  • Minshall CT, Eriksson EA, Leon SM, et al. Safety and efficacy of heparin or enoxaparin prophylaxis in blunt trauma patients with a head abbreviated injury severity score >2. J Trauma 2011;71:396–400.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.