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Articles

Staying in the game: a pilot study examining the efficacy of protective headgear in an animal model of mild traumatic brain injury (mTBI)

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Pages 1521-1529 | Received 04 Feb 2017, Accepted 07 Jul 2017, Published online: 03 Oct 2017

References

  • Petterson JA. Does rugby headgear prevent concussion? Attitudes of Canadian players and coaches. Br J Sports Med. 2002;36(1):19–22. doi:10.1136/bjsm.36.1.19.
  • Sinclair M, Cur B. BokSmart winners play smart: protective equipment in rugby a literature review. Oakglen, S. A.: South Africa Rugby; 2009.
  • Benson BW, Hamilton G, Meeuwisse WH, McCrory P, Dvorak J. Is protective equipment useful in preventing concussion? A systematic review of the literature. Br J Sports Med. 2009;43:i56–i67. doi:10.1136/bjsm.2009.058271.
  • McCrory P, Meeuwisse W, Aubry M, Cantu B, Dvořák J, Echemendia R, Engebretsen L, Johnston K, Kutcher JS, Raftery M, et al. Consensus statement on concussion in sport: the 4th International Conference on Concussion in Sport held in Zurich, November 2012. Br J Sports Med. 2013;47:250–58. doi:10.1136/bjsports-2013-092313.
  • Guskiewicz K, Mihalik J. Biomechanics of sports concussion: quest for the elusive injury threshold. Exerc Sport Sci Rev. 2011;39(1):4–11. doi:10.1097/JES.0b013e318201f53e.
  • King D, Hume P, Brughelli M, Gissane C. Instrumental mouthgaurd accleration analyses for head impacts in amateur rugby union players over a season of matches. Am J Sports Med. 2014;43(3):614–24. doi:10.1177/0363546514560876.
  • Guskiewicz K, Mihalik J, Shankar V, Marshall S, Crowell D, Oliaro S, Ciocca M, Hooker D. Measurement of head impacts in collegiate football players: relationship between head impact biomechanics and acute clinical outcome after concussion. Neurosurgery. 2007;61(6):1244–53. doi:10.1227/01.neu.0000306103.68635.1a.
  • Cloots RJH, Gervaise HM, Van Dommelen JA, Geers MG. Biomechanics of traumatic brain injury: influences of the morphologic heterogeneities of the cerbral cortex. Ann Biomed Eng. 2008;36(7):1203–15. doi:10.1007/s10439-008-9510-3.
  • Meaney DF, Smith DH. Biomechanics of concussion. Clin Sports Med. 2011;30:19–31. doi:10.1016/j.csm.2010.08.009.
  • Bruns J, Jagoda A. Mild traumatic brain injury. Mount Sinai J Med. 2009;76(2):129–37. doi:10.1002/msj.20101.
  • Ryan L, Warden D. Post concussion syndrome. Int Rev Psychiat. 2003;15:310–16. doi:10.1080/09540260310001606692.
  • Baugh C, Stamm J, Riley D, Gavett B, Shenton M, Lin A, Nowinski C, Cantu R, McKee A, Stern R. Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma. Brain Imagin Beh. 2012;6:244–54. doi:10.1007/s11682-012-9164-5.
  • Uryu K, Laurer H, McIntosh TK, Pratico D, Martinez D, Leight S, Lee V, Trojanowski J. Repetitive mild brain trauma accelerates AB deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis. J Neurosci. 2002;22(2):446–54.
  • McKee A, Cantu R, Nowinski C, Hedley-Whyte E, Gavett B, Budson A, Santini V, Lee HH, Kubilus C, Stern R. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol. 2009;68:709–35. doi:10.1097/NEN.0b013e3181a9d503.
  • Smith DH, Johnson V, Stewart W. Chronic neuropathologies of single and repetitive TBI: substrates of dementia. Nat Rev Neurol. 2013;9(4):211–21. doi:10.1038/nrneurol.2013.29.
  • Harmon K, Drezner J, Gammons M, Guskiewicz K, Halstead M, Herring S, Kutcher J, Pana A, Putukian M, Roberts O. American medical society for sports medicine position statement: concussion in sport. Br J Sports Med. 2012;47:15–26. doi:10.1136/bjsports-2012-091941.
  • Goodman J, Robertson C, Grossman R, Narayan R. Elevation of tumour necrosis factor in head injury. J Immunol. 1990;30:213–17.
  • Knoblach S, Fan L, Faden A. Early neuronal expression of tumor necrosis factor-alpha after experimental brain injury contributes to neurological impairment. Neuroimmunomodulation. 1999;95:115–25.
  • Shohami E, Novikov M, Bass R, Yamin A, Gallily R. Closed head triggers early production of Tnf-⍺ and IL-6 by brain tissue. J Cereb Blood Met. 1994;14(4):615–19. doi:10.1038/jcbfm.1994.76.
  • Jeter C, Hergenroeder G, Hylin M, Redell J, Moore A, Dash P. Biomarkers for the diagnosis and prognosis of mild traumatic brain injury/concussion. J Neurotrau. 2013;30:657–70. doi:10.1089/neu.2012.2439.
  • Neselius S, Zettterberg H, Blennow K, Marcusson J, Brisby H. Increased CSF levels of phosphorylated neurofilament heavy protein following bout in amateur boxers. PloS One. 2013;8(11):e81249. doi:10.1371/journal.pone.0081249.
  • Moriyama C, Galic M, Mychasiuk R, Pittman QJ, Perrot T, Currie RW, Esser MJ. Prenatal transport stress, postnatal maternal behavior, and offspring sex differentially affect seizure susceptibility in young rats. Epilepsy & Behaviour; 2013. 29(1) p. 19–27, In Press.
  • Mychasiuk R, Hehar H, Ma I, Candy S, Esser MJ. The direction of the acceleration and rotational forces associated with mild traumatic brain injury in rodents effect behavioural and molecular outcomes. J Neurosci Methods. 2016;257:168–78. doi:10.1016/j.jneumeth.2015.10.002.
  • Viano D, Hamberger A, Bolouri A, Saljo A. Concussion in professional football: animal model of brain injury - Part 15. Neurosurgery. 2009;64:1162–73. doi:10.1227/01.NEU.0000345863.99099.C7.
  • Viano D, Casson IR, Pellman E. Concussion in professional football: biomechanics of the struck player - Part 14. Neurosurgery. 2007;61:313–27. doi:10.1227/01.NEU.0000279969.02685.D0.
  • Schallert T, Woodlee M, Fleming S. Disentangling multiple types of recovery from brain injury. In: Krieglstein J, Klumpp S, Editors. Pharmacology of Cerebral Ischemia. Stuttgart: Medpharm Scientific Publishers; 2002. p. 201–16.
  • Corrigan F, Mander T, Leonard A, Vink R. Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation. J Neuroinflammation. 2016;13:264. doi:10.1186/s12974-016-0738-9.
  • Bachstetter A, Rowe R, Kaneko M, Goulding D, Lifshitz J, Van Eldik L. The p38alpha MAPK regulates microglial responsiveness to diffuse traumatic brain injury. J Neurosci. 2013;33:6143–53. doi:10.1523/JNEUROSCI.5399-12.2013.
  • Morganti-Kossmann M, Lenzlinger P, Hans V, Stahel P, Csuka E, Ammann E, Stocker R, Trentz O, Kossmann T. Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue. Mol Psychiatry. 1997;2:133–36. doi:10.1038/sj.mp.4000227.
  • Csuka E, Morganti-Kossmann M, Lenzlinger P, Joller H, Trentz O, Kossmann T. Il-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain injury: relationship to Il-6, TNF-alpha, TGF-beta1 and blood brain barrier function. J Neuroimmunol. 1999;101:211–21. doi:10.1016/S0165-5728(99)00148-4.
  • Frugier T, Morganti-Kossmann M, O’Reilly D, McLean A. In situ detection of inflammatory mediators in post-mortem human brain tissue after traumatic brain injury. J Neurotrau. 2010;27:497–507. doi:10.1089/neu.2009.1120.
  • England Professional Rugby Injury Surveillance Project Steering Group, England professional rugby injury surveillance project. Twickenham, UK: Rugby Football Union; 2015.
  • McIntosh A, McCrory P, Finch C, Best J, Chalmers D, Wolfe R. Does padded headgear prevent head injury rugby union football? Med. Sci Sports Exerc. 2009;41(2):306–13. doi:10.1249/MSS.0b013e3181864bee.
  • McIntosh A, McCrory P. Effectiveness of headgear in a pilot study of under 15 rugby union football. Br J Sports Med. 2001;35:167–69. doi:10.1136/bjsm.35.3.167.
  • Belanger H, Vanderploeg R, McAllister T. Subconcussive blows to the head: A formative review of short-term clinical outcomes. J. Head Trauma Rehabil. 2016; 31(3) p. 159–66; Online Nov 12, 2015.
  • Baugh C, Kiernan P, Kroshus E, Danshvar D, Montenigro P, McKee A, Stern R. Frequency of head-impact-related outcomes by position in NCAA Division 1 collegiate football players. J Neurotrau. 2015;32:1–13. doi:10.1089/neu.2014.3582.
  • Marciano P, Eberwine J, Ragupathi R, Saatman K, Meaney D, McIntosh T. Expression profiling following traumatic brain injury: A review. Neurochem Res. 2002;27(10):1147–55. doi:10.1023/A:1020973308941.
  • Xiong Y, Mahmood A, Chopp M. Animal models of traumatic brain injury. Nat Rev Neuro. 2013;14:128–42. doi:10.1038/nrn3407.
  • Zhang Z, Larner S, Kobiessy F, Hayes R, Wang KK. Systems biology and theranostic approach to drug discovery and development to treat traumatic brain injury. In: Yan Q, Editor. Systems biology in drug discovery and development: methods and protocols, methods in molecular biology. Springer Science; New York, NY, USA, 2010.
  • Shohami E, Gallily R, Mechoulam R, Bass R, Ben-Hur T. Cytokine production in the brain following closed head injury: dexanbinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant. J Neuroimmunol. 1997;72(2):169–77. doi:10.1016/S0165-5728(96)00181-6.
  • Baskaya M, Rao A, Dogan A, Donaldson D, Dempsey R. The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats. Neurosci Lett. 1997;226(1):33–36. doi:10.1016/S0304-3940(97)00239-5.
  • Van Geel WJA, Rosengren LE, Verbeek MM. An enzyme immunoassay to quantify neurofilament light chain in cerebrospinal fluid. J Immunol Methods. 2005;296:179–85. doi:10.1016/j.jim.2004.11.015.
  • Metting Z, Wilczak N, Rodiger LA, Schaaf J, Van Der Naalt J. GFAP and S100B in the acute phase of mild traumatic brain injury. Neurology. 2012;78:1428–33. doi:10.1212/WNL.0b013e318253d5c7.
  • Welch R, Ellis M, Lewis L, Ayaz S, Mika V, Millis S, Papa L. Modeling the kinetics of serum glial fibrillary acidic protein, ubiquitin carboxyl-terminal hydrolase-L1, and S100B concentrations in patients with traumatic brain injury. J Neurotrau. 2016;33:203–14. Dec 28 2016 Epub ahead of print. doi:10.1089/neu.2015.4149.
  • Kamphuis W, Mamber C, Moeton M, Kooijman L, Sluijs J, Jansen A, Verveer M, De Groot L, Smith V, Rangarajan S, et al. GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer Disease. PLoS ONE. 2012;7(8):e42823. doi:10.1371/journal.pone.0042823.
  • Broshek D, Kaushik T, Freeman J, Erlanger D, Webbe F, Barth J. Sex differences in outcome following sports-related concussion. J Neurosurg. 2012;102:856–63. doi:10.3171/jns.2005.102.5.0856.
  • Covassin T, Schatz P, Swanik B. Sex differences in neuropsychological function and post-concussion symptoms of concussed collegiate athletes. Neurosurgery. 2007;61(2):345–51. doi:10.1227/01.NEU.0000279972.95060.CB.
  • Frommer L, Gurka K, Cross K, Ingersoll C, Comstock R, Saliba S. Sex differences in concussion symptoms of high school athletes. J Athl Train. 2011;46(1):76–84. doi:10.4085/1062-6050-46.1.76.
  • Mychasiuk R, Hehar H, Ma I, Esser MJ. Dietary intake alters behavioural recovery and gene expression profiles in the brain of juvenile rats that have experienced a concussion. Front Behav Neurosci. 2015;9(Article 17):1–16. doi:10.3389/fnbeh.2015.00017.
  • Mychasiuk R, Hehar H, Ma I, Kolb B, Esser MJ. The development of lasting impairments: A mild pediatric brain injury alters gene expression, dendritic morphology, and synaptic connectivity in the prefrontal cortex of rats. Neuroscience. 2015;288:145–55. doi:10.1016/j.neuroscience.2014.12.034.

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