Suppression of Retinal Neovascularization by shRNA Targeting HIF-1α

REFERENCES

• Arjamaa O, Nikinmaa M. Oxygen-dependent diseases in the retina: Role of hypoxia-inducible factors. Exp Eye Res 2006; 83: 473–483
   PubMed Web of Science ®Google Scholar
• Bandello F, Brancato R, Menchini U, Virgili G, Lanzetta P, Ferrari E, Incorvaia C. Light panretinal photocoagulation (LPRP) versus classic panretinal photocoagulation (CPRP) in proliferative diabetic retinopathy. Semin Ophthalmol 2001; 16: 12–18
   PubMedGoogle Scholar
• Semenza G L. HIF-1: Mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 2000; 88: 1474–1480
   PubMed Web of Science ®Google Scholar
• Afzal A, Shaw L C, Ljubimov A V, Boulton M E, Segal M S, Grant M B. Retinal and choroidal microangiopathies: Therapeutic opportunities. Microvasc Res 2007; 74: 131–144
   PubMedGoogle Scholar
• Semenza G L, Wang G L. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992; 12: 5447–5454
   PubMed Web of Science ®Google Scholar
• Vengellur A, Woods B G, Ryan H E, Johnson R S, LaPres J J. Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor-1α null mouse embryonic fibroblasts. Gene Expr 2003; 11: 181–197
   PubMed Web of Science ®Google Scholar
• Zhu H, Bunn H F. Signal transduction. How do cells sense oxygen?. Science 2001; 292: 449–451
   PubMedGoogle Scholar
• Li H, Ko H P, Whitlock J P. Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF-1α. J Biol Chem 1996; 271: 21262–21267
   PubMed Web of Science ®Google Scholar
• Ozaki H, Yu A Y, Della N, Ozaki K, Luna J D, Yamada H, Hackett S F, Okamoto N, Zack D J, Semenza G L, Campochiaro P A. Hypoxia inducible factor-1α is increased in ischemic retina: Temporal and spatial correlation with VEGF expression. Invest Ophthalmol Vis Sci 1999; 40: 182–189
   PubMed Web of Science ®Google Scholar
• Wenger R H. Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. Faseb J 2002; 16: 1151–1162
   PubMed Web of Science ®Google Scholar
• Yoshida D, Kim K, Noha M, Teramoto A. Hypoxia inducible factor-1α regulates of platelet-derived growth factor B in human glioblastoma cells. J Neurooncol 2006; 76: 13–21
   PubMedGoogle Scholar
• Semenza G L. HIF-1: Using two hands to flip the angiogenic switch. Cancer Metast Rev 2000b; 19: 59–65
   PubMed Web of Science ®Google Scholar
• Robinson G S, Pierce E A, Rook S L, Foley E, Webb R, Smith L E. Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy. Proc Natl Acad Sci USA 1996; 93: 4851–4856
   PubMed Web of Science ®Google Scholar
• Reich S J, Fosnot J, Kuroki A, Tang W, Yang X, Maguire A M, Bennett J, Tolentino M J. Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. Mol Vis 2003; 9: 210–216
   PubMed Web of Science ®Google Scholar
• Shen J, Samul R, Silva R L, Akiyama H, Liu H, Saishin Y, Hackett S F, Zinnen S, Kossen K, Fosnaugh K, Vargeese C, Gomez A, Bouhana K, Aitchison R, Pavco P, Campochiaro P A. Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1. Gene Ther 2006; 13: 225–234
   PubMed Web of Science ®Google Scholar
• Bainbridge J W, Mistry A, De Alwis M, Paleolog E, Baker A, Thrasher A J, Ali R R. Inhibition of retinal neovascularization by gene transfer of soluble VEGF receptor sFlt-1. Gene Ther 2002; 9: 320–326
   PubMed Web of Science ®Google Scholar
• Elbashir S M, Lendeckel W, Tuschl T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev 2001; 15: 188–200
   PubMed Web of Science ®Google Scholar
• Brummelkamp T R, Bernards R, Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science 2002; 296: 550–553
   PubMed Web of Science ®Google Scholar
• Smith L E, Wesolowski E, McLellan A, Kostyk S K, D'Amato R, Sullivan R, D'Amore P A. Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci 1994; 35: 101–111
   PubMed Web of Science ®Google Scholar
• Rosenfeld P J, Rich R M, Lalwani G A. Ranibizumab: Phase III clinical trial results. Ophthalmol Clin North Am 2006; 19: 361–372
   PubMedGoogle Scholar
• Agrawal N, Dasaradhi P V, Mohmmed A, Malhotra P, Bhatnagar R K, Mukherjee S K. RNA interference: Biology, mechanism, and applications. Microbiol Mol Biol Rev 2003; 67: 657–685
   PubMed Web of Science ®Google Scholar
• Reynolds A, Leake D, Boese Q, Scaringe S, Marshall W S, Khvorova A. Rational siRNA design for RNA interference. Nat Biotechnol 2004; 22: 326–330
   PubMed Web of Science ®Google Scholar
• Masuda I, Matsuo T, Yasuda T, Matsuo N. Gene transfer with liposomes to the intraocular tissues by different routes of administration. Invest Ophthalmol Vis Sci 1996; 37: 1914–1920
   PubMed Web of Science ®Google Scholar
• Dorrell M I, Aguilar E, Scheppke L, Barnett F H, Friedlander M. Combination angiostatic therapy completely inhibits ocular and tumor angiogenesis. Proc Natl Acad Sci USA 2007; 104: 967–972
   PubMed Web of Science ®Google Scholar